Mean Platelet Volume In Diagnosis Research Articles

The Role of Neutrophil/Lymphocyte Ratio, Platelet/Lymphocyte Ratio and Mean Platelet Volume in Diagnosis of Hydrosalpinx

Aim: It is very important to uncover the relationship between Hydrosalpinx, which occurs as a result of chronic-inflammatory-processes, and inflammatory markers. Our study aimed to investigate the role of Neutrophil/Lymphocyte Ratio(NLR), Platelet/Lymphocyte Ratio(PLR), and Mean Platelet Volume(MPV) values in the diagnosis of patients who had Hydrosalpinx. Materials and Methods: Our study included 349 patients, who applied to our clinic between March 2018-June 2023, were diagnosed with primary or secondary infertility, and for this reason underwent Hysterosalpingography. A total of 89 patients who had Hydrosalpinx and 260 patients who did not have Hydrosalpinx were divided into 2 groups, and the demographic, clinical data were compared retrospectively. Results: Neutrophil and Platelet levels were found to be significantly higher in the Hydrosalpinx-group than the control group(p:0.000).The presence of Hydrosalpinx was found to be significantly higher in patients who were diagnosed with secondary infertility(p:0.000).Neutrophil and Platelet levels were significantly higher in the bilateral-Hydrosalpinx-group than the unilateral-Hydrosalpinx-group(p:0.036,p:0.012, respectively). The NLR and PLR were found to be significantly higher in the bilateral-Hydrosalpinx-group than the unilateral–Hydrosalpinx-group(p:0.038,p:0.009, respectively). MPV were found to be significantly lower in the bilateral-Hydrosalpinx-group than the unilateral-Hydrosalpinx-group(p:0.011). Conclusion: The findings of our study support the literature data on the relationship between NLR,PLR,MPV, and chronic inflammatory processes. These markers deserve to be evaluated again and again in prospective and controlled studies, in which they will be considered together with clinical findings, to investigate their ability to predict the diagnosis of Hydrosalpinx, its severity, and clinical outcomes in infertile patients.

Role of C reactive protein, hyperbilirubinemia and mean platelet volume in diagnosis of acute appendicitis and its correlation post operatively with histo-pathological examination

Background: Acute appendicitis is one of the most common abdominal emergencies requiring emergency surgery. The diagnosis based on the onset of symptoms and physical examination. Therefore, inaccuracies caused by subjective interpretation are frequent. This raises the need for tests to help diagnose acute appendicitis and predict the severity of the condition. aim of the study to investigate whether mean platelet volume, C-reactive protein, and hyperbilirubinemia can be used as inflammatory markers for the diagnosis of acute appendicitis and its correlation with histopathological examination. Methods: we prospectively analyzed 60 patients who were full fulling the inclusion criteria patients analysed for CBC, LFT and CRP and underwent for appendicectomy (Laparoscopic/open). Per-operative diagnosis was confirmed by histopathological examination from November 2020 to November 2022. Results: patients with CRP level > 6 and hyperbilirubinemia patients most likely to have acute appendicitis. Mean CRP level was 13.21±4.0 and mean bilirubin level 1.04±0.29 in case of acute appendicitis. CRP, hyperbilirubinemia levels were significantly higher in cases of acute appendicitis (p<0.01) while MPV value was not found significant. All patients was confirmed with histopathology examination. Conclusions: Serum bilirubin level and CRP estimation, which is a simple, cheap, and easily available laboratory test, can be added to the routine investigations in the diagnosis and severity of acute appendicitis and help in decreasing negative appendicectomy rates, especially in low modified Alvarado score.

Value of Mean Platelet Volume in Diagnosis of Neonatal Sepsis

Value of Mean Platelet Volume in Diagnosis of Neonatal Sepsis

Role of salivary c reactive protein and mean platelet volume in diagnosis of late onset neonatal pneumonia

Background: Late onset neonatal pneumonia (LONP) must be diagnosed accurately and promptly if we are to accurately assess the disease's prevalence, create better strategies for preventing and treating it, and ultimately find a cure. The combined measurement of C- reactive protein (CRP) and mean platelet volume (MPV) could be useful in determining if a patient has bacterial or viral infection and in estimating the likelihood of complications from either. The purpose of this research is to evaluate the usefulness of CRP in saliva (sCRP) and MPV in the identification of LONP. Methods: This prospective case control research was carried out on 60 full‐term neonates. The neonates were classified into 2 equal groups: Group a: included 30 neonates with LONP. Group b: included 30 healthy control neonates. All patients were subjected to thorough medical history taking and physical examination as well as measurement of salivary and serum CRP and complete blood picture for assessment of MPV. Results: MPV, sCRP, serum CRP and serum CRP / MPV are statistically significant predictors of LONP cases. SCRP at a cutoff value >3.2 is a statistically significant predictor of serum CRP> 6 in patient groups. A stastistically notable positive link between salivary and serum CRP concentrations (r = 0.476, p≤ 0.05), the research also showed significant link between serum CRP and MPV (r = 0.547, P = 0.002). There was a statistically evident link between sCRP and MPV concentrations in the pneumonic group (r =0.507, p≤ 0.05) in diagnosis of LONP. CRP/MPV ratio as predictor for diagnosis of LONP cases, was a statistically significant predictor at a cutoff value >0.6. Conclusions: Late-onset neonatal pneumonia may be diagnosed non-invasively with CRP and MPV in the saliva. The ratio of C-reactive protein to mean platelet volume (MPV) is easy to compute and has the potential to serve as a straightforward and reliable biomarker for the identification of late-onset neonatal sepsis.

Salivary C‐reactive protein and mean platelet volume in diagnosis of late‐onset neonatal pneumonia

Neonatal pneumonia is an important and major cause of neonatal morbidity and mortality worldwide therefore; its early detection plays a crucial role in successful therapy. Analysis of saliva as a non-invasive method for detection of neonatal diseases holds great promise for improving health care. Till now, salivary C-reactive protein (CRP), mean platelet volume (MPV), neutrophil/lymphocyte ratio (NLR) and platelets/lymphocytes ratio (PLR) have not been studied as markers of diagnosis in neonatal pneumonia. To assess the applicability of salivary CRP, MPV, NLR and PLR as diagnostic markers in late-onset neonatal pneumonia. A prospective case control study of 70 full-term neonates, 35 with late-onset neonatal pneumonia and 35 healthy controls, was enrolled. Serum and salivary CRP concentrations were measured by ELISA, while MPV, NLR and PLR were measured by automated blood cell counter. This study showed a statistically significant difference between salivary CRP means in neonates with late-onset neonatal pneumonia vs control neonates (6.2±4.6 and 2.8±1.9ng/L) respectively. At the cutoff point of 3.8ng/L, salivary CRP showed 91.4% sensitivity and 80.9% specificity. Salivary CRP also showed accuracy in predicting elevated serum CRP in neonates with pneumonia. MPV showed a significant difference between pneumonia and controls (mean=10.2±0.7, 8±0.5) respectively. At cutoff point 9.0, it has 80% sensitivity and specificity. The present study showed for the first time that both salivary CRP and MPV are suitable as diagnostic markers in late-onset neonatal pneumonia.

Role of Mean Platelet Volume in Diagnosis of Childhood Acute Appendicitis

Introduction. Acute appendicitis is the leading cause of abdominal pain in children requiring emergency surgical intervention. The aim of this study is to investigate the diagnostic value of MPV in early diagnosis of acute appendicitis cases in pediatric age group. Methods. This study was performed retrospectively. Three hundred five patients operated on with the diagnosis of appendicitis and pathologically found to be acute appendicitis were classified as Group 1 and 305 healthy children were classified as control Group 2. Results. One hundred ninety-seven of 305 cases in Group 1 are males (64.6%), in Group 2, 151 of 305 cases are males (49.5%). The mean MPV in Group 1 was 7.9 ± 0.9 (fL), and whereas in Group 2 was 7.7 ± 0.8 (fL). There was no statistically significant difference regarding MPV values (P > 0.05). Conclusion. In our study we detected that mean platelet volume has no diagnostic value in pediatric acute appendicitis cases.