This study presents a theoretical analysis of the thermophoretic and Brownian diffusion effects on the magnetized flow of Carreau nanofluid over a stretchable curved surface. The investigation includes the impact of heat generation and activation energy, which are incorporated into the energy and concentration equations, respectively. The mathematical model of the boundary layer flow is formulated as a set of nonlinear partial differential equations using curvilinear coordinates. These equations are transformed into ordinary differential equations through the application of appropriate similarity variables. The resulting system is solved numerically by using the shooting method along with the Runge-Kutta technique. The accuracy of the numerical results is further verified by the Keller-box method, a finite difference technique. The obtained results are also checked by giving a comparison table with the published data in the literature. Furthermore, the convergence of the solutions is also checked by a convergent series method known as the homotopy analysis method (HAM). The study examines the influence of several key parameters, including the radius of curvature, Weissenberg number, Prandtl number, Lewis number, Brownian and thermophoretic diffusions parameters, Hartmann number, heat generation parameter, activation energy parameter, temperature difference parameter, chemical reaction parameter, and power law index. The effects of these parameters on momentum, temperature, concentration distributions, mass and heat transfer rates, and as well as the skin friction coefficient are examined through graphs and tables. Graphical observations declare that the velocity field diminishes against the rising values of the Hartmann number and Weissenberg number. However, the velocity profile rises with improved values of the radius of curvature parameter and power law index parameter. It is also noticed that the magnitude of the concentration field rises with growing values of the Brownian parameter, activation energy parameter and Lewis number, whereas it shows a decreasing manner against the enhanced values of the thermophoresis parameter and temperature difference parameter.