Aerobic fitness and aerobic exercise are widely accepted as having protective effects on cognitive function and brain health, with less understood regarding muscular fitness and resistance exercise. Strength is beneficially associated with cognitive function, but the mechanisms underlying this relationship remain understudied and may relate to cerebral hemodynamics. The purpose of this study was to examine the associations between strength and cerebrovascular hemodynamics in young and middle-aged men and women. It was hypothesized that greater strength would be associated with better cerebral hemodynamics (greater mean blood velocity, lower pulsatility, greater pulsatile damping). Ninety-two generally healthy adults between 18-64 years old (36±16 yrs; BMI 25.9±4.0 kg/m2; n=39 women) underwent a hand grip strength assessment and resting cerebrovascular measures. Grip strength was measured via dynamometer and recorded as the highest value of 3 attempts. Middle cerebral artery (MCA) mean velocity and pulsatility index (PI) were measured via transcranial Doppler. Pulsatile damping was calculated as the ratio between the common carotid artery and MCA PI. Mean arterial pressure was assessed via an oscillometric blood pressure cuff. No significant associations were observed between relative grip strength and MCA mean velocity (r=-0.15), MCA PI (r=0.05), or MAP (r=0.07) after adjusting for age. Greater relative grip strength, however, was associated with greater pulsatile damping after adjusting for age (r=0.21; p<0.05). This relationship appeared to be driven by weak associations within each sex (men, r=0.10; women, r=0.02) that were not statistically significant on their own. Our preliminary results suggest there are no strong relations between grip strength and cerebral hemodynamics among generally healthy young and middle-aged adults after accounting for the effects of age and sex. Future studies should examine sex-specific associations with a larger sample, consider disease states related to cerebrovascular health, and include more comprehensive assessments of muscular strength and performance (e.g., power). This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.