Mean Concentration Of Uric Acid Research Articles

Physiological response of roe deer (Capreolus capreolus) during stalking hunts depending on age

BackgroundThe European roe deer (Capreolus capreolus) is a species particularly reactive to all kinds of negative stimuli. Hunting activity is one of the most potent stressors that disturbs the welfare of wild animals. During stress, various endocrine responses are elicited to improve the physical performance of the affected individual. A commonly assessed hormone for overcoming stressful situations is cortisol (CORT). In this study, plasma CORT levels in roe deer were assessed during the season of the most intense stalking hunts in Poland (summer vs. late autumn), the sex of the harvested animals (males vs. females), and age of harvest animal. In addition, the health status of the roe doe was evaluated on the basis of selected indices of blood chemistry, which could be associated with circulating cortisol levels.ResultsThe mean cortisol levels were 58.066 ng/ml in the male group (summer) and 27.694 ng/ml in the female group (late autumn). Higher CORT levels were associated with a significantly lower of total cholesterol, lactate dehydrogenase, and uric acid (p < 0.05). Moreover, the mean concentration of uric acid was negatively correlated with the level of CORT in the male and female groups (p < 0.05). Together with the increase in mean CORT level, the HDL cholesterol of all the tested animals increased significantly (p < 0.05).ConclusionsHigher CORT in males during the summer than in females during the late autumn were most likely due to the arousal with the mating season. The level of CORT increased with the animals’ age. Uric acid and age are both predictors of roe deer’s serum CORT level.

Effect of Dapagliflozin on Serum Uric Acid in Type 2 Diabetes Mellitus patients

Diabetes is one of the most common metabolic diseases, linked to hyperuricemia. Several studies have shown that high serum uric acid levels (SUA) are associated with an increased risk of diabetes. SGLT2 inhibitors (Sodium Glucose Cotransporter-2 Inhibitors) are a new drug for diabetes treatment. In addition to their ability to lower blood glucose, they have other benefits, including lowering serum uric acid levels. This study aimed to evaluate the effect of dapagliflozin, which is a selective inhibitor of SGLT2 Cotransporters present in the kidneys, on serum uric acid levels in patients with type 2 diabetes, compared with a control group. The study included 51 patients with type 2 diabetes, randomly selected from an endocrinology clinic, who started dapagliflozin treatment 5 and 10 mg at recruitment. The control group included 64 patients with type 2 diabetes treated with metformin. Patients were monitored for 3-6 months and serum uric acid levels were measured at baseline and after follow-up. 3 months after treatment, the mean concentration of uric acid in the dapagliflozin group was lower than that of the metformin group (4.58 vs. 5.24 mg/dl p = 0.0143). At 6 months follow-up, SUA levels decreased by 0.79 mg/dL and it was statistically significant (p = 0.0004), compared with control group where there was no statistically significant change in SUA levels. Statistically, there was no significant difference in uric acid levels between doses 5 and 10 mg. However, decreasing in SUA levels with dapagliflozin 5 mg was greater than that occurred with dapagliflozin 10 mg after 6 months of treatment. In conclusion, Dapagliflozin results in a decrease of SUA levels in patients with type 2 diabetes by increasing urinary excretion of uric acid induced by SGLT2 inhibitors.

Study of The relationship between uric acid level and some lipid profile for heart disease patients in Alnasseriya city

The present study was carried out to evaluate the relationship between uric acid level and some lipid profile for heart disease patients in Alnasseriya city in the sera samples of (75) patients, in addition to control group involving (45) apparently healthy. The current study included age ,weight , cholesterol, HDL , LDL, triglyceride ,and uric acid concentration. The study clarified no significant differences (p&gt;0.05) in mean age of patients when compared with healthy control and high significant difference of mean weight between two groups (p&lt;0.01).A highly significant elevated(P&lt; 0.01 ) in the mean concentration of cholesterol, LDL and triglyceride in patients when compared with healthy control ,no significant (P&gt; 0.05) in the mean concentration of HDL in both two groups .It also showed a highly significant increased (P&lt;0.01) in the mean concentration of uric acid in heart disease patients when the results compared with the mean concentration of uric acid in healthy control . In the present study showed there was high significant correlation between uric acid and cholesterol, LDL (P&lt;0.01) and significant correlation with triglyceride (P&lt;0.05) but no significant correlation between uric acid and HDL (P&gt;0.05 ).&#x0D;

Associations between concentrations of uric acid with concentrations of vitamin A and beta-carotene among adults in the United States

Our objective was to examine the cross-sectional associations between concentrations of vitamin A and beta-carotene, a major source of vitamin A, with concentrations of uric acid in a nationally representative sample of adults from the United States. We conducted a cross-sectional study using data from up to 10893 participants aged ≥20 years of National Health and Nutrition Examination Survey from 2001 to 2006. Concentrations of uric acid adjusted for numerous covariates increased from 305.8 μmol/L in the lowest quintile of vitamin A to 335.3 μmol/L in the highest quintile (p for linear trend <0.001). The prevalence ratio for hyperuricemia also increased progressively across quintiles of serum vitamin A reaching 1.82 (95% confidence interval [CI]: 1.52, 2.16; p for linear trend <0.001) in the top quintile in the maximally adjusted model. Adjusted mean concentrations of uric acid decreased progressively from quintile 1 (333.8 μmol/L) through quintile 4 of concentrations of beta-carotene and were similar for quintiles 4 (313.5 μmol/L) and 5 (313.8 μmol/L). Concentrations of beta-carotene were inversely associated with hyperuricemia (adjusted prevalence ratio comparing highest with lowest quintile = 0.61; 95% CI: 0.52, 0.72; p for linear trend <0.001). Concentrations of uric acid were significantly and positively associated with concentrations of vitamin A and inversely with concentrations of beta-carotene. These cross-sectional findings require confirmation with experimental studies of vitamin A and beta-carotene supplementation.

Serum uric acid level in patients with relapsing-remitting multiple sclerosis

Uric acid (UA) is a hydrophilic antioxidant product associated with multiple sclerosis (MS). We conducted a randomized case-control study to evaluate the serum level of UA in different phases of MS in comparison with levels in a healthy control population. Serum UA was checked in 130 patients with relapsing-remitting MS (85 patients in remitting and 45 patients in relapsing phase) and 50 age-matched controls using a quantitative enzyme-linked immunosorbent assay (ELISA). The mean concentrations of UA in serum was 6.41(±3.18)mg/dL in patients with remitting MS, 4.76(±1.66)mg/dL in patients with relapsing MS and 6.33(±2.94)mg/dL in controls. There was a significant difference between mean UA concentration in relapsing MS and remitting MS (p<0.001), and between patients with relapsing MS and controls (p=0.002); however, the difference between levels for patients in the remitting phase of MS and the control group was not significant (p=0.87). It seems probable that UA has a role in the prevention of disease activity in MS.

Serum Uric Acid Concentrations in Meat Eaters, Fish Eaters, Vegetarians and Vegans: A Cross-Sectional Analysis in the EPIC-Oxford Cohort

IntroductionCirculating concentrations of uric acid may be affected by dietary components such as meat, fish and dairy products, but only a few studies have compared uric acid concentrations among individuals who exclude some or all of these foods from their diet. The aim of this study was to investigate differences in serum uric acid concentrations between meat eaters, fish eaters, vegetarians and vegans.Subjects and MethodsA sample of 670 men and 1,023 women (424 meat eaters, 425 fish eaters, 422 vegetarians and 422 vegans, matched on age and sex) from the European Prospective Investigation into Cancer and Nutrition Oxford cohort were included in this cross-sectional analysis. Diet was assessed using a semi-quantitative food frequency questionnaire and serum concentrations of uric acid were measured. Mean concentrations of uric acid by diet group were calculated after adjusting for age, body mass index, calcium and alcohol intake.ResultsIn both men and women, serum uric acid concentrations differed significantly by diet group (p<0.0001 and p = 0.01, respectively). The differences between diet groups were most pronounced in men; vegans had the highest concentration (340, 95% confidence interval 329–351 µmol/l), followed by meat eaters (315, 306–324 µmol/l), fish eaters (309, 300–318 µmol/l) and vegetarians (303, 294–312 µmol/l). In women, serum uric acid concentrations were slightly higher in vegans (241, 234–247 µmol/l) than in meat eaters (237, 231–242 µmol/l) and lower in vegetarians (230, 224–236 µmol/l) and fish eaters (227, 221–233 µmol/l).ConclusionIndividuals consuming a vegan diet had the highest serum concentrations of uric acid compared to meat eaters, fish eaters and vegetarians, especially in men. Vegetarians and individuals who eat fish but not meat had the lowest concentrations of serum uric acid.

Malondialdehyde in plasma, a biomarker of global oxidative stress during mini-CABG compared to on- and off-pump CABG surgery: a pilot study

In contrast to conventional on-pump coronary artery bypass grafting only mild increase of parameters of oxidative stress is reported during and after off-pump coronary artery bypass grafting. In an attempt to reduce the side effects of extra corporeal circulation the mini- extra corporeal circulation concept was introduced. In this study peroperative oxidative stress biomarkers were compared using three different techniques for CABG (conventional, mini and off-pump). It concerns a prospective randomized pilot study of 60 aged patients (70+ years) divided over 3 study groups. During the peroperative time points there was a significant increase in the mean concentration of uric acid for the CCABG group. On arrival at the intensive care unit the mean concentrations decreased significantly. During the per-operative period all groups showed significant increase in the concentration of malondialdehyde, however, this increase was the steepest for the CCABG group. On arrival at the intensive care unit the mean concentration decreased significantly for all groups. We found only mild organ ischemia/reperfusion injury and oxidative stress in the OPCAB group and the MCABG group with respect to the CCABG group.