Malignant Melanoma Of Unknown Origin Research Articles

458 Leopard syndrome associated with metastatic malignant melanoma of unknown origin

458 Leopard syndrome associated with metastatic malignant melanoma of unknown origin

Hilar lymph node metastasis of amelanotic malignant melanoma of unknown origin

We report a case of hilar lymph node metastasis of amelanotic malignant melanoma of unknown origin. A left pulmonary nodule was detected during a check-up in a 58-year old woman. Chest computed tomography indicated a large left hilar mass located between the upper and lower lobes. She underwent left pneumonectomy with mediastinal lymph node dissection, and the tumour was diagnosed as hilar lymph node metastasis of an amelanotic malignant melanoma; however, the primary lesion could not be detected. Thus, the possibility of spontaneous regression of the primary lesion and the amelanotic subtype of malignant melanomas should be considered in clinical practice.

P2–100 - Severe Iron-Deficiency Anemia Diagnosed as Having Malignant Melanoma of Unknown Origin

Introduction: Gastrointestinal malignant tumors should be considered as a cause of iron-deficiency anemia especially in elderly people. Here we report a rare case of severe iron-deficiency anemia diagnosed as having malignant melanoma of unknown origin. Case: A 63-year-old female presented to a local hospital with dyspnea on effort and was referred to our facility for an investigation of the cause of severe anemia. After diagnosis of iron-deficiency anemia was fixed, she was hospitalized for further detailed examination. On admission her consciousness was impaired (Japan Coma Scale: between I-3 and II-10) and the head computed tomography (CT) revealed multiple metastatic lesions in her bilateral cerebral hemispheres. Furthermore, a 4-cm tumor was found in the occipital skin, whole body CT revealed multiple micronodules in the breasts, lungs and abdominal cavity, and upper gastrointestinal endoscopy showed neoplastic lesions in the duodenum. Although the primary lesion could not be determined, biopsy from the occipital, breast and duodenal tumors led to the diagnosis of malignant melanoma. Before the pathological results were established, her condition deteriorated and she died on the 12th day of hospitalization. Discussion: Malignant melanoma of unknown origin is rare disease and lymph node is considered to be the most common primary location in that case. Although we were unable to investigate the lesions in the colon, to our knowledge, this is a rare case of malignant melanoma where anemia was the first presented symptom. I will make a presentation with bibliographic consideration.

Highly sensitive DNA typing for detecting tumors transmitted by transplantation

Abstract DNA typing of a variable number of tandem repeats (VNTRs) and of short tandem repeats (STRs) is a modern forensic method for the identification of biological material. In many cases, amplification by the polymerase chain reaction (PCR), especially of STRs, allows DNA typing of minute amounts of or degraded DNA. Here we describe the successful use of forensic DNA typing to clarify the origin of a malignant tumor. We report two cases of metastatic malignant melanoma of unknown origin that developed a few months after transplantation in two recipients of kidneys from the same donor. Fresh metastatic tissue and blood from the first recipient, reference DNA of the donor, and only paraffin-embedded tissue from the second recipient were available for analysis. To investigate whether the melanoma originated in the donor, DNA analysis of nine polymorphic loci was performed. The results of the analysis showed that, in both cases, the tumors were genetically different from the recipient DNA but matched the donor DNA. One incident of allele loss was attributed to a mutation event. We conclude that the metastatic melanoma in both recipients originated in the donor and was transmitted by renal transplantation.

ヒトメラノーマ関連抗原に対するモノクローナル抗体にて診断しえた原発巣不明の無色素性悪性黒色腫の１例

今回我々は, 以下の特徴を有する悪性黒色腫の1例を経験した。1) リンパ節転移を初発症状とし, 剖検によっても原発巣を確認できなかったこと。2) メラニン含有細胞を認めないこと。3) ドーパ反応, マッソン-フォンタナ染色HMB-45: 陰性; 電顕でメラノゾームを認めないこと。4) 12種のヒトメラノーマ関連抗原に対する抗体に陽性であること。