Purpose. To evaluate the clinical efficacy of subthreshold laser treatment for focal DME with continuous and micropulse mode based on navigated technology. Methods. We observed 17 patients (17 eyes) with DME at the age from 25 to 71 years (on average 44±1.6 years). After the stage of diagnostic search for morphological changes in the retina and preoperative planning all patients underwent navigational laser treatment in and continuous and micropulse mode. The study evaluated the retinal thickness in the foveal avascular zone and outside it, the area of retinal ischemia, microaneurysms and edema zones at the level of the superficial vascular plexus and deep vascular complex. Follow-up periods were 1 and 3 months. Results. One month after laser treatment, all patients had positive dynamics, expressed in a decrease of edema height. BCVA increased on average to 0.8±0.06; mean central retinal sensitivity – up to 24.65±0.47 dB. After 3 months, a further decrease in the height of the edema was observed. BCVA increased on average for the group to 0.85±0.06, mean central retinal sensitivity – 25.5±0.3 dB. Сonclusion. Our preliminary results indicate the effectiveness of navigational subthreshold laser treatment for DME, based on targeted topographically oriented laser exposure according to OCT-angiography. Keywords: diabetic macular edema, navigational laser treatment, subthreshold laser therapy.