We use a kernel density estimator method to evaluate the stellar velocity dispersion in the open cluster NGC 2571. We derive the 3D velocity dispersion using both proper motions as extracted from Gaia Data Release 3 and single-epoch radial velocities as obtained with the instrument FLAMES at ESO's Very Large Telescope. The mean-square velocity along the line of sight is found to be larger than the one in the tangential direction by a factor of 6–8. We argue that the most likely explanation for such an occurrence is the presence of a significant quantity of unresolved binary and multiple stars in the radial velocity sample. Special attention should be paid to single-line spectroscopic binaries (SB1) since in this case we observe the spectral lines of the primary component only, and therefore the derived radial velocity is not the velocity of the binary system center of mass. To investigate this scenario, we performed numerical experiments varying the fractional abundance of SB1 in the observed sample. These experiments show that the increase of the mean-square radial velocity depends on the fractional abundance of SB1 to a power in the range [0.39, 0.45]. We used the 3D velocity dispersion obtained by the dispersions in the tangential directions and the assumption that the radial velocity dispersion is the same as a tangential one to estimate the virial cluster mass and the cluster mass, taking into account the gravitational field of the Galaxy and the nonstationarity of the cluster. These estimates are 650 ± 30 M ⊙ and 310 ± 80 M ⊙, respectively, in substantial agreement with the photometric cluster mass.