Mean Platelet Volume Values In Patients Research Articles

Low plateletcrit is associated with reduced progression: Free and overall survival in chronic lymphocytic leukemia.

Alterations of plateletcrit and mean platelet volume (MPV) and pathogenesis of chronic lymphocytic leukaemia (CLL) have been linked to various inflammatory disorders. The prognostic impact of plateletcrit and MPV were evaluated. MPV and plateletcrit levels of both CLL and control group were compared and then in CLL patients, additional diseases, leukocyte count, platelet count, lactate dehydrogenase, Rai stage, progression-free and overall survival, mutations, if any, and chemotherapy, if any, were recorded. Then, the relationship between MPV and plateletcrit values and these parameters were evaluated in CLL patients. Platelet and plateletcrit values were found to be significantly lower in CLL patients than the control group (p<0.001) for both. Plateletcrit and MPV values of patients who did not receive chemotherapy were higher than those who received chemotherapy (p=0.03, p=0.02, respectively). Being over 75 years old, plateletcrit value less than 0.1565 %, platelet level below 175 x 109/L, and leukocyte count greater than 53.5 x 109/L was found to significantly reduce overall survival. Male gender, each stage increase, plateletcrit less than 0.1565 % and leukocyte count greater than 53.5 x 109/L was related to reduce treatment-free survival in CLL patients. Plateletcrit can be a viable prognostic marker for defining both treatment free and overall survival.

Evaluation of inflammatory parameters in patients who attempted suicide by taking drugs.

Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and mean platelet volume (MPV) are markers reflecting the inflammation process that can be easily calculated in the hemogram examination. In this study, we aimed to investigate the changes in NLR, PLR and MPV values ​​in patients who attempted suicide by taking drugs. In total, 124 patients who were admitted to the emergency department after attempting suicide by taking drugs and who were followed up in the internal medicine department for observation purposes for 24-72 hours were included in the study. The study was retrospective and the data of the patients were recorded by scanning the hospital automation system. The NLR, PLR and MPV of the patients at the time of admission to the emergency department and at the time of discharge were evaluated and compared with each other. The NLR and PLR values ​​of the patients at admission were found to be significantly higher than those values ​​at discharge. In our study, NLR and PLR values were found to be high during the period when patients attempted suicide. The high detection of these markers of inflammation suggests that it may be a marker predictive of suicide attempt by taking medication (Tab. 4, Ref. 28).

The relationship between mean platelet volume and reverse dipping blood pressure pattern in patients with essential hypertension

ABSTRACT Objective An association between increased mean platelet volume (MPV) and cardiovascular events is well established. Recent studies suggest that a nondipper blood pressure pattern is closely related to increased MPV. Because little information has been revealed about the relationship between reverse dipper hypertension (RDHT) and MPV, we aimed to investigate this relation. Methods A total of 317 patients were retrospectively evaluated by analyzing the records of ambulatory blood pressure monitoring (ABPM). Patients were categorized into three groups according to their ABPM values as RDHT (n = 63), non-dipper hypertension (NDHT) (n = 95), and dipper hypertension (DHT) groups (n = 159). MPV and biochemical analyses were recorded from the hospital database. Results The largest MPV was found in patients with RDHT, followed by patients with NDHT and DHT group (9.1 ± 0.4 fl, 8.8 ± 0.6 fl, and 8.6 ± 0.5 fl, respectively, for all p < .05). MPV was positively correlated with mean 24-hour systolic blood pressure (SBP), mean 24-hour diastolic blood pressure (DBP), mean daytime SBP, mean nighttime SBP and mean nighttime DBP. In multivariate logistic regression analysis, MPV (OR 1.761, 95% CI 1.329 to 2.334, p = .001) and age (OR 1.065, 95% CI 1.019 to 1.113, p = .001) were found to be associated with RDHT. ROC curve analysis of MPV for prediction of RDHT showed that at the cutoff value of >9,1 fl with a sensitivity of 60% and specificity of 69%, respectively (AUC = 0.696 ± 0.035, 95% CI: 0.627–0.764). Our data show that the RDHT pattern is associated with increased MPV values in patients with essential hypertension.

MO296MEAN PLATELET VOLUME IN FAMILIAL MEDITERRANEAN FEVER RELATED AMYLOIDOSIS AND COMPARISON WITH COMMON PRIMARY GLOMERULAR DISEASES

Abstract Background and Aims Compared to healthy controls, mean platelet volume (MPV) is frequently higher in patients with Familial Mediterranean fever (FMF) but lower in amyloidosis patients. The cause of differing MPV levels in FMF patients with and without amyloidosis is not clear. We hypothesized that severe proteinuria and renal dysfunction in amyloidosis could be responsible from low MPV in contrast to FMF patients without amyloidosis. We aimed to compare MPV levels of FMF patients with amyloidosis and MPV values of patients with different glomerular diseases to understand if low MPV is unique to amyloidosis or MPV is similar in all glomerular diseases indicating that it is a consequence of proteinuria and/or renal dysfunction. Method We compared pre-biopsy MPV levels of patients with amyloidosis secondary to FMF, to MPV levels of patients with membranous glomerulonephritis, focal segmental glomerulosclerosis (FSGS) and IgA nephropathy that all present with proteinuria and renal dysfunction. Factors affecting MPV were also determined. Results 703 patients (411 male, 292 female) were included in the study. Mean age was 42.6±14.3 years. There were 124 patients with amyloidosis, 224 patients with IgA nephropathy, 188 patients with membranous glomerulonephritis and 167 patients with FSGS. Patients with amyloidosis had lower MPV compared to patients without amyloidosis (7.9±1.2 fL vs. 8.2±0.9 fL respectively, p=0.008). Patients with amyloidosis had also significantly lower MPV compared to patients with each of the other diagnoses. MPV was negatively correlated with platelet count (r = - 0.351, p &amp;lt;0.001). There was no significant correlation of MPV with serum creatinine and proteinuria. Conclusion This study is the largest study of MPV in patients with biopsy proven amyloidosis and confirms previous studies reporting low MPV in amyloidosis. This study indicates that low MPV in amyloidosis cannot be explained with severe proteinuria and renal dysfunction.

Mean Platelet Volume and Red Cell Distribution Width Values in Patients with COVID-19 Admitted to Intensive Care Units or Wards from Emergency Department

Background: Mean platelet volume (MPV) and red cell distribution width (RDW) values are components of complete blood count (CBC) which is a routine, cheap and fast test used in the evaluation of patients admitted to the emergency department (ED). The present study aimed to investigate RDW and MPV values in patients with Novel Coronavirus Disease 2019 (COVID-19) admitted to intensive care units (ICU) or wards from the ED. Methods: A retrospective data analysis of patients who were admitted to Ankara City Hospital ICUs and wards with the diagnosis of COVID-19 was performed. Group 1 included patients admitted to ICUs and Group 2 included those admitted to wards. Results: A total of 127 patients were admitted with a COVID-19 diagnosis. Mean age in Group 1 and Group 2 were 46±17 and 41±14, respectively. The number of patients admitted to ICU (Group 1) was 46 (36.2%), and the number of patients admitted to wards (Group 2) was 81 (63.7%). Of all patients, 122 patients (96.06%) were discharged and 5 patients (3.9%) died. RDW values in Group 1 was higher than those in Group 2 (p<0,001). Similarly, MPV was higher in Group 1 than Group 2 (p<0,001). Conclusion: In patients with COVID-19, RDW and MPV values are higher in those admitted to ICU than patients admitted to wards from the ED.

Dynamic Change in Mean Platelet Volume and Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage.

Background: The mean platelet volume (MPV) has been shown to predict short-term outcomes in patients who have experienced aneurysmal subarachnoid hemorrhage (aSAH). The purpose of this study was to explore the temporal variation of MPV in patients with aSAH and its relationship to the development of delayed cerebral ischemia (DCI).Methods: Data from 197 consecutive aSAH patients who were treated at our institution between January 2017 and December 2019 were collected and analyzed. Blood samples to assess MPV were obtained at 1–3, 3–5, 5–7, and 7–9 d after the initial hemorrhage. Univariate and multivariate analyses were performed to investigate whether MPV was an independent predictor of DCI and the receiver operating characteristic (ROC) curve and area under the curve (AUC) were determined.Results: The MPV values in patients with DCI were significantly higher compared to those without DCI at 1–3, 3–5, 5–7, and 7–9 d after hemorrhage (P < 0.001). The trend for MPV in patients with DCI was increased at first and then decreased. The transition from increases to decreases occurred at 3–5 d after hemorrhage. The optimal cutoff value for MPV to accurately predict DCI was 10.35 fL at 3–5 d after aSAH in our cohort. Furthermore, the MPV observed at 3–5 d was an independent risk factor for DCI [odds ratio (OR) = 4.508, 95% confidence interval (CI): 2.665–7.626, P < 0.001].Conclusions: MPV is a dynamic variable that occurs during aSAH, and a high MPV at 3–5 days after hemorrhage is associated with the development of DCI.

AS A CARDIOVASCULAR RISK FACTOR IN GRAVES PATIENTS: MPV AND RDW

AMAÇ: Bu çalışmada graves hastalarının sağlıklı kontrol grubuna göre ortalama trombosit hacmi (MPV) ve kırmızı kan hücresi dağılım genişliği (RDW) değerlerinin karşılaştırılması ve kardiyovasküler risk faktörleri ile ilişkisinin olup olmadığı amaçlandı.GEREÇ VE YÖNTEM: 50 graves hastası ve 50 sağlıklı kontrol hasta retrospektif olarak incelendi. Diabetes mellitus (DM), demir eksikliği anemisi, kronik böbrek hasarı, hipertansiyon (HT), daha önce geçirilmiş myokard infarktüsü, konjestif kalp yetmezliği, kronik inflamatuar hastalığı, malignitesi olan ve antihiperlipidemik ilaç kullanan hastalar çalışmaya dahil edilmedi. Sağlıklı kontrol grubunun başvuru anında, graves grubunun ise tanı anında henüz tedavileri başlanmadan tam kan sayımının içinde rutinde bakılan MPV ve RDW değerleri kaydedildi. Aynı zamanda her iki grubun LDL kolesterol (LDL-C), Hdl kolesterol (HDL-C), trigliserid (TG) değerleri, sigara kullanıp kullanmadığı, boy, kilo ve vücut kitle indeksleri (VKİ) dosyalarından retrospektif olarak incelendi. MPV ve RDW değerlerinin karşılaştırılması student-t testi ile, kardiyovasküler risk faktörleri ile olan ilişkisi pearson korelasyon testi ile değerlendirildi.BULGULAR: Graves hastası olup henüz ilaç tedavisi başlanmamış olan hastaların MPV değerleri ile sağlıklı kontrol grubunun MPV değerleri arasında anlamlı farklılık saptanmadı (p=0.291). İki grup arasında RDW değerlerine bakıldığında; graveslilerin RDW değerleri kontrol grubuna göre anlamlı düşük saptandı (p&amp;lt;0.05). Gravesli kadın hastalar ile kontrol grubundaki kadın hastalar MPV ve RDW değerleri açısından karşılaştırıldığında; kontrol grubundaki kadın hastaların MPV ve RDW değerleri gravesli kadın hastalara göre anlamlı yüksek saptandı (sırasıyla p=0.047, p=0.012). Gravesli hastalarda kardiyovasküler risk faktörlerinden sigara içimi, ileri yaş ve VKİ ile MPV, RDW değerleri arasında korelasyon saptanmadı. Gravesli grupta LDL-C ile RDW arasında korelasyon saptanmazken, LDL-C ile MPV arasında negatif korelasyon saptandı (p=0.016, r=-0.443).SONUÇ: İnflamasyonun göstergesi ve kardiyovasküler hastalık risk göstergesi olarak kabul gören MPV ve RDW değerlerininin graves hastalarında kardiyovasküler risk faktörleri ile ilişkisi saptanmamıştır.

Mean platelet volume in arterial and venous thrombotic disorders

Abstract The mean platelet volume (MPV) is an easy, rapid and inexpensive laboratory parameter which basically mirrors platelet size. Due to the essential role of platelets in hemostasis, many studies have assessed the MPV value in patients with arterial and venous thrombotic disorders. These have then been summarized in some interesting meta-analyses and recent studies that will be discussed in this narrative review. Taken together, the currently available evidence suggests that the MPV may be substantially increased in concomitance with acute episodes of coronary artery disease, venous thromboembolism, portal vein thrombosis, stroke, erectile dysfunction and preeclampsia. In many of these conditions, an increased MPV value may also be associated with unfavorable outcomes. Despite these convincing findings, some important technical issues should be considered for improving the clinical usefulness of this measure. These essentially include anticoagulant, timing of sample collection, the sample storage conditions, the influence of the analytical techniques, the approaches used for its calculation, the accurate definition of reference ranges and diagnostic cut-offs, as well as the current lack of standardization, which makes data obtained with different techniques/analyzers poorly comparable. Provided that the impact of these variables can be abated or minimized, the MPV can gain a valuable role in the laboratory workout of many arterial and venous thrombotic disorders.

EP1.01-90 The Prognostic Role of Mean Platelet Volume in Patients with Advanced Non-Small Cell Lung Cancer

Previous studies suggest the potential correlation between increased mean platelet volume (MPV) and survival in non-small cell lung cancer (NSCLC), but results are often contradictory. We herein aimed to further evaluate the prognostic value of MPV in patients with advanced-stage NSCLC in the real-world setting of a tertiary referral oncology center. Demographic, clinicopathological and laboratory data (including complete blood count parameters) of 30 patients with stage IIIB or IV NSCLC were retrieved from the Lung Cancer registry of the Oncology Clinic of Sotiria Athens General Hospital and analyzed. All the above variables (including MPV) were correlated to each other, as well as with overall survival (OS) and progression-free survival (PFS). Mean patients’ age was 68,5 (SD=7,5) years. The majority of patients were male (76.7%), had positive smoking history (90%), squamous cell carcinoma (53.3%), and stage IV disease (76.7%). No statistically significant correlations between survival and sex, age, smoking history or tumor histology (squamous cell carcinoma versus adenocarcinoma), or between MPV and histology were noted. Worse performance status (p=0.004) and higher white blood cell count (p=0.01) were correlated with reduced OS, while increased MPV was strongly correlated both with OS and PFS (p<0.0001 in both cases). Increased MPV may correlate with improved survival of patients with NSCLC, thus potentially representing a marker of favorable prognosis. Our study findings warrant confirmation in larger prospective series

Can neutrophil-lymphocyte, platelet-lymphocyte ratio and mean platelet volume be marker in tonsil hemorrhage?

The aim of this study was to determine the relationship between neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and mean platelet volume (MPV) in patients with bleeding after tonsillectomy surgery compared to non-bleeding patients, and to determine the risk of bleeding in patients undergoing surgery. Thirty patients with pediatric hemorrhage after the adenotonsillectomy and tonsillectomy surgery at the Otorhinolaryngology Clinic of Afyon Kocatepe University Hospital between 2012-2016 and 30 patients without any infection were included in the study. Patients were evaluated retrospectively. Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and mean platelet volume (MPV) values were recorded in preoperative patients. They were compared with control patients. There were 30 patients in both groups (n=30). The average age was 8 in the control group and 7 in the patient group. There was no significant difference in NLR. (p=0.085). There was a significant difference in terms of PLR (p=0.039). There was a significant difference in MPV. (p=0.022). There was no significant difference in PLR and MPV values in patients with bleeding after tonsillectomy. There was no significant difference in NLR values.

Relationship between mean platelet volume and metabolic syndrome in Chinese patients

Mean platelet volume (MPV) is a determinant of activation and variability of platelets (PLT). The focus of this study was to to investigate MPV values in patients with and without metabolic syndrome (MS). It also evaluates the association between them. There are close connections among MPV, MS, and cardiometabolic risk. We compiled age, body mass index, blood cell counts, MPV, and other data of 59976 self-reported healthy volunteers (28428 male, 31548 female), 24.65% of who have MS. The mean age of the group was 48.21 years old. The data was grouped by sex and values of data between men and women groups were analyzed by independent sample’s t-test. The relationship between sex and MS was evaluated by chi-square tests. Crude odd ratios of MS between MPV quartiles and 95% confidence intervals were analyzed by binary logistic regression in this study. We found women had higher levels of MPV (10.09 vs. 9.98, P < 0.01) and PLT (228.68 vs. 212.11, P < 0.01) than men. In females, the prevalence of MS was higher in low MPV group than in high MPV groups. The odds of having MS were significantly lower in higher MPV quartiles compared with MPV Quartile 1 in women (Adjusted OR < 1, P < 0.01). This study indicated that MS was inversely associated with MPV in females only.

Mean Platelet Volume is Increased Only by Subcutaneous Allergen Immunotherapy But not in Allergic Diseases

Objective: Platelets play a role in the pathogenesis of inflammation beside hemostasis. Mean platelet volume (MPV) is used as a biomarker of platelet activation. Although the platelet’s role in the pathogenesis of allergic diseases is well known, the MPV value is still controversial in allergic diseases. The objective is to observe the changes of the MPV value in patients with allergic diseases and patients receiving subcutaneous venom and aeroallergen immunotherapy (SCIT). Materials and Methods: Patients who are followed by our pediatric allergy and immunology clinic were enrolled in the study. The study group included patients with atopic dermatitis, food allergy, chronic urticaria, allergic rhinitis, asthma and obese asthmatics. The control group consisted of age- and gender-matched and otherwise healthy children. The value of MPV was recorded and compared to the control group’s value. The value of MPV was evaluated at the beginning and at the second year of SCIT. Results: Study subgroups included patients with atopic dermatitis (n:132), food allergy (n:47), allergic rhinitis (n:48), chronic urticaria (n:102 ), asthma (n:22), and obese asthmatics (n:31). The value of MPV was not statistically different between the patient and control groups. The severity of atopic dermatitis, autoimmunity of chronic urticaria and presence of obesity in asthmatic patients did not influence the value of MPV. The beginning and the second year median (IQR) MPV levels of the patients receiving SCIT were 7.5 (7.1-8.1) fl and 8.6 (7.6-9.2) fl respectively in the aeroallergen immunotherapy (IT) group, and 7.9 (7.2-8.4) fl and 8.8 (8.3-9.3) fl respectively in the venom immunotherapy (VIT) group (p<0.001). Conclusion: This study has shown that MPV changes significantly over the years in SCIT.

Evaluation of Mean Thrombocyte Volumes in Asthma Patients During Acute Exacerbations and Stable Periods

Objective: Asthma is a heterogeneous disease characterized by chronic airway inflammation. Mean Platelet Volume (MPV) is one of the markers of platelet activation. The disease activity has been shown to have an important role as a marker for the efficacy of anti-inflammatory therapy and inflammation. The aim of this study was to investigate the relationship between disease activity and mean platelet volume and to determine the mean platelet volume (MPV) and CRP values during asthma exacerbations and stable periods. Methods: In this study, data from 50 patients with asthma exacerbations, 50 stable asthmatic patients and 40 healthy subjects were evaluated retrospectively. Results: Even though the MPV values of patients with an asthma exacerbation was lower (9.2 ± 0.9 fL) than those of stable asthmatic patients (9.6 ± 1.3 fL), we did not find statistical differences between the groups in terms of MPV results (P = 0.374). Leukocyte, neutrophil counts and percentages and CRP levels were significantly higher in patients with an exacerbation than in stable asthmatic and control groups (p = 0.000). There was no difference in , neutrophil counts and percentages and CRP levels between stable asthmatic patients and healthy controls (p> 0.05). Conclusion: In conclusion, there was no statistically significant relationship between the MPV values and disease activity in asthmatic patients. We believe that prospective studies involving a larger number of patients are needed to determine the place of MPV in asthmatic patients, since the number of patients and controls in our study was low.

Mean platelet volume is increased in patients with chronic hepatitis B

Background. Hepatitis secondary to infection with the hepatitis B virus (HBV) is one of the most common causes of viral hepatitis worldwide. Multiple extrahepatic manifestations of HBV infection have been recognized. However, the effect of HBV infection on the mean platelet volume (MPV) is unknown. The aim of this study was to assess the MPV, an indicator of platelet activation, in patients with chronic hepatitis B. Methods. The study group consisted of 50 patients with chronic hepatitis B. An age, gender, and body mass index-matched control group consisted of 50 healthy volunteers. All patients and control participants underwent echocardiographic examination. We measured the serum MPV values in patients and control participants. Results. Mean platelet volume was significantly higher among patients with HBV when compared with the control group (9.2±2.2 vs 7.1±1.6 fl, respectively; p <0.001). Conclusion. We have shown that MPV was significantly elevated in patients with chronic hepatitis B compared to control participants. According to our knowledge, there has been no previous study of MPV in chronic HBV patients. Therefore, we have investigated the possible association between HBV infection and MPV.

Mean Platelet Volume in Women with Gestational Diabetes

Purpose: Mean platelet volume (MPV) is an indicator of platelet activation which plays an important role in the pathogenesis of atherosclerosis. The purpose of this study was to compare MPV values in patients with previous gestational diabetes (pGDM), who have different degrees of carbohydrate intolerance with that in women without pGDM; and to retrospectively analyze MPV in these women during pregnancy. Material and Method: One hundred and five consecutive women with gestational diabetes mellitus (GDM) and 40 women with negative screening for GDM were studied. Results: There was no statistically significant difference in MPV between women with pGDM and health controls. Although not significant, women with pGDM developing type 2 diabetes had elevated levels of MPV compared to their normoglycemic counterparts (p=0.092). MPV was positively correlated with fasting glucose levels (r=0.215, p=0.009). During pregnancy, the mean platelet volume was significantly higher in women with GDM than in healthy pregnant controls (p<0.05). Discussion: Our results suggest that alterations in MPV levels are associated with diabetic state rather than underlying insulin resistance.

Prognostic implications of mean platelet volume on short- and long-term outcomes among patients with non-ST-segment elevation myocardial infarction treated with percutaneous coronary intervention: A single-center large observational study

Background: Mean platelet volume (MPV) is a simple and reliable indicator of platelet size that correlates with platelet activation and their ability to aggregate. We studied the predictive value of MPV in patients with non-ST-segment elevation myocardial infarction (NSTEMI) treated with percutaneous coronary intervention (PCI).Methods: We analyzed the consecutive records of 1001 patients who were hospitalized due to NSTEMI at our center. The primary end point was a composite end point that included the rates of all-cause death, non-fatal myocardial infarction, and acute coronary syndrome (ACS) driven revascularization at 12 months. The enrolled patients were stratified according to the quartile of the MPV level at admission.Results: Along with the increasing quartile of MPV, the 12-month composite end point increased significantly (p = 0.010), and this association remained significant after the risk-adjusted analyses (per 1 fL higher MPV; adjusted hazard ratio [HR] 1.13; 95% confidence interval [CI] 1.02–1.27; p = 0.026). In the multivariate analysis, the MPV was also an independent factor of all-cause mortality (per 1 fL increase; adjusted HR 1.34; 95% CI 1.12–1.61; p = 0.0014) and death or non-fatal myocardial infarction (per 1 fL increase; adjusted HR 1.16; 95% CI 1.03–1.31; p = 0.017).Conclusion: In patients with NSTEMI treated with PCI, a high MPV value was associated with a significantly increased incidence of long-term adverse events, particularly for all-cause mortality.

Mean platelet volume play a role in disease severity in patients with obstructive sleep apnea syndrome?

This study aims to show the effects of nasal continuous positive airway pressure (CPAP) treatment on platelet activation in patients with severe obstructive sleep apnea syndrome (OSAS). Forty-six patients (29 males, 17 females; mean age 48.2±7.6 years; range 40 to 56 years) with severe OSAS with apnea/hypopnea index (AHI) ≥30 were included in this study. Complete blood counts were analyzed and mean platelet volume (MPV) values were compared in patients before and after CPAP treatment at six months. The mean MPV values before CPAP were 8.9±1.3 (p<0.001), while the mean values were 7.7±1.1 (p<0.001) at six months after CPAP treatment in patients with severe OSAS. There was a statistically significant decrease in the MPV values after CPAP treatment. Patients' number of platelets which was measured six months after the CPAP treatment increased at a significant level compared to baseline (p<0.001). Continuous positive airway pressure treatment caused a significant decrease in the MPV values in patients with severe OSAS. As a negative acute phase reactant, MPV can be used as a marker to exert the cardioprotective effect of CPAP.

Is Mean Platelet Volume a Reliable Marker to Predict Ischemic Stroke in the Follow-Up of Patients with Carotid Stenosis?

The objective of the study is to evaluate the reliability of mean platelet volume (MPV) for predicting ischemic stroke (cerebrovascular event [CVE]) among patients with different degrees of carotid stenosis. Fifty-two patients with CVEs, 136 patients with carotid artery disease (CAD), and 40 healthy volunteers were enrolled in this study. All participants were divided into the following groups according to CAD: absence of stenosis, less than 50% stenosis, 50%-69% stenosis, and 70% or more to total occlusion of the internal carotid artery. For each participant, the parameters of CAD were assessed using ultrasonography. To obtain the values of CRP and MPV and the leukocyte and platelet counts, all samples were processed within 30 minutes after blood collection. Univariate and multivariate analyses were used to evaluate the association between the values of serum C-reactive protein (CRP) and MPV and carotid stenosis. In terms of age and gender, there was no statistically significant difference between the groups (P = .094 and P = .428, respectively). However, CRP values in patients with CAD and CVEs were significantly higher than those in the controls (P < .001). There was no statistically significant difference between the CRP values in patients with CAD and CVEs (P = .249). Moreover, the MPV values did not show any significant difference between the groups (P = .053) and among the patients with CAD (P = .64). There was no positive correlation between serum CRP and MPV values in patients with CAD regarding the degree of carotid stenosis (r = .061, P = .477). The findings of this study claim that MPV has no predictive value during follow-up of the patients with CAD for CVEs.

Is mean platelet volume a new activity criteria in Behçet's disease?

The aim of this study was to assess mean platelet volume (MPV) and its relationship with disease activity in patients with Behçet's disease. Thirty-six patients with an age of 38.9 ± 11 (mean ± SD) years and 40 controls aged 36.5 ± 12 (mean ± SD) years were enrolled the study. Demographic data, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), MPV, clinical findings such as oral aphthae, genital aphthae, erythema nodosum, acne, central nervous system involvement, uveitis, arthritis and arthralgia were all recorded. The MPV value in patients with Behçet's disease was 8.06 ± 1.0 (mean ± SD) and the MPV value of the control participants was 7.45 ± 0.6 (mean ± SD). MPV was statistically higher in patients with Behçet's disease than in the controls (P = 0.003). There were also significant differences between patients and controls according to ESR and CRP values (P < 0.001 and P = 0.001, respectively). MPV was positively correlated with arthralgia (P < 0.001, r = 0.438), arthritis (P = 0.008, r = 0.307), erythema nodosum (P = 0.002, r = 0.354), central nervous system involvement (P = 0.002, r = 0.357), acne (P = 0.008, r = 0.312), genital aphthae (P < 0.001, r = 0.401) and oral aphthae (P = 0.001 r = 0.377). MPV can be easily obtained from the patients. It was a cheap and practical method. In the future, MPV may be used as a new marker to detect the activation of BD.

Does varicocele correction lead to normalization of preoperatively elevated mean platelet volume levels?

There are several studies on the relationship between increased mean platelet volume (MPV) and varicocele. We investigated the relationship between preoperative and 6-month postoperative MPV values in patients whose varicocele was corrected with surgery. A total of 282 patients underwent surgery at our urology clinic between December 2011 and December 2013 for primary varicocele. We retrospectively examined the records of 61 patients who came to the 6-month postoperative follow-up. The preoperative varicocele diagnosis was made with physical examination findings and supported with colour Doppler ultrasonography. The varicocele was grade I in 12 patients, grade II in 34 patients and grade III in 11 patients. When the preoperative and 6-month postoperative haemoglobin (Hb), MPV, mean corpuscular volume, platelet, and platelet distribution width (PDW) values were compared, there was a significant decrease in MPV (p = 0.019), and a significant increase in Hb (p < 0.001). A noticeable increase was also present in PDW, but it was not statistically significant (p = 0.058). We found that MPV increased in patients with varicocele and tended to decrease again after the varicocele was surgically corrected. However, we feel larger prospective series are needed.