Maximum Attenuation Research Articles

Ultra-low frequency active vibration isolation system with quasi-zero stiffness characteristic using self-tuning filter-based feedforward control

Purpose of studyThis study aims to resolve the compromise between low suspension stiffness and high load-bearing capability in vibration isolation and enhance the suppression performance of ultra-low frequency vibration through advanced active feedforward control methods, featuring high-performance precision isolation for large-scale ultra-precision instruments. Describe methodsAn air-magnetic hybrid parallel configuration of positive and negative stiffness is employed to achieve adjustable stiffness, endowing the vibration isolation system with quasi-zero stiffness characteristics. A novel self-tuning feedforward control strategy is proposed through a self-tuning filter to update the controller parameters online, minimizing the loss caused by model uncertainties. ResultsThe vertical and horizontal natural frequencies of the system exhibit a remarkably low resonance frequency of lower than 0.5 Hz. With the self-tuning feedforward strategy, the maximum vibration attenuation reaches 78 dB in the vertical direction and 70 dB in the horizontal direction, reducing the cumulative power at 100 Hz by 61.4 % and 47.8 %, respectively. The above results showcase the proposed approach with excellent performance in isolating low-frequency vibrations. Conclusions/DiscussionThe ultra-low frequency active vibration isolation system designed in this paper achieves exceptionally low suspension stiffness. The implemented self-tuning feedforward controller isolates large precision machinery from broadband floor vibrations and significantly enhances the vibration isolation performance of the system.

Usefulness of Dual-Energy CT for Differentiating Hemorrhage From Iodine Extravasation in Meningiomas After Preoperative Embolization

Objective Discriminating between hemorrhage and iodine extravasation can pose challenges in conventional computed tomography (CCT) images following preoperative embolization for meningioma. This study aimed to assess the efficacy of dual-energy computed tomography (DECT) in differentiating hemorrhage from iodine extravasation after preoperative embolization for meningioma. Methods Twenty-one consecutive meningioma patients who underwent CCT before and DECT immediately after preoperative embolization were included in this study. Two independent observers conducted qualitative assessments on CCT and virtual noncontrast (VNC) images and iodine maps (IMs) to differentiate between hemorrhage and iodine extravasation. One observer recorded CT values of hemorrhage and iodine extravasation on CCT and VNC images. The ratio of maximum attenuation to minimum attenuation on VNC images was defined as the VNC ratio. Statistical analysis included Kappa (κ) statistics, unpaired t tests, and receiver operating characteristic (ROC) analysis. Results Interobserver agreement for qualitative assessment was fair (κ = 0.231) for CCT alone and good (κ = 0.723) for CCT plus VNC imaging and IM. The addition of VNC imaging and IM to CCT improved differential confidence in 16 (76%) and 18 (86%) cases of the two observers, respectively, increasing the area under the receiver operating characteristic curve (AUROC) from 0.868 to 0.895 and 0.658 to 0.947, respectively. At a cutoff value of 1.527, the VNC ratio was significantly higher for hemorrhage than iodine extravasation (P < 0.05), with the highest diagnostic performance (AUROC, 1). Conclusions DECT with VNC imaging and IM is useful for differentiating hemorrhage from iodine extravasation in meningiomas with preoperative embolization.

Multifunctional integrated droplet lens based on microfluidics.

A multifunctional integrated droplet lens based on microfluidics is proposed. The lens consists of a microfluidic chip, four droplets with different properties, and transparent silicone oil. Visible-light, infrared, narrow wavelength band, and light-switching droplets can be used for imaging in the VIS-NIR (visible to near-infrared), narrow wavelength band, and blocking light, respectively. The optical focal power of the proposed lens is -134.6 D ∼ -91.62 D with visible-light droplet and -21.1 D ∼ -12.9 D with infrared droplet. When the droplet lens is used as an optical switch, the maximum optical attenuation is 251:1. It is measured that the transmitted power can be adjusted from 0.015 mW to 0.096 mW when the initial incident power is 0.776 mW. The proposed lens integrates the functions of zoom and optical attenuation. It offers important advantages in providing lightweight, high integration and shows a wide range of potential applications in microscopy systems, microfluidic systems, and variable optical attenuators.

Computed tomography for prediction of stent underexpansion after percutaneous recanalization of calcified coronary chronic total occlusions

Abstract Background Coronary calcifications are the leading cause of stent underexpansion after percutaneous coronary intervention (PCI) and are commonly encountered in chronic total occlusions (CTO). Coronary computed tomography angiography (CCTA) is uniquely suited for pre-procedural assessment of coronary calcifications. Recently quantitative CCTA, providing exact volumes of each plaque component, has shown additional value in future risk assessment compared with conventional qualitative CCTA. Purpose The aim of this study was to evaluate whether CCTA predicts intravascular ultrasound (IVUS)-defined suboptimal stent expansion following percutaneous recanalization of calcified CTO lesions. Methods We retrospectively identified consecutive patients with a CCTA performed within 6-months prior to successful PCI of a calcified CTO (defined as calcification within the target lesion on CCTA). All patients had final IVUS of implanted stents (Figure 1). Patients requiring atherectomy were excluded. The primary outcome was IVUS-derived stent expansion index (SEI), defined as stent area divided by vessel area (both measured at the site of maximum calcium). SEI<0.4 indicated suboptimal stent expansion. The site of maximum calcium was a cross-section with greatest calcium arc on pre-stent IVUS within the target lesion. CCTA calcium analysis was performed by a researcher blinded to the IVUS and angiography results. Measurements included total-, vessel-, and lesion-specific calcium score (CAC), total calcium length, maximum calcium thickness and maximum CT calcium attenuation at the target lesion defined as occlusion site and adjacent severely diseased segments. Calcium quantification was performed using a semi-automated software to obtain volumes and burdens of calcified and non-calcified plaque components within the target lesion. Results The cohort included 43 patients (age 64.9±10.0 years, 88% males) with 43 CTO lesions. Mean final stent area at maximum calcium by IVUS was 8.2±2.1mm². Mean SEI was 0.47±0.1, and suboptimal SEI of <0.4 was found in 10 (23.3%) lesions. Lesions with suboptimal stent expansion (SEI<0.4) were characterized by numerically higher total-, vessel- and lesion-specific CAC, higher maximum calcium attenuation, greater calcium length and remodeling index compared with patients with optimal stent expansion (Table 1). However, only calcified plaque volume (105 [IQR 27-271] vs. 29 [4-96]mm³, P=0.02) and calcified plaque burden (16 [7-24] vs. 6 [1-10]%, P=0.03) were significantly greater in lesions with suboptimal stent expansion compared with lesions with optimal stent expansion, respectively. Calcified plaque volume ≥51 mm³ within the target lesion predicted suboptimal stent expansion with 70% sensitivity and 62.5% specificity (AUC 0.74). Conclusion CCTA-derived calcium volume identifies CTO lesions at greater risk of stent underexpansion. Such lesions require more aggressive plaque modification prior to stent implantation.

Experimental investigation on maximum ceiling temperature and longitudinal attenuation in a closed tunnel with an inclined shaft

For tunnel fires with open and closed tunnel ends, the smoke flow pattern and air supply conditions vary considerably, resulting in different maximum excess ceiling temperature (ΔTmax) and its longitudinal distribution (ΔTx). However, few studies have focused on the tunnel closed at both ends with an inclined shaft (typical tunnel structure during construction). Hence, tunnel model 1 (tunnel closed at both ends with an inclined shaft) and tunnel model 2 (tunnel open at both ends) are built for comparison and analysis. The results show that tunnel model 1 has higher ceiling temperatures and slower attenuation than tunnel model 2. Therefore, the ΔTx in tunnel model 1 needs to be re-analyzed in detail. Different inclined shaft slopes, fire heat release rates, longitudinal and vertical fire positions are considered. In tunnel model 1, for h (lifting height of burner surface) = 0, the ΔTmax value tends to be constant for the same heat release rate, irrespective of the longitudinal fire position. For h = 5 cm, the ΔTmax value takes on a rising trend with the fire moving downstream. Moreover, the inclined shaft slope within this study has little influence on ΔTx. As the fire moves downstream, the downstream ΔTx/ΔTmax value decreases more rapidly. From h = 0 to h = 5 cm, the value of ΔTx/ΔTmax drops slightly faster, but the gap is small and can be ignored. Finally, the experimental correlations are proposed to estimate the longitudinal ceiling temperature distribution in a closed tunnel with an inclined shaft.

Size effect on tensile bonding strength between new and old concrete

The interface between new and old concrete plays a significant role in reinforced concrete engineering due to its size effect and weak strength. To investigate the size effect of tensile strength in new-to-old concrete, splitting tensile tests and computed tomography (CT) scans on composite specimens were conducted. Specimen size, interface roughness, volume fraction of polyvinyl alcohol fiber and adhesive were considered. The tensile bonding strength initially increases and then decreases with interface roughness and fiber content, while size effect on the strength shows a downward trend before rising. The adhesive notably enhances the tensile bonding strength and weakens its size effect. The interface roughness, polyvinyl alcohol fibers and interface agents influence the size effect by modifying the bonding area, specimen uniformity, and characteristic structure of the interface region. At an interface roughness of 5.5 mm and a polyvinyl alcohol fiber content of 0.5 %, the maximum strength was achieved and the maximum attenuation of size effect occurred. The size effect laws of tensile bonding performance were presented based on the Weibull statistical theory, Bažant energy theory and Carpinteri multi-fractal theory. The experimental values exhibit good consistency with the predictions from the size effect models.

Clinical impact of deep learning-derived intravascular ultrasound characteristics in patients with deferred coronary artery

Prognostic markers for long-term outcomes are lacking in patients with deferred (nonculprit) coronary artery lesions. This study aimed to identify the morphological criteria for predicting adverse outcomes and validate their clinical impact.Using deep learning models, we extracted geometrical parameters and maximal attenuation (or calcium) burden index (ABI-max or CBI-max) from the intravascular ultrasound (IVUS) images of nonculprit vessels in 1115 patients. The endpoints included cardiac death, myocardial infarction, and target vessel revascularization of nonculprit vessel.Cardiac death occurred in 27 (2.4 %) patients at 3 years and 39 (3.5 %) patients at 5 years. At 5 years, the cardiac death-free survival rate was significantly lower with ABP-max ≥11.37 % vs. < 11.37 % (90.0 % vs. 98.7 %), CBI-max ≥13.40 % vs. < 13.40 % (92.8 % vs. 98.4 %), and percent atheroma volume ≥ 51.35 % vs. < 51.35 % (94.0 % vs. 97.7) (all log-rank p < 0.001). The independent predictors of 5-year cardiovascular mortality were age (hazard ratio [HR] 1.21), female sex (HR 0.33), history of heart failure (HR 6.06), chronic kidney disease (HR 18.28), ABI-max (HR 1.04), and CBI-max (HR 1.05). The independent determinants of 5-year target vessel revascularization of nonculprit vessel were fractional flow reserve (HR 0.95 per 0.01 increase), minimal lumen area (HR 0.63), and plaque burden (HR 1.15).In patients with nonculprit coronary artery lesions, a large burden of attenuated or calcified plaques predicted cardiac mortality, while IVUS geometry was associated with repeat revascularization. Thus, deep learning–based IVUS analysis of the whole target vessel may help clinicians identify high-risk lesions.

Radiation protection in dental imaging: Evaluating the impact of the SABA thyroid shield during panoramic and cone beam computed tomography

BackgroundDental panoramic radiography (DPR) and cone beam computed tomography (CBCT) are an imaging modalities in dentistry. However, these procedures involve exposure to ionising radiation, raising concerns about radiation-induced thyroid damage. To mitigate these risks, thyroid shields have been introduced. This study aimed to evaluate the effectiveness of the SABA thyroid shield in reducing thyroid radiation exposure during DPR and CBCT scans. MethodAn experimental study to measure surface dose in the thyroid region during (DPR) and (CBCT) scans using an Anthropomorphic Phantom and a Solid-State Detector. The attenuation percentage was calculated between radiation surface doses with and without shielding. The significance of the Saba thyroid shield was calculated using a t-test. ResultsFor DPR scans, the average surface doses in the thyroid reduced significantly from 301.1 μGy (at 85 kVp) and 170.3 μGy (at 60 kVp) to 64.43 μGy and 12.94 μGy, respectively, when the Saba thyroid shield was used. For CBCT scans, the average surface doses in the thyroid decreased significantly from 814.43 μGy (for 11 × 13 cm2 field size) and 32.40 μGy (for 5 × 5 cm2 field size) to 62.91 μGy and 12.07 μGy, respectively, with the application of the Saba thyroid shield. The maximum attenuation percentages in the thyroid for the DPR and CBCT scans were 92.40% and 92.27%, respectively. Statistically significant differences between the surface dose reduction with the Saba shield and without it was observed in both DPR scans (p < 0.0000) and CBCT scans (p < 0.0003). ConclusionThe study demonstrates that Saba thyroid shields effectively reduce doses in the thyroid region during dental DPR and CBCT scans. The dose reduction depends on tube voltage for DPR scans, field size, and its position for CBCT scans. Findings highlight the importance of using Saba thyroid shields to minimise radiation exposure and protect the thyroid gland during dental scans.

Experimental study on the free and constrained vibration performance of composite wave springs

This article proposes a glass fiber reinforced plastic (GFRP) wave spring and conducts a study on its free and constrained vibration characteristics and compression performance. Initially, a stiffness prediction model for composite wave spring is established using laminated plate theory and Moore’s theorem. Additionally, the failure mode of the composite wave spring was predicted and experimentally confirmed using ABAQUS and the 3D-Hashin failure criterion. Finally, the vibration characteristics of composite wave spring and metal helical spring are investigated using the B&K testing system in both free and constrained states. The experimental stiffness and ultimate load of the composite wave spring are 20.67 N/mm and 1386.67 N. The composite wave spring exhibits good vibration reduction performance in both free and constrained states, with maximum vibration attenuation amplitudes of 122.71 and 144.93 dB. In comparison, the metal helical spring has maximum vibration attenuation amplitudes of 41.65 and 111.89 dB.

Effects of fluid saturation and viscosity on seismic dispersion characteristics in Berea sandstone

Despite additional availability of laboratory data from water-saturated sandstone at seismic frequencies, measurements of rock samples saturated with high viscous fluids, particularly at partial saturation, are still rare. To quantify the effects of fluid viscosity and saturation levels on seismic dispersion and attenuation characteristics, we conducted two comparative forced-oscillation measurements in partially saturated sandstone with varying fluid viscosity (e.g., water, glycerin) at seismic frequencies (2–400 Hz). The results demonstrate that fluid viscosity and saturation levels substantially influence the dispersion and attenuation characteristics at the measured frequencies. Significant dispersion and attenuation are observed in the presence of a relatively small amount of gas (approximately 6%–8%) for glycerin and water saturation cases but vary in their magnitudes and characteristic frequencies. Specifically, the maximum extensional attenuation (approximately 0.024) occurs at approximately 200 Hz for water-saturated rock at 94% saturation, whereas at approximately 30 Hz with a peak of 0.032 for glycerin-saturated rock at 92% saturation. Based on theoretical modeling analysis, we suggest that mesoscopic fluid flow might be a dominant mechanism accounting for the observed attenuation in partial water or glycerin saturation, while the microscopic (squirt) flow mechanism possibly dominates the fully saturated cases.

Development of polyurethane urea（PUU）– Waste rubber particles (WRP) composite materials for active ice-breaking of groove-filled asphalt pavement

The grooved-filled asphalt pavement has certain advantages in terms of pavement ice-breaking and anti-skid. However, the performances of the filling material limit its development. In this study, a polyurethane urea (PUU) - waste rubber particles (WRP) composite filling material was prepared by using a polyurethane (PU) and adding polyurea (PUa) with a similar microstructure as the cementing material, and adding WRP as the elastic reinforcing phase. The proportions of nine PUU-WRP composite materials were designed by changing the particle size and content of WRP, and then the filled composite materials were evaluated in terms of physical and mechanical properties, ice adhesion properties, interface bonding properties and aging resistance. The test results showed that the shore hardness, tensile strength, compression permanent deformation, and contact angle of PUU-WRP composite decreased as content of the WRP increased. Except the ice adhesion force results were the opposite. On the other hand, increased the WRP size resulted in increase in PUU-WRP composite’s shore hardness, compression permanent deformation, and ice adhesion force, while the tensile strength and contact angle were the opposite. The surface of the PUU-WRP composite material was hydrophobic, and the maximum contact angle was 102.3°. The reduction of WRP particle size and dosage was beneficial for reducing the ice adhesion force on the surface of PUU-WRP composite materials. The maximum interfacial shear and tensile strength of PUU-WRP composite material were 1.082 MPa and 0.244 MPa, respectively. After 42 days of UV aging, the maximum attenuation rate did not exceed 30 %. After the immersion test, the tensile strength attenuation of PUU-WRP composite material was basically controlled within 10 %. Finally, based on the fuzzy comprehensive evaluation (FCE) method, it was recommended to use WRP with a particle size of 0.6 mm and a dosage of 30 wt%-40 wt%.

Investigation of hydrogen explosion effects based on cavity structure-porous material coupling

Porous materials have good wave-absorbing and shock-absorbing effects, so it is one of the common measures to adopt them for explosion isolation in the field of safe transportation of hydrogen energy, but the need for filling inside the pipeline limit its application. In this paper, based on the structure-material coupling mechanism, the porous material is placed in the vacuum cavity structure. The explosion-proof performance of the polyurethane(PU) filled with different pore sizes and the composite material is investigated, which provides theoretical support and experimental basis for the application of porous material in the field of the explosion-proof. It is found that the coupling mechanism of "vacuum cavity - porous material" can effectively reduce the explosion pressure in the pipeline, and the smaller the pore size of the porous material, the stronger the effect of explosion isolation, and the maximum reduction in explosion pressure of 74 %. On this basis, the shear thickening gel (STG) and PU composite, give it the performance of impact hardening, and improved mechanical properties, the experimental results show that the composite material after the explosion isolation performance is stronger, the maximum explosion pressure attenuation of 87 %, the explosion isolation performance increased by 18 %.

Discussion and Demonstration of RF-MEMS Attenuators Design Concepts and Modules for Advanced Beamforming in the Beyond-5G and 6G Scenario-Part 2.

In this paper, different concepts of reconfigurable RF-MEMS attenuators for beamforming applications are proposed and critically assessed. Capitalizing on the previous part of this work, the 1-bit attenuation modules featuring series and shunt resistors and low-voltage membranes (7-9 V) are employed to develop a 3-bit attenuator for fine-tuning attenuations (<-10 dB) in the 24.25-27.5 GHz range. More substantial attenuation levels are investigated using fabricated samples of coplanar waveguide (CPW) sections equipped with Pi-shaped resistors aiming at attenuations of -15, -30, and -45 dB. The remarkable electrical features of such configurations, showing flat attenuation curves and limited return losses, and the investigation of a switched-line attenuator design based on them led to the final proposed concept of a low-voltage 24-state attenuator. Such a simulated device combines the Pi-shaped resistors for substantial attenuations with the 3-bit design for fine-tuning operations, showing a maximum attenuation level of nearly -50 dB while maintaining steadily flat attenuation levels and limited return losses (<-11 dB) along the frequency band of interest.

Ultra-wide band gap and wave attenuation mechanism of a novel star-shaped chiral metamaterial

A novel hollow star-shaped chiral metamaterial (SCM) is proposed by incorporating chiral structural properties into the standard hollow star-shaped metamaterial, exhibiting a wide band gap over 1 500 Hz. To broaden the band gap, solid single-phase and two-phase SCMs are designed and simulated, which produce two ultra-wide band gaps (approximately 5 116 Hz and 6 027 Hz, respectively). The main reason for the formation of the ultra-wide band gap is that the rotational vibration of the concave star of two novel SCMs drains the energy of an elastic wave. The impacts of the concave angle of a single-phase SCM and the resonator radius of a two-phase SCM on the band gaps are studied. Decreasing the concave angle leads to an increase in the width of the widest band gap, and the width of the widest band gap increases as the resonator radius of the two-phase SCM increases. Additionally, the study on elastic wave propagation characteristics involves analyzing frequency dispersion surfaces, wave propagation directions, group velocities, and phase velocities. Ultimately, the analysis focuses on the transmission properties of finite periodic structures. The solid single-phase SCM achieves a maximum vibration attenuation over 800, while the width of the band gap is smaller than that of the two-phase SCM. Both metamaterials exhibit high vibration attenuation capabilities, which can be used in wideband vibration reduction to satisfy the requirement of ultra-wide frequencies.

Impact of natural aggregates and some industrial wastes on radiation shielding properties of heavyweight concrete: Experimental and theoretical study

The methodology to produce five concrete specimens with high density has been conducted, incorporating natural aggregates such as sand and basalt as well as commercial aggregates like lead and copper. These specimens have been designed for use in structural and radiological shielding purposes. The five specimens exhibit exceptional mechanical features, characterized by superior performance and remarkable stability. The specimen labeled heavyweight concrete with 36% Pb (HWC36Pb) has been found to have a compressive strength of 28 MPa and a tensile strength of 2.76 MPa. Furthermore, the current work specimens show excellent potential for attenuating gamma, neutron, proton, and alpha radiation, particularly at low energies. This supports their potential use in medical and nuclear facilities. Radiation attenuation results show that the specimen with the ID HWC36Pb exhibits the maximum attenuation coefficient for gamma and neutron radiation among the other investigated specimens, which were either doped with a small quantity of lead or doped with copper. The mass attenuation coefficient of HWC36Pb at a gamma energy of 662 keV was determined to be 0.0905 cm2/g. Furthermore, it demonstrates the highest fast neutron removal cross-section, measuring 0.0944 cm−1.

EMI shielding study of PVC-PT-Ag/ZnS nanocomposites in microwave region

Chemical oxidative polymerization and hydrothermal methods were employed to synthesize polythiophene (PT) and silver-doped zinc sulfide (Ag/ZnS) nanoparticles for electromagnetic interference (EMI) shielding applications. Composite films based on PVC were fabricated by incorporating these nanoparticles, both Ag/ZnS and PT-Ag/ZnS. Initially, X-ray diffraction and zetasizer technology were utilized to analyze the crystal structure and particle size of these nanoparticles. Subsequently, the nanocomposite films were assessed for various properties, including electrical conductivity and transmittance in the near-infrared wavelength range of 200–800 nm, as well as their effectiveness in shielding electromagnetic interference in the microwave frequency range of 0.1–20 GHz. The aforementioned features were investigated using DC conductivity, vector network analysis, and NIR spectroscopy. It was discovered that both conductance and shielding effectiveness increased to 0.029 S/cm and 54 dB, respectively, as the nanoparticle density increased. At 20 wt% PT-Ag/ZnS, the maximum attenuation value within the 0.1–20 GHz frequency band reached 54 dB, with transmittance below 0.5 %.

Analysis on characteristics of ground vibration induced by underground high-speed trains based on in-situ test

With the increasingly emerging traffic intersection form of high-speed railways passing underneath integrated transport terminals, the ground vibration induced by trains running on underground high-speed railways has attracted extensive attention. In combination with the engineering example of a high-speed railway in construction passing underneath an airport, the wheel-drop impact test in the high-speed railway tunnel was designed to obtain the vibration characteristics of surrounding soil. The vehicle-track-tunnel-ground semi-analytical three-dimensional model was established to determine the initial dynamic load condition of the vehicle loads. The amplitude-frequency characteristic and transmission law of the ground vibration induced by trains running on underground high-speed railways were predicted and analyzed. The influences of different operation conditions, track parameters, and tunnel burial depths were compared. The research results show that the ground vibration obtained through the wheel-drop test is greatly attenuated within 10 m from the track centerline, with an attenuation rate up to 70%. The vertical vibration amplitude is obviously larger than that of the other two directions. The lateral ground vibration amplitude is the smallest with the slowest vibration attenuation speed. When the high-speed train passes through at the speed of 350 km/h, the vertical and lateral vibration levels of the ground surface within 80 m range are 20∼80 dB and 43∼72 dB, respectively. The maximum attenuation coefficient of Z-vibration level reaches 0.276 dB/m. For each increase of 50 km/h of the train speed, the Z-vibration level of the ground increases by about 2 dB. The smaller fastener stiffness leads to the greater ground vibration within 20∼50 Hz. The ground vibration level is positively correlated with the fastener stiffness above 79 Hz. When the burial depth of the tunnel is greater than 14 m, the burial depth of the tunnel has little effect on the change of the Z-vibration level of the ground.

Study on the microstructure and strength characteristics of marine soft soil under wet-dry cycle condition

For marine soft soil under the periodic wave loading, the pore water content in soil suffering dry-wet cycle for a long time, which affects its microstructure and macroscopic mechanical strength, resulting in insufficient bearing capacity and excessive deformation of soft soil. To reveal the microstructural characteristics and strength attenuation law of marine soft soil under dry-wet cycle condition, electron microscopy scanning and direct shear tests under different times of dry-wet cycles were carried out, and the mathematical equations of pore structure and strength parameters were established based on fractal theory. The research results showed that: (1) The pore structure changed considerably after the first dry-wet cycle, and then changed gently with the increase of dry-wet cycle times, which was reflected by the fractal dimension D value decreases to a constant value gradually. (2) The shear strength of the soil diminishes with an increase in the number of dry-wet cycle times, and the maximum attenuation occurs after the first dry-wet cycle. (3) The relationship between cohesion (c), internal friction angle (φ), and fractal dimension (D) is exponential, with the curve shapes being concave and convex, respectively.

Simultaneous Activity and Attenuation Estimation in TOF-PET With TV-Constrained Nonconvex Optimization.

An alternating direction method of multipliers (ADMM) framework is developed for nonsmooth biconvex optimization for inverse problems in imaging. In particular, the simultaneous estimation of activity and attenuation (SAA) problem in time-of-flight positron emission tomography (TOF-PET) has such a structure when maximum likelihood estimation (MLE) is employed. The ADMM framework is applied to MLE for SAA in TOF-PET, resulting in the ADMM-SAA algorithm. This algorithm is extended by imposing total variation (TV) constraints on both the activity and attenuation map, resulting in the ADMM-TVSAA algorithm. The performance of this algorithm is illustrated using the penalized maximum likelihood activity and attenuation estimation (P-MLAA) algorithm as a reference.

Japanese encephalitis virus hijacks ER-associated degradation regulators for its replication.

Flaviviruses target their replication on membranous structures derived from the ER, where both viral and host proteins play crucial structural and functional roles. Here, we have characterized the involvement of the ER-associated degradation (ERAD) pathway core E3 ligase complex (SEL1L-HRD1) regulator proteins in the replication of Japanese encephalitis virus (JEV). Through high-resolution immunofluorescence imaging of JEV-infected HeLa cells, we observe that the virus replication complexes marked by NS1 strongly colocalize with the ERAD adapter SEL1L, lectin OS9, ER-membrane shuttle factor HERPUD1, E3 ubiquitin ligase HRD1 and rhomboid superfamily member DERLIN1. NS5 positive structures also show strong overlap with SEL1L. While these effectors show significant transcriptional upregulation, their protein levels remain largely stable in infected cells. siRNA mediated depletion of OS9, SEL1L, HERPUD1 and HRD1 significantly inhibit viral RNA replication and titres, with SEL1L depletion showing the maximum attenuation of replication. By performing protein translation arrest experiments, we show that SEL1L, and OS9 are stabilised upon JEV infection. Overall results from this study suggest that these ERAD effector proteins are crucial host-factors for JEV replication.