Melanoma Of Uterine Cervix Research Articles

Primary Malignant Melanoma of Uterine Cervix with Disseminated Involvement of Lower Genitourinary Tract

Introduction: Primary malignant melanomas (MM) of the female urogenital tract are extremely rare and aggressive neoplasms. The majority of these neoplasms occur in postmenopausal women, originate from the vulva and vagina, and involvement of the uterus, cervix, and ovary is exceedingly uncommon. Case Presentation: We presented a patient with MM of the uterine cervix, first diagnosed with a punch biopsy of the lesion, which was distributed from the cervical mass to the vestibule and labia minor. She underwent anterior pelvic exenteration. Pathology evaluation revealed primary MM of uterine cervix in FIGO stage III. She received adjuvant treatment with radiation and immunotherapy. On her fallow up 1 year after her disease diagnosis, she is still alive without evidence of distant metastasis. Conclusions: When feasible, pelvic exenteration offers appropriate initial management in cervical MM.

Primary malignant melanoma of uterine cervix treated with pembrolizumab as adjuvant immunotherapy

This is the case report of primary malignant melanoma (MM) of uterine cervix treated by immune checkpoint inhibitor: the Pembrolizumab. Despite the merge of the novel drugs that has been strikingly improving prognosis of MM, we still struggle treatment of MM of uterine cervix that has aggressive characteristics with unknown etiology. We present our case to contribute its rarity of the disease case report, the primary MM of the uterine cervix that had poor response to pembrolizumab and had OS of 6months. The treatment ineffectiveness is mainly considered for mucosal MM of low tumor mutation burden and its unusual type of pathology. Accumulation of retrospective studies exclusively on cervical melanoma needs to be proceeded to investigate on characteristics between poor and long survival to establish standardized treatment.

Primary malignant melanoma of uterine cervix in a young female - Report of a rare case

Primary malignant melanoma of uterine cervix in a young female - Report of a rare case - ACHR- Print ISSN No: - 2581-5725 Online ISSN No:- 2456-9267 Article DOI No:- 10.18231/2456-9267.2018.0022, IP Archives of Cytology and Histopathology Research-IP Arch Cytol Histopathol Res

PRIMARY MALIGNANT MELANOMA UTERINE CERVIX

A 40-year-old premenopausal female presented with foul-smelling per vaginal discharge for 3 months. Diagnostic work revealed a locally advanced primary malignant melanoma of uterine cervix. The patient declined pelvic surgery and was treated with Dacarbazine. Malignant melanoma is a rare tumour of skin and has been ranked in the top ve cancers of Australia and Sweden. It is a tumour of melanocytes which forms melanin pigment in the skin. In men, the most common site is trunk while in females common site is limbs. However, melanoma can arise from mucosal surfaces where the melanocytes are present. Most common mucosal sites are head and neck followed by female genital tract. Key words: Cervix, dacarbazine, malignant melanoma

Primary malignant melanoma of uterine cervix: A rare occurrence

Primary malignant melanoma of uterine cervix is a rare and aggressive neoplasm. In women, genital tract is the site of approximately 3%-7%of malignant melanomas. Majority of these occur in vulva or vagina, but cervix is a rare site. Cervical melanoma is reported in the age range of 19 to 83 years with peak incidence between 60 to 70 years. Malignant melanoma presents with vaginal bleeding or discharge and appears as exophytic, polypoid, pigmented or colorless cervical mass. Diagnosis is by histopathology which should be confirmed by immunohistochemical staining with S100 protein and HMB45.

Malignant melanoma of uterine cervix: A case report and cytological study.

A case of malignant melanoma arising in uterine cervix of a 68-year-old woman is reported. The tumor had giant cells with bizarre nuclei, prominentnucleoli, abnormal cytoplasm and melanin pigment.Immunocytochemically, tumor cells revealed expression of HMB-45. Cytology and immunocytochemistry were very effective for diagnosis and to understand biological behavior in the tumor.