Abstract In response to the escalating inventory of laboratory equipment, the inadequacy of traditional manual management practices has become increasingly apparent. Current management challenges are underscored by historical data, which reveals a borrowing rate of approximately 30%, a concerning return rate of only about 5%, and an equipment loss rate of 10%. To address these inefficiencies, this paper introduces an advanced, intelligent laboratory equipment management system leveraging STM32 and GM65 technologies, designed to significantly enhance the return rate and minimize equipment loss. The system is meticulously engineered, featuring three integral modules: the scanning module, the core board module, and the communication module. The scanning module employs GM65 technology to rapidly scan and decode QR codes, facilitating the swift transmission of critical data to the core board for intelligent processing and interaction with the laboratory equipment. At the heart of the system, the core board module serves as the central processing unit, adeptly managing data from the scanning module. It intelligently discerns various information types and dynamically updates the TFT-LCD screen with the current status of equipment, ensuring that all users have access to real-time and accurate information regarding the borrowing and returning of equipment. The communication module is pivotal in bolstering the system's connectivity capabilities. Designed with a robust structure, the system is characterized by its simplicity of operation and robust practicality. It not only significantly improves the efficiency of laboratory equipment management but also plays a transformative role in modernizing laboratory management practices. By streamlining the management process and ensuring the optimal utilization of resources, this system provides a solid foundation for the sustainable advancement of laboratory operations.