Event Abstract Back to Event Targeting auditory cortex: combining physiology and anatomy to identify higher auditory regions Anatomical studies of human and non-human primates have suggested that the auditory cortex is divided into hierarchically connected core, belt, and parabelt regions distinguished by both thalamocortical and corticocortical connectivity (Hackett et al, 1998). However, to date there exists little physiological evidence for a similarly defined parabelt region. The paucity of physiological data within this region largely results from lack of reliable in vivo indicators of its boundaries. Previously, we reported a new method to address this difficulty by measuring the Current-Source-Density (CSD) to register a single electrode penetration as belonging within a given cortical region. Post-mortem histological staining (PV, vGlut2, AChE, and Nissl) confirmed a tight relationship between shifting anatomical patterns of lemniscal input and the presence of a defined layer IV current sink in the CSD. Here, a linear discriminant analysis (LDA) exploiting defined spectral and temporal features of the CSD was used to determine two planes of maximum separation which resulted in a highly probable assignment of neural location to a particular anatomically defined region. Additionally, we report our first single neuron and local-field-potential (LFP) recordings from three areas, core, belt, and parabelt identified with our new approach that links both anatomical and physiological classification of these regions. Using a single tungsten electrode the LFP was measured at 100µ steps orthogonal to the laminar striations and used to compute the CSD for an individual recording track. These recordings were made across the medial-to-lateral surface of the awake marmoset auditory cortex. Single-units and LFPs recorded within a penetration were grouped using boundaries determined with our new method and histologically as originating from the core, belt, or parabelt. Across these boundaries physiological differentiation was observed for both single-units and LFP responses. These included marked changes in latency, bandwidth, and synchronization to modulated sounds. Specifically, both latency and spectral tuning width increased from the core to belt and parabelt whereas the frequency at which cells could synchronize to modulated sounds decreased along the same dimension. These findings provide evidence for a physiologically defined parabelt region, in addition to sharpening existing core and belt distinctions, and suggest that CSD-based electrode registration offers a useful measure for identifying the location of recorded neural responses in the primate auditory cortex across the medial-to-lateral dimension. Conference: Computational and systems neuroscience 2009, Salt Lake City, UT, United States, 26 Feb - 3 Mar, 2009. Presentation Type: Poster Presentation Topic: Poster Presentations Citation: (2009). Targeting auditory cortex: combining physiology and anatomy to identify higher auditory regions. Front. Syst. Neurosci. Conference Abstract: Computational and systems neuroscience 2009. doi: 10.3389/conf.neuro.06.2009.03.192 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 03 Feb 2009; Published Online: 03 Feb 2009. Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Google Google Scholar PubMed Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.