In this study, a pre-matching method was developed based on measured performance parameters and theoretical calculations of turbochargers. First, the turbocharger of a natural gas engine was subjected to a comprehensive performance experiment. According to the experimental results, the maximum efficiencies of the turbine and compressor are 70% and 75%, respectively, and the efficiency of the turbine drops sharply from 70% to 56.6% as the pressure ratio increases from 1.25 to 2.4. In this thesis, a specific turbocharger pre-matching software has been developed in conjunction with a database. Three turbines and three compressors were selected from the self-developed database for matching and comparative study using this method. The simulation results showed that the maximum efficiency of turbine #1, #2 and #3 is 71.3%, 72.2% and 72.7%, respectively, and the efficiency of these three turbines is concentrated between 65% and 72.5%. Obviously, the maximum efficiency of the turbine has increased by 1.3–2.7% and the overall efficiency has improved after the pre-matching. Therefore, this developed pre-matching method can reduce time cost, improve work efficiency and engine performance, and is important for the design and development of turbochargers.