• Describe how web and mobile-based symptom management interventions may alleviate physical symptoms in patients with advanced, life limiting illness.• Describe the inclusion criteria, search strategy and analysis used in a meta-analysis of web and mobile-based symptom management interventions of physical symptoms in patients with advanced, life limiting illness. Web and mobile-based interventions are promising modalities in which patients with advanced, life-limiting diagnoses can attain symptom-focused care as part of comprehensive palliative care. Systematically review and meta-analyze studies to summarize evidence on the effectiveness of web or mobile-based interventions impacting physical symptoms in patients with advanced, life-limiting diagnoses. Titles and abstracts published from 2004-2019 were identified using PubMed, PsycINFO, and CINAHL. RCTs involving adults with advanced, life-limiting diagnoses using a web or mobile-based intervention to manage their disease or symptoms were included. Interventions must have reported physical symptom outcomes. Risk of bias was assessed using the ROBINS-I tool. Studies that reported mean scores for physical symptoms using validated tools for the intervention and control groups were analyzed. These scores were pooled using a random effects model, and standardized mean difference (SMD) and 95% confidence intervals were reported. Heterogeneity was assessed using the I2 statistic. Eleven of the 1177 screened studies met the inclusion criteria. Interventions focused on five diagnoses (Cancer n=7, COPD n=3, Parkinson’s Disease n=1, Multiple Sclerosis n=1, Post-Polio Syndrome n=1). Intervention components included: general information, messaging a provider, tracking/monitoring, and feedback/tailored information. Eight studies evaluated physical symptoms using a multi-symptom tool and three evaluated specific symptoms (e.g. pain or fatigue). Web or mobile-based interventions significantly improved physical symptoms (SMD -0.34, -0.64 to -0.03, I2=88%). A subgroup analysis including studies using a multi-symptom tool observed a similar trend in improvement of physical symptoms (SMD -0.48, -0.86 to -0.09, I2=91%). This meta-analysis demonstrated that web and mobile-based symptom management interventions are effective modalities to alleviate physical symptoms in adults living with advanced, life-limiting diagnoses. Significant heterogeneity was noted among included studies.