Cellular manufacturing is a lean manufacturing approach that involves grouping machines, processes, and workstations into self-contained cells to reduce material handling, waiting times, and inventory. The layout design of cellular manufacturing facilities has a significant impact on their efficiency, productivity, and throughput. However, traditional trial-and-error methods for facility layout design can be time-consuming, costly, and risky. Digital twin simulation offers a powerful alternative by allowing designers to create virtual models of the facility and test different layout configurations before physically implementing them. Our study shows that digital twin simulation can help identify the optimal layout design that maximizes productivity, minimizes waste, and ensures the smooth flow of materials and products. Additionally, it enables us to evaluate the impact of changes in the production system on the facility's performance, helping decision-makers make informed decisions. Overall, this paper highlights the potential of digital twin simulations as a powerful tool for optimizing cellular manufacturing facility layout design and improving operational performance.