Matsudai Knee Osteoarthritis Survey Research Articles

The Matsudai Knee Osteoarthritis Survey showed the longitudinal changes of knee phenotypes in alignment and structure during 23-28years.

The longitudinal changes in alignment and structure, including the joint line and cortical bone thickness (CBT) of the femur and tibia, and knee phenotype in patients with knee osteoarthritis (OA) remain unknown. The aim of this retrospective study was to clarify the longitudinal changes in matched healthy subjects. The follow-up Matsudai Knee Osteoarthritis Survey was administered between 23 and 28years. This study included 285 healthy knees from 235 females with an average age of 53 ± 6years at baseline. The non-OA individuals, with an average age of 79 ± 4years, were divided into three groups at baseline according to their follow-up radiographic results [the non-OA (n = 52), early OA (n = 131), and advanced OA groups (n = 102)]. Changes in alignment, joint line, CBT, and knee phenotype were assessed at baseline and at follow-up using standing anteroposterior radiographs. This study showed significant varus changes in the alignment (p < 0.001) and tibial and femoral joint line parameters (p < 0.05) in the OA group. Decreased CBT and increased mediolateral CBT ratios were observed in all groups (p < 0.001). The knee phenotypes in the OA groups were changed to varus angles, especially in the alignment and tibial joint line. The longitudinal changes of knee phenotypes in alignment and structure (CBT and joint line) from baseline to follow-up were shown in the OA groups. In addition, alignment and tibial structural factors at baseline are useful in predicting the incidence of knee OA in daily practice. III.

New evaluation indexes for estimated rotational knee angles in stading anteroposterior knee radiographs from Matsudai knee osteoarthritis survey

New evaluation indexes for estimated rotational knee angles in stading anteroposterior knee radiographs from Matsudai knee osteoarthritis survey

The relationship between knee osteoarthritis and femoral distal cortical bone thickness. case control study from the matsudai knee osteoarthritis survey

Purpose: Knee osteoarthritis (OA) is a multifactorial disease and strongly affected by mechanical factors. We have previously reported that varus knee alignment is one of the risk factor for the development of knee OA in women. As knee OA progressed, the proximal medial tibial cortical bone thickness (MTCBT) is increased. However the relationship of its femur side with knee OA progression is unclearly. In this study, we investigated whether distal medial femoral cortical bone thickness (MFCBT) at baseline survey predicts the development of knee OA at follow-up survey.

Relevance of sarcopenia and knee extensor muscle strength in the Matsudai knee osteoarthritis survey

Relevance of sarcopenia and knee extensor muscle strength in the Matsudai knee osteoarthritis survey

The effect of varus alignment and obesity on the onset and progression in medial knee osteoarthritis: case control study from the longitudinal evaluation of matsudai knee osteoarthritis survey

The effect of varus alignment and obesity on the onset and progression in medial knee osteoarthritis: case control study from the longitudinal evaluation of matsudai knee osteoarthritis survey

Quadriceps muscle weakness is related to increased risk of radiographic knee OA but not its progression in both women and men: the Matsudai Knee Osteoarthritis Survey.

The purpose of this study was to investigate the causal relationship between quadriceps muscle strength and radiographic knee osteoarthritis (OA) in a longitudinal study. The present study included 976 knees from 488 subjects who participated in both the 5th (2007) and 7th (2013) surveys of the Matsudai Knee Osteoarthritis Survey. Bilateral quadriceps strengths of each subject were measured using the quadriceps training machine (QTM-05F, Alcare Co., Ltd., Tokyo, Japan). Additionally, weight-bearing standing knee radiographs were obtained, and knee OA was graded according to the Kellgren-Lawrence classification system. The relationships between quadriceps strength and the incidence and progression of radiographic knee OA were assessed using multiple logistic regression analysis. After adjusting for age and body mass index (BMI), both female and male knees in the lowest quantile of quadriceps strength had higher risk of the incidence of radiographic knee OA compared with the highest quantile of quadriceps strength (women: OR 2.414, 95% CI 1.098-5.311; men: OR 2.774, 95% CI 1.053-7.309). In contrast, after adjusting for age, BMI and femorotibial angle, both female and male knees in the lowest quantile compared with the highest quantile of quadriceps strength did not differ in risk of the progression of radiographic knee OA (women: OR 1.040, 95% CI 0.386-2.802; men: OR 2.814, 95% CI 0.532-14.898). Quadriceps muscle weakness was related to increased risk of the incidence of radiographic knee OA, but not its progression, in both women and men. Therefore, the clinically important finding of this study is that, in both women and men, maintaining higher quadriceps muscle strength may be one of the most effective prevention methods for incident radiographic knee OA. II.

Association of mechanical factors with medial knee osteoarthritis: Across-sectional study from Matsudai Knee Osteoarthritis Survey.

Knee osteoarthritis (OA) is a multifactorial disease that is affected by mechanical factors. The aim of present study was to investigate the association between multiple mechanical factors and medial knee OA in a large epidemiological cohort. Six hundred and ninety-nine subjects (323 males and 376 females), participating in the Matsudai Knee Osteoarthritis Survey 2010, were included. Twelve mechanical factors were selected and their association with the radiographic grade of knee OA, the Western Ontario and McMaster University Index (WOMAC) pain score, and the WOMAC function score was evaluated. A logistic regression analysis identified varus thrust to be associated with the radiographic grade of knee OA in males (OR: 1.876, 95% CI: 1.332-2.663) and females (2.61, 1.922-3.542), the WOMAC pain score in males (1.997, 1.463-2.672), and the WOMAC function score in females (1.449, 1.12-1.874). Quadriceps muscle strength was associated with the radiographic OA grade in males (0.605, 0.399-0.917) and females (0.636, 0.469-0.863), the WOMAC pain score in females (0.537, 0.445-0.789), and the WOMAC function score in males (0.581, 0.44-0.766). The knee flexion angle was also associated with the radiographic OA grade in males (0.344, 0.19-0.621) and females (0.121, 0.022-0.653), and the WOMAC pain score in males (0.287, 0.156-0.53) and females (0.537, 0.336-0.859). Obesity was associated with the radiographic OA grade in males (1.543, 1.041-2.287) and females (1.589, 1.176-2.146), the WOMAC pain score in female (2.017, 1.517-2.68). Femolo-tibial angle had no significant association with the radiographic knee OA grade or with the WOMAC pain and function scores. Among patients with medial knee OA, dynamic mechanical factors, such as varus thrust, quadriceps muscle strength, and range of motion were more likely to be associated with the radiographic grade of knee OA and to be the WOMAC pain and function scores, compared to static mechanical factors.

Association of mechanical factors with medial knee osteoarthritis: A cross-sectional study from Matsudai Knee Osteoarthritis Survey

Abstract Background Knee osteoarthritis (OA) is a multifactorial disease that is affected by mechanical factors. The aim of present study was to investigate the association between multiple mechanical factors and medial knee OA in a large epidemiological cohort. Methods Six hundred and ninety-nine subjects (323 males and 376 females), participating in the Matsudai Knee Osteoarthritis Survey 2010, were included. Twelve mechanical factors were selected and their association with the radiographic grade of knee OA, the Western Ontario and McMaster University Index (WOMAC) pain score, and the WOMAC function score was evaluated. Results A logistic regression analysis identified varus thrust to be associated with the radiographic grade of knee OA in males (OR: 1.876, 95% CI: 1.332–2.663) and females (2.61, 1.922–3.542), the WOMAC pain score in males (1.997, 1.463–2.672), and the WOMAC function score in females (1.449, 1.12–1.874). Quadriceps muscle strength was associated with the radiographic OA grade in males (0.605, 0.399–0.917) and females (0.636, 0.469–0.863), the WOMAC pain score in females (0.537, 0.445–0.789), and the WOMAC function score in males (0.581, 0.44–0.766). The knee flexion angle was also associated with the radiographic OA grade in males (0.344, 0.19–0.621) and females (0.121, 0.022–0.653), and the WOMAC pain score in males (0.287, 0.156–0.53) and females (0.537, 0.336–0.859). Obesity was associated with the radiographic OA grade in males (1.543, 1.041–2.287) and females (1.589, 1.176–2.146), the WOMAC pain score in female (2.017, 1.517–2.68). Femolo-tibial angle had no significant association with the radiographic knee OA grade or with the WOMAC pain and function scores. Conclusion Among patients with medial knee OA, dynamic mechanical factors, such as varus thrust, quadriceps muscle strength, and range of motion were more likely to be associated with the radiographic grade of knee OA and to be the WOMAC pain and function scores, compared to static mechanical factors.

Usefulness of urinary CTX-II and NTX-I in evaluating radiological knee osteoarthritis : the Matsudai knee osteoarthritis survey

BackgroundTo assess the usefulness of the urinary crosslinked C-telopeptide of type II collagen (uCTX-II) or crosslinked N-telopeptide of type I collagen (uNTX-I) for evaluating radiological knee osteoarthritis (OA), a crosssectional study was conducted in the cohorts of the Matsudai knee osteoarthritis survey performed in Niigata, Japan. MethodsUrine specimens and standing knee AP X-rays were obtained from 1040 subjects who provided informed consent. The relationship between these markers and gender, age (patients aged 40-59 or 60-79 years), use of bisphosphonates, and OA grades (K–L classification) were analyzed. The diagnostic ability of uCTX-II to detect radiological knee OA was confirmed in the over 60-year-old subjects using a ROC curve. ResultsThe over 60-year-old men with OA grade 3,4 group had significantly higher uCTX-II levels than the other OA grade groups. In the over 60-year-old women, the uCTX-II levels significantly increased according to the progression of the knee OA grade. No significant difference was observed between the uNTX-I levels in the different OA grade groups. From the standpoint of biomarkers, the higher quartiles of the uCTX-II and uNTX-I levels gradually included higher numbers of grade ≥2 OA subjects in the over 60 year-old women. The area under the curve (AUC) in ROC analysis of uCTX-II exhibited a significant association with the diagnosis of knee OA in women (AUC 0.63), although the accuracy was evaluated to be low in the single measurement of our health checkup-based analysis. ConclusionsThis population-based study indicates that the uCTX-II level is strongly correlated with the knee OA grade in women over age 60. A further analysis is needed to clarify its predictive accuracy.

Quadriceps muscle strength and its relationship to radiographic knee osteoarthritis

Quadriceps muscle strength and its relationship to radiographic knee osteoarthritis

Quadriceps muscle strength and its relationship to radiographic knee osteoarthritis in Japanese elderly

BackgroundKnee osteoarthritis (OA) is a multifactorial disease and strongly affected by mechanical factors. The aims of the present study were to assess validity and reliability of a new muscle strength measuring device, the Quadriceps Training Machine (QTM) and evaluate the relationship between quadriceps strength measured by QTM and radiographic knee OA by epidemiological survey. MethodsThe isometric knee extension muscle strength of QTM was compared with BIODEX in 24 healthy adults. Then, the relationship between radiographic knee OA and quadriceps strength using QTM was investigated with 2,032 knees in 1,016 subjects by an epidemiological survey (Matsudai Knee Osteoarthritis Survey). ResultsSignificant correlation was observed between QTM and BIODEX (r=0.69, 0.82). In the Matsudai Knee Osteoarthritis Survey, the prevalence of radiographic OA (grade II or higher upon Kellgren–Lawrence classification) was: 13, 36.9, 67.8, and 86.5%, regarding women in their fifties, sixties, seventies, and eighties, respectively, and was 1.7, 13.4, 33.5, and 66.2% regarding men, respectively. Quadriceps muscle strength declined following 50years of age, and significant decline was observed in the their sixties and seventies. Quadriceps muscle strength of the OA group (grades II, III and IV) was significantly declined compared with that of the Non-OA group (grade-0 and I). Furthermore, the tendency of the muscle strength level to decline with the progression of knee OA grade was particularly observed between grade 0 and grade I in both men and women and between grade I and grade II in men. ConclusionThe relationship between radiographic knee OA and quadriceps strength was quantitatively evaluated by an epidemiological survey, and we found a correlation between knee OA and the decline in quadriceps strength. Furthermore, it was suggested that the decline in quadriceps muscle strength may be more strongly related to the incidence of knee OA than to its progression.

Quadriceps muscle strength and its relationship to radiographic knee osteoarthritis

Quadriceps muscle strength and its relationship to radiographic knee osteoarthritis

Urinary ctx-ii is more useful in postmenopausal women than in men to detect radiological knee OA: the matsudai knee osteoarthritis survey

Urinary ctx-ii is more useful in postmenopausal women than in men to detect radiological knee OA: the matsudai knee osteoarthritis survey

Relationship between radiological knee osteoarthritis and biochemical markers of cartilage and bone degradation (urine CTX-II and NTX-I): the Matsudai Knee Osteoarthritis Survey

Biochemical markers of cartilage and bone degradation are becoming increasingly important in the evaluation of knee osteoarthritis (OA). To clarify the correlation between radiological knee OA and urine CTX-II (C-terminal crosslinking telopeptide of collagen type II) or urine NTX-I (N-terminal crosslinking telopeptide of type I collagen), we conducted a cross-sectional study in the cohorts of the epidemiological knee survey at the Matsudai district in Niigata Prefecture, Japan. Urine specimens were collected from 296 subjects, and CTX-II and NTX-I were measured using ELISA. Standing knee AP X-rays were obtained and graded according to the Kellgren-Lawrence classification. The subjects were then divided by gender, age (40- to 59-year-old group and 60- to 79-year-old group), and the X-ray grade (Grade 0, 1, Grade 2, and Grade 3, 4). In non-OA (Grade 0, 1) subjects, the 60- to 79-year-old group had significantly higher CTX-II values than the younger group only in females. The subjects of both genders aged over 60 years of age with OA Grade 3, 4 had significantly higher CTX-II values than the Grade 0, 1 group or the Grade 2 group. For NTX-I, there were no significant differences between each OA grade although the Grade 3, 4 group females from 60 to 79 years of age had higher values than the Grade 2 group. In addition, in the 60- to 79-year-old subjects of both genders, a positive correlation was observed between the urine CTX-II and urine NTX-I. For the subjects ranging from 60 to 79 years of age in both genders, the urine CTX-II values indicate the progression of OA. In addition, the weak but positive correlation between urine CTX-II and urine NTX-I in the subjects ranging from 60 to 79 years of age in both genders suggests that bone resorption and cartilage degradation appear to develop in parallel.

Obesity and osteoarthritis of the knee in women: results from the Matsudai Knee Osteoarthritis survey

A 14-year longitudinal study of middle-aged women was conducted to evaluate the role of obesity in the initiation and progression of idiopathic knee osteoarthritis and to investigate the effect of weight loss on its natural course. Of the 1191 women participating in the first Matsudai Knee Osteoarthritis Survey in 1979, 608 women without possible secondary osteoarthritis were re-evaluated in 1993. Data were collected by questionnaire, physical examination, and weight-bearing anteroposterior knee radiographs. The mean age of the subjects was 51.3 (range 40–65) years with mean body mass index (BMI) of 23.0 (range 16.0–34.7) at the first survey. Incident disease was defined if a grade 0 knee (a modified Kellgren and Lawrence scale) at the first survey advanced to grade 2 or higher at follow-up. Progression of the disease was defined if a grade 1 or 2 knee advanced to a higher grade at follow-up. We found that higher BMI at the first survey increased the risk of both the initiation and progression of knee osteoarthritis. Obese women (BMI≧25.0) with a decrease in body mass index of 2 units or more during the 14 years had a lower risk for radiological deterioration, although weight gain did not alter the risk significantly.

Epidemiology of osteoarthritis of the knee in a rural Japanese population

To investigate the prevalence and risk factors of idiopathic osteoarthritis of the knee in a rural Japanese population, we studied 1547 subjects between the ages of 54 and 79 years who participated in the third Matsudai Knee Osteoarthritis Survey. Data were collected by questionnaire, physical examination, and anteroposterior standing radiographs of both knees. Eighty-four individuals with possible secondary osteoarthritis were excluded from the study. Radiographs were graded from 0 to 4 according to a modified Kellgren and Lawrence scale. Osteoarthritis was defined as being present in a knee if radiographic grades of 2 or higher were detected. Measurement of the femorotibial angle reflected the alignment of the lower extremity. The prevalence of radiographic osteoarthritis of the knee increased with age, and was significantly higher in women than in men (29.7% vs. 10.9%, respectively). However, the prevalence of symptomatic knees with radiographic osteoarthritis (grade 2 or higher) was not significantly different between females and males (35.6% vs. 26.5%, respectively). The femorotibial angle increased with the severity of knee osteoarthritis. Almost all of the knees with radiographic osteoarthritis exhibited a varus deformity due to the loss of cartilage in the medial tibiofemoral compartment. The body mass index increased significantly with each higher radiographic grade of knee osteoarthritis in women, but not in men.