Mean Visceral Adiposity Index Research Articles

Association of sleep duration with Visceral Adiposity Index: a cross-sectional study based on the NHANES 2007–2018

ObjectiveWe aimed to assess the associations between sleep duration and Visceral Adiposity Index (VAI).DesignCross-sectional study.SettingThe National Health and Nutrition Examination Survey (2007–2018).ParticipantsA total 11 252 eligible participants who have complete...

Association of visceral adiposity index with cardiovascular risk factors among young adults

Introduction and Aim: The frequent cause of mortality today is cardiovascular disease. Though dyslipidemia predicts cardiovascular risk, the possibility of risk cannot be excluded in normal lipid profile. Therefore, the study was conducted to associate visceral adiposity index (VAI) with cardiovascular risk factors among young adults. Materials and Methods: It is a cross-sectional study in which 150 men and 150 women between the ages of 20 and 40 participated. A detailed clinical history, anthropometric measurements, fasting plasma glucose and fasting lipid profile were estimated. VAI was calculated. Results: Mean VAI was 2.13±0.5 in men and 2.65±0.8 in women. Based on visceral adiposity index, 53% men and 61% women have a high risk of cardiovascular disease. VAI correlated positively with waist circumference, BMI, waist hip ratio, blood pressure, fasting plasma glucose, serum triglyceride, lipid ratios. VAI showed significant negative correlation with HDL cholesterol. Conclusion: We explored the increase in cardiovascular risk among young adults. Though mean values of lipid profile and lipid ratios were within the desired range in our study, around 50% of the young adults had high risk for cardiovascular disease. Hence, VAI index can be used along with the existing lipid profile to identify those at increased cardiovascular risk.

The Impact of Visceral Adiposity on Testosterone Levels in American Adult Men: A Cross-Sectional Analysis.

BACKGROUND Testosterone decline and deficiency importantly affect men's health, and may be associated with excessive deposition of visceral adipose tissue. This study was conducted to explore the association between visceral adiposity index (VAI) and testosterone level. MATERIAL AND METHODS A total of 1551 participants from the NHANES 2013-2013 cycle and 2015-2016 cycle were selected for our analyses. The VAI index was calculated based on waist circumference (WC), body mass index (BMI), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-c), and serum testosterone was measured by isotope dilution liquid chromatography tandem mass spectrometry. Multivariable adjusted linear and logistic regression were utilized to investigate the associations between VAI index and testosterone level and testosterone deficiency, respectively. Additionally, subgroup analyses were performed to identify sensitive populations. RESULTS A total of 1551 participants with mean VAI index of 1.95±0.08 were eligible for our analysis. After adjusting for all potential cofounders, men with higher VAI index displayed a lower level of total testosterone level (ß: -11.74, 95% CI: -17.33, -6.15, P<0.0001), and higher risk of testosterone deficiency (OR: 1.24, 95% CI: 1.09, 1.40, P=0.0022). Comparing to VAI quartile 1, quartile 4 showed the most decreased testosterone level (ß: -94.59, 95% CI: -130.04, -59.14, P<0.0001), and highest risk of testosterone deficiency (OR: 5.07, 95% CI: 2.41,10.63, P<0.0001). Subgroup analysis demonstrated that VAI index was strongly related to testosterone level and testosterone deficiency in aged and obese men. CONCLUSIONS Men with higher VAI index displayed lower testosterone levels and higher risk of testosterone deficiency, especially in aged men and obese men.

A cross-sectional analysis of association between visceral adiposity index and serum anti-aging protein Klotho in adults.

The visceral adiposity index (VAI) is regarded as a reliable indicator to assess body fat distribution and dysfunction. Klotho protein is a hormone with anti-aging biological functions. However, the relationship between them has not been researched. This study aimed to evaluate the association between VAI and serum anti-aging protein klotho in American adults. A cross-sectional study of participants was conducted based on the National Health and Nutrition Examination Surveys (NHANES) 2007-2016. Visceral adiposity was determined using the VAI score, while the klotho protein concentration was measured by ELISA kit. After adjusting some possible confounding variables, multivariate regression model was conducted to estimate the relationship between VAI and klotho protein. Furthermore, the smooth curve fitting and the segmented regression model were applied to examine the threshold effect and to calculate the inflection point. In total, 6 252 adults were eligible, with a mean VAI of 2.04 ± 0.03 and a mean klotho protein concentration of 848.79 ± 6.98 pg/ml. Multivariate regression analysis indicated that serum klotho protein concentration was lower in participants with high VAI score. When VAI was divided into quartiles, participants in the fourth quartiles of higher VAI had lower klotho protein levels (Q4: -32.25 pg/ml) than participants in the lowest quartile (Q1) after full adjustment (P < 0.05). Segmented regression suggested that the turning point value of VAI was 3.21.A 1-unit increase in VAI was significantly associated with lower klotho protein levels by -18.61 pg/ml (95% CI: -28.87, -8.35; P < 0.05) when VAI ranged from 0.29 to 3.21(accounting for 83.7% of the participants), however, the association was not significant when VAI ranged from 3.21 to 11.81 (P = 0.77). There was a nonlinear correlation between VAI score and the serum anti-aging protein klotho concentrations, showing a saturation effect. When VAI was less than 3.21, they were negatively correlated, and when VAI was greater than 3.21, they had no obvious correlation.

The visceral adiposity index and lipid accumulation product as predictors of cardiovascular events in normal weight subjects.

Visceral adipose tissue (VAT) has an important role in the incidence of cardiovascular disease (CVD) than obesity by itself. The visceral adiposity index (VAI) and lipid accumulation product (LAP) are surrogate indices for measuring VAT. The aimed of this study was to investigate the association of these markers with cardiovascular events among populations with different BMI category in Mashhad, northeast of Iran. The present study comprised a prospective cohort of 9685 men and women (35-65 years) who were recruited from MASHAD study. BMI category was defined as normal weight (BMI <25), over weight (25≤BMI<30) and obese (BMI≥30). Demographic, laboratory evaluations, anthropometric and metabolic parameters were performed. Logistic and Cox regression analyses were used to determine the association and risk of cardiovascular events with VAT and LAP. The mean VAI and LAP in CVD patients were significantly higher than in healthy ones in all 3 groups. In terms of CVD event prediction, VAI and LAP had significant association with the incidence of CVD in the second (RR (95% CI): 2.132 (1.047-4.342) and 2.701 (1.397-5.222), respectively) and third tertiles (RR (95% CI): 2.541 (1.163-5.556) and 2.720 (1.159-6.386), respectively) in the normal group, but this association was only found in the third tertiles (RR (95% CI): 2.448 (1.205-4.971) and 2.376 (1.086-5.199), respectively) in the overweight group. The result couldn't find this association for the obese group. In this study, we found that there was a significant association between LAP and VAI and cardiovascular events in normal weight and over-weight groups; however, no significant relationship was found in the obese group.

Abstract #1167463: Abnormal Visceral Adiposity Index among Females with Polycystic Ovarian Syndrome and its association with Phenotypes and Cardiometabolic risk

Polycystic ovarian syndrome (PCOS) is a frequently encountered endocrine disorder in females of reproductive age. Visceral adiposity index (VAI) is indicative of visceral adiposity and dysfunction. The study aimed to evaluate the visceral adiposity index (VAI) and its association with cardiometabolic risk in females with PCOS. This case-control study was done on 100 females diagnosed with PCOS as per Rotterdam's criteria and 50 age and body mass index (BMI) matched controls. Patients were studied for clinical characteristics, anthropometric, biochemical and hormonal investigations and ultrasound scans. Participants were classified into different phenotypes of PCOS. VAI was calculated using waist circumference (WC), BMI, serum triglyceride (TG), and High-density lipoprotein (HDL) cholesterol levels. The mean age of the subjects with PCOS was 28.8±10.6 years, whereas that of controls was 27.6±9.2 years. The phenotype D of PCOS was predominant form 47%, followed by phenotype C, A and B in 31%, 15% and 7%, respectively. Mean VAI was significantly higher in females with PCOS than controls (2.90 vs. 1.84) (P < 0.001). Mean VAI in phenotype A, B, C, and D was 3.46, 2.48, 2.37, and 1.98, respectively. Metabolic syndrome was prevalent in 28%. A total of 44% of women with PCOS were at risk and 32% at high risk for cardiometabolic disease. VAI was significantly associated with obesity, WC, hirsutism, phenotype A, plasma glucose, testosterone, TG and polycystic ovarian morphology. Logistic regression analysis showed that VAI positively correlated with obesity, WC, phenotype A and testosterone. VAI can be used as a simple and effective tool for assessing the cardiometabolic risk in females with PCOS. VAI had a positive correlation with serum testosterone.

Visceral adiposity index is associated with arterial stiffness in hypertensive adults with normal-weight: the china H-type hypertension registry study

BackgroundLimited information is available on arterial stiffness risk among hypertensive patients with metabolically abnormal but normal weight. Visceral adiposity index (VAI) is a novel indicator for visceral fat mass and metabolism, however, whether can be used to assessed arterial stiffness in a normal-weight population remains unclear. The goal of this study was to examine the independent association of VAI with arterial stiffness in normal-weight hypertensive patients.Methods3258 participants recruited from the China H-type Hypertension Registry Study. VAI value was calculated using sex-specific equations. High arterial stiffness was defined as baPWV ≥ 18 m/s. Multivariable regression analysis was used to identify the association of VAI with baPWV and high arterial stiffness.ResultsOf participants, 50.5% (1644) were males, the mean age was 65.5 (SD, 9.1) years. Mean VAI and baPWV were 2.0 (SD, 2.3) and 18.2 (SD, 3.9) m/s, respectively. For each unit increase of lg VAI in multivariable regression analysis, there was a 1.05 m/s increase in baPWV (95% CI 0.67, 1.43) and a 2.13-fold increase in the risk of high arterial stiffness (95% CI 1.59, 2.86). In all models, the VAI was consistently and significantly associated with baPWV after adjustment for different confounders. High VAI levels were stably associated with baPWV in all subgroups.ConclusionsWe found positive association of VAI with baPWV and high arterial stiffness in normal-weight adults with hypertension. The establishment of this association could help the arterial stiffness risk stratification in normal-weight hypertensive populations, who are frequently overlooked in preventing cardiovascular disease.

Association between Visceral Adiposity Index, Binge Eating Behavior, and Grey Matter Density in Caudal Anterior Cingulate Cortex in Severe Obesity.

Visceral adipose tissue accumulation is an important determinant of metabolic risk and can be estimated by the visceral adiposity index (VAI). Visceral adiposity may impact brain regions involved in eating behavior. We aimed to examine the association between adiposity measurements, binge eating behavior, and grey matter density. In 20 men and 59 women with severe obesity, Grey matter density was measured by voxel-based morphometry for six regions of interest associated with reward, emotion, or self-regulation: insula, orbitofrontal cortex, caudal and rostral anterior cingulate cortex (ACC), ventromedial prefrontal cortex (vmPFC), and dorsolateral prefrontal cortex (DLPFC). Binge eating behavior, depression and impulsivity was assessed by the Binge Eating Scale, Beck Depression Inventory and UPPS Impulsive Behavior Scale, respectively. Men and women were distinctively divided into two subgroups (low-VAI and high-VAI) based on the mean VAI score. Women with high-VAI were characterized by metabolic alterations, higher binge eating score and lower grey matter density in the caudal ACC compared to women with low-VAI. Men with high-VAI were characterized by a higher score for the sensation-seeking subscale of the UPPS–Impulsive Behavior Scale compared to men with low-VAI. Using a moderation–mediation analysis, we found that grey matter density in the caudal ACC mediates the association between VAI and binge eating score. In conclusion, visceral adiposity is associated with higher binge eating severity in women. Decreased grey matter density in the caudal ACC, a region involved in cognition and emotion regulation, may influence this relationship.

Visceral Adiposity Index and its Correlation with other Anthropometric Indicators of Obesity in a group of Bangladeshi Patients with Acute Coronary Syndrome

Background: The visceral adiposity index (VAI) is proposed as a substitute marker of dysfunction and distribution of adipose tissue and is found to be independently correlated with cardiometabolic risk associated with visceral obesity. However, VAI is not well studied in Bangladeshi population. Objectives: This study was aimed to determine the visceral adipose dysfunction (VAD) based on VAI in a group of patients with Acute Coronary Syndrome (ACS) admitted in a tertiary care hospital of Bangladesh and also to determine the correlation of VAI with other anthropometric indicators of obesity. Methods: This descriptive cross-sectional study was conducted on 96 admitted patients of ACS at the Department of Cardiology, Abdul Malek Ukil Medical College &amp; Hospital, Noakhali, Bangladesh from January 2019 to June 2019. Fasting serum lipid profile was obtained within 24 hours of hospitalization and demographic and anthropometric parameters [Body Mass Index (BMI), Waist Circumference (WC) and Waist to Height Ratio (WHtR)] were documented. VAI was calculated and VAD was determined for each patients. Results: The mean age of the subjects were 57.7±14.4 years with majority (71.9%) being male. Based on BMI 50% patients were obese. 69.8% and 81.3% had central obesity based on WC and WHtR criteria respectively. Overall, mean VAI was high (7.48±2.85) and significantly higher in female than male (8.83±2.89 versus 6.95±2.67; p=0.003). All patients had VAD. WHtR had significant positive correlation with VAI (r=0.338; p=0.001). Conclusion: VAD was highly prevalent in this group of ACS patients and WHtR was better than WC and BMI to measure the visceral fat.

Impact of high visceral adiposity index associated with metabolic syndrome on erectile function in sexually active men: Results of a cross-sectional study.

Erectile dysfunction (ED) is a common condition affected by many factors. We aimed to show the impact of the metabolic syndrome (MeTS) on male sexual function based on visceral adiposity index (VAI). Participants who met MeTS criteria (Group 1, n=96) and did not meet MeTS criteria (Group 2, n=189) were included in this cross-sectional study. The MeTS diagnosis was made in the presence of at least 3 of the following criteria: fasting serum glucose level higher than 100 mg/dL, HDL cholesterol level below 40 mg/dL, triglyceride level higher than 150 mg/dL, waist circumference higher than 102 cm and blood pressure higher than 130/85 mmHg. Demographic data were recorded; biochemical and hormonal tests were measured. Erectile and other sexual function scores were recorded. The VAI was calculated using the [(Waist Circumference/39.68) + (1.88 × body mass index)] × triglyceride/1.03 × 1.31/HDL formula. Mean age, smoking volume, testosterone (T) and testosterone/estradiol (T/E2 ) ratios of the groups were similar (P>.05). The mean VAI was two-fold higher in patients in Group 1 (P<.001) and erectile function score was lower in Group 1 than Group 2 (P=.001). Other sexual function scores were similar (P>.05). The METS was associated with an increased risk of ED (P=.001). Logistic regression analysis showed that each integer increase in the VAI was associated with a 1.4-fold increased risk of ED (P<.001). Higher T values were associated with a better erectile function (P=.03). For the VAI=4.33, receiver-operating characteristic analysis showed a sensitivity of 89.6% and specificity of 57.7%. Compared with non-MeTS, the presence of MeTS has emerged as a risk factor for patients with ED with high VAI levels while the other sexual functions are preserved. Management of ED patients with MeTS should cover a comprehensive metabolic and endocrinological evaluation in addition to andrological work up.

Effects of oral contraceptives on serum concentrations of adipokines and adiposity indices of women with polycystic ovary syndrome: a randomized controlled trial.

To compare the effects of oral contraceptives (OCs) with different progestins, including Levonorgestrel (LNG), Desogestrel (DSG), Cyproterone Acetate (CPA), and Drospirenone (DRSP) on adipokines levels and adiposity indices in women with polycystic ovary syndrome (PCOS). In this parallel randomized clinical trial, 120 women with PCOS randomly assigned to intervention with OCs containing LNG, DSG, CPA, or DRSP. Outcomes of interest, including serum concentrations of adiponectin, leptin, and resistin, and adiposity indices, i.e., body mass index (BMI), waist circumference (WC), obesity, central obesity, waist to hip ratio (WHR), waist to height ratio (WHtR), lipid accumulation product (LAP), a body shape index (ABSI), body roundness index (BRI), and visceral adiposity index (VAI), and lipid profiles were assessed at baseline, and 6months of treatment. This study showed no significant differences in serum concentrations of adipokines between the four study groups after 6months of treatment. Our results also showed that patients treated with various compounds of OC for 6months had no significant differences in their adiposity indices, except for LAP (p = 0.04), and VAI (p = 0.03). PCOS patients treated with OCs containing CPA had significantly a higher mean LAP, compared to those using products containing LNG. Besides, patients treated with OCs containing CPA had significantly a higher mean VAI, compared to those treated with OCs containing DRSP. This study demonstrated that OCs with low androgenic and antiandrogenic activities had identical effects on serum concentrations of adipokines, and adiposity indices, except LAP, and VAI parameters. IRCT20080929001281N3.

P0749THE ASSOCIATION OF VISCERAL ADIPOSITY INDEX WITH PROGRESSION OF CHRONIC KIDNEY DISEASE

Abstract Background and Aims Obesity is becoming an important health problem as its prevalence is increasing. Obesity is also a factor that causes an increase in chronic kidney disease (CKD) cases by facilitating the development of diabetes and hypertension, which leads to CKD, and by a direct effect on the kidney and endocrine mechanism. Obesity is generally defined by body mass index (BMI), which is not a good indicator for visceral adipose tissue (VAT), as visceral fat has been shown to be more metabolically active. A new method called the visceral adiposity index (VAI) has been developed, which is considered to be an indicator for the metabolic function of VAT. Previous studies have confirmed the association between the VAI and CKD prevalence. In this study, we attempted to investigate the association between estimated glomerular filtration rate (eGFR) decline and visceral adiposity. Method Data were collected from 129 patients aged 18-80 years with stage 2-5 CKD and not on dialysis; these patients were followed up in the Nephrology Department of Usak University Hospital between December 2017 and November 2018. Results Of 129 patients with stage 2-5 CKD enrolled in this study, 64 (40.6%) were females and 66 (59.4%) were males. The mean age was 66.8 (35-80 years). The mean VAI values of patients were 2.86±1.63, and the mean eGFR decline was -12.8±19.0 ml/min/1.73m2. No correlation was observed between the VAI values and decline in eGFR in 1 year. Patients with DM had statistically significant higher eGFR decline (p=0.04) and higher VAI values (p=0.03). Conclusion The VAI, which is used to assess the metabolic function of VAT, was not associated with the eGFR decline in 1 year for patients with stage 2-5 CKD.

Association between coronary atherosclerosis and visceral adiposity index

Background and aimsVisceral obesity is a marker of dysfunctional adipose tissue and ectopic fat infiltration. Many studies have shown that visceral fat dysfunction has a close relationship with cardiovascular disease. For a better identification of visceral adiposity dysfunction, the visceral adiposity index (VAI) is used. Coronary artery calcium score (CACS) is known to have a strong correlation with the total plaque burden therefore provides information about the severity of the coronary atherosclerosis. CACS is a strong predictor of cardiac events and it refines cardiovascular risk assessment beyond conventional risk factors. Our aim was to evaluate the association between VAI and CACS in an asymptomatic Caucasian population. Methods and resultsComputed tomography scans of 460 participants were analyzed in a cross-sectional, voluntary screening program. A health questionnaire, physical examination and laboratory tests were also performed. Participants with a history of cardiovascular disease were excluded from the analysis. Mean VAI was 1.41 ± 0.07 in men and 2.00 ± 0.15 in women. VAI showed a positive correlation with total coronary calcium score (r = 0.242) in males but not in females. VAI was stratified into tertiles by gender. In males, third VAI tertile was independently associated with CACS>100 (OR: 3.21, p = 0.02) but not with CACS>0 after the effects of conventional risk factors were eliminated. ConclusionVAI tertiles were associated with calcium scores and the highest VAI tertile was an independent predictor for the presence of CACS>100 in males but not in females.

Assessment of cardiovascular risk in post-menopausal women in Ghana

Background: Cardiovascular diseases (CVD) continue to be a major cause of death among post-menopausal women. We sought to assess cardiovascular risk among pre- and post-menopausal women living within the Cape Coast Municipality by comparing the lipid profiles and other emerging biomarkers of CVD, i.e. the atherogenic index of plasma (AIP), visceral adiposity index (VAI), body adiposity index (BAI) and Castelli index I (CRI-I). Methods: A comparative cross-section of 150 women (75 pre-menopausal women and 75 post-menopausal women) visiting the University of Cape Coast hospital for regular checkups were randomly recruited into the study. Socio-demographic and clinical characteristics of participants were obtained with the aid of a structured questionnaire. Blood pressure (BP) was measured and lipid profile was estimated using fasting blood samples. Other markers of cardiovascular risk such as BMI, AIP, VAI, BAI and CRI-I were estimated. Results: We report elevated levels of total cholesterol (TC) (p&lt;0.0001), low density lipoprotein (LDL) (p&lt;0.0001), very low-density lipoprotein (VLDL) (p=0.0021), triglycerides (TG) (p&lt;0.0001) and non-high-density lipoprotein (non-HDL-C) cholesterol (p&lt;0.0001) in post-menopausal women compared with pre-menopausal women. High-density lipoprotein (HDL) (p&lt;0.0001) was, however, decreased in post-menopausal women. Mean AIP (p&lt; 0.0001), VAI (p&lt; 0.0001), BAI (p&lt; 0.0038) and CRI-I (p&lt;0.0001) were significantly increased in post-menopausal women compared to pre-menopausal women. We also report a positive correlation of TC, TG, VLDL and non-HDL with atherogenic markers AIP, VAI and CRI-I in post-menopausal women. A negative correlation of HDL with AIP, VAI, and CR in post-menopausal women was also observed. Conclusions: Menopause could lead to changes in lipid profile to atherogenicity with associated increase in the risk of CVD. Atherogenic markers such as AIP, VAI, BAI, and CR can serve as potential biomarkers for predicting CVD.

Trend of various adiposity indices in women with and without history of gestational diabetes: a population-based cohort study

BackgroundData of studies focusing on the trends of adiposity indices among women with prior gestational diabetes mellitus (GDM), are limited and controversial. The aim of this study was to compare overtime trends of adiposity indices in women with and without history of GDM, using data of the long term longitudinal population-based Tehran-Lipid and Glucose-Study (TLGS).MethodsA total of 3395 eligible women aged (20–50 years), including 801 women with prior history of GDM and 2594 non-GDM controls were recruited from among Tehran-Lipid and Glucose-Study participants. Generalized estimating equations were applied to assess the time trend of adiposity indices including obesity, central obesity, body mass index (BMI), lipid accumulation product index (LAP), visceral adiposity index (VAI) and a body shape index (ABSI) in women with prior GDM and the non-GDM groups after further adjustment for age and BMI.ResultsMedian follow-up years for the GDM and non-GDM groups were 12.12 and 11.62 years, respectively. Women with GDM at initiation had worse adiposity indices than their healthy counterparts. While overall odds of obesity in women with prior GDM were significantly higher those of the non-GDM groups (OR: 1.35; 95% CI, 1.03–1.7; P = 0.03), both these groups overtime revealed a positive trend in obesity (P trend < 0.001), an incremental trend which was less pronounced in GDM women (OR: 0.87; 95% CI, 0.80, 0.95; P interaction = 0.001). Women with prior GDM had higher odds of central obesity, compared to non-GDM groups (OR: 1.44; 95% CI, 1.06–1.96; P = 0.02) and showed a significant an incremental trend overtime for both groups (P trend < 0.001 for both) without statistically significant interaction in terms of their GDM status (P interaction = 0.134). Mean VAI in women with prior GDM was significantly higher than the non-GDM group (19.7, 95%CI: 6.24, 33.15, P = 0.004), although both groups overtime experienced a negative trend (− 10.9, 95%CI: -13.1, − 2.1, P < 0.001); the GDM group showed a higher decrease in VAI (mean changes: -6.62; 95% CI, − 11,-2.1; P interaction = 0.001). However overtime there was a positive trend in LAP and ABSI among both women with and without prior-GDM, though the mean changes were less obvious in women with prior GDM.ConclusionWomen with prior GDM gained better control of their adiposity than non-GDM women. Nevertheless the increasing numbers of individuals with GDM and uncontrolled adiposity indices, require prompt attention be paid to the issue.

Visceral Adiposity Index: Simple Tool for Assessing Cardiometabolic Risk in Women with Polycystic Ovary Syndrome.

Aim:To study visceral adiposity index (VAI) and its association with cardiometabolic risk in different phenotypes of polycystic ovary syndrome (PCOS).Materials and Methods:It is a case–control cross-sectional study where 100 reproductive age (18–35 years) women with PCOS were classified in different phenotypes as per Rotterdam criteria and compared with age and Body mass index (BMI) matched 50 eumenorrheic and nonhirsute women. Various anthropometric, clinical, biochemical, and hormonal parameters were measured in both women with PCOS and controls. VAI was calculated using waist circumference (WC), BMI, serum triglyceride, and High density lipoprotein (HDL) cholesterol levels in all the subjects and compared between cases and controls. Subsequently, women with PCOS were assessed for cardiometabolic risk according to androgen excess society statement 2010 as “at risk” and “at high risk.” Finally, risk was correlated with VAI for all the phenotypes of PCOS.Results:Mean VAI was significantly higher (P < 0.001) in cases than controls (2.07 vs. 1.27). Mean VAI in phenotype A (O+P+HA), B (O+HA), C (P+HA), and D (O+P) was 2.46, 2.48, 1.47, and 1.70, respectively. A total of 56% of women with PCOS were at risk and 12% at high risk for cardiometabolic disease. Metabolic syndrome was prevalent in 11% of cases and 1% had type 2 diabetes mellitus. Phenotypically, 88% of women with PCOS with phenotype A (O+P+HA), 67% of B (O+HA), 67% of C (P+HA), and 55% of D (O+P) were at increased risk. VAI was found to be positively correlated with WC (r, 0.550), waist to hip ratio (r, 0.295), Homeostasis model assessment of insulin resistance (HOMA IR) (r, 0.455), and cardiometabolic risk (r, 0.399). Also, it was the best factor associated with cardiometabolic risk (area under curve, 0.793).Conclusion:This study concluded that visceral adiposity index can be used as simple and effective tool for assessing the cardiometabolic risk in women with PCOS as higher VAI values were observed in those cases who were at high risk for developing cardiometabolic disorder in future.

Visceral adiposity index is associated with premature ejaculation inversely: a cross-sectional study

Objective: Visceral adiposity index (VAI) is a novel indicator for the assessment of visceral obesity. In this study, we aimed to evaluate the relationship between VAI and premature ejaculation (PE).Materials and method: A total of 300 men were included in the study. Hundred and fifty men with PE and 150 men without PE (control). All men were evaluated for PE by premature ejaculation diagnostic tool (PEDT). VAI levels were calculated using body mass index (BMI), high density lipoprotein and triglyceride (TG) levels.Results: Mean age of the study groups was 34.3 ± 5.2 (30–60) years and the mean age of the controls were 35.9 ± 5.3 (30–60) years. The men with PE had lower BMI, TG levels, waist circumference (WC) and higher high-density lipoprotein-cholesterol (HDL-C) levels. Mean VAI level was 4.13 ± 0.7 in study group and 5.72 ± 1.6 in control group, respectively. VAI levels were statistically higher in men without PE (p < .001).Discussion: Our cross-sectional study demonstrated a negative correlation between VAI and PE. VAI is superior index for the evaluation and calculation the relationship between obesity and PE.

Association of Visceral Adiposity Index Score with the Severity of Coronary Artery Disease in Patients with Ischemic Heart Disease

Background: Ischemic Heart Disease (IHD) is the leading cause of death throughout the world and obesity especially visceral adiposity (central obesity has significant influence for its development &amp; progression. Visceral adiposity index (VAI) is a novel sex specific index which had significant correlation with visceral adiposity.Objectives: To evaluate the impact of cut-off points of VAI defining visceral adipose dysfunction (VAD) on the angiographic severity of coronary artery disease in patients of IHD.Methods: A total of 100 patients with IHD were divided into Case (of which 50 patients of IHD with VAD positive) and Control group (of which 50 patients of IHD with VAD negative). Then clinical, biochemical, echocardiographic and coronary artery angiographic indexes (determined by Gensini score) were acquired in relation to VAI.Results: VAD positive group had more significant form of coronary artery disease in term of Gensini score than VAD negative group.The mean level of Visceral Adiposity Index (VAI) was observed 3.1±0.9 and 2.1±0.6 in significant CAD (Gensini score ?36) and insignificant CAD (Gensini score&lt;36) respectively. The difference of mean VAI between the significant and insignificant CAD groups were statistically significant (p=&lt;0.001). First group (VAD positive) also had more CAD risk factors like hypertension, diabetes mellitus and dyslipidemia which were significantly higher than second group (VAD negative) (p=0.02, 0.002, 0.01). Univariate and multivariate analysis revealed that out of the 8 variables hypertension, dyslipidemia, diabetes mellitus, waist circumference and visceral adiposity index were found to be the independently significant predictors of severe CAD patients with ORs being 1.61 vs. 1.52, 1.97 vs. 1.36, 2.19 vs. 1.97, 1.94 vs. 1.61 and 3.89 vs. 3.49 respectively. Thus the VAI was found to be more strong predictor of the severity of CAD.Conclusion: VAI is a simple indicator of visceral adipose mass &amp; was markedly associated with the severity of coronary artery disease in IHD patients.Bangladesh Heart Journal 2017; 32(1) : 36-39

Influencia de la actividad física y el consumo calórico sobre la adiposidad visceral en adultos de la ciudad de Cuenca, Ecuador

IntroductionThe visceral adiposity index (VAI) is a simple and cost effective method for the determination of visceral adiposity. The objective of this study is to evaluate the relationship between VAI and different cardiovascular risk factors, sociodemographic variables, and psychobiological habits in the adult population of the city of Cuenca, Ecuador. Materials and methodsA descriptive cross-sectional study was performed on 318 adult individuals selected by multistage random sampling, who underwent a clinical, anthropometric and laboratory evaluation. VAI was determined using the proposed formula that used abdominal circumference, body mass index, triglycerides, and HDL-Cholesterol. A multiple logistic regression model was used to determine the main factors associated with the highest values of visceral adiposity. ResultsThe mean VAI was 2.57 (1.66-3.94) in the 318 individuals studied, with higher values for females. In the multiple logistic regression model, significant risk factors for moderate-high VAI were: age (>60 years: OR=3.87, 95% CI: 1.15-12.96, P=.03), calorie intake, impaired fasting glucose, and leisure time physical activity. ConclusionVAI is a useful method to define those subjects with visceral adiposity in our region. Age, daily calorie intake, and impaired fasting glucose are the main factors associated with higher index values, while leisure time physical activity was a protective factor for classifying subjects in the more advanced stages.

Visceral Adiposity Index and pattern of dyslipidaemia at different stages of glucose intolerance—A study from India

AimTo see the pattern of dyslipidaemia and Visceral Adiposity Index (VAI) at different stages of glucose intolerance in Indian population. MethodsData of 600 subjects were considered for this analysis. Waist circumference and BMI were recorded. OGTT and lipid profile were done. Subjects were divided into three groups; Group 1 (Normoglycaemic), Group 2 (Prediabetes) and Group 3 (new DM). Subjects having one or more lipid parameters outside the targets recommended by ADA were considered to have dyslipidaemia. VAI, a sex-specific index, was calculated. ResultsLDL-C was the most common isolated single abnormality (84.5%), followed by HDL-C (58.7%) and triglycerides (49.7%) among the total subjects. 73% had high LDL-C and 56% had low HDL-C even in normoglycaemic subjects. LDL-C abnormality was similar in prediabetes and diabetes. Commonest combination of two abnormalities was seen mainly with LDL-C and HDL-C. Mean VAI increased at different stages of glucose intolerance and VAI≥2.3 gave sensitivity of 61.2% and specificity of 59.7% to detect glucose intolerance. ConclusionsThe most common single lipid abnormality was high LDL-C. Combination of two abnormalities was seen with LDL-C and HDL-C. VAI increased at different stages of glucose intolerance. These findings may be useful for targeting high-risk population.