Mean Red Blood Cell Distribution Research Articles

Evaluate the Complete Blood Picture and Some Biochemical Parameters in Patients referred to the dialysis unit in Diyala General Hospital

Research done on 40 patients; 24 males, 20-79 years, and 16 females, 42-67 years; referred to dialysis unit, Baqubah hospital, in November and December, 2021; January and February 2022. Creatinine, Urea and Iron, record high levels. Glucose, calcium, sodium, potassium, and phosphate, were within normal, and low levels of albumin. Means of Total Erythrocyte Counts (TECs), hemoglobin (Hb), Hematocrit% (HCT), and Mean Corpuscular Hemoglobin Concentration (MCHC), showed lowered level. While, Mean Cell Volume (MCV), Mean Corpuscular Hemoglobin (MCH), Mean Red Blood Cell Distribution Width- Standard Deviation (RDW-SD), Mean Red Blood Cell Distribution Width- Coefficient of Variation (RDW-CV), were within normal. Total Leucocyte Counts (TLCs), Neutrophils, Lymphocytes, Eosinophil, Basophils, were within normal, Platelet Counts and related parameter were within normal. Within ranges some values were higher than normal as, potassium, phosphate, (RDW-SD), (RDW-CV), Neutrophils%, Eosinophil%, Lymphocytes, Mean Platelets Volume (MPV). While some other values were lower as sodium, (TRCs), (Hb), (HCT %), (MCV), (MCH), (MCHC), (RDW-SD), (TLCs), Lymphocytes%, platelets, Platelet Distribution Width (PDW), Platelet- Large Cell Ratio (P-LCR). But some values of glucose, and calcium, were high, and some other low. At the same time Monocytes%, Basophils% was within normal range. In conclusion creatinine and urea levels have an important role in diagnosis and follow- up of kidney failure. All patients have high levels of urea, iron and creatinine. But not all have higher level of potassium and glucose. Sodium and albumin, showed decreased level. Blood picture revealed microcytic, hypochromic anemia; as (TECs), (Hb), (HCT %), (MCHC) and (RDW-SD) were of lower values.

Hematological parameters and red blood cell morphological abnormality of Glucose-6-Phosphate dehydrogenase deficiency co-inherited with thalassemia

Objective/BackgroundGlucose-6-phosphate dehydrogenase (G-6-PD) deficiency and thalassemia are genetically independent hemolytic disorders. Co-inheritance of both disorders may affect red blood cell pathology to a greater extent than normally seen in either disorder alone. This study determines the prevalence and evaluates hematological changes of G-6-PD deficiency and thalassemia co-inheritance. MethodsG-6-PD deficiency was screened from 200 male thalassemia blood samples using a fluorescent spot test. Hematological parameters and red blood cell morphology were evaluated among G-6-PD deficiency/thalassemia co-inheritance, G-6-PD deficiency alone, thalassemia alone, and normal individuals. ResultsG-6-PD deficiency was detected together with hemoglobin (Hb) E heterozygote, Hb E homozygote, β-thalassemia trait, and β-thalassemia/Hb E, α-thalassemia-2 trait, and Hb H disease. Hb level, hematocrit, mean cell volume, and mean cell Hb of G-6-PD deficiency co-inherited with asymptomatic thalassemia carriers show significantly lower mean values compared to carriers with only the same thalassemia genotypes. Higher mean red blood cell distribution width was observed in G-6-PD deficiency co-inherited with Hb E heterozygote, as with numbers of hemighost cells in G-6-PD deficiency/thalassemia co-inheritance compared to those with either disorder. Apart from Hb level, hematological parameters of co-inheritance disorders were not different from individuals with a single thalassemia disease. ConclusionG-6-PD deficiency co-inherited with thalassemia in males was present in 10% of the participants, resulting in worsening of red blood cell pathology compared with inheritance of thalassemia alone.

The Acute Effect of the Antioxidant Drug U-74389G on Red Blood Cell Distribution Width Levels During Hypoxia Reoxygenation Injury in Rats.

The AIM of this experimental study was to evaluate the effect of the antioxidant drug "U-74389G" in a rat model of hypoxia reoxygenation (HR) using the previously established protocol. Effects of treatment were evaluated by mean red blood cell distribution width (RDW) levels. 40 rats of a mean weight of 231.875 g were employed in the study. RDW levels were determined at 60 min (groups A and C) and at 120 min (groups B and D) after starting the reoxygenation. Groups A and B received no drugs, whereas rats from groups C and D were administered with U-74389G. demonstrated that U-74389G administration significantly decreased the RDW levels by 4.96% + 2.27% (p = 0.0175). Reoxygenation time non-significantly decreased the RDW levels by 0.27% + 2.41% (p = 0.8889). Together, U-74389G administration and reoxygenation time non-significantly decreased the RDW levels by 2.54% + 1.39% (p = 0.0679). U-74389G administration particulary in concert without reperfusion declines the RDW levels even within the short - time context of 1.5 hours reperfusion.

Assessments of the associations of thrombus localization with accompanying disorders, risk factors, D-dimer levels, and the red cell distribution width in pulmonary embolism

OBJECTIVE:Pulmonary embolisms occur as a wide spectrum ranging from clinically asymptomatic thrombi to massive thrombi that lead to cardiogenic shock. The purpose of this study was to determine the associations of thrombus localization with risk factors, accompanying disorders, D-dimer levels and the red blood cell distribution width in patients with pulmonary embolism.MATERIAL AND METHODS:In 148 patients diagnosed with pulmonary embolism, the presence and anatomical localization of the thrombus were assessed via computed tomographic pulmonary angiography. The accompanying disorders, risk factors, serum D-dimer levels, and red blood cell distribution width of the patients were retrospectively evaluated. ClinicalTrials.gov: NCT02388841.RESULTS:The mean age of the patients was 54±16.0 years, and 48 patients were ≥65 years of age. The most frequent accompanying disorders were chronic obstructive pulmonary disease (22%) and malignancy (10.1%), and the most frequent risk factors were recent operation (14.1%) and immobilization (18.2%). Thrombi were most frequently observed in the right pulmonary artery (37.8%). In 31% of the patients, the thrombus was localized to the main pulmonary arteries. Immobile patients exhibited a higher proportion of thrombi in the main pulmonary arteries than mobile patients. The mean D-dimer level and the mean red blood cell distribution width in the patients with thrombi in the main pulmonary arteries were higher than those in the patients with thrombi in more distal pulmonary arterial branches.CONCLUSION:Significant associations of proximally localized thrombi with immobilization, the D-dimer levels, and the red blood cell distribution width were observed.

Effect of long-term training on physical and hematological values in young female handball players

The aim of the study was to evaluate the effect of long-term handball training on physical and hematological variables in young female handball players. Thirty girls (12.58±0.51 year) from different schools and clubs, voluntarily participated in this study for handball training. We found significant differences at height, weight, standing long jump, seated medicine ball throw and 30 m sprint test parameters ( P 0.05 ). However, significant differences was found at aspartate aminotransferase (AST‐SGOT), alanine aminotransferase (ALT‐SGPT), power of hydrogen (Ph), urine density, mean corpuscular volume (MCV), mean red blood cell distribution width (RDW) and platelet (PLT) values ( P<0.05 ). We found significant differences in hemoglobin (Hgb), creatine, fasting blood glucose, mean corpuscular volume (MCH), mean hemoglobin concentration (MCHC) and mean platelet volume (MPV) values (P<0.001 ). Research findings were obtained by using paired t test. In conclusion, significant effects were observed in some physical and physiological developments of girls. Especially, the girls who were selected for handball achieved major degree at the end of young women's Championships.

Effect of long-term training on physical and hematological values in young female handball players

The aim of the study was to evaluate the effect of long-term handball training on physical and hematological variables in young female handball players. Thirty girls (12.58±0.51 year) from different schools and clubs, voluntarily participated in this study for handball training. We found significant differences at height, weight, standing long jump, seated medicine ball throw and 30 m sprint test parameters (P 0.05). However, significant differences was found at aspartate aminotransferase (AST–SGOT), alanine aminotransferase (ALT–SGPT), power of hydrogen (Ph), urine density, mean corpuscular volume (MCV), mean red blood cell distribution width (RDW) and platelet (PLT) values (P<0.05). We found significant differences in hemoglobin (Hgb), creatine, fasting blood glucose, mean corpuscular volume (MCH), mean hemoglobin concentration (MCHC) and mean platelet volume (MPV) values (P<0.001). Research findings were obtained by using paired t test. In conclusion, significant effects were observed in some physical and physiological developments of girls. Especially, the girls who were selected for handball achieved major degree at the end of young women's Championships. Key words: Handball, training, female, blood.

Pica associated with iron deficiency or depletion: clinical and laboratory correlates in 262 non-pregnant adult outpatients

BackgroundThere are many descriptions of the association of pica with iron deficiency in adults, but there are few reports in which observations available at diagnosis of iron deficiency were analyzed using multivariable techniques to identify significant predictors of pica. We sought to identify clinical and laboratory correlates of pica in adults with iron deficiency or depletion using univariable and stepwise forward logistic regression analyses.MethodsWe reviewed charts of 262 non-pregnant adult outpatients (ages ≥18 y) who required treatment with intravenous iron dextran. We tabulated their sex, age, race/ethnicity, body mass index, symptoms and causes of iron deficiency or depletion, serum iron and complete blood count measures, and other conditions at diagnosis before intravenous iron dextran was administered. We excluded patients with serum creatinine >133 μmol/L or disorders that could affect erythrocyte or iron measures. Iron deficiency was defined as both SF <45 pmol/L and TS <10%. Iron depletion was defined as serum ferritin (SF) <112 pmol/L. We performed univariable comparisons and stepwise forward logistic regression analyses to identify significant correlates of pica.ResultsThere were 230 women (184 white, 46 black; ages 19-91 y) and 32 men (31 white, 1 black; ages 24-81 y). 118 patients (45.0%) reported pica; of these, 87.3% reported ice pica (pagophagia). In univariable analyses, patients with pica had lower mean age, black race/ethnicity, and higher prevalences of cardiopulmonary and epithelial manifestations. The prevalence of iron deficiency, with or without anemia, did not differ significantly between patients with and without pica reports. Mean hemoglobin and mean corpuscular volume (MCV) were lower and mean red blood cell distribution width (RDW) and platelet count were higher in patients with pica. Thrombocytosis occurred only in women and was more prevalent in those with pica (20.4% vs. 8.3%; p = 0.0050). Mean total iron-binding capacity was higher and mean serum ferritin was lower in patients with pica. Nineteen patients developed a second episode of iron deficiency or depletion; concordance of recurrent pica (or absence of pica) was 95%. Predictors of pica in logistic regression analyses were age and MCV (negative associations; p = 0.0250 and 0.0018, respectively) and RDW and platelet count (positive associations; p = 0.0009 and 0.02215, respectively); the odds ratios of these predictors were low.ConclusionsIn non-pregnant adult patients with iron deficiency or depletion, lower age is a significant predictor of pica. Patients with pica have lower MCV, higher RDW, and higher platelet counts than patients without pica.