The transformation of industrial structure is a key task for realizing high-quality economic development. Different from western economics, which locates the industrial structure and its transformation in the ratio of the three industries of the national economy and their changes, this paper logically analyzes the theoretical content of Marxist political economy, takes into account the "qualities" of the organic composition of capital of the industry, and summarizes the transformation of the industrial structure as the process of optimizing the ratio between the two categories of social reproduction and their intersectoral relations to realize the upgrading of the industry in the contradictory movement of the productive forces and the relations of production. The transformation of industrial structure is summarized as the process of industrial upgrading, in which scientific and technological innovation promotes the adjustment of the organic composition of capital, optimizes the proportion between the two major categories of social reproduction and their respective sectors. This process has different manifestations at micro, meso and macro levels, and is constrained by the objectives of total social reproduction balance, structural balance and productive labor-based. Accordingly, the article proposes that we should base ourselves on the level of development of productive forces, strengthen the real economy, adjust the relations of production, improve the form of ownership, strengthen macroeconomic regulation and control, and promote scientific and technological innovation in order to realize the transformation of China's industrial structure.