Detection Of Masses In Mammograms Research Articles

Improved PAA algorithm for breast mass detection in mammograms

Mammography screening is instrumental in the early detection and diagnosis of breast cancer by identifying masses in mammograms. With the rapid development of deep learning, numerous deep learning-based object detection algorithms have been explored for mass detection studies. However, these methods often yield a high false positive rate per image (FPPI) while achieving a high true positive rate (TPR). To maintain a higher TPR while also ensuring lower FPPI, we improved the Probability Anchor Assignment (PAA) algorithm to enhance the detection capability for mammographic characteristics with our previous work. We considered three dimensions: the backbone network, feature fusion module, and dense detection heads. The final experiment showed the effectiveness of the proposed method, and the TPR/FPPI values of the final improved PAA algorithm were 0.96/0.56 on the INbreast datasets. Compared to other methods, our method stands distinguished with its effectiveness in addressing the imbalance between positive and negative classes in cases of single lesion detection.

A comparative study of YOLO models and a transformer-based YOLOv5 model for mass detection in mammograms

A comparative study of YOLO models and a transformer-based YOLOv5 model for mass detection in mammograms

Enhancement Technique Based on the Breast Density Level for Mammogram for Computer-Aided Diagnosis.

Mass detection in mammograms has a limited approach to the presence of a mass in overlapping denser fibroglandular breast regions. In addition, various breast density levels could decrease the learning system's ability to extract sufficient feature descriptors and may result in lower accuracy performance. Therefore, this study is proposing a textural-based image enhancement technique named Spatial-based Breast Density Enhancement for Mass Detection (SbBDEM) to boost textural features of the overlapped mass region based on the breast density level. This approach determines the optimal exposure threshold of the images' lower contrast limit and optimizes the parameters by selecting the best intensity factor guided by the best Blind/Reference-less Image Spatial Quality Evaluator (BRISQUE) scores separately for both dense and non-dense breast classes prior to training. Meanwhile, a modified You Only Look Once v3 (YOLOv3) architecture is employed for mass detection by specifically assigning an extra number of higher-valued anchor boxes to the shallower detection head using the enhanced image. The experimental results show that the use of SbBDEM prior to training mass detection promotes superior performance with an increase in mean Average Precision (mAP) of 17.24% improvement over the non-enhanced trained image for mass detection, mass segmentation of 94.41% accuracy, and 96% accuracy for benign and malignant mass classification. Enhancing the mammogram images based on breast density is proven to increase the overall system's performance and can aid in an improved clinical diagnosis process.

Anchor-free YOLOv3 for mass detection in mammogram

Automatic detection of mass in mammograms is a big challenge and plays a crucial role in assisting radiologists for accurate diagnosis. Applying excellent deep learning based detection networks to medical image is a direction. In this paper, an anchor-free YOLOv3 network is proposed for mass detection in mammogram. The main improvements are as follows. Anchor-based (AB) detection scheme may involve too many negative boxes, which may aggravate the unbalance between positive boxes and negative boxes. Aiming at this problem, a novel anchor-free (AF) detection scheme is developed for box regression. To alleviate the problem caused by using mean square error (MSE) as box regression loss, generalized intersection over union (GIoU) loss is adopted to train bounding box regression. Focal loss is adopted as the objectness prediction loss, which can prevent the network degradation caused by the vast number of easy negatives. Moreover, a new feature aggregation manner by summing is designed and employed in the up to down pathway. Comparative experiments are performed on two databases (publicly available dataset INbreast and private dataset TXMD). For INbreast dataset, the proposed method achieved 0.95 true positive rate (TPR) with 1.7 false positives per image (FPs/I). For TXMD dataset, the proposed method achieved 0.94 TPR with 5.75 FPs/I. Experimental results demonstrate that the proposed method outperforms YOLOv3 network and gets a promising result compared with existing mass detection methods.

A Bottom-Up Review of Image Analysis Methods for Suspicious Region Detection in Mammograms.

Breast cancer is one of the most common death causes amongst women all over the world. Early detection of breast cancer plays a critical role in increasing the survival rate. Various imaging modalities, such as mammography, breast MRI, ultrasound and thermography, are used to detect breast cancer. Though there is a considerable success with mammography in biomedical imaging, detecting suspicious areas remains a challenge because, due to the manual examination and variations in shape, size, other mass morphological features, mammography accuracy changes with the density of the breast. Furthermore, going through the analysis of many mammograms per day can be a tedious task for radiologists and practitioners. One of the main objectives of biomedical imaging is to provide radiologists and practitioners with tools to help them identify all suspicious regions in a given image. Computer-aided mass detection in mammograms can serve as a second opinion tool to help radiologists avoid running into oversight errors. The scientific community has made much progress in this topic, and several approaches have been proposed along the way. Following a bottom-up narrative, this paper surveys different scientific methodologies and techniques to detect suspicious regions in mammograms spanning from methods based on low-level image features to the most recent novelties in AI-based approaches. Both theoretical and practical grounds are provided across the paper sections to highlight the pros and cons of different methodologies. The paper’s main scope is to let readers embark on a journey through a fully comprehensive description of techniques, strategies and datasets on the topic.

Automatic breast mass detection in mammograms using density of wavelet coefficients and a patch-based CNN.

For the purpose of accurate and efficient mass detection in full-field digital mammograms, weproposeamethodfor automated mass detection that consists oftwostages: suspicious region localization and false-positive (FP) reduction, by classifying these regions into mass and non-mass regions (normal tissues). In the first stage, the density of the wavelet coefficients based on Quincunx Lifting Scheme (DWC-QLS) is used to find suspicious regions (regions of interest, ROIs) in full mammograms. In the second stage, a patch-based CNN classifier is developed as an FP reduction to classify the suspicious regions. The main aim of this stage is to reduce the false-positive suspicious regions while keeping the true-positive suspicious regions. To further improve the performance of the FP reduction, the effectiveness of different transfer learning strategies is further explored and the best fine-tuning strategy in training InceptionV3 model is determined experimentally. The experimental results show that the proposed method can achieve an overall performance of 0.98 TPR @1.43 FPI on the INbreast database. In addition, the suggested segmentation method detects the mass location with 100% sensitivity and average of 5.4 false positives per image. Based on the obtained results,the introduced method was able to successfully detectand classify suspicious regions in digital mammograms and provide better TPR and FPI results in comparison with other state-of-the-art method.

Act Like a Radiologist: Towards Reliable Multi-View Correspondence Reasoning for Mammogram Mass Detection.

Mammogram mass detection is crucial for diagnosing and preventing the breast cancers in clinical practice. The complementary effect of multi-view mammogram images provides valuable information about the breast anatomical prior structure and is of great significance in digital mammography interpretation. However, unlike radiologists who can utilize the natural reasoning ability to identify masses based on multiple mammographic views, how to endow the existing object detection models with the capability of multi-view reasoning is vital for decision-making in clinical diagnosis but remains the boundary to explore. In this paper, we propose an anatomy-aware graph convolutional network (AGN), which is tailored for mammogram mass detection and endows existing detection methods with multi-view reasoning ability. The proposed AGN consists of three steps. First, we introduce a bipartite graph convolutional network (BGN) to model the intrinsic geometric and semantic relations of ipsilateral views. Second, considering that the visual asymmetry of bilateral views is widely adopted in clinical practice to assist the diagnosis of breast lesions, we propose an inception graph convolutional network (IGN) to model the structural similarities of bilateral views. Finally, based on the constructed graphs, the multi-view information is propagated through nodes methodically, which equips the features learned from the examined view with multi-view reasoning ability. Experiments on two standard benchmarks reveal that AGN significantly exceeds the state-of-the-art performance. Visualization results show that AGN provides interpretable visual cues for clinical diagnosis.

Multi-Model Approach and Fuzzy Clustering for Mammogram Tumor to Improve Accuracy

Breast Cancer is one of the most common diseases among women which seriously affect health and threat to life. Presently, mammography is an uttermost important criterion for diagnosing breast cancer. In this work, image of breast cancer mass detection in mammograms with 1024×1024 pixels is used as dataset. This work investigates the performance of various approaches on classification techniques. Overall support vector machine (SVM) performs better in terms of log-loss and classification accuracy rate than other underlying models. Therefore, further extensions (i.e., multi-model ensembles method, Fuzzy c-means (FCM) clustering and SVM combination method, and FCM clustering based SVM model) and comparison with SVM have been performed in this work. The segmentation by FCM clustering technique allows one piece of data to belong in two or more clusters. The additional parts are due to the segmented image to enhance the tumor-shape. Simulation provides the accuracy and the area under the ROC curve for mini-MIAS are 91.39% and 0.964 respectively which give the confirmation of the effectiveness of the proposed algorithm (FCM-based SVM). This method increases the classification accuracy in the case of a malignant tumor. The simulation is based on R-software.

A Review on Feature Selection Techniques in Digital Mammograms

The most of the women in the world are suffering from a deadly disease called Breast Cancer (BC). Breast cancer is analyzed by using imaging modalities such as mammograms, magnetic resonance imaging, ultrasound, and thermograms. Among all, mammograms are the low dosage, less cost, more effective, and accurate method to detect BC in early stages. There are many Computer-Aided Detection (CAD) systems for the automatic detection of masses in mammograms. These techniques are helping radiologists and physicians in diagnosing disease. The objective of this paper is to overview different CAD systems in which mainly we focused on feature selection, as feature selection techniques are used to reduce the complexity of the classifiers and also increase the accuracy. We conclude that suitable optimization techniques should be chosen to increase the accuracy of the classifier so that we can increase the survival rate of the patient.

Mammogram mass segmentation and detection using Legendre neural network-based optimal threshold.

Breast cancer is a leading cause of mortality affecting women across the world. Early detection and diagnosis can decrease the mortality rate due to this cancer. Machine learning-based models are gaining popularity for biomedical applications due to the ability of nonlinear mapping between input and output patterns using supervised training phase. The research work in the paper is focused on the optimal adaptive threshold for mammogram mass segmentation, and detection in order to assist radiologist in accurate diagnosis Legendre neural network with single layer is used to develop the model, and the training is performed through Block Based Normalized Sign-Sign Least Mean Square (BBNSSLMS) algorithm. Legendre neural network expands the input vector using standard Legendre polynomial, and the recursive update principle is followed for the weight vector in higher dimension. The optimal threshold isindirectly used for proper segmentation of mammogram mass. The proposed segmentation method involves training phase with 30 images and testing phase by 151 images obtained from standard Mammogram Image Analysis Society (MIAS) database. The proposed model achieved a sensitivity of 95% and accuracy of 96% with false positives per image calculated as 1.19. • Threshold selection is carried out using single-layer Legendre NN with reduced computational complexity. BNSSLMS algorithm process the data samples block wise instead of sample by sample basis. Optimal threshold is generated according to the varying image properties which helps in correct segmentation and detection. • Due to sparse nature of the adaptive model, more numbers of weight coefficients are tending to zero which also helps in faster convergence. Mammogram Mass Detection Steps.

Breast Cancer Mass Detection in Mammograms Using Gray Difference Weight and MSER Detector

Breast cancer is a deadly and one of the most prevalent cancers in women across the globe. Mammography is widely used imaging modality for diagnosis and screening of breast cancer. Segmentation of breast region and mass detection are crucial steps in automatic breast cancer detection. Due to the non-uniform distribution of various tissues, it is a challenging task to analyze mammographic images with high accuracy. In this paper, background suppression and pectoral muscle removal are performed using gradient weight map followed by gray difference weight and fast marching method. Enhancement of breast region is performed using contrast limited adaptive histogram equalization (CLAHE) and de-correlation stretch. Detection of breast masses is accomplished by gray difference weight and maximally stable external regions (MSER) detector. Experimentation on Mammographic Image Analysis Society (MIAS) and curated breast imaging subset of digital database for screening mammography (CBIS-DDSM) show that the method proposed performs breast boundary segmentation and mass detection with best accuracies. Mass detection achieved high accuracies of about 97.64% and 94.66% for MIAS and CBIS-DDSM dataset, respectively. The method is simple, robust, less affected to noise, density, shape and size which could provide reasonable support for mammographic analysis.

Classification of Benign and Malignant Breast Masses on Mammograms for Large Datasets using Core Vector Machines.

Breast cancer is one of the most leading causes of cancer deaths among women. Early detection of cancer increases the survival rate of the affected women. Machine learning approaches that are used for classification of breast cancer usually takes a lot of processing time during the training process. This paper attempts to propose a Machine Learning approach for breast cancer detection in mammograms, which does not depend on the number of training samples. The paper aims to develop a core vector machine-based diagnosis system for breast cancer detection using the date from MIAS. The main motivation behind using this system is to reduce the computational and memory requirement for large training data and to improve the classification accuracy. The proposed method has four stages: 1) Pre-processing is done to extract the breast region using global thresholding and enhancement using histogram equalization; 2) identification of potential mass using Otsu thresholding; 3) feature extraction using Laws Texture energy measures; and 4) mass detection is done using Core vector machine (CVM) classifier. Comparative analysis was done with different existing algorithms: Artificial Neural Network (ANN), Support Vector Machine (SVM), and Fuzzy Support Vector Machines (FSVM). The results illustrate that the proposed Core Vector Machine (CVM) classifier produced a promising result in terms of sensitivity (96.9%), misclassification rate (0.0443) and accuracy (95.89%). The time taken for training process is 0.0443, which is less when compared with other machine learning algorithms. Performance analysis shows that CVM classifier is superior to other classifiers like ANN, SVM and FSVM. The computational time of the CVM classifier during the training process was also analysed and found to be better than other discussed algorithms. The results achieved show that CVM classifier is the best algorithm for breast mass detection in mammograms.

Mass detection in mammograms by bilateral analysis using convolution neural network

Background and objectiveAutomatic detection of the masses in mammograms is a big challenge and plays a crucial role to assist radiologists for accurate diagnosis. In this paper, a bilateral image analysis method based on Convolution Neural Network (CNN) is developed for mass detection in mammograms. MethodsThe proposed bilateral mass detection method consists of two networks: a registration network for registering bilateral mammograms and a Siamese-Faster-RCNN network for mass detection using a pair of registered mammograms. In the first step, self-supervised learning network is built to learn the spatial transformation between bilateral mammograms. This network can directly estimate spatial transformation by maximizing an image-wise similarity metric and corresponding points labeling is not needed. In the second step, an end-to-end network combining the Region Proposal Network (RPN) and a Siamese Fully Connected (Siamese-FC) network is designed. Different from existing methods, the designed network integrates mass detection on single image with registered bilateral images comparison. ResultsThe proposed method is evaluated on three datasets (publicly available dataset INbreast and private dataset BCPKUPH and TXMD). For INbreast dataset, the proposed method achieves 0.88 true positive rate (TPR) with 1.12 false positives per image (FPs/I). For BCPKUPH dataset, the proposed method achieves 0.85 TPR with 1.86 FPs/I. For TXMD dataset, the proposed method achieves 0.85 TPR with 2.70 FPs/I. ConclusionsRegistration experimental result shows that the proposed method is suitable for bilateral mass detection. Mass detection experimental results show that the proposed method performs better than unilateral mass detection method, different bilateral connection schemes and image level fusion bilateral schemes.

Multicontext multitask learning networks for mass detection in mammogram.

In this paper, for the purpose of accurate and efficient mass detection, we propose a new deep learning framework, including two major stages: Suspicious region localization (SRL) and Multicontext Multitask Learning (MCMTL). In the first stage, SRL focuses on finding suspicious regions [regions of interest (ROIs)] and extracting multisize patches of these suspicious regions. A set of bounding boxes with different size is used to extract multisize patches, which aim to capture diverse context information. In the second stage, MCMTL networks integrate features from multisize patches of suspicious regions for classification and segmentation simultaneously, where the purpose of this stage is to keep the true positive suspicious regions and to reduce the false positive suspicious regions. According to the experimental results on two public datasets (i.e., CBIS-DDSM and INBreast), our method achieves the overall performance of 0.812 TPR@2.53 FPI and 0.919 TPR@0.12 FPI on test sets, respectively. Our proposed method suggests comparable performance to the state-of-the-art methods.

Unsupervised domain adaptation with adversarial learning for mass detection in mammogram

Many medical image datasets have been collected without proper annotations for deep learning training. In this paper, we propose a novel unsupervised domain adaptation framework with adversarial learning to minimize the annotation efforts. Our framework employs a task specific network, i.e., fully convolutional network (FCN), for spatial density prediction. Moreover, we employ a domain discriminator, in which adversarial learning is adopted to align the less-annotated target domain features with the well-annotated source domain features in the feature space. We further propose a novel training strategy for the adversarial learning by coupling data from source and target domains and alternating the subnet updates. We employ the public CBIS-DDSM dataset as the source domain, and perform two sets of experiments on two target domains (i.e., the public INbreast dataset and a self-collected dataset), respectively. Experimental results suggest consistent and comparable performance improvement over the state-of-the-art methods. Our proposed training strategy is also proved to converge much faster.

Automatic mass detection in mammograms using deep convolutional neural networks.

With recent advances in the field of deep learning, the use of convolutional neural networks (CNNs) in medical imaging has become very encouraging. The aim of our paper is to propose a patch-based CNN method for automated mass detection in full-field digital mammograms (FFDM). In addition to evaluating CNNs pretrained with the ImageNet dataset, we investigate the use of transfer learning for a particular domain adaptation. First, the CNN is trained using a large public database of digitized mammograms (CBIS-DDSM dataset), and then the model is transferred and tested onto the smaller database of digital mammograms (INbreast dataset). We evaluate three widely used CNNs (VGG16, ResNet50, InceptionV3) and show that the InceptionV3 obtains the best performance for classifying the mass and nonmass breast region for CBIS-DDSM. We further show the benefit of domain adaptation between the CBIS-DDSM (digitized) and INbreast (digital) datasets using the InceptionV3 CNN. Mass detection evaluation follows a fivefold cross-validation strategy using free-response operating characteristic curves. Results show that the transfer learning from CBIS-DDSM obtains a substantially higher performance with the best true positive rate (TPR) of at 1.67 false positives per image (FPI), compared with transfer learning from ImageNet with TPR of at 2.1 FPI. In addition, the proposed framework improves upon mass detection results described in the literature on the INbreast database, in terms of both TPR and FPI.

Novel automatic seed selection approach for mass detection in mammograms

Novel automatic seed selection approach for mass detection in mammograms

Novel automatic seed selection approach for mass detection in mammograms

The success of mass detection using seeded region growing segmentation depends on seed point selection operation. The seed point is the first point from which starts the process of aggregation. This point must be inside the mass otherwise the segmentation fails. There are two principal ways to perform the seed point selection. The first one is manual, performed by a medical expert who manually outlines the point of interest using a pointer device. The second one is automatic; in this case the whole process is performed without any user interaction. This paper proposes a novel approach to select automatically the seed point for further region growing expansion. Firstly, suspicious regions are extracted by a thresholding technique. Secondly, the suspicious region whose features match with the predefined mass features is identified as the region of interest. Finally, the seed point is placed inside the region of interest. The proposed method is tested using the IRMA database and the MIAS database. The experimental results show the performance and robustness of the proposed method.

Detection of Masses in Mammograms using Bayesian Method and Machine learning

Every 100th cases in cancer we come across are of breasts cancer cases. It is becoming very common in woman of all ages. Correct detection of these lesions in breast is very important. With less of human intervention, the goal is to do the correct diagnosis. Not all the cases of breast masses are futile. If the cases are not dealt properly, they might create panic amongst people. Human detection without machine intervention is not hundred percent accurate. If machines can be deeply trained, they can do the same work of detection with much more accuracy. Bayesian method has a vast area of application in the field of medical image processing as well as in machine learning. This paper intends to use Bayesian probabilistic in image segmentation as well as in machine learning. Machine learning in image processing means application in pattern recognition. There are various machine learning algorithms that can classify an image at their best. In the proposed system, we will be firstly segment the image using Bayesian method. On the segmented parts of the image, we will be applying machine learning algorithm to diagnose the mass or the growth.

Automatic Detection of Masses in Mammograms Using Bi-Dimensional Empirical Mode Decomposition

Automatic Detection of Masses in Mammograms Using Bi-Dimensional Empirical Mode Decomposition