This article presents a case study illustrating the successful management of skeletal Class III malocclusion in an adult through an orthodontic-surgical approach. The clinical case outlines the entire process, from initial assessment to post-treatment outcomes, conducted within our service. Key steps include diagnostic planning using advanced tools such as 3D imaging and virtual surgery simulation. Pre-surgical orthodontic treatment was carefully planned to prepare dental and skeletal structures for surgical correction. Orthognathic surgery was performed precisely according to the established plan, followed by a post-surgical orthodontic phase to finalize occlusion. Short-term and long-term outcomes are evaluated, highlighting significant improvement in facial aesthetics, occlusal function, and post-treatment stability. This case study demonstrates the effectiveness of our integrated approach in managing skeletal Class III malocclusions in adults, underscoring the importance of interdisciplinary collaboration for optimal outcomes