As one of the most commonly used energy-saving methods in buildings, thermal insulation layer is widely used in building façade and it also endangers the human safety in buildings due to its combustibility. U-shaped facade is a commonly used structure in high-rise buildings since it could improve both the light and ventilation conditions indoors. This paper investigated the flame acceleration over the thermal insulation in u-shaped building facade fires. It was found that the flame spread rate over u-shaped facade had an exponential growth with time as the direction of preheating zone location is the same direction of the heat transfer from the pyrolysis zone. The air entrainment and the upward induced airflow played an important role in the acceleration. As the side wall length increased or the back wall length decreased, the flame spread rate accelerated more rapidly. Furthermore, a mathematical prediction model of the unsteady flame spread rate over u-shaped structure façade was established and validated through experiments. This study provides technical guidance for the fire safety design of building facade.