In this study, we describe a novel approach to quantum phenomena of the generalized electromagnetic fields of dyons with quaternionic analysis. Starting with quaternionic quantum wave equations, we have established a quantized condition for time coordinate that transforms microscopic to macroscopic fields. In view of the classical electromagnetic field equations, we propose a new set of quantized Proca–Maxwell’s equations for dyons. Furthermore, a quantized form of four-current densities and the quantized Lorentz gauge conditions for electric and magnetic potentials, respectively, of dyons are obtained. We have established the new quantized continuity equations for electric and magnetic densities of dyons, which are associated with a torque density result from the two spin states. The quantized Klein–Gordon-like field equations and the unified quaternionic electromagnetic potential wave equations for massive dyons are demonstrated. Moreover, we investigate the quaternionic quantized relativistic Dirac field equations for massive dyons, which indicate that the antiparticle of dyons will exist, called antidyons.