Objectives: Pulpotomy works to retain a healthy tooth in the mouth till exfoliation by protecting the radicular pulp. The coronal pulp must be removed, and the radicular pulp must be given medication, in order to maintain the tooths health and function. Subject and Methods: The children who took part in this clinical investigation were chosen aged 4 to 8 years old, following approval from the Ethical Committee and obtaining signed informed consent from their parents. Based on the type of pulpotomy material used, the NHAp group and the PRF group, and 40 mandibular primary teeth that needed pulpotomy treatment were split into two groups (n=20). The split-mouth prospective clinical trial design for this study was authorized. Three distinct follow-up intervals of 6 weeks, six, and twelve months were used to note and evaluate the clinical and radiological outcomes. Results: The teeth treated with PRF had improved clinical and radiographic outcomes at the three distinct follow-up intervals of 6 weeks, 6, and 12 months, but there was no statistically significant difference between them and the teeth treated with NHAp. Conclusion: The results of the pulpotomized primary molars clinical and radiographic outcomes could be improved by using PRF as a pulp dressing agent.