Purpose: This paper develops a high-precision yield fusion prediction model for the sugarcane industry in Chongzuo, Guangxi, based on the trend yield and meteorological yield using the long short-term memory (LSTM) model to cope with the multiple factors affecting sugarcane production. Decision support is provided to agricultural producers, policymakers, and supply chain managers so that they can plan resource allocation, market strategies, and policy directions more effectively. Methods: The paper modeled trend yield and weather yield separately to explore the complex relationship between the two in influencing sugarcane production. Trend yields were predicted using the exponential smoothing and multilayer perceptron (MLP) models, while meteorological yields were modeled using stepwise regression. The predicted yields were used again as input variables into the LSTM deep learning network to fit the nonlinear relationship between the two yields. Results: The results showed that (1) the fusion strategy of meteorological yield and MLP trend yield adopted by the model was superior to the fusion strategy of meteorological yield and exponentially smoothed trend yield, achieving a very low mean square error (MSE) of 0.011 and a goodness of fit as high as 0.979, which indicated that the model prediction was highly in agreement with the actual yield, confirming the validity of the method. (2) The prediction curve is basically consistent with the trend of actual sugarcane yield, which predicts that the sugarcane yield in Chongzuo, Guangxi, is expected to maintain a stable and small growth trend in the next eight years. (3) The fusion prediction model proposed in this study provides an accurate and practical solution for sugarcane yield prediction in Chongzuo, Guangxi, with the unique advantage of effectively analyzing and integrating the natural and socio-economic factors affecting the yield, which is of significant reference value for the prediction of sugarcane yield in the local area and even in similar ecoregions.