AbstractBackgroundInsight 46 is a longitudinal neuroscience sub‐study of the MRC National Survey of Health and Development (the British 1946 Birth Cohort). In March 2020, the COVID‐19 pandemic, and the introduction of lockdown measures across the UK, demanded a transition from traditional face‐to‐face data collection methods to teleconference‐based testing, to ensure the safety of our vulnerable cohort and the ongoing collection of longitudinal data. We present our approach to adapting and expanding our existing telephone assessment procedures to include as many tests as possible from our standard neuropsychology battery.MethodsParticipants with a computer or tablet with a webcam, microphone, and screen dimensions greater than 9 inches were offered a Microsoft Teams videoconference assessment; those without were offered a telephone visit to ensure maximum data collection. Videoconference and telephone batteries were created under copyright agreements. Item‐by‐item responses were collected digitally, and audio‐recording software was used to capture verbal responses where appropriate. Pre‐visit packs containing assessment materials in sealed envelopes (to prevent advance sight of materials) were sent ahead of each assessment. Due to specific equipment or software requirements, computerised assessments could not be performed (see Table 1).Result65% of the remaining eligible participants completed a remote assessment (see table 2). Despite offering one‐to‐one videoconferencing training, a major reason for drop‐out was concerns about technology, in addition to hearing difficulties and other health considerations. During administration, challenges included ensuring a standardised research environment and overcoming technological issues. Detailed scripts and protocols were implemented to guarantee uniform administrations, as well as detailed recording of unexpected events such as distractions and technology failures.ConclusionOur methods allowed for the continuation of longitudinal data collection, demonstrating the feasibility of teleneuropsychology in elderly populations. Positive feedback demonstrated participants’ acceptance of telehealth approaches and their appreciation of the value of continuing research. Future implementation of these methods could increase retention in populations previously prevented by physical barriers. However, careful consideration must be given to the validity and reliability of remote administration, and the differences between telephone and videoconferencing methods.