ArticlesSPINAL CORD REGENERATION IN THE RATO. Sugar, and R. W. GerardO. Sugar, and R. W. GerardPublished Online:01 Jan 1940https://doi.org/10.1152/jn.1940.3.1.1MoreSectionsPDF (3 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited BySpinal interneurons and cell transplantationCerebellar Transplantation: A Potential Model to Study Repair and Development of Neurons and Circuits in the Cerebellum25 February 2023The PI3K / AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities26 June 2022 | Cell Proliferation, Vol. 55, No. 9Hypergravity Attenuates Reactivity in Primary Murine Astrocytes13 August 2022 | Biomedicines, Vol. 10, No. 8Characterization of Cortical Glial Scars in the Diisopropylfluorophosphate (DFP) Rat Model of Epilepsy16 March 2022 | Frontiers in Cell and Developmental Biology, Vol. 10GEMINI-supported spinal cord transplantation for the treatment of chronic spinal paralysis: Overview and initial clinical translationCell transplantation to repair the injured spinal cordEstablishing the ground squirrel as a superb model for retinal ganglion cell disorders and optic neuropathiesLaboratory Investigation, Vol. 101, No. 9Preparation of Neural Stem Cells and Progenitors: Neuronal Production and Grafting Applications26 May 2021Astrocytic reprogramming combined with rehabilitation strategy improves recovery from spinal cord injury25 September 2020 | The FASEB Journal, Vol. 34, No. 11Dissecting the Dual Role of the Glial Scar and Scar-Forming Astrocytes in Spinal Cord Injury3 April 2020 | Frontiers in Cellular Neuroscience, Vol. 14Choosing the right cell for spinal cord repair1 November 2018 | Journal of Neuroscience Research, Vol. 97, No. 2Dissecting spinal cord regeneration16 May 2018 | Nature, Vol. 557, No. 7705Spinal Cord and Peripheral Nerve Regeneration Current Research and Future Possibilities22 April 2017Cerebellar Transplantation: A Potential Model to Study Repair and Development of Neurons and Circuits in the Cerebellum28 July 2017Neurotransplantation and the Restoration of Motor Behavior in Parkinson’s Disease7 May 2014Skilled motor control for the preclinical assessment of functional deficits and recovery following nigral and striatal cell transplantationA pilot study of poly(N-isopropylacrylamide)-g-polyethylene glycol and poly(N-isopropylacrylamide)-g-methylcellulose branched copolymers as injectable scaffolds for local delivery of neurotrophins and cellular transplants into the injured spinal cordJournal of Neurosurgery: Spine, Vol. 15, No. 6Neurotrophins: Potential Therapeutic Tools for the Treatment of Spinal Cord Injury9 September 2011 | Neurotherapeutics, Vol. 8, No. 4Chemical priming for spinal cord injury: a review of the literature. Part I—factors involved18 December 2010 | Child's Nervous System, Vol. 27, No. 8Feasibility, Safety, and Efficacy of Directly Transplanting Autologous Adult Bone Marrow Stem Cells in Patients With Chronic Traumatic Dorsal Cord InjuryNeurosurgery Quarterly, Vol. 20, No. 3Lugaro's Forgotten Legacy: The Hypothesis of Negative NeurotropismJournal of the History of the Neurosciences, Vol. 19, No. 3Chapter 55 Neural transplantationCell Grafting for Spinal Cord Injury Repair: Cell Replacement and Bridging StrategiesEncouraging Regeneration of Host Neurons:Encouraging Regeneration of Host Neurons:Cellular transplantation strategies for spinal cord injury and translational neurobiologyNeuroRX, Vol. 1, No. 4Restoration of function after spinal cord transection using a collagen bridge1 January 2004 | Journal of Biomedical Materials Research, Vol. 70A, No. 4Spontaneous regeneration of the corticospinal tract after transection in young rats: a key role of reactive astrocytes in making favorable and unfavorable conditions for regenerationNeuroscience, Vol. 126, No. 2Bridging a Spinal Cord Defect Using Collagen FilamentSpine, Vol. 28, No. 20CNS regeneration: clinical possibility or basic science fantasy?Journal of Clinical Neuroscience, Vol. 10, No. 5Second Sir George Montario Bedbrook Oration − 1999 Some milestones in the life of George Bedbrook. Their relationship to management and research of spinal cord injuries7 August 2003 | ANZ Journal of Surgery, Vol. 73, No. 8A NEW EXTRA-VERTEBRAL TREATMENT MODEL FOR INCOMPLETE SPINAL CORD INJURIES7 July 2009 | International Journal of Neuroscience, Vol. 113, No. 2Functional recovery in chronic paraplegic rats after co-grafts of fetal brain and adult peripheral nerve tissueSurgical Neurology, Vol. 55, No. 5Neural Transplantation in Spinal Cord Injury2 March 2017 | Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Vol. 28, No. 1Grafting of neural tissue in chronically injured spinal cord: influence of the donor tissue on regenerative activitySurgical Neurology, Vol. 54, No. 2Fetal Neuronal Grafting for CNS RegenerationSpinal Cord RegenerationThe Ability of Human Schwann Cell Grafts to Promote Regeneration in the Transected Nude Rat Spinal CordExperimental Neurology, Vol. 148, No. 2Altered Differentiation of Cns Neural Progenitor Cells after Transplantation into the Injured Adult Rat Spinal Cord22 June 2017 | Cell Transplantation, Vol. 6, No. 3Reinnervation of peripheral nerve segments implanted into the hemisected spinal cord estimated by transgenic miceSpinal Cord, Vol. 33, No. 7A question of making it workNature, Vol. 367, No. 6459Estado actual de los intentos de regeneración medular utilizando transplantes neuralesNeurocirugía, Vol. 4, No. 1Delayed transplantation of foetal cerebral tissue into injured spinal cord of adult ratsActa Neurochirurgica, Vol. 115, No. 3-4Open fetal spinal cord surgery in rats with low mortality achieved by prevention of oligohydramniosJournal of Neuroscience Methods, Vol. 42, No. 1-2Central nervous system transplantation benefitted by low-power laser irradiationLasers in Medical Science, Vol. 7, No. 1-4Grafts of embryonic tissue into spinal cord: A possible strategy for treating neuromuscular disordersNeuromuscular Disorders, Vol. 1, No. 2Neural transplantation: An historical perspectiveNeuroscience & Biobehavioral Reviews, Vol. 14, No. 4Predegenerated peripheral nerve grafts facilitate neurite outgrowth from the hippocampusBrain Research Bulletin, Vol. 25, No. 5A comparison of the regeneration potential of dorsal root fibers into gray or white matter of the adult rat spinal cordExperimental Neurology, Vol. 109, No. 1Strategies to Promote Regeneration and Recovery in the Injured Spinal CordNeurosurgery Clinics of North America, Vol. 1, No. 3Evaluation of blood vessel and neurite growth into a collagen matrix placed within a surgically created gap in rat spinal cordBrain Research, Vol. 511, No. 1Transected spinal cords grafted with in situ self-assembled collagen matricesNeuroscience, Vol. 36, No. 1The cone electrode: a long-term electrode that records from neurites grown onto its recording surfaceJournal of Neuroscience Methods, Vol. 29, No. 3Studies on embryonic transplants to the transected spinal cord of adult ratsJournal of Neurosurgery, Vol. 70, No. 3Motoneurons reinnervate skeletal muscle after ventral root implantation into the spinal cord of the catNeuroscience, Vol. 29, No. 3Cytochemical restoration in the upper dorsal horn after transganglionic degenerative atrophy: Temporospatial and fine structural correlatesNeuroscience, Vol. 33, No. 1Perspectives in anatomy and pathology of paraplegia in experimental animalsBrain Research Bulletin, Vol. 22, No. 1Spinal traumas: Some postoperative complications in experimental animalsBrain Research Bulletin, Vol. 22, No. 1Intraspinal transplants of serotonergic neurons in the adult ratBrain Research Bulletin, Vol. 22, No. 1Spinal cord regeneration: new experimental approachSpinal Cord, Vol. 26, No. 5Spinal cord transections in fetal rats. Open intrauterine surgery with low mortalityBrain Research, Vol. 454, No. 1-2Chapter 19 Transplantation of fetal serotonin neurons into the transected spinal cord of adult rats: morphological development and functional influenceChronic regenerative changes in the spinal cord after cord compression injury in ratsSurgical Neurology, Vol. 27, No. 3Peripheral nerve grafting in the spinal cord: a histological and electrophysiological studySpinal Cord, Vol. 24, No. 6Intraspinal transplantation of embyronic spinal cord tissue in neonatal and adult ratsThe Journal of Comparative Neurology, Vol. 247, No. 3Neural Transplantation in Spinal Cord under Different Conditions of Lesions and Their Functional SignificanceUnequivocal Regeneration of Rat Optic Nerve Axons into Sciatic Nerve IsograftsQuantitative Studies of Reactive Events in the Site of Injury Following Transection of the Spinal Cord in the RatRecovery of Motor Skill Following Deprivation of Direct Sensory Input to the Motor Cortex in the MonkeyRegeneration of Axons in the Mammalian Visual SystemRegenerative Growth of Retinofugal Axons into and through Neocortical Transplants Following Transection of the Optic Tract in Adult RatsTransplantation of Pacinian corpuscles of the rat into the brainActa Neuropathologica, Vol. 69, No. 3-4Regeneration in peripheral nerve grafts to the cat spinal cordBrain Research, Vol. 362, No. 1Regeneration of rat optic axons into peripheral nerve graftsExperimental Neurology, Vol. 91, No. 1Ontogeny of the Encephalization ProcessOntogeny of the Encephalization ProcessCentral nervous system axonal regeneration into sciatic nerver grafts: Physiological properties of the grafts and histologic findings in the neuraxisExperimental Neurology, Vol. 90, No. 2Peripheral nerve autografts to the injured spinal cord of the rat: An experimental model for the study of spinal cord regenerationActa Neurochirurgica, Vol. 78, No. 1-2Peripheral nerve implants in the spinal cord in experimental animalsSpinal Cord, Vol. 22, No. 4Identified central axons differ in their response to spinal cord transectionBrain Research, Vol. 305, No. 1Evaluation of transected spinal cord regeneration in the ratExperimental Neurology, Vol. 84, No. 1Use of CNS Implants to Promote Regeneration of Central Axons across Denervating Lesions in the Adult Rat BrainTransplantation Strategies in Spinal Cord RegenerationSpinal cord injury modelsProgress in Neurobiology, Vol. 22, No. 4Time course of segmental reflex changes after chronic spinal cord hemisection in the ratActa Physiologica Scandinavica, Vol. 119, No. 4Cytological effects of triiodothyronine on dorsal root regeneration in adult ratExperimental Neurology, Vol. 80, No. 3Regeneration of rat hippocampal fimbria fibers after fimbria transection and peripheral nerve or fetal hippocampal implantationExperimental Neurology, Vol. 79, No. 2Connectivity of Transplants in the Cerebellum: A Model of Developmental Differences in NeuroplasticityGROWTH FACTORS IN REGENERATION OF NEURAL TISSUESIMMUNOLOGIC CONSIDERATIONS IN NERVOUS SYSTEM REPAIRSpinal cord grafts: An intraocular approach to enigmas of nerve growth regulationBrain Research Bulletin, Vol. 9, No. 1-6Catecholamine fiber regeneration across a collagen bioimplant after spinal cord transectionBrain Research Bulletin, Vol. 9, No. 1-6Peripheral nerve autografts to the rat spinal cord: Studies with axonal tracing methodsBrain Research, Vol. 237, No. 1Transplantation of Neurons and Sheath Cells — A Tool for the Study of RegenerationReconstruction of the contused cat spinal cord by the delayed nerve graft technique and cultured peripheral non-neuronal cellsActa Neuropathologica, Vol. 57, No. 1Axonal Elongation in Peripheral and Central Nervous System TransplantsInfluences of the Glial Environment on the Elongation of Axons After Injury: Transplantation Studies in Adult Rodents1 December 1981 | Journal of Experimental Biology, Vol. 95, No. 1Regeneration of the septohippocampal pathways in adult rats is promoted by utilizing embryonic hippocampal implants as bridgesBrain Research, Vol. 210, No. 1-2ReferencesFRAP: Histochemistry of the Primary Nociceptive NeuronProgress in Histochemistry and Cytochemistry, Vol. 14, No. 1Section of the pituitary stalk in the rhesus monkey: Morphological and endocrine observationsAnnals of Neurology, Vol. 8, No. 3Evaluation of the use of enzymes for functional restitution after spinal cord severance in the ratExperimental Neurology, Vol. 68, No. 2Axons from CNS neurones regenerate into PNS graftsNature, Vol. 284, No. 5753NeurotropismExperimental Neurology, Vol. 67, No. 2Vascular permeability and axonal regeneration in tissues autotransplanted into the brainActa Neuropathologica, Vol. 49, No. 3Regeneration of the magnocellular system of the rhesus monkey following hypothalamic lesionsAnnals of Neurology, Vol. 5, No. 5Functional deficits and anatomical alterations after high cervical spinal hemisection in the ratExperimental Neurology, Vol. 58, No. 3Early history of mammalian nerve regenerationNeuroscience & Biobehavioral Reviews, Vol. 2, No. 1The mechanism of spinal cord cavitation following spinal cord transectionJournal of Neurosurgery, Vol. 46, No. 6The possibility of structural and functional restitution after spinal cord injury. A reviewExperimental Neurology, Vol. 55, No. 1Factors in recovery from spinal cord injuryExperimental Neurology, Vol. 53, No. 3Increases in collateral axonal growth rostral to a thoracic hemisection in neonatal and weanling ratThe Journal of Comparative Neurology, Vol. 166, No. 2Changes in the magnocellular portion of the red nucleus following thoracic hemisection in the neonatal and adult ratThe Journal of Comparative Neurology, Vol. 166, No. 2A fine structural study of degenerative-regenerative pathology in the surgically deafferentated lateral vestibular nucleus of the ratActa Neuropathologica, Vol. 33, No. 3History of central nervous system regeneration researchExperimental Neurology, Vol. 48, No. 3Amino acid transmitters in the mammalian central nervous system23 June 2010Injuries of the Vertebral Column and Spinal CordRegenerative reconstruction of a tract in a rat's brainExperimental Neurology, Vol. 34, No. 3Growth of central catecholamine neurones into smooth muscle grafts in the rat mesencephalonBrain Research, Vol. 31, No. 1Development and growth of axonal sprouts from noradrenaline and 5-hydroxytryptamine neurones in the rat spinal cordBrain Research, Vol. 31, No. 1Spinal cord function in postischemic rigidity in the ratBrain Research, Vol. 19, No. 3AMŒBIASISThe Lancet, Vol. 291, No. 7533INTRAMEDULLARY NEUROMAS AND SPINAL CORD REGENERATIONThe Lancet, Vol. 291, No. 7533The Cellular Morphology of Tissue RepairAxon regeneration after spinal cord injurySpinal Cord, Vol. 4, No. 3The neuropathology of traumatic paraplegiaSpinal Cord, Vol. 1, No. 4Regeneration in The Vertebrate Central Nervous SystemFactors Promoting Regeneration of Spinal Neurons: Positive Influence of Nerve Growth FactorPeripheral Nerve Implantation in Experimental ParaplegiaJournal of Neurosurgery, Vol. 20, No. 7Regeneration of the spinal cord in the rat effects of PiromenR and acth upon the regenerative capacityThe Journal of Comparative Neurology, Vol. 119, No. 1Effects of heavy, ionizing, monoenergetic particles on the cerebral cortex. II. Histological appearance of laminar lesions and growth of nerve fibers after laminar destructions8 October 2004 | Journal of Comparative Neurology, Vol. 115, No. 3Bioelectrical characteristics of regenerated fibers in the feline spinal cordExperimental Neurology, Vol. 2, No. 5The Problem of Neuronal Regeneration in the Central Nervous SystemJournal of Neurosurgery, Vol. 17, No. 3Regeneration in the dorsal spino-cerebellar tract of the catThe Journal of Comparative Neurology, Vol. 109, No. 2The regeneration of peripheral nerves inserted into the cerebral cortex and the healing of cerebral lesionsThe Journal of Comparative Neurology, Vol. 109, No. 1Sekundäre, retrograde und transsynaptische DegenerationResearch on the regeneration of the spinal cord in the cat submitted to the action of pyrogenous substances (5 or 3895) of bacterial originThe Journal of Comparative Neurology, Vol. 105, No. 2Development of local coordination centers. I. Brachial centers in the salamander spinal cordJournal of Experimental Zoology, Vol. 132, No. 3Reactions of mammalian fetal spinal cord, spinal ganglia, and brain to injuryJournal of Experimental Zoology, Vol. 132, No. 2Regeneration of spinal cord fibers in the catThe Journal of Comparative Neurology, Vol. 102, No. 3Regeneration of severed nerve fibers in the spinal cord of the adult catThe Journal of Comparative Neurology, Vol. 101, No. 3Regeneration in the spinal cord of the cat and dogThe Journal of Comparative Neurology, Vol. 93, No. 2Neurophysiology, 1942–1948New England Journal of Medicine, Vol. 240, No. 22FORM AND CAUSALITY IN NEUROGENESISBiological Reviews, Vol. 23, No. 1Abortive regeneration of the transected spinal cordThe Journal of Comparative Neurology, Vol. 87, No. 2Retrograde degeneration. Effect of hemisections on the axons of the fasciculus gracilis and cuneatus in the newborn catThe Journal of Comparative Neurology, Vol. 81, No. 3RECOVERY OF NERVE FUNCTIONThe Lancet, Vol. 241, No. 6235SURGERY IN THE TROPICSThe Lancet, Vol. 241, No. 6235Regulation and reconstitution in FundulusJournal of Experimental Zoology, Vol. 90, No. 1Reactions of dorsal root ganglion cells to section of peripheral and central processesThe Journal of Comparative Neurology, Vol. 73, No. 3 More from this issue > Volume 3Issue 1January 1940Pages 1-19 https://doi.org/10.1152/jn.1940.3.1.1History Published online 1 January 1940 Published in print 1 January 1940 Metrics