Resilience describes the capability of manufacturing systems to resist disturbances while minimizing the loss of revenue or productivity. In order to achieve robustness against disturbances under consideration of operational costs, multiple planning parameters and strategies must be taken into account simultaneously. This leads combinatorial optimization problems with complex modeling and time-consuming computations. To still evaluate many strategies within a short time Quantum Annealing (QA) can be used, which shows potentials to solve such complex assignment problems within seconds. Consequently, a QA-based resilience optimization approach for manufacturing systems is presented. The approach shows potentials regarding scalability, solution quality, and computing time.