Mean Number Of Hairs Research Articles

Evaluation effects of essential amino acids and zinc and iron supplementation on the prevention of early hair loss after sleeve gastrectomy

Background: Due to the reduction in micronutrients and proteins available to the body after LSG, we evaluated effects of various supplements and rate of hair loss in the postoperative period. Material and Methods: In this interventional study, we examined female candidates of LSG. individuals randomly divided into three groups. Group 1 received routine multivitamin mineral supplements, group 2 took received zinc + iron + B vitamins supplements plus routine multivitamin mineral until the end of the third month after surgery, and group 3 took supplements containing wheat and sesame proteins and methionine and cysteine in addition to Zinc + Iron + B vitamins supplements and routine multivitamin mineral supplements. number of hairs in the frontal area were counted using trichoscope before surgery and after 3 month follow up. Results: the mean number of hairs in the frontal area in group 1 before and after surgery was about143 and 100 hairs per cm² respectively, in group 2 was 142 and 116 and In group 3, 137 and 177 hairs per cm². the mean number of trichoscopic hairs in the frontal area, was significantly higher in group 3 than other groups. (p < 0.001) Conclusion: The present study clearly showed that the use of protein supplements, in addition to the use of micronutrients in individuals, more and better reduces the rate of hair loss after LSG. This can be considered and evaluated for future surgeries

The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial.

Platelet-rich plasma (PRP) has emerged as a new treatment modality in regenerative plastic surgery, and preliminary evidence suggests that it might have a beneficial role in hair regrowth. Here, we report the results of a randomized, evaluator-blinded, placebo-controlled, half-head group study to compare, with the aid of computerized trichograms, hair regrowth with PRP versus placebo. The safety and clinical efficacy of autologous PRP injections for pattern hair loss were investigated. PRP, prepared from a small volume of blood, was injected on half of the selected patients' scalps with pattern hair loss. The other half was treated with placebo. Three treatments were administered to each patient at 30-day intervals. The endpoints were hair regrowth, hair dystrophy as measured by dermoscopy, burning or itching sensation, and cell proliferation as measured by Ki67 evaluation. Patients were followed for 2 years. Of the 23 patients enrolled, 3 were excluded. At the end of the 3 treatment cycles, the patients presented clinical improvement in the mean number of hairs, with a mean increase of 33.6 hairs in the target area, and a mean increase in total hair density of 45.9 hairs per cm² compared with baseline values. No side effects were noted during treatment. Microscopic evaluation showed the increase of epidermis thickness and of the number of hair follicles 2 weeks after the last PRP treatment compared with baseline value (p < .05). We also observed an increase of Ki67(+) keratinocytes in the epidermis and of hair follicular bulge cells, and a slight increase of small blood vessels around hair follicles in the treated skin compared with baseline (p < .05). Relapse of androgenic alopecia was not evaluated in all patients until 12 months after the last treatment. After 12 months, 4 patients reported progressive hair loss; this was more evident 16 months after the last treatment. Those four patients were re-treated. Our data clearly highlight the positive effects of PRP injections on male pattern hair loss and absence of major side effects. PRP may serve as a safe and effective treatment option against hair loss; more extensive controlled studies are needed. Platelet-rich plasma (PRP) has emerged as a new treatment modality in regenerative plastic surgery, and preliminary evidence suggests that it might have a beneficial role in hair regrowth. Here, the results of a randomized, placebo-controlled, half-head group study to compare the hair regrowth with PRP versus placebo are reported. Hair regrowth was quantified by a blinded evaluator using computerized trichograms. The safety and clinical efficacy of autologous PRP injections for pattern hair loss were investigated. Of the 23 patients enrolled, 3 were excluded. At the end of the 3 treatment cycles, the patients presented clinical improvement in the mean number of hairs, with a mean increase of 33.6 hairs in the target area and a mean increase in total hair density of 45.9 hairs per cm² compared with baseline values. No side effects were noted during treatment. The data clearly highlight the positive effects of PRP injections on male pattern hair loss and absence of major side effects. PRP may serve as a safe and effective treatment option against hair loss; more extensive controlled studies are needed.

The effect of autologous activated platelet rich plasma (AA-PRP) injection on pattern hair loss: clinical and histomorphometric evaluation.

To investigate the safety and clinical efficacy of AA-PRP injections for pattern hair loss. AA-PRP, prepared from a small volume of blood, was injected on half of the selected patients' scalps with pattern hair loss. The other half was treated with placebo. Three treatments were given for each patient, with intervals of 1 month. The endpoints were hair re-growth, hair dystrophy as measured by dermoscopy, burning or itching sensation, and cell proliferation as measured by Ki-67 evaluation. At the end of the 3 cycles of treatment, the patients presented clinical improvement in the mean number of hairs, with a mean increase of 18.0 hairs in the target area, and a mean increase in total hair density of 27.7 ( number of hairs/cm2) compared with baseline values. Microscopic evaluation showed the increase of epidermis thickness and of the number of hair follicles two weeks after the last AA-PRP treatment compared to baseline value (P < 0.05). We also observed an increase of Ki67+ keratinocytes of epidermis and of hair follicular bulge cells and a slight increase of small blood vessels around hair follicles in the treated skin compared to baseline (P < 0.05).

The effect of CD34+ cell‐containing autologous platelet‐rich plasma injection on pattern hair loss: a preliminary study

Mobilized CD34+ cells in peripheral blood have angiogenic potential, which is an important factor in active hair growth. In addition, activated autologous platelet-rich plasma (PRP) has been reported to induce the proliferation of dermal papilla cells. To investigate the clinical efficacy of interfollicular injection of CD34+ cell-containing PRP preparation for pattern hair loss. CD34+ cell-containing PRP preparation was injected on the scalps of 13 patients with pattern hair loss, and 13 patients were treated with interfollicular placental extract injection as a control. The numbers of platelets in PRP were microscopically counted and CD34+ cells were evaluated with flow cytometry. Three months after the first treatment, the patients presented clinical improvement in the mean number of hairs, 20.5 ± 17.0% (P < 0.0001), mean hair thickness, 31.3 ± 30.1% (P < 0.0001), and mean two-point score, 84.4 ± 51.7% (P < 0.0001) compared with baseline values. At 6 months, the patients presented clinical improvement in mean hair count, 29.2 ± 17.8% (P < 0.0001), mean hair thickness, 46.4 ± 37.5% (P < 0.0001), and mean two-point score, 121.3 ± 66.8% (P < 0.0001) compared with baseline. The MIXED procedure revealed that CD34+ cell-containing PRP treatment presented a higher degree of improvement than placental extract treatment in hair thickness (P = 0.027) and overall clinical improvement (P = 0.023). Our data suggest that the interfollicular injection of autologous CD34+ cell-containing PRP preparation has a positive therapeutic effect on male and female pattern hair loss without remarkable major side-effects.

EVOLUTIONARY MODIFICATION IN CLARKIA I. SELECTION FOR HAIRLESSNESS

Plants of Clarkia unguiculata with moderate numbers of long hairs on the ovary and calyx were selected for relative “hairlessness” through 11 generations. Inbreeding depression, manifested as a high degree of sterility, necessitated co‐selection for fertility. The proportion of fertile plants among families ranged from 0–50% in the 5th selected generation and increased to a range of 53–100% in the 10th selected generation. At the same time, the mean number of hairs on the ovary decreased from a range of 0.0–1.1 to a range of 0.0–0.2; and the mean number of hairs per sepal from 0.5–16.0 to 0.1–2.2. The percentage of plants per family with no hairs on the ovary and no hairs on the calyx increased from a range of 0–63 in the 5th selected generation to a range of 4–88 in the 10th selected generation. Nonselected progenies have long hairs on both ovary (mean 10–17) and sepals (mean 46–50) in all plants. The demonstrated response to selection has important implications regarding catastrophic selecion and the evolution of Clarkia species in marginal habitats.

Evolutionary Modification in Clarkia. I. Selection for Hairlessness

Plants of Clarkia unguiculata with moderate numbers of long hairs on the ovary and calyx were selected for relative “hairlessness” through 11 generations. Inbreeding depression, manifested as a high degree of sterility, necessitated co-selection for fertility. The proportion of fertile plants among families ranged from 0–50% in the 5th selected generation and increased to a range of 53–100% in the 10th selected generation. At the same time, the mean number of hairs on the ovary decreased from a range of 0.0–1.1 to a range of 0.0–0.2; and the mean number of hairs per sepal from 0.5–16.0 to 0.1–2.2. The percentage of plants per family with no hairs on the ovary and no hairs on the calyx increased from a range of 0–63 in the 5th selected generation to a range of 4–88 in the 10th selected generation. Nonselected progenies have long hairs on both ovary (mean 10–17) and sepals (mean 46–50) in all plants. The demonstrated response to selection has important implications regarding catastrophic selecion and the evolution of Clarkia species in marginal habitats.