The wetting condition is an important factor that affects the cooling performance of an indirect evaporative cooler (IEC). Applying hydrophilic coatings to the wet channels is an effective way to enlarge the wetting area and enhance evaporative cooling. However, long-term hydrophilic durability tests for the coated surface are rarely discussed in existing studies. Moreover, the evaluation of performance improvement of a hydrophilic-coated IEC is usually based on testing the prototype as a whole, without giving attention to the internal wetting behavior inside the core. Therefore, a TiO2/SiO2 nano-coated polypropylene (PP) IEC is manufactured for studying the wetting and evaporative performance by considering the hydrophilic durability and internal wetting behavior with a specially-designed visualized experiment, aiming at promoting its application and guiding the design. Firstly, the microstructure, thermal conductivity, drop-surface characteristics and hydrophilic durability of the coated samples were studied. Secondly, the internal water distribution was studied under the influence of spray time (5 s ∼ 180 s), water flow rate (2 L/min ∼ 6 L/min), air velocity (2 m/s ∼ 3.5 m/s) and nozzle height (50 mm ∼ 250 mm) by combining fluorescence tracer and digital image processing methods. Lastly, the evaporative performance of the nano-coated IEC was tested under two spray strategies. Results show the hydrophilicity of polished nano-coated PP is durable in a dark and water-scouring environment with a steady contact angle of 30.9°. The coated core shows super hydrophilicity by forming a thin water film and being fully wetted within 60 s. Compared to the continuous spray, the intermittent spray can provide a larger evaporative mass transfer coefficient by 23.5% and a higher coefficient of performance by 114%.