Sciatica (or sciatic neuritis) is a set of symptoms, including pain that may be caused by either general compression or irritation of one of five spinal nerve roots and sciatic nerve. The symptoms of Gridhrasi can be compared with Sciatica, in which a form of radicular pain in the peripheral nervous system is defined. Gridhrasi (Sciatica) is one out of eighty types of Vata Nanatmaja Roga under severe distressing syndromes among all neurological disorders. This review's objective was to determine the applicability of the Ayurveda treatment modalities in Gridhrasi Vyadhi (Sciatica). All the ancient Ayurveda texts and modern databases were selected as data sources for this study. The present study exhibited the five types of exploratory diagnostic methods and principles of treatment modalities according to ancient works of literature. Ayurveda, Snehana, Swedana, Vamana, Virechana, Basti, Siravedha, Raktamokshana, Viddha Karma, and Agnikarma were found to be the most common primary treatment procedures for Sciatica.