Matter Volume In Brain Regions Research Articles

Evaluation of brain structure abnormalities in children with autism spectrum disorder (ASD) using structural magnetic resonance imaging

BackgroundAutism spectrum disorder (ASD) is a group of developmental disorders of the nervous system. Since the core cause of many of the symptoms of autism spectrum disorder is due to changes in the structure of the brain, the importance of examining the structural abnormalities of the brain in these disorder becomes apparent. The aim of this study is evaluation of brain structure abnormalities in children with autism spectrum disorder (ASD) using structural magnetic resonance imaging (sMRI). sMRI images of 26 autistic and 26 Healthy control subjects in the range of 5–10 years are selected from the ABIDE database. For a better assessment of structural abnormalities, the surface and volume features are extracted together from this images. Then, the extracted features from both groups were compared with the sample t test and the features with significant differences between the two groups were identified.ResultsThe results of volume-based features indicate an increase in total brain volume and white matter and a change in white and gray matter volume in brain regions of Hammers atlas in the autism group. In addition, the results of surface-based features indicate an increase in mean and standard deviation of cerebral cortex thickness and changes in cerebral cortex thickness, sulcus depth, surface complexity and gyrification index in the brain regions of the Desikan–Killany cortical atlas.ConclusionsIdentifying structurally abnormal areas of the brain and examining their relationship to the clinical features of Autism Spectrum Disorder can pave the way for the correct and early detection of this disorder using structural magnetic resonance imaging. It is also possible to design treatment for autistic people based on the abnormal areas of the brain, and to see the effectiveness of the treatment using imaging.

Glucometabolic Changes Are Associated with Structural Gray Matter Alterations in Prodromal Dementia.

Glucometabolic changes, such as high glycemic load (GL) diet and insulin resistance (IR), are potential risk factor of Alzheimer's disease (AD). Yet, the effect of these factors on brain alterations that contribute to AD pathology has not been clearly demonstrated. We aimed to assess the relationship of GL and IR with gray matter volumes involved in prodromal dementia. GL and Triglyceride-Glucose (TyG) index, an IR surrogate marker, were calculated in 497 participants who underwent magnetic resonance imaging (MRI). The gray matter volumes most related to prodromal dementia/mild cognitive impairment (diagnosed in 18/158 participants during the 7-year follow-up) were identified using a data-driven machine learning algorithm. Higher GL diet was associated with reduced amygdala volume. The TyG index was negatively associated with the hippocampus, amygdala, and putamen volumes. These results suggest that GL and IR are associated with lower gray matter volumes in brain regions involved in AD pathology.

Pain, But Not Physical Activity, Is Associated with Gray Matter Volume Differences in Gulf War Veterans with Chronic Pain.

Chronic musculoskeletal pain (CMP) is a significant burden for Persian Gulf War Veterans (GWVs), yet the causes are poorly understood. Brain structure abnormalities are observed in GWVs, however relationships with modifiable lifestyle factors such as physical activity (PA) are unknown. We evaluated gray matter volumes and associations with symptoms, PA, and sedentary time in GWVs with and without CMP. Ninety-eight GWVs (10 females) with CMP and 56 GWVs (7 females) controls completed T1-weighted magnetic resonance imaging, pain and fatigue symptom questionnaires, and PA measurement via actigraphy. Regional gray matter volumes were analyzed using voxel-based morphometry and were compared across groups using analysis of covariance (ANCOVA). Separate multiple linear regression models were used to test associations between PA intensities, sedentary time, symptoms, and gray matter volumes. Familywise cluster error rates were used to control for multiple comparisons (α = 0.05). GWVs with CMP reported greater pain and fatigue symptoms, worse mood, and engaged in less moderate-to-vigorous PA and more sedentary time than healthy GWVs (all p values < 0.05). GWVs with CMP had smaller gray matter volumes in the bilateral insula and larger volumes in the frontal pole (p < 0.05adjusted). Gray matter volumes in the left insula were associated with pain symptoms (r partial = 0.26, -0.29; p < 0.05adjusted). No significant associations were observed for either PA or sedentary time (p > 0.05adjusted). GWVs with CMP had smaller gray matter volumes within a critical brain region of the descending pain processing network and larger volumes within brain regions associated with pain sensation and affective processing, which may reflect pain chronification.SIGNIFICANCE STATEMENT The pathophysiology of chronic pain in Gulf War veterans is understudied and not well understood. In a large sample of Gulf War veterans, we report veterans with chronic musculoskeletal pain have smaller gray matter volumes in brain regions associated with pain regulation and larger volumes in regions associated with pain sensitivity compared with otherwise healthy Gulf War veterans. Gray matter volumes in regions of pain regulation were significantly associated with pain symptoms and encompassed the observed group brain volume differences. These results are suggestive of deficient pain modulation that may contribute to pain chronification.

The Psychopath's Brain: Is it Structurally Different From the Normal Brain?

Antisocial personality disorder, also called psychopathy, is caused by an individual’s brain structure. This paper analyzes the methods, limitations, and findings of the research that supports this claim. Case studies and correlational studies show a connection between gray matter volume in brain regions and psychopathic emotionlessness. Experiments show the inner workings of a psychopath’s brain as they display dishonesty and lack of empathy. Furthermore, this paper will also explain the relevance of this research to the field of psychology, and the practical applications of the research in society as a whole outside, including in the fields of law and medicine.

Rajyoga Meditation Experience Induces Enhanced Positive Thoughts and Alters Gray Matter Volume of Brain Regions: A Cross-sectional Study

ObjectivesMany studies on various meditation types have reported regional gray matter volume changes using voxel-based morphometric analysis of structural MRI, but there are no studies done on structural MRI of Rajyoga meditators. The objective of the present study is to analyze and compare gray matter volume changes of brain regions in meditators and non-meditators and further study the effects of meditation experience on alterations in various brain regions. These regions were then correlated and compared to positive thought scores of participants.MethodsForty participants in each group (closely matched for age, gender, and handedness) were selected after obtaining their informed consent, and voxel-based morphometric analysis was carried out using their structural MRI scans.ResultsOn voxel-wise comparison of the brain scans, meditators were observed to have significantly higher global gray matter volume and significant regional gray matter volume increases in the right superior frontal gyrus, left inferior orbitofrontal cortex, left inferior parietal gyrus, left posterior cerebellum, left middle temporal gyrus, bilateral precuneus, and cuneus. Additionally, long-term meditators particularly had significantly higher positive thinking scores compared to non-meditators. On multiple regression analysis, gray matter volume of the left superior parietal gyrus and left inferior parietal gyrus had a positive association, whereas the left posterior cerebellum had a negative association with hours of meditation experience. With the positive thoughts score, a significant relationship was found in the right superior temporal gyrus in meditators.ConclusionsThese findings indicate that Rajyoga meditation experience/practice enhances gray matter volume of specific brain regions and positive thoughts.

Effect of cognitive reserve on structural and functional MRI measures in healthy subjects: a multiparametric assessment.

Cognitive reserve (CR) contributes to inter-individual variability of cognitive performance and to preserve cognitive functioning facing aging and brain damage. However, brain anatomical and functional substrates of CR still need to be fully explored in young healthy subjects (HS). By evaluating a relatively large cohort of young HS, we investigated the associations between CR and structural and functional magnetic resonance imaging (MRI) measures in early adulthood. A global Cognitive Reserve Index (CRI), combining intelligence quotient, leisure activities and education, was measured from 77 HS and its brain anatomical and functional substrates were evaluated through a multiparametric MRI approach. Substrates of the three subdomains (cognitive/social/physical) of leisure activities were also explored. Higher global and subdomain CRIs were associated with higher gray matter volume of brain regions involved in motor and cognitive functions, such as the right (R) supplementary motor area, left (L) middle frontal gyrus and L cerebellum. No correlation with measures of white matter (WM) integrity was found. Higher global and subdomains CRIs were associated with lower resting-state functional connectivity (RS FC) of L postcentral gyrus and R insula in sensorimotor network, L postcentral gyrus in salience network and R cerebellum in the executive-control network. Moreover, several CRIs were also associated with higher RS FC of R cuneus in default-mode network. CR modulates structure and function of several brain motor and cognitive networks responsible for complex cognitive functioning already in young HS. CR could promote optimization of the recruitment of brain networks.

When affect overlaps with concept: emotion recognition in semantic variant of primary progressive aphasia.

The most recent theories of emotions have postulated that their expression and recognition depend on acquired conceptual knowledge. In other words, the conceptual knowledge derived from prior experiences guide our ability to make sense of such emotions. However, clear evidence is still lacking to contradict more traditional theories, considering emotions as innate, distinct and universal physiological states. In addition, whether valence processing (i.e. recognition of the pleasant/unpleasant character of emotions) also relies on semantic knowledge is yet to be determined. To investigate the contribution of semantic knowledge to facial emotion recognition and valence processing, we conducted a behavioural and neuroimaging study in 20 controls and 16 patients with the semantic variant of primary progressive aphasia, a neurodegenerative disease that is prototypical of semantic memory impairment, and in which an emotion recognition deficit has already been described. We assessed participants' knowledge of emotion concepts and recognition of 10 basic (e.g. anger) or self-conscious (e.g. embarrassment) facial emotional expressions presented both statically (images) and dynamically (videos). All participants also underwent a brain MRI. Group comparisons revealed deficits in both emotion concept knowledge and emotion recognition in patients, independently of type of emotion and presentation. These measures were significantly correlated with each other in patients and with semantic fluency in patients and controls. Neuroimaging analyses showed that both emotion recognition and emotion conceptual knowledge were correlated with reduced grey matter density in similar areas within frontal ventral, temporal, insular and striatal regions, together with white fibre degeneration in tracts connecting frontal regions with each other as well as with temporal regions. We then performed a qualitative analysis of responses made during the facial emotion recognition task, by delineating valence errors (when one emotion was mistaken for another of a different valence), from other errors made during the emotion recognition test. We found that patients made more valence errors. The number of valence errors correlated with emotion conceptual knowledge as well as with reduced grey matter volume in brain regions already retrieved to correlate with this score. Specificity analyses allowed us to conclude that this cognitive relationship and anatomical overlap were not mediated by a general effect of disease severity. Our findings suggest that semantic knowledge guides the recognition of emotions and is also involved in valence processing. Our study supports a constructionist view of emotion recognition and valence processing, and could help to refine current theories on the interweaving of semantic knowledge and emotion processing.

Postural Control While Walking Interferes With Spatial Learning in Older Adults Navigating in a Real Environment.

Cognitive demands for postural control increase with aging and cognitive-motor interference (CMI) exists for a number of walking situations, especially with visuo-spatial cognitive tasks. Such interference also influences spatial learning abilities among older adults; however, this is rarely considered in research on aging in spatial navigation. We posited that visually and physically exploring an unknown environment may be subject to CMI for older adults. We investigated potential indicators of postural control interfering with spatial learning. Given known associations between age-related alterations in gait and brain structure, we also examined potential neuroanatomical correlates of this interference. Fourteen young and 14 older adults had to find an invisible goal in an unfamiliar, real, ecological environment. We measured walking speed, trajectory efficiency (direct route over taken route) and goal fixations (proportion of visual fixations toward the goal area). We calculated the change in walking speed between the first and last trials and adaptation indices for all three variables to quantify their modulation across learning trials. All participants were screened with a battery of visuo-cognitive tests. Eighteen of our participants (10 young, 8 older) also underwent a magnetic resonance imaging (MRI) examination. Older adults reduced their walking speed considerably on the first, compared to the last trial. The adaptation index of walking speed correlated positively with those of trajectory efficiency and goal fixations, indicating a reduction in resource sharing between walking and encoding the environment. The change in walking speed correlated negatively with gray matter volume in superior parietal and occipital regions and the precuneus. We interpret older adults’ change in walking speed as indicative of CMI, similar to dual task costs. This is supported by the correlations between the adaptation indices and between the change in walking speed and gray matter volume in brain regions that are important for navigation, given that they are involved in visual attention, sensory integration and encoding of space. These findings under ecological conditions in a natural spatial learning task question what constitutes dual tasking in older adults and they can lead future research to reconsider the actual cognitive burden of postural control in aging navigation research.

Links Between Physical Frailty and Regional Gray Matter Volumes in Older Adults: A Voxel-Based Morphometry Study

ObjectivesThe relationship between physical frailty and regional gray matter volume in the brain was investigated among community-dwelling older Japanese people. MethodsParticipants (N = 835; age range 65–89 years) were community-dwelling older adults in Obu City and Higashiura Town in Aichi Prefecture, Japan. Physical frailty was determined by the modified criteria of the Cardiovascular Health Study, which included weight loss, slowness, weakness, exhaustion, and low physical activity. Regional gray matter volumes were evaluated from 3-dimensional T1-weighted magnetic resonance images by statistical parametric mapping. The relationship between physical frailty and regional gray matter volume was analyzed with an analysis of covariance design using statistical parametric mapping adjusting for age, sex, and education level. ResultsThe voxel-based analyses showed that physical frailty per se was not significantly associated with any brain region. However, weakness was associated with reduced gray matter volumes in the hippocampus, amygdala, and fusiform gyrus, and slowness was associated with reduced gray matter volumes in the hippocampus, amygdala, fusiform gyrus, medial prefrontal and orbitofrontal cortex, inferior frontal gyrus, primary somatosensory cortex, insula, superior temporal sulcus, and cerebellum. Other components of physical frailty were not associated with the gray matter volumes in any regions. Conclusions and implicationsThe weakness and slowness components of physical frailty were linked to reduced gray matter volume in brain regions associated with not only physical mobility but also cognitive functions and social processes. This study addressed the underlying mechanisms in the progression of physical, cognitive, and social frailty, from the perspective of brain structures that are associated with frailty.

Neural substrates of sexual arousal are not sex dependent

Sexual arousal is a dynamical, highly coordinated neurophysiological process that is often induced by visual stimuli. Numerous studies have proposed that the cognitive processing stage of responding to sexual stimuli is the first stage, in which sex differences occur, and the divergence between men and women has been attributed to differences in the concerted activity of neural networks. The present comprehensive metaanalysis challenges this hypothesis and provides robust quantitative evidence that the neuronal circuitries activated by visual sexual stimuli are independent of biological sex. Sixty-one functional magnetic resonance imaging studies (1,850 individuals) that presented erotic visual stimuli to men and women of different sexual orientation were identified. Coordinate-based activation likelihood estimation was used to conduct metaanalyses. Sensitivity and clustering analyses of averaged neuronal response patterns were performed to investigate robustness of the findings. In contrast to neutral stimuli, sexual pictures and videos induce significant activations in brain regions, including insula, middle occipital, anterior cingulate and fusiform gyrus, amygdala, striatum, pulvinar, and substantia nigra. Cluster analysis suggests stimulus type as the most, and biological sex as the least, predictor for classification. Contrast analysis further shows no significant sex-specific differences within groups. Systematic review of sex differences in gray matter volume of brain regions associated with sexual arousal (3,723 adults) did not show any causal relationship between structural features and functional response to visual sexual stimuli. The neural basis of sexual arousal in humans is associated with sexual orientation yet, contrary to the widely accepted view, is not different between women and men.

Assessing the marks of change: how psychotherapy alters the brain structure in women with borderline personality disorder.

There is increasing evidence that psychotherapy can alter the function of the brain of patients with borderline personality disorder (BPD). However, it is not known whether psychotherapy can also modify the brain structure of patients with BPD. We used structural MRI data of female patients with BPD before and after participation in 12 weeks of residential dialectical behavioural therapy (DBT) and compared them to data from female patients with BPD who received treatment as usual (TAU). We applied voxel-based morphometry to study voxel-wise changes in grey matter volume over time. We included 31 patients in the DBT group and 17 in the TAU group. Patients receiving DBT showed an increase of grey matter volume in the anterior cingulate cortex, inferior frontal gyrus and superior temporal gyrus together with an alteration of grey matter volume in the angular gyrus and supramarginal gyrus compared with patients receiving TAU. Furthermore, therapy response correlated with increase of grey matter volume in the angular gyrus. Only women were investigated, and groups differed in size, medication (controlled for) and intensity of the treatment condition. We found that DBT increased grey matter volume of brain regions that are critically implicated in emotion regulation and higher-order functions, such as mentalizing. The role of the angular gyrus for treatment response may reside in its cross-modal integrative function. These findings enhance our understanding of psychotherapy mechanisms of change and may foster the development of neurobiologically informed therapeutic interventions.

Psychopathy and Responsibility: Empirical Data and Normative Judgments

Psychopathy and Responsibility:Empirical Data and Normative Judgments Walter Glannon (bio) Keywords Empirical data, normative judgments, philosophers, psychopathy, responsibility, social scientists Psychopathy is one of the most frequently cited disorders in discussions of moral and criminal responsibility. Many philosophers and psychologists have argued that psychopaths’ impaired capacity for empathy, diminished responses to fear-inducing stimuli, and failure to conform to social norms indicate that they are not responsible for their actions. In “Philosophers on psychopaths: A cautionary tale in interdisciplinarity,” Jarkko Jalava and Stephanie Griffiths (2017) cite psychological data from case studies, the moral/conventional distinction task, fear conditioning and facial affect recognition experiments in arguing that philosophers systematically misinterpret or simplify the data to support their conclusions about psychopaths’ responsibility. Jalava and Griffiths state that “inconsistent but suggestive data do not imply merely reduced responsibility, nor do they allow for tentative conclusions about responsibility. Any responsibility claim on the basis of these data is equally suspect” (2017, p. 9). Although the authors are right to point out the need for philosophers to be more circumspect in drawing inferences from the results of psychology experiments to responsibility judgments, their claims are too strong and not supported by their discussion. Moreover, it is unclear what the implications of the inconclusive nature of empirical data on psychopaths are for the actual practice of holding people morally and criminally responsible for their behavior. Much of the recent empirical evidence influencing philosophers’ claims about psychopaths’ diminished responsibility is from neuroimaging studies. Curiously, the authors do not include these among their data sources. At least one study involving magnetic resonance imaging (MRI) has shown a reduction in gray matter volume in brain regions associated with empathic processing, prosocial emotions, and moral reasoning in violent criminal psychopaths compared with normal controls (Gregory et al., 2012). Some functional magnetic resonance imaging (fMRI) studies have shown functional abnormalities in pathways between the amygdala and ventromedial prefrontal cortex, which also mediate the capacity for moral reasoning (Blair, 2007, 2013). Correlations between brain abnormalities and psychopathic [End Page 13] behavior do not imply that the first cause the second. Yet if the abnormalities are consistent with a pattern of behavior indicating impairment in the relevant mental capacities, then the imaging data may support tentative conclusions about responsibility. Although imaging data alone would not provide sufficient evidence that an individual lacked or was impaired in these capacities, the data might confirm such a judgment made on the basis of the individual’s behavior. Provided that it supplements rather than supplants behavioral evidence, neuroimaging may provide helpful information about the functional or dysfunctional neural bases of that behavior and can be used legitimately as one factor in assessing responsibility. Even if philosophers overstate correlations between particular brain features and behavior, they are not alone in doing this. Social scientists have claimed on the basis of neuroscientific evidence that highly psychopathic individuals are not responsible and should not be punished for their criminal behavior (Glenn & Raine, 2014). It is unfair to single out philosophers for drawing these conclusions too easily. In their critique of philosophers’ reliance on empirical data to argue that psychopaths are not responsible or have reduced responsibility because they are impaired in the necessary mental capacities, the authors say nothing about the reliance of some social scientists on this data to argue that psychopaths are responsible. They have but fail to exercise these capacities (Cima, Tonnaer & Hauser, 2010). If we should be skeptical of claims about psychopaths’ diminished responsibility based on studies in experimental psychology, then we should also be skeptical of claims about full responsibility based on similar studies. If drawing inferences from inconclusive data to negative judgments about responsibility is questionable, then drawing inferences from inconclusive data to positive judgments about responsibility is equally questionable. There is no reason to assume that data suggesting that a psychopath has the mental capacities necessary for responsibility is any more scientifically robust than data suggesting that he or she lacks these capacities. If we rely primarily on experimental data in trying to show that a psychopath is or is not responsible, and if the data are limited in this regard, then this suggests that there are no grounds for...

The brain anatomical basis of emotional face advantage

Human beings are quite efficient in emotional face processing, which is of great importance for individuals in their social interactions. Previous studies showed that processing of emotional face was significantly faster than that of neutral face, and individuals showed variability in emotional face processing efficiency. Evidences from functional magnetic resonance imaging researches indicated that brain regions such as amygdala were significantly activated at the present of emotional faces. However, the brain structural basis of this superiority of emotional face processing had not been revealed. The present study combined visual search paradigm and structural magnetic resonance imaging to explore the brain structural basis of individual difference of emotional processing efficiency. In the visual search experiment, we asked the subjects to search for an emotional (a happy or fearful face) face or a target gender (a neutral face). Two-way (set size×target type) repeated measure analysis of RTs were done respective to happy and fearful face and their corresponding face gender search. We found significant interaction of set size and target type for both of them, and the main effects of set size and target type were significant as well. For further analysis, we compare the search slopes of emotional face and face gender search, and found that every subject showed a shallower search function for emotional face search than face gender search, indicating a stable emotional face advantage. Happy and fearful face advantage indexes were calculated for each subject. We then collected structural MRI images of each subject. Then we used multiple regression analysis to explore the correlation between the emotional face advantage indexes and the brain gray matter volume. We found that both the processing advantages of happy and fearful face were significantly correlated with gray matter volume of brain regions in the right posterior cingulate cortex and the left superior parietal lobe. The GMV in the left superior parietal lobe was positively correlated with the emotional face advantage indexes while the GMV in the right posterior cingulate cortex was negatively correlated with them. Previous studies found that superior parietal lobe was involved in attentional shift for different targets, larger GMV of this region might indicate better ability to search a certain target. Posterior cingulate cortex was widely found to participate in the interaction of emotion regulation and memory arousal. It was also an important part in the target-negative network and showed decreased activation in attention-related task, which was consistent with the results in the present study. In addition to these common areas, there were brain areas that only showed correlation with one of the emotional face advantage index. In the fearful face advantage analysis, left temporal gyrus and left posterior cingulate cortex were also significantly correlated with fearful face advantage index. In the happy face advantage analysis, right superior parietal lobe was found to be significantly correlated with happy face advantage index. These results indicated that different emotional face processing included different composition. These results showed that regardless of different composition of different emotional face processing, individual difference for different emotional face processing might have a common brain structural basis.

Female adolescents with severe substance and conduct problems have substantially less brain gray matter volume.

ObjectiveStructural neuroimaging studies have demonstrated lower regional gray matter volume in adolescents with severe substance and conduct problems. These research studies, including ours, have generally focused on male-only or mixed-sex samples of adolescents with conduct and/or substance problems. Here we compare gray matter volume between female adolescents with severe substance and conduct problems and female healthy controls of similar ages. Hypotheses: Female adolescents with severe substance and conduct problems will show significantly less gray matter volume in frontal regions critical to inhibition (i.e. dorsolateral prefrontal cortex and ventrolateral prefrontal cortex), conflict processing (i.e., anterior cingulate), valuation of expected outcomes (i.e., medial orbitofrontal cortex) and the dopamine reward system (i.e. striatum).MethodsWe conducted whole-brain voxel-based morphometric comparison of structural MR images of 22 patients (14-18 years) with severe substance and conduct problems and 21 controls of similar age using statistical parametric mapping (SPM) and voxel-based morphometric (VBM8) toolbox. We tested group differences in regional gray matter volume with analyses of covariance, adjusting for age and IQ at p<0.05, corrected for multiple comparisons at whole-brain cluster-level threshold.ResultsFemale adolescents with severe substance and conduct problems compared to controls showed significantly less gray matter volume in right dorsolateral prefrontal cortex, left ventrolateral prefrontal cortex, medial orbitofrontal cortex, anterior cingulate, bilateral somatosensory cortex, left supramarginal gyrus, and bilateral angular gyrus. Considering the entire brain, patients had 9.5% less overall gray matter volume compared to controls.ConclusionsFemale adolescents with severe substance and conduct problems in comparison to similarly aged female healthy controls showed substantially lower gray matter volume in brain regions involved in inhibition, conflict processing, valuation of outcomes, decision-making, reward, risk-taking, and rule-breaking antisocial behavior.

The association of gray matter volumes in the frontoparietal attention network with temperamental effortful control in young adults: A voxel-based morphometry study

Structural MRI studies have identified a link between cortical maturation and temperamental effortful control (EC), which is a trait-like risk factor for psychopathology during adolescence. However, little research has explored the underlying neural basis of EC in adults. We aimed to examine the relationship between EC and brain structure in young adults. High-resolution T1-weighted images were acquired from 27 undergraduates who completed the Adult Temperament Questionnaire-short form. The data were analyzed with SPM8 using voxel-based morphometry (VBM). A priori region of interest (ROI) analyses indicated that EC was positively associated with gray matter volumes in brain regions that included the bilateral dorsolateral prefrontal cortex, the left supplementary motor area, the right orbitofrontal cortex, the left anterior cingulate cortex, and the left superior and inferior parietal lobes. These results suggest that temperamental EC in young adults is related to variations in gray matter volumes, particularly within the frontoparietal attention network, and yield insight into the relation between the vulnerability to psychopathology and the neurobiological basis of individual differences in temperamental EC.

IDENTIFYING THE SHARED NEUROBIOLOGICAL UNDERPINNINGS OF NEGATIVE URGENCY AND NEUROTICISM

ObjectiveNegative urgency, or the tendency to act rashly when experiencing negative affect, is a transdiagnostic risk factor for vulnerability to a number of psychopathologies. When combined with high levels of...

The Self-Liking Brain: A VBM Study on the Structural Substrate of Self-Esteem

Abundant evidence suggests that self-esteem is an important personality resource for emotion regulation in response to stressful experiences. It was thus hypothesized that the relative grey matter volume of brain regions involved in responding to and coping with stress is related to individual differences in trait self-esteem. Using structural magnetic resonance imaging of 48 healthy adults in conjunction with voxel-based morphometry and diffeomorphic anatomical registration using exponentiated lie algebra (VBM-DARTEL), positive associations between self-esteem and regional grey matter volume were indeed found in the anterior cingulate cortex (ACC), right lateral prefrontal cortex (LPFC), right hippocampus, and left hypothalamus. In addition, self-esteem positively covaried with grey matter volume in the right temporo-parietal junction (TPJ), which has been implicated in pride and theory of mind. The results suggest that persons with low self-esteem have reduced grey matter volume in brain regions that contribute to emotion/stress regulation, pride, and theory of mind. The findings provide novel neuroanatomical evidence for the view that self-esteem constitutes a vital coping resource.

Higher volume of ventral striatum and right prefrontal cortex in pathological gambling

Functional neuroimaging studies have implicated an involvement of the prefrontal cortex and mesolimbic reward system (i.e., ventral striatum) in pathological gambling (PG). However, there is a lack of studies focusing on structural changes in frontostriatal brain regions in adult subjects with PG. In order to study differences in local grey matter volume, 20 male subjects with PG and 21 matched controls underwent structural magnetic resonance imaging. Structural brain data were analysed via voxel-based morphometry with a focus on prefrontal areas and ventral striatum. By comparing grey matter volumes in brain regions highly relevant for brain functional changes in PG, the present study found a higher volume in right ventral striatum and right prefrontal cortex by means of voxel-wise morphometry in PG subjects as compared to controls. Our findings demonstrate local grey matter changes in brain areas that have previously been associated with functional changes in PG. Hypertrophy in the prefrontal cortex might be an adaptation at least partly induced by the higher grey matter volume in the ventral striatum and may help to increase cognitive control over gambling impulses. Future research should explore the relationship between functional and structural alterations as well as the course of changes in PG.

Brain structural basis of cognitive reappraisal and expressive suppression

Cognitive reappraisal and expressive suppression, two major emotion regulation strategies, are differentially related to emotional well-being. The aim of this study was to test the association of individual differences in these two emotion regulation strategies with gray matter volume of brain regions that have been shown to be involved in the regulation of emotions. Based on high-resolution magnetic resonance images of 96 young adults voxel-based morphometry was used to analyze the gray matter volumes of the a priori regions of interest, including amygdala, insula, dorsal anterior cingulate and paracingulate cortex, medial and lateral prefrontal cortex (PFC) and their association with cognitive reappraisal and expressive suppression usage as well as neuroticism. A positive association of cognitive reappraisal with right and tendentially left amygdala volume and of neuroticism with left amygdala volume (marginally significant) was found. Expressive suppression was related to dorsal anterior cingulate/paracingulate cortex and medial PFC gray matter volume. The results of this study emphasize the important role of the amygdala in individual differences in cognitive reappraisal usage as well as neuroticism. Additionally, the association of expressive suppression usage with larger volumes of the medial PFC and dorsal anterior/paracingulate cortex underpins the role of these regions in regulating emotion-expressive behavior.

DISC1 (disrupted-in-schizophrenia 1) is associated with cortical grey matter volumes in the human brain: A voxel-based morphometry (VBM) study

DISC1 (Disrupted-In-Schizophrenia 1), one of the top candidate genes for schizophrenia, has been associated with a range of major mental illnesses over the last two decades. DISC1 is crucially involved in neurodevelopmental processes of the human brain. Several haplotypes and single nucleotide polymorphisms of DISC1 have been associated with changes of grey matter volumes in brain regions known to be altered in schizophrenia and other psychiatric disorders. The aim of the present study was to investigate the effects of two single nucleotide polymorphisms (SNPs) of DISC1 on grey matter volumes in human subjects using voxel-based morphometry (VBM). 114/113 participating subjects (psychiatric patients and healthy controls) were genotyped with respect to two at-risk SNPs of DISC1, rs6675281 and rs821616. All participants underwent structural magnetic resonance imaging (MRI). MRI data was statistically analyzed using voxel-based morphometry. We found significant alterations of grey matter volumes in prefrontal and temporal brain regions in association with rs6675281 and rs821616. These effects of DISC1 polymorphisms on brain morphology provide further support for an involvement of DISC1 in the neurobiology of major psychiatric disorders such as schizophrenia.