The purpose of this study was to compare single-cycle axial load and stiffness between inverted triangle and vertical configurations of three Kirschner wires (K-wires) for femoral neck fracture fixation in small dog cadaveric models. In each of the eight cadavers, the basilar femoral neck fracture model was prepared on both sides of the femur. One side of the femur was stabilized with three 1.0 mm K-wires of an inverted triangle configuration (group T), and the other femur was stabilized with a vertical configuration (group V). Postoperatively, the placement of the K-wires was evaluated with radiographic and computed tomography (CT) images, and static vertical compressive loading tests were performed. The mean yield load and the lateral spread were significantly higher in group T compared to group V (p = 0.023 and <0.001). On the cross-section of femoral neck at the level of the fracture line, the surface area between K-wires was significantly larger (p < 0.001) and the mean number of cortical supports was significantly higher in group T (p = 0.007). In this experimental comparison, the inverted triangle configuration of three K-wires was more resistant to failure under axial loading than the vertical configuration for canine femoral neck fracture fixation.