This study examines the association between key quality factors of an English as a Medium of Instruction (EMI) program delivered at a Spanish university with the students’ satisfaction. The significant growth of demand and offer of bilingual and plurilingual studies in Higher Education in the last decade in many non-Anglo-Saxon countries, recommends conducting more evaluation research studies aimed at measuring quality and impact of EMI programs on students’ performance and satisfaction. To respond to that need, this ex-post facto research study included a sample of 131 self-selected students. The dependent variable student satisfaction was measured with a questionnaire (α=0.82 and a ω= 0.85) delivered through a computer-assisted web interviewing technique. Nonparametric regression analysis results confirm partially two out of the four hypotheses tested with an average of the mean estimate of 3.7 (on a 5 points scale) and the (only) average marginal significant effect of teachers teaching practices estimated to be 0.7, p < 0.01. The model (M6) with all predictions and controls explains 40.69% of the variation of the dependent variable. Finally, some conclusions and recommendations are drawn to increase future students’ satisfaction about this type of Higher Education.