The purpose of this present study is investigating of relationship and compare between emotion regulation, marital satisfaction and lifestyle of the fertile and infertile couples in Isfahan. The sample consisted of two groups of 200 people in fertile and infertile couples in Isfahan who were selected based on availability. To collect information was used from questionnaires lifestyle, marital satisfaction and cognitive emotion regulation. The results showed that lifestyle and marital satisfaction in fertile and infertile no significant difference in cognitive emotion regulation fertile and infertile couples, but there is a significant difference. Infertile couples have lower cognitive emotion regulation. As well as lifestyle and marital satisfaction in fertile and infertile couples have a significant positive relationship that the relationship is stronger for infertile couples. Lifestyle and cognitive emotion regulation, marital significant negative relationship with cognitive emotion regulation has a significant positive relationship between fertile and infertile couples 17.7 % of fertile couple’s marital satisfaction and cognitive emotion regulation with fertile couples to explain them is not a predictor of marital satisfaction. But lifestyle 22.6 % of infertile couples infertile couples marital satisfaction and cognitive emotion regulation in the first and 7.4% of infertile couples to predict marital satisfaction, Therefore, it is essential that interventions for infertile couples to be cognitive of the training set to handle the excitement of infertility and prevent problems related to it.