<h2>Abstract</h2> With more prevalent legalization, marijuana has become more widely available and increasingly perceived as safe. Impacts of marijuana use by both parents before conception and during pregnancy is an important topic of study. This video introduces research and findings from the Cannabis-Induced Potential Heritability of Epigenetic Revisions in Sperm (CIPHERS) study at Duke University. Male marijuana use affects sperm health and may pose risks to development of their children. CIPHERS human and rat studies comparing samples from exposed and non-exposed males have shown that marijuana use changes the sperm epigenome in genes associated with growth, development, and behavior. The offspring of male rats inherited these changes and showed behavioral impairments. Further study will determine if human children inherit epigenetic changes and, if so, how it affects health and development. CIPHERS recently found that stopping marijuana use for at least 11 weeks, or one sperm regeneration cycle, reduces the number of sperm showing marijuana-associated epigenetic changes at genes that are important for early childhood development. People need to be aware of the potential health effects caused by male consumption of marijuana and how to reduce risks through marijuana abstinence. This video links to educational resources on the CIPHERS website.