The aim of the paper is to present epidemiological situation concerning zoonotic diseases in Belgrade. It also presents the results of research in this area, for the period 1988-2007. According to the data in mandatory reports, to be sent to Institute of Public Health of Belgrade, in the past 20 years (1988-2007), there were 467,556 acute infections in Belgrade. Among them, zoonoses were present with 4,6% (21,536 cases), with average annual incidence rate of 66,5 and 0,09/100,000 populations mortality. The reports for cases of infectious diseases, annual reports, epidemiological polis and results of active research served as the source of our data. We have to monitor 13 zoonotic diseases as mandatory. Analysis of these data, shows the following frequency: asmonellosis is registered in 71,2% of the cases; Lyme borreliosis - in 19,3%; Trichenellosis in 7,4% and the cases of zoonotic diseases that had not been seen in many years in this area - brucellosis, Q- fever and tularemia. Due to the lack of diagnostic materials, we are unable to make laboratory confirmation of clinical presentation of the above diseases, which poses a huge problem for us. Another problem is the lack of proper surveillance over the persons injured by animals. Education for health, cooperation of healthcare and veterinary services are an important drawback in preventing and controlling zoonotic diseases.