Landslides, the most significant geohazards in Iran, adversely affect the region's socioeconomic conditions and the environment. Landslide susceptibility mapping is crucial for proactive risk management, sustainable development, and protecting human lives, infrastructure, and the environment. It enables decision-makers to make informed choices, implement appropriate mitigation measures, and plan for potential landslide events, leading to safer and more resilient communities. Using a recommended subdivision methodology, this research has developed a landslide susceptibility map for a significant Gilan, Iran region. The production of the map involved utilizing an artificial neural network (ANN) model. This model incorporated sixteen causal components from several characteristics, including topographic and geomorphologic features, geological factors, land use patterns, hydrological aspects, and hydrogeological properties. Three hundred seventy instances were identified using multiple verified sources and analyzing aerial photographs to create the landslide inventory map. Examining and verifying the weights assigned to the causal elements were conducted per accepted mathematical standards, incorporating sensitivity analysis, earlier research, and empirical data on landslides. The area under the receiver operating characteristic curve (AUROC) was used to compare the various models. The study's findings indicated that the best swarm size value for COA-MLP11Cuckoo Optimization Algorithm (COA). is equal to 450, and the accuracy indices for this algorithm were 0.998 and 0.995 in training and testing datasets, respectively. Similarly, the AUC22Area under the curve (AUC). for the HS-MLP,33Harmony Search Algorithm (HS). SFS-MLP,44Stochastic Fractal Search (SFS). and TLBO-MLP55Teaching- Learning-Based Optiization (TLBO). were 0.997, 0.999, and 0.999 in training and 0.995, 0.996, and 0.995 in the testing dataset, respectively. Therefore, the use of optimization algorithms leads to an increase in the performance and accuracy of the neural network, and the high accuracy of the SFS-MLP model demonstrates the existence of a dependable criterion for delineating the susceptibility zones about forthcoming landslide occurrences. The model is a cost-effective and potentially indispensable tool for urban planners in growing cities and municipalities. Its effectiveness is demonstrated by comparisons with previous susceptibility analyses conducted in the region.