Risk Of Abuse Research Articles

Combat readiness, alcohol abuse, and posttraumatic stress disorder among Uganda peoples’ defence forces soldiers

BackgroundThis cross-sectional study assessed combat readiness, alcohol abuse and post-traumatic stress disorder (PTSD) among Uganda Peoples’ Defense Forces (UPDF) soldiers returning from Operation Lightning Thunder (OLT) in South Sudan and Central African Republic.MethodsOne hundred fifty participants recruited from UPDF soldiers who had recently withdrawn from OLT, and were based in Singo Peace Support Operation School were screened for combat readiness, alcohol abuse and PTSD. The Perceived Combat Readiness Questionnaire, Alcohol Use Disorder Identification Test, and PTSD checklist military version were used to measure the variables. Inferential analyses were performed to determine the association between combat readiness, alcohol abuse, and PTSD, while controlling for sociodemographic factors.ResultsWe found that 16% of UPDF soldiers met positive screening results for PTSD, and 21% met the positive screening results for moderate substance use disorder. UPDF soldiers who benefited from combat readiness were less likely to develop PTSD or alcohol abuse. Our results showed a mediating effect of alcohol abuse on combat readiness and PTSD among soldiers with UPDF.ConclusionOur results highlight the high rates of PTSD and alcohol abuse among UPDF soldiers returning from military deployment. These findings provide insight into the role of combat readiness in reducing the risk of alcohol abuse and vulnerability to PTSD in the aftermath of military deployment.

Cannabidiol exerts antipyretic effects by downmodulating inflammatory mediators in LPS-induced fever

Contrasting to tetrahydrocannabinol (THC), cannabidiol (CBD) has virtually no psychoactive effects and thus presents a minor risk for abuse. Furthermore, emerging preclinical and clinical evidence indicates that CBD exerts several beneficial pharmacological effects, including anti-inflammatory and antioxidant properties. Even though fever is one of the responses associated with systemic inflammation, no previous study assessed the putative impact of CBD on lipopolysaccharide (LPS)-induced fever. The present study aimed to evaluate whether CBD exerts effects on febrile responses, by modulating the hypothalamic-pituitary-adrenal (HPA) axis, and the inflammatory reflex, in this response. CBD caused no change in euthermic mice, indicating that it does not alter euthermia. Conversely, CBD blunted all the assessed systemic inflammation parameters including fever (a hallmark of infection), plasma pro-inflammatory cytokines and prostaglandin E2 (PGE2) surges, and hypothalamic PGE2 (the proximal mediator of fever) synthesis. Moreover, CBD also reduced LPS-induced increase in plasma corticosterone levels and spleen TNF-α. These data are consistent with the notion that CBD has antipyretic effects, reducing peripheral febrigenic signaling (plasma pro-inflammatory cytokines levels), and eventually down-modulating hypothalamic PGE2 production, possibly in a corticosterone- and inflammatory reflex-dependent manner.

Adverse childhood experiences, brain function, and psychiatric diagnoses in a large adult clinical cohort.

Adverse childhood experiences (ACEs) are linked to higher rates of psychiatric disorders in adults. Previous neuroimaging studies with small samples have shown associations between ACEs and alterations in brain volume, connectivity, and blood flow. However, no study has explored these associations in a large clinical population to identify brain regions that may mediate the relationship between ACEs and psychiatric diagnoses. This study aims to evaluate how patient-reported ACEs are associated with brain function in adults, across diagnoses. We analyzed 7,275 adults using HMPAO SPECT scans at rest and during a continuous performance task (CPT). We assessed the impact of ACEs on brain function across psychiatric diagnoses and performed mediation analyses where brain functional regions of interest acted as mediators between patient-reported ACEs and specific psychiatric diagnoses. We further evaluated the risk of being diagnosed with specific classes of mental illnesses as a function of increasing ACEs and identified which specific ACE questions were statistically related to each diagnosis in this cohort. Increased ACEs were associated with higher activity in cognitive control and default mode networks and decreased activity in the dorsal striatum and cerebellum. Higher ACEs increased the risk of anxiety-related disorders, substance abuse, and depression. Several brain regions were identified as potential mediators between ACEs and adult psychiatric diagnoses. This study, utilizing a large clinical cohort, provides new insights into the neurobiological mechanisms linking ACEs to adult psychiatric conditions. The findings suggest that specific brain regions mediate the effects of ACEs on the risk of developing mental health disorders, highlighting potential targets for therapeutic interventions.

Father–Child Relationship Quality and Social Functioning Among Children at Risk for Child Maltreatment

AbstractDespite the considerable growth and advancement in fatherhood research, relatively little is known about the effects of father–child relationship quality on social functioning among children who experience child maltreatment. Applying the strengths-based perspective, the current study sought to examine the association between father–child relationship quality and social functioning (social competence and positive peer relationships) among at-risk children, and to determine whether these associations are moderated by perpetrator type. This study included a sample of 681 US children (age 12 years) drawn from the Longitudinal Studies of Child Abuse and Neglect. We conducted a series of ordinary least squares multiple regression analyses. Higher-quality father–child relationships were associated with higher levels of social competence (B = 0.19, SE = 0.06, p = .002) and positive peer relationships (B = 0.05, SE = 0.02, p = .005). Significant interaction effects were found. The positive association between father–child relationships and peer relationships was significantly stronger among children with a history of maltreatment perpetrated by fathers with or without mothers (B = 0.16, SE = 0.05, p = .002). Findings highlight the importance of positive father–child relationships in building social resilience among children who experience maltreatment. Practitioners working with youth who are at risk for maltreatment should consider engaging fathers in services to support the development of strong father–child relationships.

Legal aspects of ensuring state Security of Ukraine with the help of artificial intelligence in the light of the experience of the Olympic Games in Paris 2024

In this article, the authors research the legal aspects of ensuring the State security of Ukraine with the help of artificial intelligence, taking into account the experience of the Olympic Games in Paris in 2024. The relevance of the research is due to the growing challenges to the use of artificial intelligence in public life and the need to respect the right to privacy. It is established that after lengthy discussions, the technology of face recognition using artificial intelligence was not introduced at the Olympic Games in Paris. It is substantiated that the main areas for improving the current regulatory framework in Ukraine for the use of artificial intelligence and ensuring the privacy of citizens and avoiding possible human rights violations are as follows: in the context of the introduction of face recognition technology, it is important to have detailed rules governing the scope and application of measures, as well as reliable safeguards against the risk of abuse and arbitrariness (the need for legal safeguards is much greater when it comes to the use of real-time face recognition technology); the processing of personal data in the application of face recognition technology must be justified and require a high level of justification; the use of face recognition technology for forensic identification of suspects. It is proved that when identifying real threats to the state security of Ukraine at the present stage in the context of the possible introduction of face recognition technology, it is important to have detailed rules governing the scope and application of measures, as well as reliable guarantees against the risk of abuse and arbitrariness. The inevitable need for legal guarantees for the implementation and protection of citizens’ privacy, especially when it comes to the use of real-time face recognition technology, is derived from the content of the State Security Strategy.

Assessing risk of physical child abuse recidivism using the HCR-20V3

Physical child abuse has been associated with a myriad of harms, not limited to physical injury. Thus, it is vital that children are protected. Forensic psychologists who are required to assess future risk of physical abuse often use the Historical-Clinical-Risk Management-20 Version 3 (HCR-20V3), a well-established tool for general violence. However, the validity of the HCR-20V3 amongst perpetrators of physical child abuse has not yet been established and, whilst there are likely to be similarities between the two groups, there may also be important differences. We explore the potential strengths and limitations of the HCR-20V3 when used with perpetrators of physical child abuse, with reference to the developing evidence base for this type of offence, including indications of unique risk factors that may merit additional attention.

Evaluating the effectiveness of Smoke-Free Home SafeCare, an integrated intervention, among families at risk for secondhand smoke exposure and child maltreatment in the United States: a study protocol for a hybrid type 1 trial

BackgroundSecondhand smoke exposure (SHS) and child maltreatment (CM) are preventable yet have negative lifelong impacts on health. When considered together, the risk for negative health outcomes may be compounded, especially for people living in low-resource settings. Evidence-based interventions exist for preventing CM and reducing SHS among families with low resources; however, no programs jointly target SHS exposure and maltreatment risk.MethodsThis study is a hybrid type 1 trial to examine the effectiveness of a systematically braided intervention to target CM risk and SHS in the home. Fifty SafeCare Providers will be randomized to deliver either standard SafeCare (i.e., the SafeCare model alone; active treatment control; n = 25) or Smoke-Free Home SafeCare (SFHSC; treatment condition; n = 25), the braided intervention that includes both SafeCare and the Smoke-Free Homes: Some Things are Better Outside intervention to N = 500 families. Aim 2 is to assess family-level outcomes. The primary outcome is a full home smoking ban, validated by air nicotine monitors; secondary outcomes include parenting and smoking outcomes. Aim 3 is to evaluate process and implementation outcomes, including cost–benefit. We will use multilevel models and ROC analyses to evaluate and validate the primary outcome. We will use tests of non-inferiority to evaluate secondary outcomes. Cost-effectiveness analyses will be used to assess cost–benefit of SFHSC.DiscussionThis study will be the first to document the outcomes of a multi-component intervention to address cumulative risk factors that impact cancer risk among children whose parents are at risk or involved in child-protective services. Integrating an evidence-based intervention that targets SHS exposure in the home with a broadly disseminated CM prevention intervention may be a sustainable way to help reduce the compounded effects of SHS in the home and CM.Trial registrationClinicaltrials.gov, NCT05000632. Registered on August 11, 2021.

The compromises and contradictions of ‘feminist’ sex and relationships education in the home: empowerment vs. protection in digital risk societies

ABSTRACT This paper discusses findings from interviews conducted in England with 15 self-identified feminist mothers about sex and relationships education in the home. Participants’ understandings and enactments of being sexuality educators for their children involved what they described as open and honest ‘sex positive’ communication with their children, based on their subjective views about gender and sexual rights, safety and wellbeing. Participants were concerned about protecting their children from oftentimes gendered risks of judgement shame and abuse. Feminist sex and relationships education in the home for these mothers was shaped, and sometimes constrained, by the gendered sociocultural conditions of their children’s lives. Implications are discussed regarding the need for self-reflexivity amongst feminist mothers, supported by collaborative local and community educational initiatives to identify and collectively tackle the social contexts in which risks and harms arise for children.

Risk of online abuse in social media: Legal and safety risk management strategies for athlete welfare in a technology-driven era.

Risk of online abuse in social media: Legal and safety risk management strategies for athlete welfare in a technology-driven era.

Dynamic polysaccharide/platelet-rich plasma hydrogels with synergistic antibacterial activities for accelerating infected wound healing

Platelet-rich plasma (PRP) has been recognized as an effective therapy in regenerative medicine and surgery, which can reduce the risk of antibiotic abuse and promote the healing of infected wounds. Recent advances in PRP-based treatments have focused on the controlled release of growth factors in PRP with biocompatible hydrogels and antimicrobial promotion by introducing hydrogel components or antibiotics, while the inherent antimicrobial activity of PRP is mostly neglected or sacrificed. Here, we demonstrate the combination of an antimicrobial polysaccharide, carboxymethyl chitosan, and PRP to construct an antimicrobial hydrogel via dynamic bonding with oxidized chondroitin sulfate. Significant inhibitory effects against Staphylococcus aureus and Escherichia coli (95 % of inhibition rate) are achieved through the synergistic contributions of the polysaccharide and PRP. Additionally, the resulting hydrogel promotes the migration of NIH-3T3 fibroblasts and collagen deposition by approximately 1.7 and 1.8 times, respectively, thereby accelerating the healing process of infected wounds. This work may bring new perspectives for potent applications of PRP-based hydrogel dressings for antibiotic-free management of infected wounds.

Strategi BNNK Sleman dalam Mengurangi Penyalahgunaan dan Peredaran Gelap Narkoba: Perspektif Collaborative Governance

Drug abuse and illicit trafficking remain pressing issues for Indonesia through 2024. This is evident from the increase in drug abuse prevalence in Indonesia by 1.73%, according to a National survey conducted in 2023. The widespread negative impacts make addressing this issue increasingly complex and multidimensional. Sleman has become one of the districts in Yogyakarta that receives special attention in this matter topic. Factors such as student migration, urbanization, and tourism development are the main drivers of the high risk of drug abuse in this area. BNNK Sleman is responsible for designing and implementing effective strategies to reduce and prevent drug abuse and illicit trafficking in the Sleman District. The primary goal of this study is to identify and analyze BNNK Sleman's strategies through the lens of Collaborative Governance. The research method used in this study is a descriptive qualitative approach, with purposive sampling selected as the sampling method. Data were collected through three main methods: direct observation, in-depth interviews, and documentation. The comparison of observational and interview data reveals that the principles of inclusiveness, transparency, accountability, cross-sector collaboration, face-to-face dialogue, and trust-building have been integrated into effective strategies with varying degrees of success. Active community participation, the use of digital technology, and strong accountability are key elements of this strategy. This study highlights the importance of enhancing transparency and accountability through technology to improve public participation and the sustainability of cross-sector collaboration, while also providing significant insights into the implementation of Collaborative Governance at the local level.

Purchasing medicines and functional foods on the internet: a cross-sectional study investigating the knowledge, attitudes, and experience of Vietnamese people in 2023

ObjectiveTo investigate Vietnamese people’s knowledge, attitudes, and experience in purchasing medicines and functional foods online.MethodsVia an online survey, the data of 1,070 participants were collected, including their general characteristics, Internet use, previous experience, knowledge, and attitudes towards purchasing medicines/functional foods online. Factors associated with their knowledge and attitudes were identified via multivariate linear regression models.ResultsDuring 2022–2023, about 97.2% of participants used the Internet to seek health information (self-diagnosis: 65.0%, self-medication: 72.6%). Roughly 52.8% bought medicines and/or functional foods online. Among 565 buyers, 41.8% felt satisfied. Only 19.9% understood that selling medicines online was illegal in Vietnam. The main benefits of purchasing medicines/functional foods online that many people agreed on included convenience (87.1%), freedom from location (84.8%), and being able to order/buy products after opening hours (84.7%). Many people felt worried about the ability to buy counterfeit or substandard products (87.7%), inaccurate product information (85.0%), the lack of supervision of the authorities (83.7%), and increasing risks of drug abuse, self-medication, and treatment non-adherence (82.5%). Roughly 84.3% found distinguishing between legal and illegal online pharmacies difficult. Participants’ average knowledge and attitude scores were 6.514 ± 2.461 (range: 0–16) and 89.330 ± 13.720 (range: 23–115), respectively. The main factors associated with people’s knowledge and attitudes towards purchasing these products online included their frequency of Internet use, seeking health information online for self-medication, feeling satisfied with previous experience, and having at least one chronic disease.ConclusionsMany Vietnamese people’s knowledge about purchasing medicines/functional foods online was limited. With the increasing need for online shopping, enhancing their knowledge is paramount. In the forthcoming years, when the Ministry of Health and relevant authorities publish legal documents and enact laws involving online pharmacies and trading medicines on the Internet, ways to recognize licensed online pharmacies must be widely propagated and disseminated in the community.

Health Workers in Sexual and Gender Based Violence (SGBV) Care for Refugees: Insights from Frontline Health and Humanitarian Professionals in Rhino Camp Refugee Settlement, Uganda

In the wake of the COVID-19 pandemic, a marked global increase in cases of Sexual and Gender Based Violence (SGBV) has been noted (Johnson et al. 2020). In the refugee settlements of Uganda, this is dramatically illustrated by an escalating crisis of teenage pregnancies (UN Women 2020; Diallo et al. 2023). During lockdowns, conflicts among families and couples increased and vulnerable community members, particularly children and young people, were exposed to heightened risks of abuse (Datzberger et al. 2023). For the humanitarian community, the escalation of the past years highlights the urgent need to sustainably improve SGBV prevention, care and case management in refugee settings.

How the COVID-19 Pandemic Influenced Veteran Parents’ Harsh Parenting: Do Parental PTSD and Parental Role Matter?

AbstractPrior studies show a heightened risk of child maltreatment during the COVID-19 pandemic because of financial difficulties and parenting stress, but little is known about what happened to the veteran families. This study aimed to examine the influences of the COVID-19 pandemic on veteran parents’ harsh parenting – creating a potential for child maltreatment. Further, we explored the potential moderating effects of parental PTSD and parental role on the association between COVID-19 impacts and veteran harsh parenting. We recruited 509 veteran parents from Qualtrics online research panel and assessed the impacts of the COVID-19 pandemic (e.g., perceived threat, financial and psychological impacts) on the participants, parental PTSD, and parents’ past year prevalence of corporal punishment and psychological aggression. We used Mplus 8.8 to build main models, two-way moderation models, and three-way moderation models. There was a significant association between COVID-19 pandemic impacts and harsh parenting (Corporal punishment: β = 0.09, p < 0.05; Psychological aggression: β = 0.10, p < 0.05), while parental PTSD was a significant moderator (Corporal punishment: β = 0.10, p < 0.05; Psychological aggression: β = 0.08, p < 0.05). Parents with higher levels of PTSD were more vulnerable to the negative influences of COVID-19 on their harsh parenting. However, the association between COVID-19 pandemic impacts and harsh parenting did not differ by parental role. Our study findings contribute to the current knowledge of veteran families during the COVID-19 pandemic and provide implications for both Veteran Affairs services and child protective services.

Marriage migration, intimacy and genre in Helen Hoang’s The Bride Test (2019) and Brigitte Bautista’s You, Me, U.S. (2019)

A significant strand of cultural and social studies research on late modernity has focused on intimacies; in particular, ‘mediated intimacies’ (Attwood et al., 2017; Barker et al., 2018; Gill, 2009), exploring how the media, in its various forms, represents and affects intimate relationships. Romance fiction, the most popular global genre, offers a key source text for exploring intimate and romantic relationships and the ways culturally and politically specific forms of intimacy are shared transnationally. Of particular interest is the increase in the twenty-first century of romantic stories that deal with the intersection of intimacy and migration. This article brings together critical work on intimacy and affect, scholarship on popular romance, and research on migration and transcultural exchange to explore how contemporary Anglophone popular romance fiction mediates intimate relationships in the context of migration. Focusing on two romance novels featuring South East Asian migration to the USA — Brigitte Bautista’s You, Me, U.S. (2019) and Helen Hoang’s The Bride Test (2019) — I explore how these novels represent marriage migration and its relationship to and impact on intimacy. Both novels are aware of existing stigmas around marriage migration (the risk of abuse or fraudulent marriage), but the association of marriage with ‘authentic’ romantic love in the romance genre ultimately serves to uphold such stigmas, rather than challenge them. The texts pay equally close attention to the performativity of romantic love, noting how heteronormative, western norms of romance are required for migrants but, in the case of You, Me, U.S., can also be queered. These texts are concerned with the movement of people and cultures while themselves travelling across borders as products of a transnational, global publishing market. These fictions, then, showcase how their particular articulations of intimacy offer new insights for scholars interested in marriage migration.

A Review of Academic Use of the Term "Minor Attracted Persons".

Although it originated within online pro-pedophile groups, the term "minor attracted person" (MAPs) has been adopted by some academic researchers as a neutral and non-stigmatizing alternative to the term "pedophile." The transferral of this term from pedophile advocates to academic scholarship has been highly controversial. Claims that the use of the term "minor attracted people" normalizes or endorses pedophilia deserve closer scrutiny. This paper is based on a rapid evidence review of all peer-reviewed papers between 2015 and 2023 that used variants of the term "minor attracted" in their title and/or abstract. After screening, 30 studies were identified for review. Our analysis took a thematic approach to understanding the construction and use of the term MAPs in this scholarship. The analysis found that the term MAPs was operationalized in different and contradictory ways, however, the literature broadly agreed that MAPs constitute an oppressed sexual minority who are subject to undue stigmatization and discrimination. We point to the similarities between this sympathetic framing of MAPs and the political goals of the pro-pedophile advocacy groups that created the term MAPs, and from which many MAPs studies recruit their research participants. The review concludes that, in the absence of adequate self-reflexivity and awareness of bias, academic collaborations with pro-pedophile groups can produce work that minimizes the risk and harm of child sexual abuse and has the potential to delegitimize child sexual abuse prevention and treatment efforts.

Between a rock and a hard place: domestic abuse and being a migrant woman in England and Wales

Legal responses to domestic abuse have been a political priority of the UK Government since at least 2010, eventually leading to the passing of the seminal legislation in this area for England and Wales, the Domestic Abuse Act 2021. However, the exclusion of protection for migrant victim-survivors with precarious immigration statuses under the Act demonstrates a failure in understanding that the experience and risk of domestic abuse differ for these individuals from that of the mainstream, due to their intersectional identities as (predominantly) migrant women. Many migrant victim-survivors still find themselves trapped in abusive situations, as the law fails to safeguard their rights to reside legally should they choose to present themselves to authorities by reporting their abuse. A distinct lack of acknowledgment as to inequalities faced by those at the intersection of migrant status and gender (Crenshaw, 1989; 1991) has led to increased insecurity for some of the most vulnerable. This article shines a light on this discrimination under the law in England and Wales. It adopts an intersectionality framework to examine such inequality, analysing Appendix Violence Domestic Abuse and the Migrant Victim Domestic Abuse Concession in UK immigration law, as well as the Support for Migrant Victims Pilot and its relevant Evaluation Report, against the international standards of the Istanbul Convention. It argues that the UK Government is failing to tackle the problem of migrant victim-survivors’ protection concerning domestic abuse, and in some situations, has made it worse.This article aims to state the law as of 1 May 2024.

Research on Network Security and Privacy Protection Technology of Autonomous Vehicle

With the rapid development of information technology and the increasing maturity of intelligent transportation systems, autonomous vehicles, as an important carrier of future travel, are gradually moving from concept to commercial application. However, the highly connected and intelligent nature of autonomous vehicles also makes them face unprecedented cybersecurity and privacy protection challenges. This paper deeply discusses the security threats and privacy disclosure risks of autonomous vehicles in network architecture, data transmission, data processing and other links, and systematically reviews the current technical means and research progress to address these challenges. This paper Outlines the data collection and transmission mechanism of autonomous vehicles, including the collection and processing of sensor data as well as the communication process between vehicles and the cloud, other vehicles and transportation infrastructure, and analyzes in detail the network security threats faced by autonomous vehicles, including remote control attacks, malware attacks, communication hijacking, etc. These threats can lead to serious consequences such as vehicle failure, data breach, or system crash. At the same time, the paper also points out the challenges faced by autonomous vehicles in terms of privacy protection, such as the risk of leakage of sensitive data such as personal location information and driving habits, as well as the risk of data abuse and sharing. In order to address the above challenges, this paper focuses on the technical research progress of cybersecurity and privacy protection of autonomous vehicles. In the aspect of network security, this paper discusses the key technical means such as data encryption, access control, intrusion detection and response system, and emphasizes the importance of security hardware and software in improving the overall security of the system. In terms of privacy protection, this paper proposes strategies such as anonymization and desensitization technology, privacy protection protocols and standards to protect users' privacy from invasion.

Mental health conditions of Colombian adolescent population: An approach to risk.

To determine the mental health conditions of adolescents in the city of Manizales, Colombia, and explore risk regarding gender-based differences. Quantitative, nonexperimental, descriptive research with associative scope. A total of 316 adolescents were assessed using five scales to evaluate mental health conditions: the Perceived Stress Scale, Patient Health Questionnaire-9, Generalized Anxiety Disorder Scale, Penn Alcohol Craving Scale and The Substance Dependence Severity Scale. Univariate and bivariate analysis was performed, Chi square and Odds Ratio were tested. The findings indicated that being female is a risk factor for high levels of perceived stress, depressive episodes and anxiety. Additionally, adolescents who are not attending school are at higher risk for dependence and abuse of psychoactive substances. Conversely, being female acts as a protective factor against dependence on psychoactive substances. The findings suggest a higher tendency among the participants towards experiencing depressive episodes. Regarding perceived stress, 71.5% of the participants fell into the low category, while 70.6% experienced a current episode of generalized anxiety.

Adverse childhood experiences and multimorbidity of internalising and cardiometabolic conditions in an older-age population.

BackgroundTackling multimorbidity (ICM-MM) of internalising conditions (IC) and cardiometabolic conditions (CM) is key to improving the future of healthcare. Early life factors such as adverse childhood experiences (ACEs) have been linked to long term, poor mental and physical health conditions. AimsThis study investigated whether: 1) ACEs increase the risk of IC, CM and ICM-MM; 2) the effect of ACEs on risk of developing CM depends on the presence of IC and vice versa; 3) how risk differs by gender, socioeconomic status and ethnicity. MethodsIn UK Biobank, the Childhood Trauma Screener was used to identify 157,256 participants with ACE data. Electronic healthcare records (EHR) and interview data identified those with anxiety or depression (IC) and those with hypertension, obesity, type 2 diabetes, dyslipidaemia or chronic kidney disease (CM). Multivariate logistic regression models were employed to find associations between ACEs and IC, CM and ICM-MM. Covariates included age, gender, ethnicity, socioeconomic status, diet, alcohol intake, smoking behaviour and physical activity. ResultsAll ACEs significantly increase risk for IC (all ACEs, p = <2e-16). Emotional neglect, physical neglect and emotional abuse increase risk of CM (e.g. physical neglect, OR = 1.43, CF = 1.30-1.58, p = 1.88e-13). ACEs appear to increase IC and CM risk independently. ConclusionsThe effects of ACEs last well into adulthood and confer risk for IC and, sometimes, CM. ACE history should be included in routine primary care and the development of therapeutic interventions tailored to older adults with ACEs is key to reducing poor health.