Major Non-communicable Diseases Research Articles

Determinants of Type 2 Diabetes Mellitus Among Adults in Dill-Chora Referral Hospital, Dire Dawa, East Ethiopia.

Ethiopia has been exhibiting trends that are shifting the populace's way of life toward urbanization. As a result, the country's primary focus is on treating infectious diseases, whereas chronic noncommunicable diseases receive less attention. Type 2 diabetes has emerged as a major noncommunicable disease that is endangering African nations' economic, social, and cultural underpinnings. There has been research mostly on prevalence, factors associated, and glycemic control of diabetes but not adequate on the causes of T2DM in Ethiopia, particularly in the study region. To identify the determinants of type 2 diabetes mellitus among adults at Dill-Chora hospital, from August 30 to October 30, 2021. An unmatched case-control study was carried out at Dill-Chora referral hospital using face-to-face interviews. The data was collected, cleaned, coded, and entered to epi data version 3.1 before being exported to SPSS version 23 for analysis. The analyses used were descriptive and logistic regression. The study included 331 individuals, 113 cases and 218 controls. Cigarette smoking (AOR: 3.15, 95% CI: 1.24-7.96), extra salt consumption (AOR: 5.52, 95% CI: 2.33-13.05), low fruit consumption (AOR: 5.28, 95% CI: 2.12-13.16), infrequent physical activity (AOR: 3.72, 95% CI: 1.65-8.39), waist to hip ratio (AOR: 18.88, 95% CI: 7.35-48.42), and triglyceride level (AOR: 2.93, 95% CI: 1.34-6.32) were strongly linked to the onset of type 2 diabetes mellitus. This study discovered a variety of risk factors for type 2 diabetes, including triglyceride levels, fruit consumption, smoking, increased salt consumption, irregular exercise, and waist to hip ratio. By focusing preventative efforts on these risk factors, the occurrence of type 2 diabetes may be reduced. Furthermore, diabetes mellitus screening is crucial, particularly in those with a high waist-to-hip ratio, a smoking history, and high triglyceride levels.

The Epidemiological Characteristics of Noncommunicable Diseases and Malignant Tumors in Guiyang, China: Cross-sectional Study.

Studies that address the changing characteristics of diseases are of great importance for preventing and controlling the occurrence and development of diseases and for improving health. However, studies of the epidemiological characteristics of noncommunicable diseases (NCDs) and malignant tumors (MTs) of the residents in Guiyang, China, are lacking. The aim of this study was to evaluate the prevalences of NCDs and MTs in residents of Guiyang, Guizhou Province, China, and analyze differences among ages, genders, and regions. A multistage stratified cluster sampling method was used. Based on the inclusion and exclusion criteria, 81,517 individuals were selected for the study. Of these, 77,381 (94.9%) participants completed the study. Structured questionnaires were used to collect information on demographic characteristics, NCDs, and MTs. The chi-square test (with 95% confidence intervals) was used to analyze differences in disease prevalence among genders, ages, and geographical regions. The major chronic NCDs of Guiyang residents are obesity, hypertension, and diabetes. MTs in women are mostly breast cancer, cervical cancer, and endometrial cancer, whereas in men, MTs are mainly lung cancer, rectal cancer, and gastric cancer. The prevalences of hypertension and diabetes in women are higher than in men, but the prevalences of lung cancer and gastric cancer in men are higher than in women. The epidemiological characteristics of individuals in different life stages are dissimilar. In terms of regional distribution, the prevalences of the above diseases in the Baiyun and Yunyan districts of Guiyang are relatively high. Several NCDs (obesity, hypertension, and diabetes) and MTs (women: breast cancer, cervical cancer, and endometrial cancer; men: lung cancer, rectal cancer, and gastric cancer) should be the focus for the prevention and control of chronic diseases in the future. In particular, the Baiyun and Yunyan districts of Guiyang are the important regions to emphasize.

Comparison of low-salt preference trends and regional variations between patients with major non-communicable diseases and the general population.

We compared low-salt preference between patients with major chronic diseases, also known as non-communicable diseases (hereinafter referred to as '"major NCD patients'"), and the general population. We used data extracted from the Korea Community Health Survey Community during the period of 2008-2019. We evaluated the low-salt preference of 13 major NCD patients by year and region to analyse recent changes in low-salt preference trends, using joinpoint regression. A greater majority of major NCD patients had a higher low-salt preference than general population; however, the overall trend was not significantly significant. The low-salt preference rate (Type III) was highest among patients with diabetes (15.6%), followed by hypertension (14.1%) and dyslipidaemia (13.4%), with the general population displaying the lowest rate (11.3%). The rates of adherence to a low-salt diet and fried food without soy sauce gradually increased until 2013 and then declined. The rate of adherence to not adding salt and soy sauce at the table gradually increased and maintained a high rate of adherence until 2019, except for patients with some diseases. Regional variations in low-salt preference tended to be greater in patients with major NCDs than general population. There is a need to improve the low-salt diet behaviour of not only major NCD patients, but also the general population. Various low-salt diet programs need to be promoted, such as education on a low-salt diet, certification for low-salt restaurants, and sodium tax. Moreover, it is necessary to continuously monitor the low-salt preferences of major NCD patients.

Metabolic Syndrome in Fasting and Non-Fasting Participants: The UAE Healthy Future Study.

Metabolic syndrome (MetS) is a multiplex of risk factors that predispose people to the development of diabetes and cardiovascular disease (CVD), two of the major non-communicable diseases that contribute to mortality in the United Arab Emirates (UAE). MetS guidelines require the testing of fasting samples, but there are evidence-based suggestions that non-fasting samples are also reliable for CVD-related screening measures. In this study, we aimed to estimate MetS and its components in a sample of young Emiratis using HbA1c as another glycemic marker. We also aimed to estimate the associations of some known CVD risk factors with MetS in our population. The study was based on a cross-sectional analysis of baseline data of 5161 participants from the UAE Healthy Future Study (UAEHFS). MetS was identified using the NCEP ATP III criteria, with the addition of HbA1c as another glycemic indicator. Fasting blood glucose (FBG) and HbA1c were used either individually or combined to identify the glycemic component of MetS, based on the fasting status. Multivariate regression analysis was used to test for associations of selected social and behavioral factors with MetS. Our sample included 3196 men and 1965 women below the age of 40 years. Only about 21% of the sample were fasting at the time of recruitment. The age-adjusted prevalence of MetS was estimated as 22.7% in males and 12.5% in females. MetS prevalence was not statistically different after substituting FBG by HbA1c in the fasting groups (p > 0.05). Age, increased body mass index (BMI), and family history of any metabolic abnormality and/or heart disease were consistently strongly associated with MetS. MetS is highly prevalent in our sample of young Emirati adults. Our data showed that HbA1c may be an acceptable tool to test for the glycemic component of MetS in non-fasting samples. We found that the most relevant risk factors for predicting the prevalence of MetS were age, BMI, and family history.

The burden of disease due to COVID-19 in Sweden: a disability-adjusted life years (DALY) study

Abstract Background Many countries have been severely affected by the COVID-19 pandemic, including Sweden, which has been in the spotlight regarding its policies and their impact on mortality and morbidity. Therefore, it is of high interest to measure the disease burden of COVID-19 in terms of disability-adjusted life years (DALYs). DALYs have two main components: the years of life lost through premature death (YLL) and the number of years lived with disability (YLD). This study aims to measure DALYs due to COVID-19 in Sweden. Methods This study used data from the nationwide multi-register observational study SCIFI-PEARL (Swedish COVID-19 Investigation for Future Insights - a Population Epidemiology Approach using Register Linkage) covering the entire Swedish population. The methodology used in the modelling and calculation of DALYs was based on the Global Burden of Disease guidelines, using Sweden-specific life tables for estimated life expectancies. Results In Sweden, 152877 DALYs were lost to COVID-19 between March 2020 and October 2021, corresponding to 1447/ 100 000, 99,3% of which was attributed to YLL. DALYs loss occurred mainly among elderly groups with 66,78 % of DALYs being attributed to individuals above 70 years old. 57,6% of the lost DALYs occurred among men that lost more DALYs compared to females in all age groups. Conclusions Similar to other countries, the burden of COVID-19 in Sweden is concentrated mainly among the elderly, which contributed to the highest DALY loss due to mortality. Yet, DALY loss remains lower for COVID-19 compared to other major non-communicable diseases such as cardiovascular diseases and neoplasms. The contribution of YLD was minimal. However, YLD due to post-Covid is not well understood and long-term disability is likely still underestimated. Key messages • The burden of COVID-19 was mainly due to premature mortality in the older age groups. • More research is needed especially on post-COVID disability to derive better estimates of YLD.

Association Between Obesity and Blood Pressure Among Iranian Children and Adolescents: A Sub-analysis from the SHED LIGHT Study.

Childhood obesity has become a major non-communicable disease worldwide. It is associated with an increased risk of cardiometabolic factors, including diabetes and hypertension (HTN). The purpose of this study was to evaluate the association between obesity and HTN among Iranian children and adolescents. Cross-sectional data from the SHED LIGHT study performed in Tehran urban area were used in this report. The anthropometric values and blood pressure were analyzed. The obesity status was identified based on body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR). The blood pressure status was defined using percentiles for height, age, and sex. A total of 14,641 children with a mean age of 12.28 ± 3.1years (6-18) were assessed, and 52.8% of them were boys. The prevalence of HTN was higher among obese compared to healthy weight subjects (p < 0.001). HTN had the strongest association with the central obesity by WC (odds ratio [OR] 4.098, 95% confidence interval [CI] 3.549-4.732), generalized obesity by BMI (OR 3.000, 95% CI 2.749-3.274), and central obesity by WHtR (OR 2.683, 95% CI 2.451-2.936). Moreover, parental university education, having studied in private schools, and the smaller number of household children increased the risk of obesity. The rate of HTN was high among children and adolescents with generalized and central obesities. HTN, elevated blood pressure, boy gender, and socioeconomic status were associated with obesity, emphasizing on the importance of screening and implementing lifestyle changes to decrease future risk of cardiovascular diseases.

Nasal Microbiome and Its Interaction with the Host in Childhood Asthma.

Childhood asthma is a major chronic non-communicable disease in infants and children, often triggered by respiratory tract infections. The nasal cavity is a reservoir for a broad variety of commensal microbes and potential pathogens associated with respiratory illnesses including asthma. A healthy nasal microenvironment has protective effects against respiratory tract infections. The first microbial colonisation in the nasal region is initiated immediately after birth. Subsequently, colonisation by nasal microbiota during infancy plays important roles in rapidly establishing immune homeostasis and the development and maturation of the immune system. Dysbiosis of microbiota residing in the mucosal surfaces, such as the nasopharynx and guts, triggers immune modulation, severe infection, and exacerbation events. Nasal microbiome dysbiosis is related to the onset of symptomatic infections. Dynamic interactions between viral infections and the nasal microbiota in early life affect the later development of respiratory infections. In this review, we summarise the existing findings related to nasal microbiota colonisation, dynamic variations, and host–microbiome interactions in childhood health and respiratory illness with a particular examination of asthma. We also discuss our current understanding of biases produced by environmental factors and technical concerns, the importance of standardised research methods, and microbiome modification for the prevention or treatment of childhood asthma. This review lays the groundwork for paying attention to an essential but less emphasized topic and improves the understanding of the overall composition, dynamic changes, and influence of the nasal microbiome associated with childhood asthma.

Promoting Health and Behavior Change through Evidence-Based Landscape Interventions in Rural Communities: A Pilot Protocol.

Rural communities in the United States have many public health issues, including a high prevalence of physical inactivity, obesity, and higher risks for major non-communicable diseases. A lack of safe and convenient places to exercise could intensify healthy lifestyle disparities. Individually adapted physical activity prescriptions at the primary level of healthcare could play a role in behavior change for rural residents. Healthcare professionals and designers created the rural wellness hub concept, which integrates walking trails and therapeutic landscape features on the clinic site, to support patient physician-prescribed activities and treatments. This research protocol reports the design and implementation of the rural wellness hub at a clinic in Clay County, West Virginia. Following a participatory, evidence-based landscape intervention (EBLI) protocol, 58 user representatives (patient = 49; clinic employee = 9) participated in the four-phase protocol: (1) pre-design survey, (2) design and development, (3) post-design interview, and (4) post-occupancy evaluation. Survey and interview data from all phases were collected and analyzed. The preliminary results indicate that the redesigned clinic campus could promote several health programs among local communities, with the benefits of walking trails, in particular, highlighted. The rigorous EBLI protocol could serve as a template for rural communities that seek to develop similar healthcare intervention programs.

Noncommunicable diseases associated with household air pollution from biomass fuel in South-East Asia region

Introduction: The WHO states that around 2.6 billion people still cook using solid fuels (such as wood, crop wastes, charcoal, coal, and dung) and kerosene in open fires and inefficient stoves. Evidence suggests that exposure to indoor air pollution by biomass fuel cooking is associated with chronic obstructive pulmonary disease, asthma, cardiovascular diseases, lung cancer, hypertension, depression, breast cancer, and cataract. This systematic review aims at providing evidence-based insight into indoor air pollution by comprehensively assessing the association of major noncommunicable diseases with the household air pollution from biomass solid fuel. Methods and Analysis: We will undertake a systematic search in PubMed, EMBASE, Scopus, OVID, MEDLINE, and Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library from January 2000 to April 2022. The study designs to be included will be cross-sectional, case-control, cohort, and randomized controlled trials. Subgroup analyses will be performed, and sensitivity analyses will be conducted to assess the robustness of the findings. Ethics and Dissemination: No ethical issues are foreseen. Dissemination will be done by submitting scientific articles to academic peer-reviewed journals. We will present the results at relevant conferences and meetings. Study Design: Systematic review and meta-analysis. Conclusion: This systematic review will collate empirical evidence to assess the association of NCDs with the household air pollution from biomass fuel. Prospero Registration: CRD42022356857.

The review of the bronchial asthma morbidity in the population of the Russian Federation

According to the World Health Organization (WHO), bronchial asthma (BA) is a major non-communicable disease which affects both adults and children and thereby impacts the economy.The aim. To analyze the bronchial asthma morbidity and follow-up care in Russia in 2019 as compared with 2014.Methods. The official statistical data of the Ministry of Health of Russia and the Federal State Statistics Service (Rosstat) on BA was used. BA was defined as class X J45 – J46 (asthma, asthmatic status) according to the International Classification of Diseases and Health-Related Problems, the 10th revision of 1 989 (ICD-10).Results. The BA morbidity was 961.6 in 2014 and 1085.0 (+11.4%; p &lt; 0,001) per 100 thousand of the total population in 2019 (1,592,596 people). BA accounted for 2.7% of all respiratory diseases (RD) morbidity. The BA morbidity in 2014 and 2019 were higher than average in 4 federal districts (FD) with the maximum rate in the Siberian FD (1,185.5 and 1,507.1 per 100 thousand of the total population, respectively). In 2019, the BA morbidity decreased among children aged 0 – 14 years, did not change among children aged 15 – 17 years and increased among the adults. In 2019, the highest rates among children aged 15 – 17 years were registered in the North-Western FD (2,943.7 per 100 thousand in the corresponding age group). 87.1% of BA patients received follow-up care. In 2019, 32.3% of all people with respiratory diseases (944.3 per 100 thousand of the total population) were under follow-up care. The highest number of BA patients under follow-up care was recorded in the Siberian FD (1,328.3 per 100 thousand of the total population), the lowest number – in the North Caucasian FD (288.3).Conclusion. There was an increase of BA morbidity from 2014 to 2019 with the highest numbers reported in the total population of Siberian FD and the lowest – in adolescents aged 15 – 17 years in North-Western FD. The quality of medical care correlated with high coverage with follow-up care.

Self-Assessment of Non-communicable Diseases related Competencies among Interns of a Medical Institute of Nepal

Introduction: One of the essential strategies to tackle rising burden of non- communicable diseases (NCD) is development of competent local human resource. Assessing the level of competencies in pre-service curriculum is the first step towards building an NCD-ready health workforce. This study aimed to assess perception of competence in delivering World Health Organization Package of Essential Non- communicable diseases (WHO-PEN) interventions among interns of Maharajgunj Medical Campus of Institute of Medicine (IOM). Methods: A survey was conducted at Maharajgunj Medical Campus of Institute of Medicine among interns using online questionnaire. The questionnaire contained seven sections on different competencies to prevent and manage NCDs. Ethical approval was obtained from Institutional Review Committee of IOM. Descriptive analysis was done to identify the level of competencies. Statistical analysis was performed using Microsoft Excel and IBM SPSS version 20. Results: Majority of the interns expressed low to moderate confidence in managing patients with presenting complaints of major NCDs. Most interns could perform diagnostic procedures and screening related to NCDs and mental disorders under supervision only (56.9%-68.6%), and one third felt they were unable to perform spirometry and visual inspection of cervix with acetic acid. Most interns could provide counseling on major NCD risk factors, self-care and palliative care only under supervision. Majority could not identify key NCD service performance measures and their data sources. Conclusion: Skills of independently diagnosing and screening for NCDs, counselling on healthy lifestyle, alcohol and tobacco cessation and conduct motivational interviewing, self-care and palliative care were limited.

S09-1 Which transport policies increase physical activity of the whole of society? A Systematic Review

BackgroundThere is strong evidence of the links between car-dependence and the global physical inactivity epidemic. If eliminated, physical inactivity would remove between 6% and 10% of major non-communicable diseases that are the leading cause of death globally, killing 38 million people each year. Research consistently shows that unlike passive transport (e.g. driving a car), active transport (i.e., walking, cycling) is associated with higher total daily physical activity (PA). While there are public policies that support PA in transport and, as a result, overall PA levels, the specific quantitative effect of such policies on PA behaviour has not been sufficiently investigated. The aim of this systematic review is to determine the level and type of evidence for policies in the area of transport that contribute to higher PA levels of society at large.MethodsSix databases (MEDLINE (Ebsco), SportDiscus, Cinahl, Cochrane library, Web of Science, and Scopus) were searched for key concepts of policy, transport, evaluation and PA. Methodological quality was assessed using standardised tools. The strength of the evidence of policy impact was described based on pre-determined categories of positive, negative, inconclusive or untested.Results17 of 2,549 studies were included in the data synthesis. The authors identified three main transport policy areas with 60 individual policy actions that had a direct or indirect effect on PA. The policy areas were: convenient transport infrastructure development, active travel promotion and shift of transport mode. These areas correspond to Haddon's methodological approach of the transport system division in to three elements (human, vehicle, road). More than half of the policy actions identified (53%) had a positive effect on PA. Study quality ratings were moderate to good.ConclusionsPA levels can be increased by implementing policies that provide convenient, safe, and connected walking and cycling infrastructures, promote active travel and give strong support to public transport. There is also clear evidence that active travel policies work best when implemented in a comprehensive way (very often as a combination of several policies). This may include infrastructure and facility improvements as well as educational programmes to achieve substantial shifts towards active modes of travel.

Association between socioeconomic status and health behaviour change before and after non-communicable disease diagnoses: a multicohort study

Behavioural risk factors of non-communicable diseases (NCDs) are socially patterned. However, the direction and the extent to which socioeconomic status (SES) influences behaviour changes before and after the diagnosis of NCDs is not clearly understood. We aimed to investigate the influence of SES on behaviour changes (physical inactivity and smoking) before and after the diagnosis of major NCDs. In this multicohort study, we pooled individual-level data from six prospective cohort studies across 17 countries. We included participants who were diagnosed with either diabetes, cardiovascular disease, chronic lung disease, or cancer after recruitment. Participants were surveyed every 2 years. Education and total household wealth were used to construct SES. We measured behaviour changes as whether or not participants continued or initiated physical inactivity or smoking after NCD diagnosis. We used multivariable logistic regression models to estimate odds ratios (ORs), prevalence ratios (PRs), and 95% CIs for the associations between SES and continuation or initiation of unfavourable behaviours. We included 8107 individuals recruited between March, 2002, and January, 2016. Over the 4-year period before and after NCD diagnosis, 886 (60·4%) of 1466 individuals continued physical inactivity and 1018 (68·8%) of 1480 participants continued smoking; 1047 (15·8%) of 6641 participants with physical activity before diagnosis initiated physical inactivity after diagnosis and 132 (2·0%) of 6627 non-smokers before diagnosis initiated smoking after diagnosis. Compared with participants with high SES, those with low SES were more likely to continue physical inactivity (244 [70·3%] of 347 vs 23 [50.0%] of 46; PR 1·41 [95% CI 1·05-1·99]; OR 2·28 [1·18-4·41]), continue smoking (214 [75·4%] of 284 vs 39 [60·9%] of 64; PR 1·27 [1·03-1·59]; OR 2·08 [1·14-3·80]), but also to initiate physical inactivity (188 [26·1%] of 720 vs 47 [7·4%] of 639; PR 3·59 [2·58-4·85]; OR 4·31 [3·02 - 6·14]). Low SES was associated with continuing or initiating physical inactivity and continuing smoking after NCD diagnosis. Reducing socioeconomic inequality in health behaviour changes should be prioritised and integrated into NCD-prevention programmes. Zhejiang University and Fundamental Research Funds for the Central Universities.

Evaluation of interleukin -17a levels in Iraqi patients with type 2 diabetes mellitus

Type 2 Diabetes mellitus (T2DM) is one of the major non-communicable diseases worldwide. Interleukin-17 (IL-17, also known as IL-17A) is a key cytokine that links T cell activation to neutrophil mobilization and activation. In the cytokine storm, up-regulation of T-helper 17 cell cytokine IL-17A, and maybe also IL-17F, is primarily responsible for the immunopathology. This study aims to assess the Interleukin-17 A levels among the susceptibility of T2DM Iraqi diabetic patients as well as to determine the Interleukin-17 A levels among those patients and controls. A total of 70 participants 50 confirmed type 2diabetic patients and 20 apparently healthy individuals as controls were selected using a convenient sampling method. Evaluation of serum levels of IL-17A were performed using by enzyme-linked immunosorbent assay technique (ELISA) using a Human- IL-17A kit. (Elabscience Company /china). The results of the current study indicated that the levels of this interleukin were higher in the sera of patients with type 2 diabetes compared to healthy controls, although there were no significant differences, in patients (243.7233±38.45944), vs. controls (148.8930±11.79280), P= 0.135. We conclude that there may be a correlation between high levels of IL-17A and T2DM.

Monitoring the effect of cell wall integrity in modulating the starch digestibility of durum wheat during different steps of bread making

Reduction of starch digestibility in starchy foods is beneficial for lowering the risks for major non-communicable diseases. Preserving cell integrity is known to delay starch digestibility in flour but its effect in bread is not clear. In this study, the effect of increasing particle size on in vitro starch digestibility of durum wheat flour, dough, and bread was investigated. Cell integrity was retained during bread processing for medium (1000 µm-1800 µm), and large (>1800 µm) flour, whereas in small one cell walls were mostly damaged (<350 µm). In vitro starch digestibility of flour decreased increasing particle size, but no difference was found in dough. In bread, instead, a modest decrease of starch digestibility for the bread made by large particle was observed, likely due to its dense structure. In conclusion, a high particle size could limit starch digestibility in durum wheat flour but not in bread.

The Associations Between Urban Form and Major Non-communicable Diseases: a Systematic Review.

In the current century, non-communicable diseases (NCDs), particularly cardiovascular diseases, diabetes, cancer, and chronic respiratory diseases, are the most important cause of mortality all over the world. Given the effect of the built environment on people's health, the present study seeks to conduct a systematic review in order to investigate the relationship between urban form and these four major NCDs as well as their main risk factors. Two independent reviewers in November 2020 after an extensive search through PubMed and Scopus identified 77 studies. Studies published in English were included if they addressed one or more attributes of urban form in relation to any major NCDs and their main risk factors. Publication date, country, geographical scale, study design, methods of built environment measurement, and findings of the relationships among variables were extracted from eligible studies. The findings suggest that the elements of urban form (density, transportation and accessibility, characteristics of building and streetscape, land use, spatial layouts and configuration) could increase or inhibit these diseases through their effect on physical activity, diet, air pollution, blood pressure, and obesity. However, there are study shortages, contradictions, and ambiguities in these relationships which are mainly due to methodological and conceptual challenges. As a result, more in-depth research is needed to achieve solid and consistent results that could be made into clear guidelines for planning and designing healthier cities.

Prevalence of Diabetes in Odisha, India

Objective: The objective of this review was to summarize and compare the estimates of diabetes among adults in community and hospital-based settings in Odisha, India. Introduction: Diabetes Mellitus (DM) is a major non-communicable disease as well as a risk factor. In a vast and diverse country such as India, where health is a state subject, regional synthesized and up to date estimates of DM burden is necessary for informed policy making. No such estimates are currently available for the state of Odisha. Materials and Methods: Peer-reviewed published original research articles related to prevalence DM in the state of Odisha published between 2011 and 2022 were retrieved from 4 medical databases and analysed. Study screening, selection, data extraction and critical appraisal was done by 2 independent review authors. Data synthesis and assessment of certainty of the evidence was done in meta-analysis of the results. Results: A total of 15 studies, that included 17339 participants, with overall good methodological quality were included in the review. The overall prevalence of DM among adults in the state of Odisha based on Community based surveys was 6.8% (95% CI: 2.3–13.4%). The prevalence in older adults aged 60 years or above is higher at 22.2% (95% CI: 8.6–39.9%). The prevalence in studies that relied on self-reported methods of screening was 4.8% (95% CI: 1.7–9.3%) as compared to those that diagnosed participants based on standard criteria (12.1%; 95% CI: 8.1–16.7%). Conclusions: We found a high prevalence of DM in the state of Odisha, which was higher than previously available national and regional estimates. This prevalence was much lower in community-based studies and in self-reported surveys pointing towards significant under diagnosis of hypertension in the state of Odisha and highlighting a need for a robust community-based screening program among adults in the state.

Characterization and screening of antidiabetic property of Siddha drug Puttransoru by using in vitro alpha-amylase and alpha-glucosidase inhibition assay

Background: Diabetes mellitus is a major noncommunicable disease worldwide. According to the World Health Organization, it is a chronic, metabolic disease characterized by elevated levels of blood glucose, which leads over time to serious damage to the heart, blood vessels, eyes, kidneys, and nerves. Many researchers were presently aiming to establish novel drugs from natural resources. Objective: The present study aimed to analyze the physico chemical properties and nutritional value and to screen the glucose uptake activity (antidiabetic) of Puttransoru (PS) using in vitro prohibition assay. Materials and Methods: The in vitro antidiabetic assay was carried out by inhibition of alpha-amylase and alpha-glucosidase method. Results: The results of in vitro antidiabetic assay revealed that PS showed significant inhibition against alpha-glucosidase enzyme with a maximum inhibition of about 41.3% and the corresponding IC50 is 1009 μg/mL, a similar pattern of activity were observed against alpha-amylase enzyme with the inhibition of 55.91%, and the corresponding IC50 is 539.7 μg/mL. Conclusion: It was concluded from the results that the test drug PS reveals potential antidiabetic activity by effective inhibition of both alpha-amylase and alpha-glucosidase enzymes. However, the principle nutrient and components that are responsible for the inhibitory action need to be further identified and characterized.

Countrywide cardiovascular disease prevention and control in 49 countries with different socio-economic status.

Cardiovascular disease (CVD) is the major noncommunicable disease (NCD) accounting for 17.9 million deaths. If current trends continue, the annual number of deaths from CVD will rise to 22.2 million by 2030. The United Nations General Assembly adopted a sustainable development goal (SDG) by 2030 to reduce NCDmortality by one-third. The purpose of this study was to analyze the CVD mortality trends in different countries implementing World Health Organization (WHO) NCD Action Plan and emphasize effective ways to achieve SDG. WHO statistics, based on the Member-States unified mortality and causes-of-death reports were used for analyzing trends and different interventions. Reduction of CVD mortality from 2000 to 2016 in 49 countries was achieved for stroke at43% and ischemic heart disease at 30%. Smoking prevalence and raised blood pressure (RBP) decreased in 84% and 55% of the countries. Eighty-nine percent of high-income countries (HIC) demonstrated a decline in tobacco smoking against 67% in middle-income countries (MIC). Sixty-nine percent of HIC demonstrated a decline in RBP against 15% in MIC. CVD management, tobacco, and unhealthy diet reduction measures are significantly better in HIC. The air pollution level was higher in MIC. Building partnerships between countries could enhance their efforts for CVD prevention and successful achievement of SDG.

A Comparison of Three Research Methods: Logistic Regression, Decision Tree, and Random Forest to Reveal Association of Type 2 Diabetes with Risk Factors and Classify Subjects in a Military Population

Background: Type 2 diabetes mellitus (T2DM) is one of the major non-communicable diseases, causing morbidity and mortality worldwide. There is no study on T2DM status in Iran Army Forces. Objectives: We aimed to measure the prevalence of T2DM in this population and identify variables associated with T2DM risk in order to classify individuals. Methods: Data from 3661 Iran Army Ground Forces were employed. Characteristics of the subjects with and without T2DM were compared. We examined the classification ability of logistic regression with two tree-based supervised learning algorithms, decision tree and random forest (RF). The ethical committee of AJA University of Medical Sciences approved this study by the approval code 995685. Results: The prevalence of T2DM was 3% less than in the general population. Our results showed that the incidence of T2DM increases as subjects become older. The proportions of staff members with T2DM were more than the other military ranks. T2DM is more common in obese and overweight groups. The highest prevalence of T2DM is in the subjects with high levels of lipid profile. The areas below the receiver operating characteristic curve for logistic regression, decision tree, and RF were 73.8%, 77.1%, and 97.1%, respectively. Conclusions: Age, body mass index, total cholesterol, low-density lipoprotein cholesterol, and triglyceride are associated with T2DM risk. The RF has superior classification performance in comparison with logistic regression and decision tree.