Mean Values Of Total Cholesterol Research Articles

Effect of ethanolic leaves extract of Myrianthus arboreus on lipid profile of Wistar rats

This study investigated the effect of ethanolic leaves extract of Myrianthus arboreus on lipid profile of Wistar rats. A total of 24 albino Wistar rats divided into 8 groups of three rats each, were orally administered with DMSO as control and varying doses of 1500 mg/KgBw, 1000 mg/KgBw and 500 mg/KgBw for 7days and 14 days respectively. After 7 and 14 days groups 1-4 and 5-8 were sacrificed respectively. Blood samples and hearts of rats were collected for biochemical and histopathology investigations respectively. The result showed non-significant differences (p>0.05) in the mean values of total-cholesterol (T-Chol) and Low density lipoprotein-cholesterol (LDL-Chol.) in all the extract treated groups for 7 and 14 days when compared to mean control values. Mean values of triglyceride (Tg) and very low density lipoprotein-cholesterol (VLDL-Chol) significantly increased (p<0.05) in 1500 and 1000 mg/kgbw extract treated groups for 7days and decreased significantly (p<0.05) in 500 mg/kgbw for 14 days when compared with mean control values. The results also reveal a significant decrease (p<0.05) in the level of high density lipoprotein-cholesterolHDL-Chol) for groups treated 1500 1000 and 500 mg/kgbws for 14 days when compared with control. Phytochemical screening of the plant revealed the presence of alkaloids, flavonoids, glycosides, phenols, saponins and tannins with phenols and tannins having the highest and lowest concentrations of 1185.04 and 16.75 mg/100g respectively. The histopathology results showed normal histology of the heart tissues of animals in groups 1,3-8 while that of group 2 showed inflammation of the heart tissues. In conclusion, oral administration of ethanol leaves extract of Myrianthus arboreus is safe for the heart.

Level of biochemical parameters in patients with type 2 diabetes mellitus depending on the genotype of the FokI polymorphism in the vitamin D3 receptor (VDR gene).

Diabetes mellitus type 2 (T2DM) is a multifactorial and polygenic disorder characterised by chronic hyperglycaemia accompanied by impaired lipid, carbohydrate, and protein metabolism. The disease is associated with several genetic polymorphisms, including the FokI polymorphism in the vitamin D receptor (VDR) gene. We conducted a study of 327 probands (191 T2DM patients, 136 controls), with a mean age 65.06 (SD ± 10.88) years of patients with T2DM and 58.89 (SD ± 6.59) years in the healthy probands. We investigated the association between FokI polymorphism and biochemical parameters in T2DM patients in the Slovak population. Anthropometric measurements, biochemical, and genetic analysis were statistically evaluated by Statistica ver.13 software using t-tests. Biochemical analysis confirmed significantly higher mean values of total cholesterol (TC), triglyceride (TG), glucose (GLU), and uric acid (UA) (p < 0.001) in T2DM probands and statistically significantly lower values of high-density lipoprotein (HDL), cholesterol and vitamin D (p < 0.001). Allele frequencies and genotype distributions of the FokI (rs2228570) polymorphism were not significantly different between T2DM patients and controls (p = 0.909). Patients with T2DM and TT genotype had the highest glucose level of 11.39 (SD ± 2.32) uU/ml (p < 0.001). Our study did not provide evidence for an association of the investigated FokI polymorphism of the VDR gene with T2DM in the Slovak population. Further research is needed to evaluate the impact of single nucleotide polymorphisms (SNPs) in the VDR gene, focusing on related genetic analyses in a larger T2DM cohort.

Análisis clínico-epidemiológico de pacientes con lipoproteína(a) elevada en un hospital de tercer nivel

ObjectiveThe objective of the study is to describe the clinical and epidemiological characteristics of our patients with elevated Lp(a). Materials and methodsA descriptive cross-sectional study was conducted on 316 patients with elevated Lp(a) (>125 nmol/L) in a random sample between January and August 2022. We measured epidemiological, anthropometric, clinical and laboratory variables (lipid metabolism parameters, carbohydrates and hormones). ResultsMean age of our sample subject's was 59 ± 15 years with 56% males. The average BMI was 27.6 kg/m2 (71% with elevated BMI). Elevated waist circumference was observed in 54.1% of men and 77.8% of women. 48% had hypertension, 30.7% had diabetes mellitus and 91.5% dyslipidemia. Only 39.7% of the patients had never smoked.The mean values of total cholesterol were 158 ± 45 mg/dl, LDL was 81 ± 39 mg/dl, HDL was 53 ± 17 mg/dl, Triglycerides were 127 ± 61 mg/dl, and Lp(a) was 260 ± 129 nmol/L.Regarding lipid lowering treatment, 89% were on statins, 68.6% on ezetimibe, and 13.7% on PCSK9 inhibitors. 177 patients (57,7%) had established cardiovascular disease (CVD), 16.3% had polyvascular disease, 11.7% had subclinical CVD, and 30.6% had no known CVD. Among patients with established CVD, 174 (98.3%) were on lipid-lowering treatment (97.2% on statins) and 86.4% were on antiplatelet therapy. The mean age of cardiovascular events was 55 ± 12 years in males and 60 ± 11 years in females. 65,1% of female and 56,2% of male patients suffered an early cardiovascular event. ConclusionsPatients with elevated Lp(a) are at very high cardiovascular risk, particularly for early cardiovascular disease.

Blood glucose level and serum lipid profiles among people living with HIV on dolutegravir-based versus efavirenz-based cART; a comparative cross-sectional study

Background Antiretroviral therapy-linked metabolic abnormalities have become a growing concern among people living with HIV. There is limited data regarding the effects of dolutegravir-based treatment on blood glucose levels and serum lipid profiles in people living with HIV in Ethiopia. Thus, this study aimed to assess blood glucose levels and serum lipid profiles among people living with HIV on dolutegravir-based versus efavirenz-based therapy. Method and materials An institutional-based comparative cross-sectional study was conducted from 30 June 2021 to 30 August 2021. A total of 128 participants (64 in the dolutegravir-based group and 64 in the efavirenz-based group) were enrolled in the study. The Chi-square, independent t-test, Mann–Whitney U-test, and logistic regression were used as appropriate statistical tests using SPSS Version 26.0 for this study. A p-value of <0.05 was considered statistically significant. Result The prevalence of hyperglycemia and dyslipidemia were 17.2% (11/64) and 79.7% (51/64) in the dolutegravir group, and 9.4% (6/64) and 75% (48/64) in the efavirenz group, respectively. The efavirenz group had significantly higher mean values of total cholesterol (190.73 ± 44.13 vs. 175.27 ± 37.67 mg/dl, p = 0.035) and high-density lipoprotein (47.53 ± 14.25 vs. 40.92 ± 13.17 mg/dl, p = 0.007) than the dolutegravir group. For a Kg/m2 increase in BMI and for each month’s increase in the duration of HIV, the patients were 66% (AOR = 1.66, 95% CI: 1.13, 2.44), and 13% (AOR = 1.13, 95% CI: 1.03, 1.23) more likely to have hyperglycemia, respectively. In contrast, female patients were 3.04 times more likely to have dyslipidemia (AOR = 3.03, 95% CI: 1.14, 8.05) as compared to male patients, and with an increase in CD4 cell count of 1 cell/mm3, the odds of dyslipidemia increased by 0.3% (AOR = 1.003, 95% CI: 1.001, 1.006). Conclusion Efavirenz-based therapy resulted in higher mean values of total cholesterol and high-density lipoprotein as compared with dolutegravir-based therapy. It is important to consider and evaluate high-density lipoprotein levels in HIV patients on dolutegravir-based therapy, and total cholesterol levels in people living with HIV on efavirenz-based therapy.

Atherogenic lipid profile in patients with acute coronary syndrome

Abstract Background Adverse atherogenic lipid profile is associated with an increased risk of major adverse cardiac events in patients with acute coronary syndrome (ACS). Objective To evaluate the control status of atherogenic lipid profile among ACS patients within 12 months after discharge. Methods We retrospectively analyzed the data from the multi-center iHeart program. Twenty tertiary hospitals in China were included. Natural language processing technique was used to extract real-world data from electronic health records (EHRs). Patients with a diagnosis of ACS from January 2014 to December 2021 during index hospitalization and having at least one medical record after discharge within 12 months were enrolled. Measurements of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), non–high-density lipoprotein cholesterol (non-HDL-C), triglycerides (TGs), apolipoprotein B (ApoB), lipoprotein (a) (Lp[a]) at baseline and follow-up were collected and analyzed. Remnant cholesterol (RC) was calculated as TC minus HDL-C minus LDL-C. The treatment goal of LDL-C was defined as &amp;lt;1.8 mmol/L according to the guideline. An even lower LDL-C goal of &amp;lt;1.4 mmol/L was recommended in specific patients at extremely high risk with concomitant diabetes or ischemic cerebral vascular diseases. Results Among the 3956 patients, the mean age was 72 (12) years, and 64.8% were men. Diabetes was common (22.7%). There were 1612 (40.7%) patients with unstable angina, 391(9.9%) patients with non-ST-elevation myocardial infarction, 1146 (29.0%) patients with ST-elevation myocardial infarction, and 807 (20.4%) patients with undetermined ACS category. At baseline, the mean values for TC, LDL-C, HDL-C, non-HDL-C, ApoB, and RC were 4.61 (1.26) mmol/L, 2.83 (0.98) mmol/L, 1.12 (0.30) mmol/L, 3.38 (0.75) mmol/L, 96 (34) mg/dL, and 0.65 (0.56) mmol/L, respectively. The median values for TGs and Lp(a) were 1.44 mmol/L [1.06, 2.00] and 27.22 mg/dL [12.34, 39.2], respectively. The rate of lipid-lowering treatment was 94.8% (statins 93.1%, PCSK9 inhibitors 0.4%). The levels of TC, TGs, LDL-C, HDL-C, non-HDL-C, and ApoB were significantly decreased (P &amp;lt; 0.001) within 12 months. Median Lp(a) was 19.52 mg/dL [8.73, 39.08] (P = 0.117). Mean RC was 0.69 (1.10) mmol/L (P &amp;lt; 0.001). Overall, the proportion of patients achieving the LDL-C level of &amp;lt;1.8 mmol/L at baseline increased from 13.42% to 36.6% during follow-up. In patients with concomitant diabetes or ischemic cerebral vascular diseases, the rate of LDL-C &amp;lt;1.4 mmol/L was 17.79% and 17.52%, respectively. Conclusion Only 1/3 of patients had LDL-C &amp;lt;1.8mmol/L within 12 months after ACS. Despite the high treatment rate of statins, Lp(a) level had no change beyond the reduction in LDL-C. Elevated remnant cholesterol may be a critical contributor to residual risk. Novel therapeutics targeting the whole atherogenic lipid profile will be warranted to improve cardiovascular outcomes.LDL-C control rate within 12 months

A 7-year longitudinal association of total cholesterol with premature structural and functional cardiac damage progression in youth: the ALSPAC birth cohort study

Abstract Background Recent evidence suggests that childhood total cholesterol was associated with midlife cardiovascular mortality. Cumulative total cholesterol has been associated with subclinical atherosclerosis during growth from mid-adolescence through young adulthood. It remains unexamined whether total cholesterol independently associates with signs of premature cardiac damage in apparently healthy youth due to the paucity of repeated measures of cardiac structure and function. Purpose To investigate the longitudinal association of changes in total cholesterol with structural and functional cardiac damage progression during growth from adolescence through young adulthood. Methods From the Avon Longitudinal Study of Parents and Children (ALSPAC), UK birth cohort, 1595 adolescents aged 17 years who had fasting plasma total cholesterol measured at 17- and 24-year clinic visits were included. Repeated echocardiography measured LVM indexed for height2.7 (LVMI2.7), relative wall thickness (RWT), LV diastolic function from mitral E/A ratio (LVDF), and LV filling pressure from E/e´ ratio (LVFP) were available at baseline and follow-up. LVMI2.7 ≥51g/m2.7, RWT ≥0.44, LVDF &amp;lt;1.5, and LVFP ≥8 were categorised as LV hypertrophy, high RWT, LVD dysfunction, and high LVFP, respectively. Multivariable adjusted associations were examined using generalized linear mixed-effect models and generalized logit mixed-effect models and adjusted for sex, and time-varying covariates measured at both baseline and follow-up such as age, insulin, high-sensitivity C-reactive protein, heart rate, systolic blood pressure, glucose, fat mass, lean mass, smoking status, family history of hypertension/diabetes/high cholesterol/vascular disease, socioeconomic status, sedentary time, light physical activity, and moderate to vigorous physical activity. Results Among 1595 adolescents (mean [SD] age at baseline, 17.74 [0.38] years; 955 [59.8%] females]) mean total cholesterol values increased in males from 3.55 mmol/L to 4.25 mmol/L and in females from 3.97 mmol/L to 4.46 mmol/L, over 7 years. The prevalence of LV hypertrophy increased in males from 3.6% to 11.9% and in females from 1.6% to 4% over 7 years. The prevalence of LVD dysfunction increased in males from 7.8% to 16.6% and in females from 10.3% to 15.4%. In a fully adjusted model, each 1 mmol increase in total cholesterol was significantly associated with higher odds of LV hypertrophy progression (odds ratio 1.18; [95% CI, 1.09 – 1.27], p&amp;lt;0.0001), high RWT (1.11; [1.02 – 1.21], p=0.015), and high LVFP (1.12; [1.05 – 1.20], p=0.001) but not LVD dysfunction (1.03 [0.95 – 1.13], p=0.461), over 7 years. Conclusion Increased total cholesterol was independently associated with progressive structural and functional cardiac damage in asymptomatic youth during growth from adolescence through young adulthood.

Investigation of the effect of visceral adiposity index on venous clinical severity score in patients with chronic venous insufficiency

Introduction Chronic venous insufficiency (CVI) is a common disease affecting millions worldwide. Age, obesity, female gender, sedentary life, and long-standing at work causing orthostasis have been identified as predisposing factors. Objective The visceral adiposity index (VAI) is an important indicator of abdominal obesity. Various studies in the cardiovascular field have shown that it may be more predictive than body mass index (BMI). Methods A total of 171 consecutive patients diagnosed with low-grade (C0–C3) superficial primary CVI in our clinic, between November 2021 and December 2022, were included in this prospective study. Venous Clinical Severity Score (VCSS) values were calculated. The patients were divided into two groups according to their VCSS values (Group 1: VCSS ≤6 and Group 2: VCSS &gt;6). Results There were 110 patients in Group 1 with a median age of 42 (18–50) years. There was no difference between the groups in terms of gender, smoking, hypertension frequency, height, weight, body mass index, hemoglobin values, lymphocyte, neutrophil, mean platelet volume, urea, creatinine, high-density lipoprotein, low-density lipoprotein, triglyceride, and total cholesterol values ( p &gt; .05). Multivariate logistic regression analysis was performed to reveal the predictive factors of high VCSS values in patients. As a result of the analysis, VAI (Odds Ratio (OR): 1.775; 95% Confidence Interval (CI): 1.389–2.269; p &lt; .001) and CRP (OR: 2.641; 95% CI: 1.431–4.875; p = .002) values were identified as independent predictors in predicting high VCSS values. Conclusion This current study showed that high VAI values affect clinical complaints in patients with low-grade CVI. In line with our results, clinical recommendations can be made to reduce VAI values in low-stage CVI patients.

Lipid Disturbances in Breast Cancer Patients during Chemotherapy.

In this prospective study, 50 patients with breast cancer participated. Three biochemical-lipid hematological tests were performed: total cholesterol (TC), triglycerides (TGs), High-Density Lipoprotein (HDL-C), and Low-Density Lipoprotein (LDL-C) before initiation (pre-chemotherapy), at the start (first follow-up), and at the completion (second follow-up) of the first cycle of chemotherapy. Statistical significance was set at p < 0.05. Analyses were conducted using SPSS Statistical Software (version 22.0). Mean TC values increased significantly at second follow-up. TGs values decreased significantly from first to second follow-up. HDL-C was significantly lower at first follow-up compared with pre-chemotherapy and was similar to the pre-chemotherapy levels at second follow-up. LDL-C values were significantly higher at second follow-up compared with pre-chemotherapy measurement. Significantly positive correlations of BMI with pre-chemotherapy LDL-C, first follow-up TC, first follow-up LDL-C, second follow-up TC, and second follow-up LDL-C were found. There is a statistically significant increase in the levels of TC and LDL-C in breast cancer patients during chemotherapy. This study was not registered.

Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016.

Background The atherosclerotic effect of an adverse lipid profile is assumed to accumulate throughout life, leading to increased risk of myocardial infarction (MI). Still, little is known about age at onset and duration of unfavorable lipid levels before MI. Methods and Results Longitudinal data on serum lipid levels for 26 130 individuals (50.5% women, aged 20-89 years) were obtained from 7 population-based health surveys in Tromsø, Norway. Diagnoses of MI were obtained from national registers. A linear mixed model was applied to compare age- and sex-specific mean values of total cholesterol, high-density lipoprotein cholesterol (HDL-C), and triglyceride concentration by MI status (MI versus non-MI). Already from young adulthood, 20 to 35 years before the incident MI, individuals with a subsequent incident MI had on average more adverse lipid levels than individuals of the same age and sex without MI. Analogous to a dose-response relationship, there was a clear trend toward more severe adverse lipid levels the lower the age at incident MI (P<0.001, test for trend through ordered categories <55, 55-74, ≥75 years). This trend was particularly pronounced for high-density lipoprotein cholesterol in percentage of total cholesterol (both sexes) and for the relative relationship between triglyceride, high-density lipoprotein cholesterol, and total cholesterol level (women). The difference in mean lipid level by MI status was just as large in women as in men, but the age pattern differed (P≤0.05, tests of 3-way interaction). Conclusions Compared with general population mean levels, adverse lipid levels were seen 20 to 35 years before the incident MI in both men and women.

A Cross Sectional Study of Lipid Profile In Ultrasonography-diagnosed Fatty Liver

ABSTRACT: Objective: The aim of this study is to conduct a descriptive cross sectional study to observe the relationship of lipid profile with fatty liver, as diagnosed by ultrasonography. Methodology: Study population consisted of 105 persons (50 females &amp; 55 males) who were having non-alcoholic fatty liver disease, as diagnosed by ultrasonography. Serum lipid profile reports of the study population was tabulated and compared with grade I, II &amp; III of ultrasonography-diagnosed fatty liver. Result: Grade I (mild) non-alcoholic fatty liver disease was seen in 84.7 %, grade II (moderate) in 13.3 % and grade III (severe) in 1.9% cases. Mean age of the study population was 48.3 years ranging from 25 years (minimum) to 79 years (maximum). Dyslipidemia was found in more than two thirds of our study population. Total cholesterol, triglyceride and low-density lipoprotein were increased in 67.6%, 65.7% and 67.6% respectively. High-density lipoprotein was decreased in 60.9% cases. Mean value of total cholesterol, triglyceride, low-density lipoprotein and high-density lipoprotein were 233.5 gm/dl, 215.5 gm/dl, 148.7 gm/dl and 32.5 gm/dl respectively. When lipid profiles were compared with fatty liver, significant positive correlation was seen between non-alcoholic fatty liver disease with increased serum cholesterol, increased triglyceride, increased low-density lipoprotein &amp; decreased serum high-density lipoprotein. P value was &lt;0.001 in all the cases. Different grades of non-alcoholic fatty liver disease and individual lipid components showed no significant correlation. Conclusion: This study showed more than two thirds of ultrasonography-diagnosed non-alcoholic fatty liver had abnormal lipid profile. So, safe and non-invasive ultrasonography is very useful for screening and early detection of dyslipidemia in patients.

Characterization of the lipid profile in patients with primary Sjögren’s syndrome

IntroductionDyslipidaemia is the most prevalent metabolic disorder in primary Sjögren's syndrome (PSS) and an association between low HDL cholesterol levels and disease activity has been suggested. ObjectivesThe purpose of this study is to describe the characteristics of the lipid profile in patients with PSS and explore the correlation between the components of the lipid profile and the activity of the disease. Materials and methodsA descriptive cross-sectional study. We reviewed the medical records of patients over 18 years of age with criteria for PSS who attended the Hospital Universitario Clínica San Rafael during the period between January 2015 to December 2019. We used R-studio software version 4.0.2 for statistical analysis. A descriptive analysis of the clinical-demographic and serological variables was carried out to evaluate the correlation between them. ResultsA total of 250 medical records were reviewed, of which 35 met the inclusion criteria. The average age was 53.4 years and 88.3% were women. The median duration of disease was 42 months. The mean values for total cholesterol, HDL, LDL and triglycerides were 191 mg/dL, 42.6 mg/dL, 118.9 mg/dL and 157 mg/dL respectively. A Pearson correlation coefficient of −0.43 (95% CI −0.67 to −0.12) p-value = 0.008 was found between the ESSDAI activity index and HDL cholesterol. A linear model was performed between the total ESSDAI activity index and HDL cholesterol, finding an estimated coefficient of −0.17. A ROC curve was performed with an HDL cholesterol segregation point of 43.5 mg/dL with an area under the curve of 0.603 (95% CI 0.40–0.80). By excluding patients with high BMI, the area under the curve improved with a segregation point of 38 mg/dL. ConclusionsPatients with low levels of HDL cholesterol showed higher rates of disease activity, with a cut-off point lower than 43 mg/dL being more marked in patients with normal body mass index.

OCCURRENCE OF DYSLIPIDEMIA IN PRE-DIABETIC INDIVIDUALS: A HOSPITAL-BASED OBSERVATIONAL STUDY

Background: Pre-diabetes (PD) is the precursor stage of diabetes mellitus, in which the subject's plasma glucose is higher than normal but lower than diabetes mellitus thresholds. Lipid prole disorders are signicantly associated with prediabetes and diabetes. Individuals with pre-diabetes have a high risk of progression to diabetes. Assessment of serum lipids is warranted not only for T2DM patients but also for those with prediabetes. Methods: The study was carried out in the Department of Medicine, Gauhati Medical College and Hospital, Guwahati from 1st June 2021 to 31st May 2022. After satisfying the inclusion and exclusion criteria 120 prediabetic patients were included in the study and were evaluated. Patients were categorized according to ATP III classication. In our study group, out of 120 patient Result: s, a maximum number of patients belonged to the age group of 41-50 yrs and the mean age was 48.17±10.5 years with 60.8% male and 39.2% female cases. Among the different lipids, we found hypercholesterolemia in 23.4%, hypertriglyceridemia in 62.5%, and high LDL was found in 76.7% of prediabetic subjects. In our study, we found low HDL (&lt;40 mg/dl)levels in 64.2% of prediabetic patients. The mean value of total cholesterol was 171.1 ±50.2 , Triglyceride was 170.2 ±76.5 , HDL was 38.3 mg/dl±9.4, LDL was120.8 ±33.5 and VLDL was 30.5 ±8.6. HbA1c has a signicant positive correlation (p-value &lt;.001) with TC, TG LDL, and VLDL and a signicant negative correlation (p-value&lt; .001) with HDL. Pre-diabetic individuals often exhibit an Conclusion: atherogenic pattern of risk factors that include high levels of total cholesterol (CHOL), low-density lipoprotein cholesterol (LDL), triglycerides (TG), and low levels of high-density lipoprotein cholesterol (HDL), it predisposes to premature atherosclerosis causing cardiovascular and cerebrovascular complications in the long term in this individuals if not evaluated early

Analysis and correlation of small dense low-density lipoprotein-cholesterol (sdLDL-C) with various lipoproteins and cardiac markers in acute coronary syndrome patients associated with normal Low-density lipoprotein-cholesterol (LDL-C) level: A cross sectional study.

Title of the article: Analysis and correlation of small dense low-density lipoprotein-cholesterol (sdLDL-C) with various lipoproteins and cardiac markers in acute coronary syndrome patients associated with normal Low-density lipoprotein-cholesterol (LDL-C) level: A cross-sectional study. Aim: To analyze the levels of sdLDL cholesterol in acute coronary syndrome patients (ACS) with normal LDL cholesterol (LDL-C) and correlate with various lipoproteins and cardiac markers. Methodology: The present study included 100 patients diagnosed with ACS with normal LDL-C. Demographic details and cardiac markers were correlated with sdLDL levels. A detailed history was elicited from the patients and the details of clinical examination and laboratory findings such as cardiac Troponin, C- reactive protein, and CK-MB were obtained from patient case files. Results: The results are expressed in mean±sd. The mean age of study participants was 39.5±10.5yrs. The majority of the participants were men (69%) between the age group of 31-40 years. Mean values of total cholesterol, VLDL, sdLDL, Trop-I, CRP, and CKMB are at higher levels in men when compared to women. Whereas, mean values of triglycerides, LDL, and HDL are higher in women when compared to men. The majority of participants were having unstable angina (42%) followed by STEMI (33%) and NSTEMI (25%). Correlation between sdLDL and other parameters was carried out using Mann–Whitney–Wilcoxon test. The result showed a statistically significant correlation between sdLDL and VLDL, Trop-I, and CRP with p &lt;0.05. Patients with sdLDL of &gt; 25mg/dl had a higher incidence of unstable angina and STEMI. Conclusion: Our study result suggests that ACS with normolipidemic patients has a positive correlation with sdLDL levels and sdLDL can be a new diagnostic marker along with cardiac troponins in ACS.

Altered Liver Function Test in Type 2 Diabetes Mellitus Subjects and its Association with Dyslipidaemia and Fasting Blood Sugar: A Cross-sectional Study

Introduction: Multiple organ systems are affected due to the metabolic dysregulation associated with Diabetes Mellitus (DM). Altered lipoprotein metabolism and liver enzymes have been identified as independent risk factors for the development of Cardiovascular Disease (CVD). Routine screening of liver function and ultrasound imaging of the liver should be done at the time of diagnosis of type 2 DM and thereafter at regular intervals. Aim: To determine the association between liver function parameters and glycemic status in type 2 diabetics. Additionally, the study aimed to correlate liver enzymes and lipid profiles in Type 2 DM patients. Materials and Methods: A cross-sectional study was conducted from August 23rd, 2021 to October 23rd, 2021 on 100 Type 2 diabetic patients attending the diabetic Outpatient Department of Biochemistry, at Annapoorana Medical College and Hospital, Salem, Tamil Nadu, India. Fasting glucose, total cholesterol, triglyceride, and High-Density Lipoprotein Cholesterol (HDL) were measured using the direct enzymatic method, while LowDensity Lipoprotein Cholesterol (LDL) was calculated using Friedewald’s formula. Total bilirubin, Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP), total protein, and albumin were analysed using the ERBA EM-200 auto analyser based-on the wet chemistry principle. Pearson’s correlation analysis was performed to examine the relationship between variables. Results: Among the total of 100 type 2 diabetic patients who participated in present study, 59 were males and 41 were females. The mean±SD age of diabetic patients was 51.23±10.810 years, ranging between 35 and 76 years. The frequency of altered liver enzymes in the study sample was found to be 33, with 25 being males and 8 being females. The mean fasting blood sugar levels with normal liver function and abnormal liver function were observed to be 128.37±13.16 mg/ dL and 133.79±15.68 mg/dL, respectively, but the difference was not statistically significant. The mean values of total cholesterol, triglyceride, and low-density lipoprotein with normal liver function were observed to be 137.18±34.44 mg/ dL, 175.12±65.19 mg/dL, and 75.55±9.78 mg/dL, respectively, while with abnormal liver function, they were observed to be 196.05±52.67 mg/dL, 143.28±47.63 mg/dL, and 138.83±38.11 mg/dL, respectively, showing statistical significance. Conclusion: The present study found a strong association between deranged liver enzymes with fasting blood sugar and dyslipidaemia.

Comparative Studies of Some Biochemical Characteristics of Seminal Plasma in Wild and Cultured Male Catfish (&lt;em&gt;Clarias gariepinus&lt;/em&gt;), Burchell, 1822 Broodstock

Purpose: In aquaculture, the most important aspect to consider is ensuring the development of valuable offspring by using high-quality gametes from fish broodstock. This research aims to compare the biochemical constituents of seminal plasma in both wild and cultured Clarias gariepinus broodstock. Research Method: Apparently healthy adult male Clarias gariepinus (n=9, 900±300g mean weight per fish type (wild or cultured), 49±8.5cm mean total length) were collected from fishermen on the Oshin River, Nigeria for the wild samples and from a reputable fish farm in Ilorin and examined for some seminal plasma’s biochemical parameters following standard procedures. T-test statistics were used to compare the differences between classes. Findings: Higher values of most of the semen biochemical compositions were recorded among the cultured Clarias gariepinus with significant variations (p&lt;0.05) recorded in the mean values of total cholesterol, high-density lipoprotein-cholesterol (HDL-Cholesterol), low-density lipoprotein-cholesterol (LDLCholesterol), uric acid, Aspartate Aminotransferase (AST), total bilirubin, albumin, potassium, chloride and urea. Creatinine, glucose, sodium, and triglycerides, on the other hand, did not vary significantly (p&gt;0.05) between cultured and wild Clarias gariepinus semen. Originality/ Value: The current study’s findings on biochemical compositions could lead to more effective gamete management, higher yields, and improved semen suitability for short-term storage.

A retrospective study of lipid profile in SARS-CoV-2 infection

Background: Coronavirus disease 2019 (COVID-19), a pandemic, infected millions of individuals globally. Several studies have been done on the demographic, clinical, laboratory, and radiological parameters of SARCoV-2 disease. However, information on the association of lipid profiles with disease severity is very sparse. SAR-CoV-2 patients with dysglycemia and hypertension are shown to have a worse prognosis. Dyslipidemia is considered one of the most important cardiovascular risk factors. The association of lipid profile with disease severity is less commonly studied. Although it is a cost-effective, easily performed, and routinely done test at clinical and hospital setups, it can be an independent risk factor for assessing disease severity. Aims and Objectives: The present study was undertaken to investigate lipid profile variation in SARS-CoV-2 infections and its association with disease severity. Materials and Methods: The Institutional Ethics Committee of Malla Reddy Institute of Medical Sciences and Hospital, Hyderabad, approved this retrospective study before it was conducted there. A total of 400 SARS-CoV-2 patients were enrolled in this study. From March 2, 2021 to December 4, 2021. All the data regarding serum lipid profiles were extracted electronically. Results: We found that mean values of total cholesterol (TC) (98.15), high-density lipoprotein cholesterol (HDL-C) (25.11), and low-density lipoprotein cholesterol (LDL-C) (38.30) compared to mild cases were significantly lower in severe cases: were significantly lower T-C (132.74), HDL-C (33.50), and LDL-C (59.25). A statistically significant difference was found between both groups in terms of TC (P &lt; 0.001), HDL-C (P &lt; 0.001), and LDL-C (P &lt; 0.001). In addition, in the severe cases, triglycerides (TGs) levels showed an upward trend (256.95) and were significantly higher than in the mild cases (153.07) (P &lt; 0.001). Conclusions: Decreased levels of TC, LDL-C, and HDL-C and increased levels of TGs were observed in severely ill Covid-19 cases. Higher TG levels immediately correlate with disease severity, and lower concentrations of TC, LDL-C, and HDL-C are reciprocally associated with it. Our study about lipid profiles helps provide a new perspective on SAR-CoV-2 infection.

STUDY TO ASSESS RELATION OF LIPID PROFILE AND HYPERTENSION IN PATIENTS ATTENDING NIMS HOSPITAL, JAIPUR, RAJASTHAN

Dyslipidaemia and hypertension are major cardiovascular disease risk factors, and the Indian population experiences the highest rates of morbidity and mortality. The objective of this study was to determine the relation between lipid profiles in hypertensive patients with normotensive control subjects in patients attending NIMS Hospital, Jaipur Rajasthan. A single-Center, case-control hospital based study was carried out among 140 participants (eighty (80) patients were included in the study) from January 2021 to June 2022 in National Institute of Medical Sciences and Research, Jaipur, Rajasthan, India. Data were collected on sociodemographic factors, anthropometric measurements, blood pressure, and lipid profile including total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), and high density lipoprotein (HDL). On analysis of the lipid profile of 80 hypertensive patients and 80 Normotensive control subjects the mean TC values in cases and controls are 199 mg/dl and 167 mg/dl respectively. The mean TG values are 199 mg/dl and 123 mg/dl, the mean LDL c values are 121.5 mg/dl and 97.5 mg/dl. The serum levels of TC, TG, and LDL were higher while HDL levels were lower in hypertensive subjects compared to normotensives, which was statistically significant (P&lt;0.001). Age, waist circumference, and body mass index showed significant association with hypertensive patients (P&lt;0.0001) but not with normotensives. The logistic regression analysis showed that hypertensive patients had higher TC and TG, LDL and lower HDL than normotensives, which was statistically significant (P&lt;0.05). Hypertensive patients in NIMS hospital, Jaipur, Rajasthan have a close association with dyslipidaemia and need measurement of blood pressure and lipid profile at regular intervals to prevent cardiovascular disease, stroke, and other comorbidities.

STUDY TO ASSESS RELATION OF LIPID PROFILE AND HYPERTENSION IN PATIENTS ATTENDING NIMS HOSPITAL, JAIPUR, RAJASTHAN

Dyslipidaemia and hypertension are major cardiovascular disease risk factors, and the Indian population experiences the highest rates of morbidity and mortality. The objective of this study was to determine the relation between lipid profiles in hypertensive patients with normotensive control subjects in patients attending NIMS Hospital, Jaipur Rajasthan. A single-Center, case-control hospital based study was carried out among 140 participants (eighty (80) patients were included in the study) from January 2021 to June 2022 in National Institute of Medical Sciences and Research, Jaipur, Rajasthan, India. Data were collected on sociodemographic factors, anthropometric measurements, blood pressure, and lipid profile including total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), and high density lipoprotein (HDL). On analysis of the lipid profile of 80 hypertensive patients and 80 Normotensive control subjects the mean TC values in cases and controls are 199 mg/dl and 167 mg/dl respectively. The mean TG values are 199 mg/dl and 123 mg/dl, the mean LDL c values are 121.5 mg/dl and 97.5 mg/dl. The serum levels of TC, TG, and LDL were higher while HDL levels were lower in hypertensive subjects compared to normotensives, which was statistically significant (P&lt;0.001). Age, waist circumference, and body mass index showed significant association with hypertensive patients (P&lt;0.0001) but not with normotensives. The logistic regression analysis showed that hypertensive patients had higher TC and TG, LDL and lower HDL than normotensives, which was statistically significant (P&lt;0.05). Hypertensive patients in NIMS hospital, Jaipur, Rajasthan have a close association with dyslipidaemia and need measurement of blood pressure and lipid profile at regular intervals to prevent cardiovascular disease, stroke, and other comorbidities.

STUDY TO ASSESS RELATION OF LIPID PROFILE AND HYPERTENSION IN PATIENTS ATTENDING NIMS HOSPITAL, JAIPUR, RAJASTHAN

Dyslipidaemia and hypertension are major cardiovascular disease risk factors, and the Indian population experiences the highest rates of morbidity and mortality. The objective of this study was to determine the relation between lipid profiles in hypertensive patients with normotensive control subjects in patients attending NIMS Hospital, Jaipur Rajasthan. A single-Center, case-control hospital based study was carried out among 140 participants (eighty (80) patients were included in the study) from January 2021 to June 2022 in National Institute of Medical Sciences and Research, Jaipur, Rajasthan, India. Data were collected on sociodemographic factors, anthropometric measurements, blood pressure, and lipid profile including total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), and high density lipoprotein (HDL). On analysis of the lipid profile of 80 hypertensive patients and 80 Normotensive control subjects the mean TC values in cases and controls are 199 mg/dl and 167 mg/dl respectively. The mean TG values are 199 mg/dl and 123 mg/dl, the mean LDL c values are 121.5 mg/dl and 97.5 mg/dl. The serum levels of TC, TG, and LDL were higher while HDL levels were lower in hypertensive subjects compared to normotensives, which was statistically significant (P&lt;0.001). Age, waist circumference, and body mass index showed significant association with hypertensive patients (P&lt;0.0001) but not with normotensives. The logistic regression analysis showed that hypertensive patients had higher TC and TG, LDL and lower HDL than normotensives, which was statistically significant (P&lt;0.05). Hypertensive patients in NIMS hospital, Jaipur, Rajasthan have a close association with dyslipidaemia and need measurement of blood pressure and lipid profile at regular intervals to prevent cardiovascular disease, stroke, and other comorbidities.

Effect of smoking on vital hemodynamic parameters and lipid profile of young smokers

Background and objectives: Tobacco use is associated with cardiovascular, respiratory and peripheral vascular diseases. The short term effects of tobacco smoking on vital hemodynamic parameters and lipid profile of young smoker with increased quantity of smoking is still debatable. The objective of this study was to evaluate the effect of smoking on vital hemodynamic parameters and lipid profile of young smokers. Materials and methods: The current study was an observational cross sectional study conducted in a tertiary care hospital over a period of 18 months and included smokers and non-smokers. Data on vital hemodynamic parameters like blood pressure, heart rate, oxygen saturation (SPO2) and lipid profile were collected. Chi-square and analysis of variance (ANOVA) tests were used to analyze the data. Results: A total of 80 smokers and 80 non-smokers were enrolled in the study. Blood pressure, heart rate and mean SpO2 were significantly (p&lt;0.001) lower in non-smokers compared to smokers. Breath holding time (BHT) and single breath count (SBC) were higher in non-smokers. Mean values of total cholesterol (T-chol), low density lipoprotein (LDL) and triglyceride (TG) were significantly (p&lt;0.001) higher in smokers than non-smokers, while high density lipoprotein (HDL) was significantly low in smokers. SBP, T -chol and TG significantly (p&lt;0.05) increased as the quantity of smoking increased. Conclusion: Smoking is associated with derangement of vital hemodynamic parameters and lipid profile across the age. Anti-smoking campaign should be organized to discourage both personal smoking and smoking in public places. IMC J Med Sci. 2023. 17(1): 007. DOI : https://doi.org/10.55010/imcjms.17.007 *Correspondence: Bhupendra Kumar Jain, Department of Pulmonary Medicine, School of Chhindwara Institute Of Medical Sciences, Jabalpur Medical University, Chhindwara, Madhya Pradesh, India. Email: drbhupendrakjain@gmail.com