Malignant Proliferating Trichilemmal Tumor Research Articles

Malignant proliferating trichilemmal tumor post-chemotherapy: A case report

The malignant proliferating trichilemmal tumor (MPTT) is an exceptional adnexal neoplasm of the skin, primarily observed in the scalp of elderly women, often precipitated by local trauma or chronic inflammation. Notably, MPTT exhibits a propensity for local aggressiveness, frequently leading to diagnostic challenges reminiscent of squamous cell carcinoma. The primary treatment modality entails surgical excision with adequate margins, yielding a relatively low local recurrence rate. Herein, we present the case of a 50-year-old woman diagnosed with MPTT of the scalp several years subsequent to undergoing chemotherapy for breast cancer, initially misdiagnosed as squamous cell carcinoma upon biopsy. This case marks only the third reported instance associating MPTT with chemotherapy following breast cancer treatment. We aim to draw attention to this particularly aggressive tumor and its potential origination from benign trichilemmal cysts due to chemotherapy.

Prevention of recurrence in malignant proliferating trichilemmal tumor of scalp in young female using adjuvant radiation therapy after surgery

Background: Proliferating trichilemmal tumors (PTTs) are rare benign neoplasms that arise from the outer sheath of a hair follicle. Group III PTTs are high-grade malignant tumors reported to exhibit a high recurrence rate, lymph nodes, and a tendency to develop distant metastasis. Case Presentation: A 25 years old female patient was presented to us with a history of recurring soft tissue scalp lesions. The lesion recurred three times within 1 year. There was no history of trauma. Every time the lesion was excised but no histopathology of the specimen was done. Upon the third recurrence, it came out to be a malignant proliferating trichilemmal tumor (MPTT). Considering the young age of the patient and keeping in view the history of multiple recurrences with positive deep margin even after the third surgery, the patient was planned external beam radiotherapy (RT) 50 Gy/25 fx to scalp with 9 Mev electron using 0.5 cm bolus. The post-RT follow-up currently of 2 years is uneventful. Conclusion: The mainstay of treatment is surgery with wide surgical margins as local recurrence is most common in MPTT. Adjuvant RT was used in this case to prevent recurrence.

Malignant proliferating trichilemmal tumor: a rare neoplasm in a rarer location. Case report and review of the literature

Malignant proliferating trichilemmal tumor (MPTT) is an uncommon and malignant tumor of the skin, arising from the outer root sheath of the hair follicle. Most MPTTs occur in the head and neck area and affect the scalp predominantly. However, rarely, MPTT of other anatomical sites, such as back, buttocks, chest, elbow, vulva, mons pubis … Continued

Malignant proliferating trichilemmal tumor of thigh: a case report of an unusual location of a rare cutaneous adnexal tumor

Proliferating trichilemmal tumour (PTT) is a well-circumscribed dermal or subcutaneous neoplasm with squamoid cytologic features and trichilemmal-type of keratinization. Usually, proliferating trichilemmal cysts are benign, although rarely, can undergo malignant transformation, at which point they are referred to as malignant proliferating trichilemmal tumours (MPTTs). Ninety percent of PTTs occur on the scalp, but they have also been found on the forehead, nose, back, chest, abdomen, buttocks, elbow, wrist, mons pubis and vulva. Here a case of an 89-year-old woman with a malignant proliferating trichilemmal tumour of right thigh is discussed, which is a very rare site for occurrence of the same.

Auricular Malignant Proliferating Trichilemmal Tumor: A Case Report.

Malignant proliferating trichilemmal tumor (MPTT) is a dermal adnexal tumor originated from the external root sheath of hair follicles. In this article, we reported a rare case of auricular MPTT in a 65-year-old male with gradually enlarging and bleeding mass on the right auricle measuring 30 × 20 × 12mm in size and detailed the surgical strategy for therapy. The diagnosis of MPTT was established primarily by histopathological observation with abrupt keratinization, cytological atypia, abnormal mitoses, and infiltrating margins. Following extensive excision, no recurrence was noted for 14months. We also discuss its clinicopathological features, differential diagnoses, and treatment methods and review the relevant literature in this regard.

Proliferating Trichilemmal Tumor: A Case Study

Proliferating trichilemmal tumor (PTT) is a scarce tumor of exterior root sheath that appears to grow within the wall of a pre-existing pilar cyst in most cases. This report presents a case of malignant PTT in the posterior sacrum of a 33-year-old man presenting with limited mobility and a history of paraplegia.

MALIGNANT PROLIFERATING TRICHILEMMAL TUMOR ONE CASE AND LITERATURE REVIEW

Proliferating trichilemmal tumors (PTTs) are uncommon lesions. PTT is thought to originate from the trichilemmal cyst (TC) and have the potential for malignant transformation, at which point it is termed a malignant proliferating trichilemmal tumor (MPTT). we report an observation of a 55-year-old lady patient presenting with a malignant proliferative trichilemmal tumor, emphasizing the aggressive, rapidly extensible and metastatic character. MPTTare aggressive tumors with a bad prognosis, the treatment of which is based on surgery with margins of 1 cm, lymph node dissection in the event of lymph node involvement and radio-chemotherapy.

Malignant Proliferating Trichilemmal Tumor: A Subtle Presentation in an African American Woman and Review of Immunohistochemical Markers for This Rare Condition

A malignant proliferating trichilemmal tumor (MPTT) is thought to represent the malignant counterpart of a benign proliferating trichilemmal cyst, a keratin-filled lesion that derives from the outer hair root sheath. The clinical appearance of MPTTs does not always correlate with their histopathologic behavior, emphasizing the need for biopsy and histopathological analysis. Here, we present a 46-year-old African American woman who was evaluated for an ostensibly benign cyst on her scalp that was diagnosed as an MPTT following histopathological examination. She was treated with simple surgical resection that was flush with the cyst margins, followed by Mohs surgery to ensure complete resection. As immunohistochemistry (IHC) has often been used to characterize MPTTs, we also review the various IHC markers reported in the literature.

Malignant proliferating trichilemmal tumor of the scalp: A rare entity and a mimicker of squamous cell carcinoma

Malignant proliferating trichilemmal tumor (PTT) is a rare adnexal tumor with follicular differentiation. It mainly occurs in the scalp region of elderly females. It is a solitary, large ulceroproliferative lesion that can have an aggressive clinical course with metastases. Clinically and histologically, it is a close mimicker of squamous cell carcinoma. We report a middle-aged female who came with sudden enlargement of a longstanding nodular scalp lesion in the left parietal region. Incisional biopsy revealed a malignant PTT of the scalp. She underwent wide local excision of the mass and is doing well without any evidence of recurrence after 5 months of follow-up.

Cranial vault tumor: malignant proliferating trichilemmal tumor of the scalp

Proliferating trichilemmal tumor (PTT) is a rare cutaneous tumor that mainly occurs in the scalp, eyelids, neck, and face of elderly women. In most cases, it is a unique, large, multi-lobulated, cystic lesion originating from a hair follicle. These tumors are mostly benign and are characterized by trichilemmal keratinization. However, in rare cases, they may be aggressive with a propensityfor distant metastasis.We report the case of a 69-year-old male patient, who presentedwith as welling on his forehead that had rapidly increased in size over the past year. CT scan and magnetic resonance imaging (MRI) showed a tumor located on the cranial vault, associatedwith an intracranial extension. Chest X-ray and CT scan found a tumor in the right lung. The patient underwent surgery for the removal of the tumor. The histological examination confirmedthe diagnosis of malignant PTT (MPTT). To the best of our knowledge, only a few cases of MPTT have been published. Furthermore, only one case of MPTT of the scalp with endocranial extension and lung metastasis has been eported to date.Through this case, we discuss the prognostic factors and the management of this aggressive lesion.

Atypical Proliferating Trichilemmal Cyst with Malignant Breast Skin Transformation: A Case Report and Review of the Literature.

Proliferating trichilemmal tumors (PTTs) are benign adnexal skin neoplasms that arise from the outer root sheath of the hair follicle. These tumors are most commonly observed on the scalp and occur, most of the time, in elderly women. Malignant transformation of these neoplasms is a rare event; less than 50 cases have been reported in the English medical literature. We present the case of a 39-year-old Hispanic woman with a tumor located on the skin of one of her breasts that in her third surgical procedure the histologic examination revealed the presence of a malignant proliferating trichilemmal tumor (MPTT). Furthermore, a review of the medical literature and a discussion of the clinical and pathologic features of this rare entity are provided.

Malignant proliferating trichilemmal tumor of the scalp with secondary infection in an elderly man

A 65-year-old man presented with the complaints of a growth on the scalp, which ruptured spontaneously leading to bleeding and foul smelling discharge associated with severe pain. Examination revealed ulceroproliferative growth with slough and surrounding induration, infested with maggots. Histopathological examination revealed proliferating trichilemmal tumor (PTT) with secondary infection. Wide excision of the tumor was done with 1 cm margin all around it. PTT is a benign neoplasm that can rarely undergo malignant transformation thought to originate from trichilemmal cyst. Malignant PTT (MPTT) predominantly affects the scalp, eyelids, neck, and face and the treatment recommended being a wide local excision.

Squamous Cell Carcinoma of the Scalp Masquerading as Trichilemmal Tumor of the Scalp

ABSTRACT Background Adnexal components tumors of the skin are very rare and are seen as benign lesions of the scalp in aged women. Trichilemmal tumor is usually benign and rarely under-goes malignant transformation in a stepwise manner starting with an adenomatous stage of the trichilemmal cyst to an epitheliomatous stage of the proliferating trichilemmal tumor (PTT) evolving into the carcinomatous stage of the malignant proliferating trichilemmal tumor (MPTT). Case report A 53-year-old woman reported with huge swelling in the posterior region of the scalp. The swelling was mobile and soft to firm in consistency not fixed to the skull bone. The surface was smooth and getting under the swelling was not possible, needle biopsy reported as trichilemmal tumor. Contrast enhanced computed tomography (CECT) neck did not show any nodes in the neck, especially the posterior compartment. The tumor was widely excised with 1 cm margin and the periosteum was kept intact with split skin graft. An area of periosteal adher ence to the tumor seen was excised. The histopathology report on serial sectioning reported grade 1 moderately differentiated squamous cell carcinoma (SCC). Postoperative external beam radiotherapy of 66 Gy was given. The patient is being followed up and no recurrence is seen. Conclusion Malignant transformation in a proliferating trichilemmal tumor a rare entity and should be differentiated from SCC and the better prognostic trichilemmal carcinoma. A protocolbased adjuvant therapy is available for squamous cell carcinoma but not for trichilemmal carcinoma (TLC) and MPTT. A major meta-analysis may help to establish a clinical outcome-based classification and management protocol for these tumors. How to cite this article Nanjundappa A, Halkud R, Venugopal B, Chavan P, Sidappa KT, Biswas S, Samskruthi M, Naik SM. Squamous Cell Carcinoma of the Scalp Masquerading as Trichi-lemmal Tumor of the Scalp. Int J Head Neck Surg 2014;5(3):144-147.

Rare Case of a Malignant Proliferating Trichilemmal Tumor: A Case Report

Proliferating Trichilemmal tumors (PTT) are rare neoplasms of the external root hair sheath that are largely benign. The potential for PTT to undergo transformation to a Malignant Proliferating Trichilemmal Tumor (MPTT) is unknown, with only about 40 cases of MPTT having ever been reported. We present an exceedingly rare case of a 22-year-old female who presented with an 8 cm mass of her anterior chest which was initially diagnosed as a squamous cell carcinoma and later classified as malignant proliferating trichilemmal tumor. In this case report we discuss the diagnosis, histo-pathological characteristics, and surgical treatment of such tumors. doi: http://dx.doi.org/10.4021/jmc1007e

Malignant proliferating trichilemmal tumor

Proliferating trichilemmal tumor (PTT) is a benign tumor originating from the outer root sheath of a hair follicle. Malignant transformation in case of PTT is very rare and unusual finding. It is usually confused with squamous cell carcinoma both sharing many common features. So the identification of malignant PTT is very essential. Only 39 well-documented cases of malignant proliferating trichilemmal cyst have been published to date in the English language literature. We hereby present a case of a 75-year-old female patient with a rapidly growing swelling on the scalp.

Malignant proliferating Trichilemmal Tumor Involving the Sinuses

Proliferating trichilemmal tumor (PTT) is a rare adnexal neoplasm that arises from the outer sheath of the hair follicle. It is believed that PTTs originate in trichilemmal cysts. These tumors have the potential for malignant transformation; when this occurs, the tumor is known as a malignant PTT (MPTT). Recurrence after simple local excision is common, and it can cause considerable morbidity. We report a case of MPTT that was initially diagnosed as a benign PTT. The primary tumor had arisen from the skin over the glabella. It was excised, but it recurred 3 years postoperatively. The recurrent tumor involved the eyelid, nasal cavity, and frontal and ethmoid sinuses, and it extended into the orbit. The recurrent tumor was excised via combined endoscopic and open surgery. As far as we know, this is the first documented case of an MPTT that involved the sinuses.

La tumeur trichilemmale proliférante maligne

Proliferating trichilemmal tumor (PTT) is a rare distinctive lesion that usually occurs in the scalp of elderly women. About 40 cases of malignant PTTs have been reported. Alternatively, some authors have proposed that all PTT are squamous cell carcinomas. We report a case of a malignant PTT on the scalp in 44-year-old man. Clinical features and histological criteria for diagnosis of malignant versus benign PTT are discussed.

Proliferating Trichilemmal Tumors: A Review of the Literature

Proliferating trichilemmal tumors (PTTs) are uncommon lesions whose histologic hallmark is the presence of trichilemmal keratinization. PTT is thought to originate from the trichilemmal cyst (TC) and have the potential for malignant transformation, at which point it is termed a malignant proliferating trichilemmal tumor (MPTT). These lesions may cause considerable morbidity and even mortality, and recurrence after simple local excision is common. The objective was to review the clinical presentation, histopathologic characteristics, malignant potential, and treatment options for PTT. The English literature was reviewed regarding PTT, TC, and MPTT. PTT generally presents as a subepidermal tumor on the scalp in women over the age of 60. Histologic findings may be used to differentiate PTT from TC and MPTT. Complete surgical excision is recommended; additional radiotherapy and/or chemotherapy may be used for lesions with increased invasive potential. Adequate treatment of PTT requires skilled histopathologic examination for proper diagnosis; histologic appearance may not correlate with clinical behavior. After surgical excision, long-term clinical follow-up for evidence of metastatic disease is judicious.

Malignant Proliferating Trichilemmal Tumor of the Lower Eyelid

To report on the first case of malignant proliferating trichilemmal tumor (PTT) on the eyelid, and to describe the clinical and histopathologic findings. Interventional case report and literature review. A 42-year-old woman presented with a 2-year history of a firm, 3 x 2 cm lower eyelid mass. The mass was excised with the frozen section control. The defect in the lower eyelid was reconstructed with modified Hughes tarsoconjunctival flap and skin graft from the left postauricular area. Histopathologic examination revealed the proliferation of outer hair sheath epithelium with multiple central areas of trichilemmal keratinization. The presence of marked cellular atypia and frequent mitoses indicated the malignant transformation. Malignant PTT has not yet been reported on the eyelid. Malignant PTT should be included in the differential diagnosis for eyelid tumors.

A malignant proliferating trichilemmal tumor simulating a squamous cell carcinoma

An 84-year-old man with a 3x3 cm tumor of the nasal dorsum is described. The tumor was surgically removed, reconstruction was with a forehead flap. Histologically the tumor was a malignant proliferating trichilemmal tumor (MPTT). There has been no recurrence or distant spread two years after surgery. MPTT is a rare tumor occurring mainly on the scalp and face in elderly men. It can be difficult to differentiate from a squamous cell carcinoma (SCC), both clinically and histologically. It has a tendency to metastasize and recur more frequently than SCC. When a malignant tumor occurs on the scalp or face, the diagnosis of MPTT should be considered by both surgeon and pathologist.