Mandatory Treatment Research Articles

Can an Expert Opinion Mitigate Racially Biased Diversion Decisions? An Empirical Examination in the Context of Re-Offense Risk Assessment

Using a vignette-based experimental design, this study tested whether the racial or ethnic identity of a justice-impacted person influences jury-eligible individuals’ perceptions of post-conviction risk, placement (incarceration vs. community supervision), and need for mandated treatment. Furthermore, we examined whether the inclusion of data from a reoffense risk tool could mitigate racial bias. Participants recruited through Amazon’s MTurk ( N = 448) were randomly assigned to conditions varying by race/ethnicity of an examinee (Black, Latino, White) and if/how risk assessment data were included (no risk data, risk data only, and risk data reported by a qualified examiner). There was no statistically significant effect of the examinee’s racial/ethnic identity on ratings of reoffense risk or placement decisions; however, the Black examinee was more likely to be mandated with treatment. Regardless of examinee identity, participants exposed to risk information proffered by an expert more often calibrated their risk decisions to the examinee’s actual risk level.

In-plane electron transfer dominated carbon nitride for high-efficiency quasi-homogeneous photochemical synthesis of hydrogen peroxide

Layered materials are particularly striking at photochemical conversion, but the weakness of electron transfer and the lack of active surfaces severely limit their potential. Herein, a carbon nitride with enhanced electron transfer and abundant active surfaces (CNS) was prepared through suitable basicity assisted thermal polymerization of urea. The CNS exhibited a rate as high as 208 μM mg−1 h−1 for an easy-to-operable quasi-homogeneous photochemical synthesis of hydrogen peroxide (H2O2), and its internal quantum efficiency at multiple wavelengths is at least an order of magnitude higher than that of other prepared carbon nitride. Characterization and theoretical calculation confirmed that the quantum efficiency of electron transfer from in-plane to oxygen is superior to interplane. Moreover, the hydroxyl and cyanide groups of CNS greatly facilitates the proton-coupled electron transfer process for converting oxygen into H2O2. Our finding paves the way for applications of carbon nitride in mandatory water treatment and offers meaningful insights into modifying layered photocatalysts.

Pay-for-Performance Incentives for Home Dialysis Use and Kidney Transplant

The Centers for Medicare & Medicaid Services' mandatory End-Stage Renal Disease Treatment Choices (ETC) model, launched on January 1, 2021, randomly assigned approximately 30% of US dialysis facilities and managing clinicians to financial incentives to increase the use of home dialysis and kidney transplant. To assess the ETC's association with use of home dialysis and kidney transplant during the model's first 2 years and examine changes in these outcomes by race, ethnicity, and socioeconomic status. This retrospective cross-sectional study used claims and enrollment data for traditional Medicare beneficiaries with kidney failure from 2017 to 2022 linked to same-period transplant data from the United Network for Organ Sharing. The study data span 4 years (2017-2020) before the implementation of the ETC model on January 1, 2021, and 2 years (2021-2022) following the model's implementation. Receiving dialysis treatment in a region randomly assigned to the ETC model. Primary outcomes were use of home dialysis and kidney transplant. A difference-in-differences (DiD) approach was used to estimate changes in outcomes among patients treated in regions randomly selected for ETC participation compared with concurrent changes among patients treated in control regions. The study population included 724 406 persons with kidney failure (mean [IQR] age, 62.2 [53-72] years; 42.5% female). The proportion of patients receiving home dialysis increased from 12.1% to 14.3% in ETC regions and from 12.9% to 15.1% in control regions, yielding an adjusted DiD estimate of -0.2 percentage points (pp; 95% CI, -0.7 to 0.3 pp). Similar analysis for transplant yielded an adjusted DiD estimate of 0.02 pp (95% CI, -0.01 to 0.04 pp). When further stratified by sociodemographic measures, including age, sex, race and ethnicity, dual Medicare and Medicaid enrollment, and poverty quartile, there was not a statistically significant difference in home dialysis use across joint strata of characteristics and ETC participation. In this cross-sectional study, the first 2 years of the ETC model were not associated with increased use of home dialysis or kidney transplant, nor changes in racial, ethnic, and socioeconomic disparities in these outcomes.

Impact of Fruit Maturity on Internal Disorders in Vapor Heat Treated Mango Cv. ‘B74’

UN Sustainable Development Goal 12 (SDG 12) aims to reduce food losses in production and postharvest stages within supply chains. Identifying and addressing contributors to such losses is crucial to their reduction and to overall supply chain sustainability. Internal disorders (IDs) often contribute to postharvest losses and waste of highly perishable fruits like mangoes. Understanding and addressing influencers of susceptibility is limited but essential. Factors potentially associated with the expression of IDs in ‘B74’ mango commercial supply chains were investigated. Over three fruiting seasons (2020/21, 2021/22, and 2022/23), 43 export supply chains in Australia were monitored from two major production regions, the Northern Territory and North Queensland. Prior to export, the mangoes were subject to a mandatory phytosanitary vapor heat treatment (VHT) in which they were heated with saturated water vapor to a core temperature 46 °C maintained for 15 min and were then assessed for IDs at the end of their shelf life. The predominant IDs observed in the ‘B74’ fruit were flesh cavity with white patches (FCWP) and flesh browning (FB). VHT-induced FCWP, but not FB. Harvest maturity was identified as a predisposing factor. FB was generally positively correlated and FCWP was typically negatively correlated with fruit maturity at harvest. Relatively more-mature fruit was prone to FB irrespective of VHT, and relatively less-mature fruit was susceptible to FCWP post-VHT. Therefore, selective harvesting and/or sorting for optimum maturity after harvest can be practiced minimizing the incidence and severity of these two IDs in ‘B74’ fruit. Thus, dry matter (DM) sorting can contribute to postharvest loss reduction and the general sustainability of mango supply chains.

Implications of therapy interruption on monthly migraine days and modified migraine disability assessment in patients treated with erenumab for chronic and episodic migraine: SQUARE study interim results

BackgroundThere are limited real-world data in Switzerland examining the impact of erenumab, a fully human IgG2 monoclonal antibody targeting the calcitonin gene-related peptide (CGRP) receptor, on migraine-related quality of life.ObjectiveThis 18-month interim analysis of 172 patients with episodic or chronic migraine from the SQUARE study provides first prospective insights on the impact of mandatory erenumab treatment interruption, following Swiss-reimbursement requirements, in a real-world clinical setting in Switzerland.FindingsRecruited patients receiving 70 or 140 mg erenumab underwent treatment interruption on average 11.2 months after therapy onset with a mean duration of 4 months. There were sustained improvements in mean monthly migraine days (MMD) and migraine disability (mMIDAS) during initial treatment with erenumab. Treatment interruption was associated with a temporary worsening of condition. Symptoms ameliorated upon therapy reuptake reaching improvements similar to pre-break within 3 months.ConclusionsTreatment interruption was associated with a temporary worsening of condition, which improved again after therapy restart.

Effect of surface treatment and resin cement type on the bond strength of polyetheretherketone to lithium disilicate ceramic

BackgroundThis study aims to evaluate the effect of surface treatment and resin cement on the shear bond strength (SBS) and mode of failure of polyetheretherketone (PEEK) to lithium disilicate ceramic (LDC). This is suggested to study alternative veneering of PEEK frameworks with a ceramic material.Methodseighty discs were prepared from PEEK blank and from lithium disilicate ceramic. Samples were divided into four groups according to surface treatment: Group (A) air abraded with 110 μm Al2O3, Group (AP) air abrasion and primer application, Group (S) 98% sulfuric acid etching for 60 s, Group (SP) Sulfuric acid and primer. Each group was subdivided into two subgroups based on resin cement type used for bonding LDC:1) subgroup (L) self- adhesive resin cement and 2) subgroup (B) conventional resin cement (n = 10). Thermocycling was done for all samples. The bond strength was assessed using the shear bond strength test (SBS). Failure mode analysis was done at 50X magnification with a stereomicroscope. Samples were chosen from each group for scanning electron microscope (SEM). The three-way nested ANOVA followed by Tukey’s post hoc test were used for statistical analysis of results. Comparisons of effects were done utilizing one way ANOVA and (p < 0.05).ResultsThe highest mean of shear bond strength values was demonstrated in Group of air abrasion with primer application using conventional resin cement (APB) (12.21 ± 2.14 MPa). Sulfuric acid groups showed lower shear bond strength values and the majority failed in thermocycling especially when no primer was applied. The failure mode analysis showed that the predominant failure type was adhesive failure between cement and PEEK, while the remaining was mixed failure between cement and PEEK.ConclusionThe air abrasion followed by primer application and conventional resin cement used for bonding Lithium Disilicate to PEEK achieved the best bond strength. Primer application did not have an effect when self-adhesive resin cement was used in air-abraded groups. Priming step is mandatory whenever sulfuric acid etching surface treatment is utilized for PEEK.

Contribution of Livestock Farming to Environmental Pollution in China

Purpose: The aim of the study was to examine contribution of livestock farming to environmental pollution in China. Methodology: This study adopted a desk methodology. A desk study research design is commonly known as secondary data collection. This is basically collecting data from existing resources preferably because of its low cost advantage as compared to a field research. Our current study looked into already published studies and reports as the data was easily accessed through online journals and libraries. Findings: The study found that livestock farming in China significantly contributes to environmental pollution, posing substantial challenges to water, air, and soil quality. Intensive livestock operations, characterized by concentrated animal feeding operations (CAFOs), generate large quantities of animal waste containing nutrients and pathogens that contaminate water bodies. Additionally, livestock farming contributes to air pollution through emissions of ammonia and other pollutants, particularly in areas with intensive farming practices. Soil degradation and nutrient imbalance further exacerbate environmental degradation, with higher livestock densities associated with increased soil compaction and nutrient runoff. Unique Contribution to Theory, Practice and Policy: Tragedy of the Commons &amp; Ecological Modernization Theory may be used to anchor future studies on contribution of livestock farming to environmental pollution in China. Promote the adoption of sustainable livestock management practices through capacity building, training, and extension services for farmers. Encourage the implementation of integrated farming systems that optimize resource use, minimize waste generation, and enhance environmental resilience. Strengthen regulatory frameworks and enforcement mechanisms to ensure compliance with environmental standards and promote responsible livestock production. Implement stringent measures to control water pollution from livestock waste, including mandatory wastewater treatment and monitoring programs.

Screening children in conflict with the law in Kenya for mental health needs using the Massachusetts Youth Screening Instrument–Version 2

A growing body of research shows that justice-involved children, particularly those in conflict with the law, present with symptoms of a diagnosable mental disorder. Routine screening and assessment of young offenders assists justice actors in determining the most appropriate treatment interventions, ensures effective rehabilitation, and enhances public safety. Conversely, some child-justice jurisdictions such as Kenya have not integrated mental health screening for children entering the justice system. This lack of internal audit mechanisms by agencies can contribute to worsening of the young person’s mental status. This study sought to determine the mental health needs of 153 children in conflict with the law committed by courts to remand homes, reception centers, rehabilitation schools, Borstal institutions, youth corrective centers, probation hostels, and on community probation supervision in Nairobi country. Massachusetts Youth Screening Instrument Version-2 was used to screen the children. The findings revealed that thought disturbance in boys was the highest endorsed scale as 58.9% were within warning range scores. Clinically significant caution level scores were reported for somatic complaints (66.7%), angry-irritable (54.2%), and depressed-anxious (45.1%). There were statistically significant gender differences in somatic complaints (p = 0.021), suicidal ideation (p < 0.001) and traumatic experiences (p = 0.034). Respondents with a history of offending had higher mean scores in alcohol/drug use (M = 2.92, SD = 2.36). Significant differences were found between the institution where the child was screened and alcohol/drug use. The findings of this study could assist the Kenyan child justice system to institute mechanisms for mandatory mental health screening, assessment, and treatment of young offenders.

Treatment-relevant factors among adults receiving court-mandated substance use treatment: The role of emotion dysregulation.

Despite often being mandated to substance use treatment after release, many people on probation do not complete treatment. Several historical factors have been identified as relevant to substance use treatment in this population (i.e., past substance use, treatment history, and criminal history); however, less is known about the psychological characteristics, such as emotion dysregulation, that influence treatment-relevant factors among people in the criminal justice system. The present study used cross-sectional data to examine whether emotion dysregulation was associated with past-year substance use severity, engagement in prior drug and alcohol use treatments (yes/no, number of prior treatments), and previous criminal charges (total number of charges, number of charge types) in a sample of adults on probation who were receiving court-mandated substance use treatment (N = 163). We also examined whether these relationships varied across sex. Results showed that overall emotion dysregulation was more strongly linked to substance use severity and criminal charges for females than males. Emotion dysregulation dimensions of difficulties engaging in goal-directed behaviors and controlling impulsive behaviors when distressed were associated with more severe past-year substance use, more prior drug treatments, and a greater number of lifetime criminal charges and charge types. Emotion dysregulation plays a role in substance use treatment-relevant factors among people on probation. Sex-specific clinical implications of targeting emotion dysregulation in the context of mandated treatment in order to prevent treatment failures are discussed. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Efficacy and Acceptance of Cognitive Behavioral Therapy in Adults with Chronic Fatigue Syndrome: A Meta-analysis.

The systematic aggregation of research on cognitive behavioral therapy (CBT) in chronic fatigue syndrome (CFS) needs an update. Although meta-analyses evaluating interventions typically focus on symptom reduction, they should also consider indicators of treatment acceptability, e.g., drop-out rates. Randomized controlled trials (RCTs) investigating CBT in adults with CFS compared to inactive and non-specific control groups were included. First, efficacy was examined, considering fatigue, depression, anxiety, and perceived health. Secondly, drop-out rates through different trial stages were analyzed: Non-completion of all mandatory sessions, drop-out (primary study definition), treatment refusal (non-starters), and average of sessions completed. We included 15 RCTs with 2015 participants. CBT was more effective than controls in fatigue (g = -0.52, 95%CI -0.69 to -0.35), perceived health, depression, and anxiety at post-treatment. At long-term follow-up the effects were maintained for fatigue and anxiety. Rates of non-completion (22%, 95%CI 3-71), drop-out (15%, 95%CI 9-25), and treatment refusal (7%, 95%CI 3-15) were relatively low, with a high average proportion of sessions completed. Total time of therapy moderated the effect on fatigue, while the number of sessions moderated the effect on perceived health. Fatigue severity influenced adherence. The results indicate that CBT for CFS is effective in reducing fatigue, fatigue related impairment, and severity of depression and anxiety. Conclusions on efficacy at follow-ups are still limited. However, adherence is high in CBT. The results may help to inform clinical practice. Future research should focus on examining the maintenance of effects, while also emphasizing the importance of treatment acceptance.

The distribution of malocclusion using the index of orthodontic treatment needs at a university dental hospital in and around Pretoria, South Africa

: The study described the patterns of malocclusion traits and the orthodontic treatment needs at a Dental Hospital using the Index of Orthodontic Treatment Needs (IOTN), Dental Health Component (DHC). We evaluated 2079 pre-treatment study models and clinical records of orthodontic patients from the Department of Orthodontics waiting list. The assessment of malocclusion was measured according to the molar relationship using Angle's classification.The DHC was further used to assess the five malocclusion traits: - missing teeth, overjet, crossbite, displacement of contact point, and overbite, including open bite (MOCDO). The MOCDO score was calculated to determine the orthodontic treatment needed based on the DHC grades 1–5. The data was analysed using SPSS version 28 and the level of significance was set at p≤ 0.05.: The sample consisted of 59.3% (n=1232) females and 40.7% (n= 847) males. The mean age of the study sample was 14 years (SD±2.3) and ranged between 12 to 20 years. Angle's Class I malocclusion was found in 57.7% of the sample, followed by Class II (35.4%) and Class III (6.9%). The orthodontic treatment needs DHC grade were: 53% grade 4 (need for orthodontic treatment), 21% grade 5 (great need for orthodontic treatment), 17% grade 3 (borderline need for orthodontic treatment), 6% grade 2 (little need for orthodontic treatment), and 3% grade 1 (no orthodontic treatment need). A statistically significant difference was found in Angle Class I malocclusion and the DHC grades (p=0.001), as well as MOCDO variables and DHC grades (p=0.001).Angle's Class I malocclusion was the most predominant in our study sample compared to Class II and Class III malocclusions. The DHC of IOTN was successfully used to evaluate the severity of malocclusion with the majority of the sample in Grades 4 and 5, requiring mandatory orthodontic treatment. A high frequency of the occlusal traits included missing teeth, overjet, crossbite, displaced contacts and overbite. The results of our study showed that most patients on the orthodontic waiting list require mandatory orthodontic treatment. Therefore, it is recommended that DHC be used to place patients on the waiting list to prioritise orthodontic treatment.

Highlights of the 2022 Amendment to the Taiwan Mental Health Act

Abstract Background: Each country has each mental health act (MHA), which usually responds to the need of the society. Without exception, Taiwan has been through the enacting and amending the MHA since 1990. Methods: In the review, the authors intend to recount and to describe enacted or amended MHA in Taiwan. They are focusing on 2022 amendment to the MHA in Taiwan. Results: In Taiwan, the MHA with 52 articles was enacted in 1990, aiming at preventing and treating mental illnesses, safeguarding patient rights, promoting patient welfare, enhancing national mental health, as well as maintaining social harmony and tranquility. After several minor amendments, a significant revision took place in 2007. Since 2007, the focus of amendment to MHA was shifted from originally preventing and treating mental illnesses and protecting patient rights, to the addition of avoiding the stigmatization of mental illnesses. The goal of maintaining social harmony and tranquility was removed, but support and assistance for patients in community living were emphasized. The United Nations’ “Convention on the Rights of Persons with Disabilities” (CRPD), announced in 2006, serves as a crucial benchmark for the protection of the rights of persons with disabilities internationally. Taiwan’s implementation law for the CRPD was promulgated in 2014. According to the spirit of the CRPD, the 2022 Amendment to the MHA in Taiwan is intended to enhance the protection of the rights of patients with mental illnesses, to strengthen community support for patients, and to assist them in achieving equal living with others. The 2022 amended MHA in Taiwan comprises seven chapters and 91 articles, with key focuses on (a) promoting mental health, (b) establishing community mental health centers and diverse community support, (c) improving patient assistance and front-end prevention, strengthening patient reporting, and establishing crisis management mechanisms, (d) changing the approach to mandatory hospitalization treatment to involve judicial reservation, and (e) safeguarding patient rights, prioritizing criminal proceedings in cases of homicide and injury, and preventing stigmatization. Conclusion: The 2022 Amendment to the MHA in Taiwan is dedicated to more comprehensively caring for individuals with mental illnesses when concurrently safeguarding their rights, aligning with the modern societal emphasis on mental and physical health.

A nursing-led sepsis response team guiding resuscitation with point-of-care ultrasound: A review and model for improving bundle compliance while individualizing sepsis care.

A dysregulated host response to infection resulting in life-threatening organ dysfunction defines the onset of sepsis. Unfortunately, sepsis is common, costly, and deadly. The Surviving Sepsis Campaign publishes regularly updated, evidence-informed, detection, and treatment guidelines culminating in time-sensitive care "bundles." The goal of these bundles is to expedite sepsis recognition because it is widely held that early treatment is life-saving. Hospitals are mandated to publicly report their bundle compliance, and this will soon be tied to hospital reimbursement. For these reasons, hospitals are creating sepsis emergency response teams which are a form of a rapid response team consisting of dedicated medical professionals who evaluate patients with suspected sepsis and initiate therapy when appropriate. Evidence to date support sepsis emergency response teams as a mechanism to improve bundle compliance, and potentially, patient outcome. Nevertheless, some elements of bundled sepsis care are controversial (e.g., intravenous fluid administration) as some argue that mandated treatment precludes personalized care. Herein, we briefly describe general sepsis emergency response team structure, review evidence supporting sepsis emergency response teams to improve bundle compliance and patient outcome and report our unique experience incorporating point of care ultrasound-to guide intravenous fluid-into a nursing-led sepsis team. We propose that our sepsis emergency response team approach allays concern that sepsis care is either bundled or personalized. Instead, incorporating point of care ultrasound into a nursing-led sepsis emergency response team increases bundle compliance and individualizes care.

Clinical Outcomes with Prophylactic Corticosteroid Use for Axicabtagene Ciloleucel (axi-cel) in Patients with Relapsed/Refractory Large B-Cell Lymphoma (R/R LBCL): A Multicenter Analysis

Introduction: In Cohorts 1+2 of the ZUMA-1 Phase 1/2 study of axi-cel in R/R LBCL, 11% and 31% of patients (pts) experienced Grade ≥3 cytokine release syndrome (CRS) or neurologic evenets), respectively. To minimize the toxicities seen with axi-cel, a safety management cohort, Cohort 6 (N=40), was added to evaluate whether prophylactic (ppx) corticosteroids (CS) could decrease grade ≥ 3 CRS or ICANS. The 2-year update of ZUMA-1 Cohort 6 showed no grade ≥3 CRS and 15% grade ≥3 ICANS without any difference in objective response rate (ORR) or complete response rate (CR) when compared to cohorts 1+2 (Oluwole Blood 2022). The FDA had previously approved an update to the prescribing information for axi-cel to include use of ppx CS across all approved indications in January 2022. However, ppx CS is not a mandatory standard treatment and we sought to establish the clinical outcomes in the real-world practice. Methods: To assess the clinical outcomes of pts receiving ppx CS, we conducted a multicenter retrospective analysis of pts with R/R LBCL who were treated with axi-cel since the FDA approval of ppx CS in January 2022. Baseline characteristics, toxicities, and efficacy were compared between the no ppx and ppx CS groups. CRS and ICANS were graded based on ASTCT 2019 guidelines. Event-free survival (EFS) was defined as time from axi-cel infusion to progression, re-treatment, or death. Overall survival (OS) was defined as time from axi-cel infusion to death due to any cause. Results: A total of 66 pts at 5 centers received axi-cel between Jan 31, 2022, and June 20, 2023. Thirty-five (52%) pts received ppx CS, with a median age of 63 years (26-85 years). By histology, 75% (n=50) of the pts had DLBCL, 13.6% (n=9) had high grade B-cell lymphoma (HGBL), 9.1% (n=6) had transformed follicular lymphoma (TFL) and 1.5% (n=1) primary mediastinal LBCL (PMBCL). 59% of the pts (n=37) had IPI &amp;gt;2 and 66% (n=43) had stage III/IV disease. The baseline characteristics at the time of apheresis are shown in Table 1 and were comparable between the 2 groups, except for more HGBL, fewer prior lines of therapy and longer median time from apheresis to axi-cel infusion in the ppx CS group. Among the entire cohort, only 37% (n=25) met ZUMA-1 eligibility criteria at the time of lymphodepletion, and 67% (n=44) needed bridging therapy. Any grade CRS occurred in 88% (n=58) of the pts, with grade ≥2 CRS in 38% (n=25). Any grade ICANS occurred in 55% (n=37) of the pts, with grade ≥2 ICANS in 41% (n=27). Any grade ICANS was significantly lower in the ppx CS group than the no ppx group (45.7% vs 65.5%). The rates of any grade CRS, grade ≥2 CRS, grade ≥2 ICANS, the median time to CRS onset, ICANS onset, CRS duration, and ICANS duration were comparable between the 2 groups. Tocilizumab and steroids use was similar between two groups with a trend towards less ICU admission in patients in the ppx CS group. Overall, 14 (21%) pts developed infectious complications within 30 days of axi-cel infusion. The day 30 ORR was 84% and was comparable between the 2 groups (77% in the ppx group vs 93% in the no ppx group). The CR was 45.7% in ppx CS group compared to 65.5% in no ppx group. At a median follow up of 219 days (27-1178), 37 (56.1%) pts had progressed and 25 (37.9%) pts had died. The number of days to progress was significantly lower in the ppx CS arm. The median EFS and OS were not significant between the 2 groups. Conclusions: This multicenter retrospective study showed that the efficacy of treatment with axi-cel in R/R LBCL did not decrease with the use of ppx CS. No significant differences in efficacy or CAR-T-associated toxicities were noted in the 2 groups, potentially due to selective use with patients at presumed higher risk of severe CRS and ICANS. A larger dataset and longer follow-up is needed for risk-stratified analysis and the study is ongoing.

The metagenomic and metabolomic profile of the gut microbes in Chinese full-term and late preterm infants treated with Clostridium butyricum

The present study investigated the composition, abundance, and diversity of gut microbes in full-term and late-preterm infants from a medical center in eastern China. A total of 144 genomes of stool samples were captured for 16S rRNA metagenomic analyses. A high abundance of commensal intestinal bacteria was detected in these samples such as Phocaeicola vulgatus, Escherichia coli, and Faecalibacterium prausnitzii, indicating a relatively consistent diversity of gut microbes in the present full-term infants aged 38–40 weeks. However, late preterm infants (n = 50) with mandatory antimicrobials feeding exhibited lower diversity but a higher composition of opportunistic pathogens such as Enterococcus species. Centralized on the situation, we explored the regulatory effect of Clostridium butyricum as probiotics on these late preterm infants. The consumption of C. butyricum did not restore the composition of gut microbes altered by antimicrobials to normal levels, although several opportunistic pathogens decreased significantly after probiotic therapy including Staphylococcus aureus, Sphingomonas echinoides, and Pseudomonas putida. We also compared the effects of day-fed versus night-fed probiotics. Intriguingly, the nighttime feeding showed a higher proportion of C. butyricum compared with probiotic day-feeding. Finally, fecal metabolome and metabolites were analyzed in late preterm infants with (n = 20) or without probiotic therapy (n = 20). The KEGG enrichment analysis demonstrated that vitamin digestion and absorption, synaptic vesicle cycle, and biotin metabolism were significantly increased in the probiotic-treated group, while MSEA indicated that a series of metabolism were significantly enriched in probiotic-treated infants including glycerolipid, biotin, and lysine, indicating the complex effects of probiotic therapy on glutathione metabolism and nutrients digestion and absorption in late preterm infants. Overall, this study provided metagenomic and metabolomic profile of the gut microbes in full-term newborns and late preterm infants in eastern China. Further studies are needed to support and elucidate the role of probiotic feeding in late preterm infants with mandatory antimicrobial treatment.

Bayesian inference for spatio-temporal stochastic transmission of plant disease in the presence of roguing: A case study to characterise the dispersal of Flavescence dorée.

Estimating the distance at which pathogens disperse from one season to the next is crucial for designing efficient control strategies for invasive plant pathogens and a major milestone in the reduction of pesticide use in agriculture. However, we still lack such estimates for many diseases, especially for insect-vectored pathogens, such as Flavescence dorée (FD). FD is a quarantine disease threatening European vineyards. Its management is based on mandatory insecticide treatments and the removal of infected plants identified during annual surveys. This paper introduces a general statistical framework to model the epidemiological dynamics of FD in a mechanistic manner that can take into account missing hosts in surveyed fields (resulting from infected plant removals). We parameterized the model using Markov chain Monte Carlo (MCMC) and data augmentation from surveillance data gathered in Bordeaux vineyards. The data mainly consist of two snapshot maps of the infectious status of all the plants in three adjacent fields during two consecutive years. We demonstrate that heavy-tailed dispersal kernels best fit the spread of FD and that on average, 50% (resp. 80%) of new infection occurs within 10.5 m (resp. 22.2 m) of the source plant. These values are in agreement with estimates of the flying capacity of Scaphoideus titanus, the leafhopper vector of FD, reported in the literature using mark-capture techniques. Simulations of simple removal scenarios using the fitted model suggest that cryptic infection hampered FD management. Future efforts should explore whether strategies relying on reactive host removal can improve FD management.

Impact of stone quarries on groundwater quality at Achenkovil River Basin, Southern Western Ghats, India: Investigation using WQI and GIS

AbstractThe quality concern of groundwater owing to human activities is mounting at a shocking rate in many of the river basins in Southern India. A study was carried out in this work to determine the quality of groundwater in the Achenkovil River Basin (ARB) in the Southern Western Ghats region of Kerala, India. A total of 25 dug well water samples were collected from the vicinity of aggregate quarries during the pre and post monsoon seasons of 2020–2021. The water quality index has been applied to categorize the water quality, namely, excellent, good, poor, etc. to infer the quality of water to the people and policy makers in the concerned area. The WQI results showed that 12% of the water samples in good and 28% depict in very poor category. The Hill‐Piper Trilinear diagram reveals that the groundwater of the study area falls under Ca2+/Mg2+, and HCO3− and SO42−, Cl−, Mg2+ types. The hydro‐chemistry of the rock‐dominant water type of the quarrying area is inhibited by geogenic‐processes along with the percolation of prevailing quarry leachate and infiltration into the nearby wells. The correlation matrix has been created and analyzed to observe their significant impetus on the assessment of groundwater quality. The overall quality of groundwater systems in the quarrying area, according to the various indices, is not fit for domestic consumption without mandatory quality treatment, but is suitable for irrigation.

Effect of Sexual Empowerment Counseling on Self-efficacy, Assertive Sexual Communication, Self-awareness, and Sexual Attitude, Awareness of Sexually Transmitted Diseases, and HIV in Addicted Women - An Interventional Study

Background: Healthy and satisfying sex life is one of the important elements of well-being and quality of life in women. Objectives: This study aimed to investigate the effect of sexual counseling on self-efficacy, assertive sexual communication, self-awareness, sexual attitude, awareness of sexually transmitted diseases, and HIV in addicted women in mandatory drug treatment camps. Material and Methods: The present study was conducted on 68 women in two groups (intervention = 34, control = 34). The intervention group received the counseling program. The control group received routine services from the rehabilitation center. Results: The results showed that in the intervention group, 31 (100) before the intervention and 26 (86.7) 4 weeks after intervention (p = 0.05), had heard the name of STDs (p = 0.28). Moreover, 12 (38.7) participants in the intervention group and 12 (38.7) in the control group could name 4 symptoms of STDs in women 4 weeks after intervention (p = 0.001). Additionally, the sexual attitude was 44.64 ± 4.21 and 45.38 ± 4.09 in the intervention group and 40.66 ± 4.50 and 39.93 ± 4.71 in the control group 4 and 8 weeks after the intervention, respectively. (p = 0.01). Moreover, the obtained results showed that the mean score of sexual knowledge was 40.25 ± 3.62, 41.74 ± 3.44 and 36.36 ± 5.37 in the intervention group 4 and 8 weeks after the intervention, showing a significant difference (p = 0.02). Conclusion: The findings of this study showed that sexual knowledge, sexual attitude and selfefficacy, and sexual assertiveness could be improved through interventions based on skills and empowerment. In addition, by presenting knowledge on STDs, condom use for safe sex in addicted women can be increased.

Audit on non-invasive ventilation (NIV) in acute hypercapnic respiratory failure along with an introduction of proforma for acute NIV prescription

Hypercapnic respiratory failure is a cause of significant morbidity. It occurs in 20% of patients who are admitted with exacerbation of chronic obstructive pulmonary disease. Non-Invasive-Ventilation (NIV) is a mandatory treatment modality for them. The timely and accurate commencement along with the appropriate maintenance and weaning of NIV is crucial. In this audit cohort, most of the acute-NIV standards were not met as per the British Thoracic Society recommendations. Late detection, poor knowledge of acute NIV-Protocol, and maintenance of NIV has led to these suboptimal standards of the cohort. Therefore, we have suggested an NIV-Proforma to overcome them expecting a good outcome.

The hidden-zero effect in male individuals with opioid use disorder

ABSTRACT Background: Explicitly expressing the hidden opportunity cost in intertemporal choice significantly reduces healthy participants’ delay discounting – a phenomenon named the “hidden-zero effect,” which is undetermined in individuals with substance use disorder (SUD). Objectives: This study aimed to determine whether the hidden-zero effect occurs among individuals with opioid use disorder (OUD) and the degree to which this effect differs between the OUD group and healthy controls. Methods: In two different experiments, Exp#1) 29 male individuals with OUD (13.5 ± 6.0 months abstinence) and 29 male controls performed an intertemporal choice task (ICT); Exp#2) 28 male individuals with OUD (17.5 ± 5.6 months abstinence) and 27 male controls performed a delay discounting task (DDT). The OUD group was recruited from a mandatory treatment, and controls from WeChat. There were two choice conditions in both two tasks: the hidden-zero (H0) condition (standard), and the explicit-zero (E0) condition (explicitly expressing opportunity cost). Results: Compared with the H0 condition, all participants’ delay discounting was significantly decreased in the E0 condition (ps < .05, η p 2 = 0.254, 0.110). There was no significant difference in the changed degree between these two groups in either experiment (ps > .05). The delay discounting of the OUD group was significantly higher than that of controls only in Experiment 2 (p < .001, η p 2 = 0.376). Conclusion: This study extended the population in which the hidden-zero effect occurs to individuals with OUD. With respect to delay discounting, the hidden-zero effect benefit did not differ in OUD and control participants.