This paper presents a climatological global view on the spatial structure and interannual variability of the high-frequency migrating quarterdiurnal tide (QW4) built on a large statistics of the 21 years (2002–2022) SABER/TIMED temperature measurements. The obtained consistent picture for the vertical structure and phase coherence provide strong support that the observed oscillation is a tide which is a permanent feature of middle atmospheric dynamics while the repeating seasonal variability during all 21 years reaffirms the validity and effectiveness of the satellite data analysis method previously proposed by the same authors and used for analyzing the satellite data. The climatological tidal amplitudes rapidly growth with the height, as the 21-yearly mean amplitude changes from ∼1.6 K at 84 km to ∼7.9 K at 110 km; the latter is the largest climatologically mean tidal amplitude observed at latitude of 20°S. The tide is stronger in the SH than that in the NH particularly in the lower thermosphere and it is stronger at low latitudes than that at middle latitudes at all considered heights in the ±50° latitude range. The latitude tidal structure changes quite rapidly with height. While it is definitely asymmetric about the equator in the lower thermosphere with main enhancements at 110 km height situated around the equator, at ∼20°S and around ±(40–50°), the tidal structures at lower height levels become more symmetric as that at 84 km height with enhancements at the equator, ±35° and around ±50°. The seasonal variability based on the latitude and altitude climatological tidal structures indicated that at least four seasonal components have to be included in correctly describing the tidal seasonal behavior. The 21-year QW4 climatology reports for the first time the presence of the vertically upward propagating QW4 tide around the latitudes of ∼(0°–20°N) with a wavelength of ∼30 km, hence for correct description of the QW4 tide it is necessary besides the trapped and propagating Hough modes with very large wavelengths some propagating modes with shorter wavelengths to be included as well. This study also presents the QW4 responses to the 11-year solar cycle and the quasi-biennial oscillation at 30 hPa which define the tidal interannual variability.