Maximum Loading Force Research Articles

Experimental and numerical exploration for the design of swift-constructed demountable blind bolts

In this study, a new type of blind bolt that combines high tensile resistance and stiffness with easy and fast installation and demounting capabilities is proposed, named Swift-Constructed Demountable Blind Bolt (SCDBB). The components, intended working mechanism, and fabrication process are first introduced. Geometric constraints of critical components are then derived based on the desired behaviour. To study the performance of SCDBBs under tensile loading and their behaviour during the installation process, 9 experimental tests were conducted. Two failure modes, namely, bolt shank fracture and buckling of the expansion nut blades, were revealed when subjected to maximum tensile loading. Subsequently, finite element (FE) models were developed and validated by comparing the numerical results with the experimental data. To further explore the impact of key design parameters on the behaviour of the bolts under tensile loading and performance during installation, parametric studies consisting of 106 FE models were conducted for bolts of three sizes with variations in four key design parameters. The findings indicate that the failure modes under maximum tensile loading and maximum installation force are sensitive to the length, thickness, and gap of the elastic expansion nut. The optimised ranges for each design parameter were identified to prevent undesirable blade buckling.

Honeycomb Column Thin-Walled Structure Design and Mechanical Properties of Ti Alloy Fabricated through Selective Laser Melting.

A honeycomb column thin-walled structure (HCTS) was designed and the relative density was calculated for numerical simulation. The HCTS samples were fabricated via selective laser melting (SLM). The numerical simulation and a three-point bending test were conducted to evaluate the mechanical properties of the HCTS made of Ti6Al4V. The findings of the numerical simulation demonstrated that the HCTS had a stronger resistance to deformation and a maximum loading force 30% higher than the equivalent solid thin-walled structure (ESTS). The mechanical performance of the HCTS as determined by the three-point bending test was mostly comparable with the numerical simulation. The maximum loading force of the experimental HCTS050-E thin-walled structure was 1200 N higher than that of HCTS050-S. The numerical simulation can provide theoretical guidance for the SLM processing of HCTSs.

Adhesion in soft contacts is minimum beyond a critical shear displacement

The most direct measurement of adhesion is the pull-off force, i.e. the tensile force necessary to separate two solids in contact. For a given interface, it depends on various experimental parameters, including separation speed, contact age and maximum loading force. Here, using smooth contacts between elastomer spheres and rigid plates, we show that the pull-off force also varies if the contact is sheared prior to separation. For shear displacements below a critical value about 10% of that necessary to yield gross sliding, the pull-off force steadily decreases as shear increases. For larger shear, the pull-off force remains constant, at a residual value 10%–15% of its initial value. Combining force measurements and in situ imaging, we show how the unloading path leading to contact separation is modified by the initial shear. In particular, we find that the residual pull-off force prevails if the contact reaches full sliding during unloading. Based on those observations, a first modeling attempt of the critical shear displacement is proposed, involving a competition between jump instability and transition to sliding. Overall, those results offer new insights into the interplay between adhesion and friction, provide new constraints on adhesion measurements and challenge existing adhesive models. They will be useful wherever soft contacts undergo both normal and shear stresses, including tire grip, soft robotics, haptics and animal locomotion.

Lightweight Flame-retardant Material Reinforced with Hevea Brasiliensis Ash Intumescent Agent

Flame retardant materials play an important role in many building construction components. The ability of building components to resist fire is crucial to the safety and well-being of the occupants. This research examines a lightweight flame-retardant material-Vermiculite (V) reinforced with a renewable Hevea Brasiliensis Biomass Ash Intumescent Agent (HBAIA) in different compositions. Four specimens of vermiculite reinforced with HBAIA (V/HBAIA) with standard size 200 mm x 200 mm x 10 mm (W x Lx H) were fabricated for investigations. All V/HBAIA specimens were assessed in terms of their density, fire-resistant, fire endurance and smoke, char surface morphology, and flexural toughness. Data disclosed V/HBAIA-2 with the composition of 90% vermiculite reinforced with 10% HBAIA obtained the most prominent outcomes in overall. V/HBAIA-2 attained the lightest density of 37.5 kg/m3 and weight of 0.20 kg, with lowest end temperature of 122 °C after exposure to one-hour of 1000 °C fire. This indicated the best fire-resistant performance in V/HBAIA-2. No structural deformation and only mild smoke and odor were observed in V/HBAIA-2 during the fire endurance examination. V/HBAIA-2 was able to resist the maximum loading force of 67.4 N before and 52.5 N after the fire resistant, with the higher flexural toughness value of 1.47 MPa. Scanning electron microscopy revealed a more uniform, denser, closely connected air cavities char cell quality in V/HBAIA-2 explained its superior outcomes in fire-resistant and flexural toughness as compared to the rest of specimens.

Effects of microstructure and vibration parameters on mechanical properties of nanoimprinted FeNiCrCoCu high-entropy alloys

Molecular dynamics (MD) simulations are utilized to study the mechanical behavior of FeNiCrCoCu high-entropy alloys (HEA) during nanoimprint lithography with single-crystal, polycrystal, and nano-twinned polycrystal structures. The findings of MD simulations reveal that the microstructure and vibration parameters significantly impact the loading force, elastic recovery ratio, and deformation behavior of FeNiCrCoCu HEA. The imprinting force curve revealed that the maximum loading force is in reduced order with single-crystal, nano-twinned (NT) polycrystal, and polycrystalline structures. With the polycrystalline structure, an inverse Hall-Petch relationship is observed when the grain size varies from 5.1 nm to 9.8 nm. Grain boundary (GB) plays an important role in softening material; the splitting of grains, the migration of the GBs, and grain rotation are the main deformation mechanisms of this region. For NT polycrystals, the stability of material can be enhanced due to the existence of twin boundaries (TB), and the migration of TB is explored near the imprinted region. With polycrystalline structure, the best formability is observed for specimens with a grain size of 9.8 nm, where the average elastic recovery ratio is the smallest, and the forming shape at this grain size is the best. The mold angle of 10° and 20° result in the pattern having a good symmetrical shape, suggesting a better-imprinted shape than with other angles. Moreover, the effect of high-frequency mechanical vibration is analyzed carefully in this study. The results show that the best forming ability is achieved as the vibration amplitude is 3.0 Å. As changing vibration frequencies, the frequency of 50 GHz gives the highest forming ability.

Investigation on Dynamic Impact Mechanism of Single Crystal Sapphire 3D Model Based on Cohesive Zone Law

AbstractBased on mesh reconstruction technology, a 3D solid model of single crystal sapphire (SCS) with global embedded cohesive element is established in this study. Using exponential cohesive zone law (CZL), the anisotropy of SCS can be effectively characterized by assigning the mechanical properties of matrix element and cohesive element. Taking the C‐plane SCS model as the research object, the whole process of dynamic evolution of cracks in the model under high‐speed surface impact and high concentrated stress impact is reproduced by finite element simulation technology. The simulation is compared with the experimental results from the aspects of crack initiation morphology, crack propagation path, sample fragmentation form, and mechanical response curve. The dynamic compressive strength reaches 1630.3 MPa with the impact velocity of 30 m s–1 in surface impact type. The initial maximum loading force reaches 320 N when the impact velocity is 8.35 m s–1 in the indentation impact type. In addition, by combining the simulation results, this study clarifies the mechanism of strain rate effect exhibited by SCS from the perspective of stress–strain data and crack evolution characteristics. Therefore, the model established in this study can effectively reflect the mechanical behavior of SCS under impact load.

New Ceramic Multi-Unit Dental Abutments with an Antimicrobial Glassy Coating.

The choice of suitable materials and new designs in oral implantology and the subsequent enhancement of the characteristics of the dental implant developed is an important research topic with wide scope. The present work aims to develop a new multifunctional zirconia–ceria/alumina (Ce–TZP/Al2O3) composite with an antimicrobial glass-based coating to be used in multi-unit abutments compatible with commercially available Ti implants for peri-implantitis prevention. An airbrush spraying technique was effectively applied to coat the sintered ceramic composite starting from a glass powder suspension. This deposition technique was appropriate for obtaining continuous antimicrobial glass-based coatings with homogenous thickness (~35 µm) on ceramic dental implant components. The dental implant systems with the antimicrobial glassy coating were subjected to a mechanical integrity test following ISO 14801 to determine their long-term stability. The tested implant-coating structure seems to be stable under in vitro conditions with ultimate applied forces exceeding the maximum physiological occlusal loading force. This paper also presents a pilot clinical case report that shows peri-implant tissue around the mechanically stable glass coating with no signs of inflammation 1 year after implant insertion. This result is a preliminary probe of the durability and biological tolerance of the glassy material by the gingiva, as well as the antimicrobial effect on the peri-implant microbiota displayed by the coating.

Study of fracture processes in sandstone subjected to four-point bending by means of 4D X-ray computed micro-tomography

<p class="Abstract">High-resolution X-ray computed micro-tomography (CT) is a powerful technique for studying the processes of crack propagation in non-homogenous quasi-brittle materials such as rocks. To obtain all the significant information about the deformation behaviour and fracture characteristics of the studied rocks, the use of a highly specialised loading device suitable for the integration into existing tomographic setups is crucial. Since no adequate commercial solution is currently available, a completely newly-designed loading device with a four-point bending setup and vertically-oriented scanned samples was used. This design of the loading procedure, coupled with the high stiffness of the loading frame, allows the loading process to be interrupted at any time and for CT scanning to be performed without the risk of the sudden destruction of the scanned sample.</p>This article deals with the use of the 4D CT for the visualisation of crack initiation and propagation in clastic sedimentary rocks. Two types of quartz-rich sandstones of Czech provenance were used for tomographic observations during the four-point bending loading performed on chevron notched test specimens. It was found that the crack begins to propagate from the moment that ca. 80 % of the maximum loading force is applied.

Custom design and biomechanical clinical trials of 3D‐printed polyether ether ketone femoral shaft prosthesis

During the surgical resection and reconstruction of a pathological femoral fracture, the removal of the femoral tumor leaves a large bone defect. Thus, it is necessary to reconstruct the defect and perform internal fixation. Polyether ether ketone (PEEK) has been widely used in spinal fusion and cranioplasty given its excellent biomechanical properties, biocompatibility, and stability. The typical design method of femoral prosthesis is based on the contralateral mirror image model (M-model), and we propose a novel method for designing femoral prosthesis, which is based on the cross section and centerline of the mirrored femur (C-model). In this study, the femoral shaft prostheses based on two models were manufactured using fused deposition modeling technology, and we use mechanical test and finite element analysis (FEA) to reveal the differences in mechanical properties of the two models. The mechanical results showed that the maximum loading force and yield strength were increased by 3% and 6% in the C-model prosthesis compared with the M-model prosthesis, respectively. In FEA, the results indicate that the C-model prosthesis could reduce the stress concentration by 5.4%-10.9% compared to the M-model prosthesis. Finally, the 3D-printed PEEK femoral shaft prosthesis based on C-model was implanted, no early complications occurred. Postoperative radiological examination indicated that the prosthesis and the femoral osteotomy end were closely matched and fixed well.

Biomechanical Analysis of Staples for Epiphysiodesis

Limb asymmetry can, and often does, cause various health problems. Blount bone staples (clips) are used to correct such uneven growth. This article analyzes the performance of a biomechanical staple during bone (tibia) growth arrest. The staples considered in this study were made of 1.4441 stainless steel, the model of tibia consisted of two materials representing corticalis and spongiosis. Hooke’s law was used for modeling materials’ behaviors for finite element analysis (FEA). The maxima of stress and total staple displacement were evaluated using the finite element method and verification of the results, along with the determination of the maximum loading (growing) force that the staples are capable of withstanding, was performed experimentally. The presented method can be used to determine the safety and usability of staples for bone growth arrest. According to our results, the design of Blount staples considered in this paper is safe and suitable for orthopedic treatment.

Study on mechanical behavior of Cu-bearing antibacterial titanium alloy implant

Cu-bearing titanium alloy has been proved to have excellent antibacterial properties, which can effectively reduce the incidence of infection caused by implantation. On the other hand, the addition of Cu in the titanium alloy can also significantly improve the strength of the alloy due to the dispersed precipitation of Ti2Cu compounds in matrix, which will enhance the biomechanical safety of Cu-bearing antibacterial titanium alloys. In this study, a Ti6Al4V5Cu antibacterial titanium alloy and the ordinary Ti6Al4V titanium alloy were used to make a variety of orthopedic trauma repair implants, including bone pin, bone screw and bone plate. Through the internationally accepted test methods, the mechanical properties such as tension, torsion and bending of the implants were studied, and the difference between the implants made of two materials was analyzed. The results showed that the tensile strength of Ti6Al4V5Cu pin was 25% higher than that of Ti6Al4V pin, the torsion strength of the screw was increased up to 89%, the static bending load of the plate was increased by 67-89%, and the maximum loading force of the plate after 1 million cycles of four point dynamic bending was increased by 41-91%. The above improvements should be attributed to the strengthening effect of Cu in the antibacterial titanium alloy, indicating that the Cu-bearing antibacterial titanium alloy implant possesses both advantages of reducing the bacterial infection and improving the biomechanical safety, and a broad clinical application prospects.

Phase transformation and microstructure evolution of nanoimprinted NiCoCr medium entropy alloys

In this study, the mechanical and processing properties of nanoimprinted nickel-cobalt-chromium medium-entropy alloy (NiCoCr MEA) are investigated using molecular dynamics (MD) simulation. The effects of microstructure, loading velocity, the taper angle of mould, and processing temperature are analyzed by loading force, deformation characteristic, crystal evolution, dislocation distribution, displacement vector, and radial distribution function. Based on the results, both stacking faults and twinning structures appear in NiCoCr MEA during the imprinting process. The formation of stacking fault is affected by grain size, and it always propagates in large grains (grain size = 8.5 nm). Besides, the maximum loading force and the residual stress increase with an increase in loading velocity (200 m/s), caused by the shorter relaxation time for the atoms in NiCoCr MEA specimen with higher loading velocity. Moreover, the temperature is found to affect the microstructure, phase transformation, and dislocation evolutions of NiCoCr MEA specimen. Most of the atoms transform into HCP or amorphous phase at a temperature of 900 K during the equilibrium process. The maximum loading force decreases with an increase in temperature, and atoms strongly adhesion on the bottom of the mould at the higher temperature (900 K). By contrast, the taper angle of mould gives little effect to the mechanical characteristics. There is no obvious trend in the deformation behaviors of the specimens with different taper angles.

Probing the Interactions between Pickering Emulsion Droplets Stabilized with pH-Responsive Nanoparticles.

The presence and adsorption of particles at the oil/water interface play a critical role in stabilizing Pickering emulsions and affecting their bulk behavior. For water-in-oil (W/O) and oil-in-water (O/W) Pickering emulsions with pH-responsive nanoparticles, their interaction forces and stabilization mechanisms at the nanoscale have not been reported. Herein, the Pickering emulsions formed by oil/water mixtures under different pH values with bilayer oleic acid-coated Fe3O4 nanoparticles (Fe3O4@2OA NPs) were characterized using microscopy imaging and zeta potential and interfacial tension (IFT) measurements. The interaction forces between formed emulsion droplets were quantified using an atomic force microscope (AFM) drop probe technique. A W/O emulsion formed at pH 2 and 4 is mainly stabilized by the steric barrier formation of confined particle layers (with Fe3O4@2OA NPs and aggregates). At pH 9 and 11, an O/W emulsion is formed, and its stabilization mechanism is mainly due to relatively low IFT, strong electrostatic repulsion due to carboxyl groups, and steric repulsion from confined nanoparticles and aggregates, leading to a stable confined thin water film. Increasing the maximum loading force and dwelling time enhances the confinement of Fe3O4@2OA particles and aggregates at the oil/water interface. This work provides useful insights into the interaction and stabilization mechanisms of Pickering emulsions with stimuli-responsive interface-active particles.

Criterion for Imminent Failure During Loading—Discrete Element Method Analysis

It has recently been reported that the equal load sharing fiber bundle model predicts the rate of change of the elastic energy stored in the bundle reaches its maximum before catastrophic failure occurs, making it a possible predictor for imminent collapse. The equal load sharing fiber bundle model does not contain central mechanisms that often play an important role in failure processes, such as localization. Thus, there is an obvious question whether a similar phenomenon is observed in more realistic systems. We address this question using the discrete element method to simulate breaking of a thin tissue subjected to a stretching load. Our simulations confirm that for a class of virtual materials which respond to stretching with a well-pronounced peak in force, its derivative and elastic energy we always observe an existence of the maximum of the elastic energy change rate prior to maximum loading force. Moreover, we find that the amount of energy released at failure is related to the maximum of the elastic energy absorption rate.

Anatomical and Biomechanical properties of MPFL reconstruction technique using Adductor Magnus tendon graft

Aims and Objectives:The main goal of the presented study was to evaluate the anatomical and biomechanical properties of the proposed surgical technique for anatomical Medial Patellofemoral ligament (MPFL) reconstruction using the flat Adductor tendon (AT) graft in order to primarily determine its overall plausibility and application potential, as well as to reveal the main risks and pitfalls of the technique.Materials and Methods:Anatomical descriptive evaluation, followed by biomechanical testing of the proposed AT- MPFL reconstruction was conducted on 12 fresh frozen human cadaveric knees. The morphological and topographical features of the AT and native MPFL were reported. The biomechanical tests were performed in order to determine the strength and resistance to maximum loading force of the reconstruction. The construct was placed in an uniaxial testing machine and cyclically loaded 500 times between 5 and 50N, followed by load to failure, measuring the maximum elongation, stiffness and maximum load respectively.Results:Regarding the anatomical evaluation of the structures in focus, several findings have been reported. The mean length of the tendon was found to be 12,59±1,54cm, the mean distance between the insertion on the Adductor tubercule and Hiatus was measured at 10,83±1,27cm, exceeding the mean desired length of the graft, found at 7,54±0,45cm by 2,43±0,56cm. The desired length of the graft was based on the measured length of the native MPFL with additional ±25-30mm of the tendon that allows for intraoperative length changes and different means of patellar fixation depending on the surgeons preference. The insertion of the Adductor tendon on the Adductor tubercule was found to be superior and posterior to the insertion of the native MPFL. The distal portion of AT was found to be consisted of two distinct parts with varying fiber orientation, the tendinous and the membranous part. After cyclic load, the maximum elongation was reported at 1,9 ± 0,4mm. The mean stiffness and load to failure of the construct were measured at 26,2±7,6N/mm and 148,74±22,01N. The graft failed at the patellar insertion site in two of the tested specimens and at the femoral insertion site in the remaining 10.Conclusion:Due to its advantageous anatomical and topographical aspects, as well as adequate biomechanical properties, the Adductor tendon graft caries a high utilization potential for MPFL reconstruction. Application that allows for primarily soft tissue fixation on the patella, in addition to absence of femoral drill holes with consequently no risk of injury to the physis, makes the AT graft choice a preferable option when considering MPFL reconstruction in patients with open growth plates. Even though it includes graft and methods of fixation alternative to the traditionally used techniques, this reconstruction is not exclusively predetermined for the skeletally immature patients and has a high application potential for the older patient population as well.

Influence of CAD/CAM Fabrication and Sintering Procedures on the Fracture Load of Full-Contour Monolithic Zirconia Crowns as a Function of Material Thickness.

The purpose of this in vitro study was to analyze the effect of computer-aided design/computer-aided manufacturing (CAD/CAM) fabrication and sintering procedures on the fracture load of monolithic zirconia crowns with different material thicknesses adhesively seated to methacrylate dies fabricated with stereolithography technology. Monolithic zirconia crowns were fabricated from inCoris TZI C material with a chairside CAD/CAM system (CEREC MCXL) comprising three material thicknesses (0.5/1.0/1.5 mm, n=8 each). Two CAD/CAM fabrication procedures (milling, MI; grinding, GR), two chairside sintering procedures (superspeed, SS; speedfire sintering, SF), and one labside sintering procedure (classic, CL) were evaluated. In total, 144 crowns were fabricated. Restorations were adhesively seated to methacrylate dies fabricated with SLA technology. Thermomechanical cycling (TCML) was performed before fracture testing. Loading forces until fracture were registered and statistically analyzed with one-way analysis of variance (ANOVA), post hoc Scheffé test, and three-way ANOVA (α=0.05). Test groups showed statistically significant differences (p<0.05). The highest mean value was found for 1.5-mm crowns of group GR_SF with 3678.6 ± 363.9 N. The lowest mean value was found for group 0.5-mm crowns of group MI_SF with 382.4 ± 30.7 N. There was a significant three-way interaction effect between thickness, sintering, and processing [F(4,126)=9.542; p<0.001; three-way ANOVA, significance level α=0.05]. CAD/CAM fabrication and sintering procedures influence the maximum loading force of monolithic zirconia crowns with different material thicknesses. A material thickness of 0.5 mm should be considered as a critical thickness for monolithic zirconia crown restorations.

Biomechanical and tomographic differences in the microarchitecture and strength of trabecular and cortical bone in the early stage of male osteoporosis.

Osteoporosis is a continuous process of loss of bone tissue. Compared to women, osteoporosis in men is associated with greater morbidity and mortality. In this study, we conducted tomographic and biomechanical evaluations of trabecular and cortical bone in the early stage of male osteoporosis. Male Wistar rats were subjected to orchiectomy and sham operation. Four weeks after being castrated, decreased levels of testosterone in plasma were found and resulted in concurrent bone loss. Separately, the orchiectomy led to significant tomographic alterations in the trabecular bone number, trabecular separation, and trabecular pattern factor. Data of a mechanistic compression test further showed that the orchiectomy diminished the maximum loading force, displacement at maximum load, energy at maximum load, and ultimate stress. Interestingly, orchiectomy-triggered changes in the maximum loading force and tomographic parameters were highly correlated. In contrast, tomographic and biomechanical analyses showed that 4 weeks after rats were orchiectomized, the thickness, area, maximum loading force, bone stiffness, energy at maximum load, and ultimate stress of the cortical bone were not changed. Taken together, this study showed specific differences in the microarchitecture and strength of trabecular bone in the early stage of male osteoporosis.

Experimental and numerical study on deformation behavior of doubly curved metal plates during incremental bending process

Doubly curved metal plates are widely used in various industrial fields, so many efforts have been made to achieve the required doubly curved metal plates at reasonable quality and high efficiency in the last few decades. This paper presents a flexible forming process called incremental bending to achieve the doubly curved metal plates. The basic deformation behavior of the metal plates during the incremental bending process, including the loading force distribution and springback amount distribution along the whole surface of the metal plates, was investigated and analyzed based on experiments and numerical simulation. Results show that the maximum loading force and the springback amount of the metal plates are significantly influenced by the punching position while not by the incremental step. The results provide an important theoretical foundation for the practical application of the incremental bending process for achieving various doubly curved metal plates in the future.

Effect of Subtalar Fusion and Calcaneal Osteotomy on Function, Pain, and Gait Mechanics for Calcaneal Malunion.

Calcaneal malunion is a common complication of nonoperative management of calcaneal fracture, which leads to a disruption of the biomechanics of the lower extremity, pain, and permanent disability. Our aim was to evaluate pain, function, and gait after combined subtalar joint fusion, calcaneal osteotomy, and lateral wall exostectomy for patients with neglected calcaneal fractures with malunion. Eighteen patients with malunited calcaneal fractures, varus deformity, and subtalar arthritis were operated upon and then followed up for 18 months. All cases were assessed clinically using the American Orthopaedic Foot & Ankle Society (AOFAS) and visual analog scale (VAS); radiologically by measuring the talar inclination, talocalcaneal and talus-first metatarsal angles, and talocalcaneal height; and biomechanically by measuring the stride duration, step width, comfortable speed, and ground reaction forces in relation to the body weight. A significant improvement in AOFAS (59.8 preoperatively to 80.2 after 18 months) and VAS (61.1 preoperatively to 29.4) was found. Also, our study revealed a significant improvement in the radiographic measurements including the valgus angle, the talocalcaneal angle, the talocalcaneal height, and the talar inclination angle. The gait analysis found that the maximum loading force in the push-off phase and comfortable speed yielded a significant improvement postoperatively. However, no significant differences between the preoperative data and the final follow-up in terms of the step width, stride duration, maximum peak force during loading phase, and minimum peak force during midstance phase were found. The combination of valgus calcaneal osteotomy, lateral wall exostectomy, and subtalar fusion resulted in pain reduction, improved function, and better gait. However, the limited bone stock for the graft used in the subtalar fusion made use of this technique in severely reduced height unadvisable. Level IV, case series.

Effects of sequential treatment with intermittent parathyroid hormone and zoledronic acid on particle-induced implant loosening: Evidence from a rat model.

Particle-induced implant loosening is a major challenge to long-term survival of joint prostheses. Administration of intermittent parathyroid hormone (PTH) has shown potential in the treatment of cases of early-stage periprosthetic osteolysis, while sequential administration of intermittent PTH (iPTH) and bisphosphonates (Bps) has achieved significant effects on treatment of postmenopausal osteoporosis. The objective of this study was to determine whether sequential treatment could preserve bone mass and implant fixation during a pathological course of peri-implant osteolysis in a rat model. Ninety male Sprague Dawley rats were randomly divided into nine groups, four of which were used for confirmation of establishment of the peri-implant osteolysis model at two time points, while the other five were used to determine the efficiency of the sequential treatment on peri-implant osteolysis. Implant fixation and peri-implant bone mass were evaluated using biomechanical testing, micro-CT analysis, and histology at 6 and 12 weeks postoperative. The biomechanical test demonstrated that the maximum loading force during a push-out test was significantly elevated in the sequential treatment group compared to the osteolysis group and iPTH withdrawal group at 12 weeks. Peri-implant bone morphology also indicated a robust increase in bone volume in the sequential treatment group. Sequential administration of iPTH and Bps was effective in preventing experimental peri-implant osteolysis, resulting in improved implant fixation and increased peri-implant bone volume. Clinical significance: The innovative application of sequential treatment in peri-implant osteolysis could be used clinically to improve the prognosis of patients with early-stage periprosthetic osteolysis. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:1489-1497, 2019.