Mean Values Of Erythrocyte Sedimentation Rate Research Articles

Association of Erythrocytes Sedimentation Rate and Platelets Indices in Diabetes in the Elderly

Recent research indicates that inflammation can contribute to the etiology of diabetes which is characterized by hyperglycemia and abnormalities in insulin secretion and/or activity. Erythrocyte sedimentation rate (ESR) is the most often utilized laboratory test for detecting systemic inflammation among all plasma inflammatory indicators. Patients with diabetes have reportedly shown altered platelets, due to "prothrombotic condition" with increased platelet reactivity leading to vascular problems. The objective of the study was to relate platelet indices and erythrocyte sedimentation rates with Diabetes. The morphology, metabolism, and function of erythrocytes are invariably subject to a number of alterations when there is persistent hyperglycemia. Few prospective studies have looked at this issue, hence, the investigation of the link between Erythrocytes Sedimentation Rate and Platelets indices in Diabetes in a private hospital in Port Harcourt (Port Harcourt, the capital of Rivers State is the major city, situated by the Bonny River in Southern Nigeria), The study had 100 subjects who gave their consent and were chosen from among others for this cross-sectional study. Fifty patients were confirmed diabetes (21 men and 29 women; mean age: 60.1±5.02 years) and 50 control subjects without diabetes (20 men and 30 women; mean age: 58.08±5.67 years). Aseptic blood collection techniques were used to obtain blood samples from the diabetic and control groups into EDTA vials. The Sysmex XE-2100 Haematology Automated Analyzer was used to estimate platelet indices, and the Western green method was used to calculate ESR. Using the Excel Data Analysis Tool pack, the estimated values of the parameters were statistically evaluated. Both the control and diabetes groups, displayed a statistically significant difference in the mean values of ESR hence the level in the diabetic group showed greater mean values when compared to the control group values 37.42±20.55 mm/hr and 29.78±13.26 mm/hr respectively at (P=0.029). Comparing the means of the platelet indices between the two groups at a significance level of (P=0.674), there was no discernible change. The clinical diagnostic utility of ESR as a helpful indicator for following diabetic patients' progress strongly correlates with the frequency and intensity of inflammation in diabetes. It was concluded that inflammation plays a role in the development of diabetes is constantly supported by this study.

Erythrocyte sedimentation rate in canine leishmaniosis diagnosis: A new resource.

This study aims to evaluate the erythrocyte sedimentation rate (ESR) in Leishmania infantum-seropositive dogs compared with healthy dogs and to assess the existence of a correlation between ESR and clinical form of Canine leishmaniosis (CanL) as well as acute phase proteins (APPs). From October 2021 to January 2022, dogs were recruited in this study if L. infantum-seropositive by enzyme-linked immunoassay and classified as exposed or affected by a CanL active form based on physical examination, clinical score, and laboratory results [i.e., complete blood count, biochemical panel such as C-reactive protein (CRP) and serum ferritin, serum protein electrophoresis, and fibrinogen concentration measurement]. To evaluate the ESR of the dogs, a point-of-care device was used with a reference interval of 0–10 mm/h. Moreover, the ESR evaluation has been also performed in clinically healthy dogs, as control group. Thirty-six L. infantum-seropositive dogs [i.e., exposed (n = 10) and affected by CanL active form (n = 26)] were included in the study. Twenty-two healthy dogs were also enrolled. The mean value of ESR in dogs affected by a CanL active form was significantly higher than in exposed and healthy dogs (p < 0.0001). The ESR level was increased in 92% of dogs with CanL active form while positive APPs such as CRP, fibrinogen, and serum ferritin were increased only in 46, 48, and 58% of the animals, respectively. In exposed dogs, the ESR level was increased in 40% of cases. In dogs with active form, a significant positive correlation between ESR and total proteins, globulins, CRP, and fibrinogen, as well as a significant negative correlation between ESR and hematocrit, hemoglobin, and albumin/globulin ratio were detected. This study provides for the first-time data on ESR in L. infantum-seropositive dogs demonstrating dogs affected by a CanL active form have the highest ESR level and the majority of these dogs presented an increased ESR compared with exposed and healthy dogs. The evaluation of ESR by a point-of-care device proved to be a simple, inexpensive, and ready-to-use benchtop tool and ESR can be considered a helpful and timely inflammatory biomarker for the diagnosis of a CanL active form.

Correlation between serum IL-17 levels with Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP) levels of new cases of pulmonary tuberculosis at Sanglah Central General Hospital, Bali, Indonesia

Background: Tuberculosis (TB) is a mycobacterial infection that usually attacks the lungs and triggers lung damage and dysfunction related to the reléase of IL-17, Erythrocyte Sedimentation Rate (ESR), and C-Reactive Protein (CRP). This study aims to evaluate the correlation between serum IL-17 levels with ESR and CRP levels in new cases of pulmonary tuberculosis at Sanglah Central General Hospital, Bali, Indonesia. Methods: A cross-sectional study was conducted among 56 TB patients treated as new pulmonary TB cases in Outpatient and Inpatient Internal Medicine at Sanglah Hospital, Bali, Indonesia. IL-17 levels in this study were the results of IL-17 examination from patient serum using the ELISA method from R&amp;Dsystems with units of pg/mL. The Erythrocyte Sedimentation Rate (ESR) in this study is the rate of blood deposition in mm/hour using a Westergreen tube. Meanwhile, the C-Reactive Protein (CRP) examination was carried out using a Roche 6000 analyzer in mg/dL. Data were analyzed with SPSS version 16 for Windows. Results: Most respondents are female (75.0%) and the 30-34 years old group (26.8%). The mean value of ESR is 40.39±25.86 mm/hour, followed by CRP (9.95±10.01 mg/dL), and IL-17 (15.21±1.20 pg/mL). There is no significant correlation between ESR to CRP (r=0.069; p=0.613) and IL-17 (r=0.135; p=0.323). In addition, there is no significant correlation between CRP and IL-17 (r=0.168; p=0.215). Conclusion: This study's results indicate no significant correlation between IL-17 levels with CRP and ESR or between CRP and ESR.

Role of erythrocyte sedimentation rate and C-reactive protein as a predictor of severity of cellulitis and necrotising fasciitis

Background: Skin infections are major cause of morbidity and mortality worldwide, affecting more than one person/1000 person/year. Sepsis has a worldwide incidence of more than 20 million cases a year, with mortality due to septic shock reaching up to 50% even in industrialized countries. Acute phase reactants like erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) have been used traditionally as markers for inflammation and are readily available in most centres. Aim was to study the correlation between the values of ESR and CRP with severity of cellulitis and necrotising fasciitis (in term of hospital stay and disease outcome).Methods: This was a prospective observational study conducted at Department of Surgery, GMC and Hamidia Hospital, Bhopal from a period of March 2016 to August 2018.Results: Skin and soft tissue infections are most commonly affects male, diabetes mellitus most common co-morbid condition. Mean value of ESR and CRP in patients who could not survived was 64.44 and 145.92 respectively and value more than 54.95 and 93.41 requires longer hospital stay.Conclusions: ESR and CRP are non-specific test but they are good predictors of severity of cellulitis and necrotising fasciitis not only in planning of management of these cases but also predicting outcome of the disease.

Effects of cigarette smoking on erythrocyte sedimentation rate, platelet count, total and differential leucocyte counts in adult male smokers

Smoking is one of the leading causes of death worldwide. Smokers have higher risk for coronary heart disease, atherosclerosis, acute myocardial infarction, hypertension, clotting disorders, inflammation, respiratory diseases, cancers, etc. A cigarette smoker is exposed to a number of harmful substances. In this study we hypothesized that smoking causes inflammatory reactions and induces hyperthrombic state in the body which may be reflected in erythrocyte sedimentation rate (ESR), total leucocyte count (TLC), differential leucocyte count (DLC) and platelet count values. The purpose of the study was to study the effects of cigarette smoking on erythrocyte sedimentation rate, total leucocyte count and platelet count in adult male smokers and to compare the results with non-smokers and to establish a relationship between the duration and quantity of smoking with the change in ESR, TLC, DLC and platelet count. A cross sectional study was conducted in the department of Pathology on 86 healthy male subjects (smokers=43 and non-smokers=43). ESR was estimated using Westergrens method. TLC, DLC and platelet counts were estimated using HORIBA Pentra ES60 autoanalyzer. TLC and basophil counts were significantly higher in smokers than in non-smokers (p&lt;0.05). The mean value of ESR was higher among smokers than non-smokers but it was statistically insignificant. Platelets counts showed no significant difference between smokers and non- smokers. No correlation was observed in various blood parameters and smoking (in pack years). We conclude that smoking initiates an inflammatory response as evidenced from raised TLC, monocyte and basophil counts.

Methotrexate in the treatment of ankylosing spondylitis

The authors carried out an open prospective study analyzing methotrexate (MTX) efficacy and toxicity in 34 patients with ankylosing spondylitis (AS) for a period of one year. All the patients presented with active axial disease, characterized by inflammatory spinal pain, prolonged morning stiffness, erythrocyte sedimentation rate (ESR) > or = 25 mm, and failure on treatment with non-steroidal anti-inflammatory drugs for a period of more than two years. MTX was taken at a single weekly intramuscular dose of 12.5 mg. Thirty-one patients (91%) concluded treatment. Eighteen patients (53%) were considered responders to MTX; most of them presented peripheral arthritis. Despite clinical improvement, axial measures were unaltered at the end of the study. The mean value of ESR decreased significantly at the end of the treatment (p=0.0001), predominantly in the responders group. Side effects were observed in 23 patients (68%) and included dyspeptic syndrome, transient elevation of liver enzymes, and dizziness. The results of this one year open study suggest that MTX can be an efficient drug in the treatment of AS.