Major Negative Life Events Research Articles

Does Perceived Posttraumatic Growth Predict Observed Changes in Current-Standing and State Posttraumatic Growth?

Research on posttraumatic growth has been marred by the ubiquity of retrospective perceived growth assessments that lack construct validity. However, one justification for assessing perceived growth is that such perceptions may be a catalyst for subsequent change. We examined this question using a measurement-burst design in a representative midlife sample who had experienced a major negative life event in the past year (Wave 1: N = 804). Participants completed three waves of retrospective measures of perceived growth (Posttraumatic Growth Inventory), current-standing measures of posttraumatic growth domains, and experience-sampling assessments of state manifestations of growth-relevant domains twice a day for 3 weeks ( Nassessments = 32,099) over 6 months. In random-intercept cross-lagged panel models, perceived growth did not predict subsequent observed change in current standing or aggregated state assessments of growth. Overall, perceived growth does not appear to serve as a catalyst for positive change in the short term.

Effects of positive reappraisal and self-distancing on the meaningfulness of everyday negative events.

Current work on meaning-making has primarily focused on major negative life events such as trauma and loss, leaving common daily adversities unexplored. This study aimed to examine how utilizing meaning-making strategies such as positive reappraisal and self-distancing (in isolation or in combination) can facilitate an adaptive processing of these daily negative experiences. Overall meaning and facets of meaning (coherence, purpose, and significance/mattering) were assessed at both global and situational levels. Results suggested that positive reappraisal was generally effective for enhancing situational meaning but not under all conditions. Specifically, when negative experiences were high on emotional intensity, reflecting on the experience from a distanced (third-person) perspective enhanced coherence and existential mattering more than engaging in positive reappraisal. However, when negative experiences were low on intensity, distanced reflection led to less coherence and mattering than positive reappraisal. The findings of this study elucidated the importance of examining the multidimensional construct of meaning at the facet level and highlighted the importance of applying different coping strategies to effectively make meaning out of daily negative experiences.

Association between driving a car and retention of brain volume in Japanese older adults

BackgroundDriving cessation is a major negative life event that has been associated with a decline in health conditions including dementia. The increase in activity owing to the expansion of life space is a possible explanation for the positive relationship between driving and brain health. The present study examined the association between driving, life space, and structural brain volume in older individuals. MethodsHigh-resolution magnetic resonance imaging was employed to examine the brain volume in 1063 older adults. Participants were classified as non-drivers, those who drove <7 days a week, and everyday drivers. They were further classified into a non-driving group, an active group (drove 10 km at least once a week), and a less-active group (drove 10 km less than once a week). ResultsThe hippocampal volume was greater in drivers than in non-drivers. Occipital cortex volume was greater in low-frequency drivers than in non-drivers and high-frequency drivers. Active drivers exhibited larger temporal cortex volumes than less-active drivers, larger cingulate cortex volumes than non-drivers and less-active drivers, and larger hippocampal volumes than non-drivers. ConclusionDriving was associated with hippocampal brain atrophy attenuation, with active drivers exhibiting decreased brain atrophy in the temporal and cingulate cortices.

Current Status of Fear of Disease Progression in Patients with Advanced Cancer and Usefulness of Dignity Therapy Intervention.

With changes in lifestyle and an increase in bad health habits, cancer has become a noncommunicable and frequently occurring disease that poses a serious threat to human life. Cancer is associated with high rates of morbidity and mortality worldwide. As a major negative life event, advanced malignancies lead to strong mood swings in most patients. Furthermore, various internal and external factors can have a huge impact on patients' physical and mental health and put them in a stressful situation, causing a series of psychological stress responses. To explore the degree of fear of disease progression in patients with advanced cancer and the usefulness of dignity therapy. Overall, 120 patients with advanced malignant tumors admitted to Shijiazhuang No. 1 hospital between January 2019 and January 2020 were enrolled. The selected patients were divided into the test and control groups (60 people per group) using a random number table. All patients received basic treatment. Patients in the trial group also received dignity therapy. The intervention period was 4 weeks. Simplified scales were used for assessing disease progression (FoP-Q-SF) and quality of life (QLQ-C30) before and after the intervention, and the scores were compared between the groups. After the intervention, the degree of fear in the experimental group was lower than that of the control group. Cognitive function, emotional function, and the scores of the overall health status of the experimental group were higher than those of the control group. Additionally, the scores of fatigue, insomnia, loss of appetite, and diarrhea in the experimental group were lower than those of the control group (P < 0.05). The social support level scale scores, depression scores, hospital anxiety and depression scale scores, and patient dignity inventory scores of the experimental group were lower than those of the control group (P < 0.05). Patients with advanced malignant tumors have fear, anxiety, and depression related to disease progression. Dignity therapy is useful for improving the patients' quality of life, increasing dignity, and enhancing social support.

Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma.

Major negative life events, such as trauma exposure, can play a key role in igniting or exacerbating psychopathology. However, few disorders are diagnosed with respect to precipitating events, and the role of these events in the unfolding of new psychopathology is not well understood. The authors conducted a multisite transdiagnostic longitudinal study of trauma exposure and related mental health outcomes to identify neurobiological predictors of risk, resilience, and different symptom presentations. A total of 146 participants (discovery cohort: N=69; internal replication cohort: N=77) were recruited from emergency departments within 72 hours of a trauma and followed for the next 6 months with a survey, MRI, and physiological assessments. Task-based functional MRI 2 weeks after a motor vehicle collision identified four clusters of individuals based on profiles of neural activity reflecting threat reactivity, reward reactivity, and inhibitory engagement. Three clusters were replicated in an independent sample with a variety of trauma types. The clusters showed different longitudinal patterns of posttrauma symptoms. These findings provide a novel characterization of heterogeneous stress responses shortly after trauma exposure, identifying potential neuroimaging-based biotypes of trauma resilience and psychopathology.

Examining Associations Between Major Negative Life Events, Changes in Weekly Reports of Post-Traumatic Growth and Global Reports of Eudaimonic Well-Being

Research on post-traumatic growth (PTG) has been compromised by methodological limitations. Recent process-oriented accounts of personality suggest, however, that positive changes may occur through short-term (i.e., state-level) changes in PTG. In the current year-long study, 1,247 participants provided weekly reports of significant negative events as well as state manifestations of PTG (up to 44 assessments per individual; 34,205 total). Trait assessments of eudaimonic well-being (EWB) were administered at intake and Weeks 45 and 52. Experiencing negative life events predicted increases in state PTG, which in turn predicted increases in EWB. However, stability was observed when modeling prospective changes in overall state PTG before and after the initial negative life event or across all negative life events occurring during the study time frame. These findings highlight the importance of studying PTG-related processes using appropriate research designs, analytic strategies, and time frames.

Double Trouble: Does Job Loss Lead to Union Dissolution and Vice Versa?

AbstractA now-substantial literature claims that job loss and union dissolution (the end of a marriage or cohabiting relationship) each increase individuals’ risk of the other, highlighting that major negative life events in the labour market and family can spill over across domains. We address three limitations of this research using UK data. First, these associations might arise from unmeasured factors which jointly predispose individuals to the two events. Second, the distinction between job loss (an event) and unemployment (the state it may lead to) has been neglected. Third, where the impact of unemployment has been considered, its duration has not. We simultaneously model both processes: does job loss (or being unemployed) lead to union dissolution, and does union dissolution (or being divorced/separated) lead to job loss? To investigate the role of unobserved, time-invariant confounders, we model the individual-specific effects as random variables allowed to correlate across the models for the two outcomes. Upon allowing such cross-process correlations, we find that job loss and union dissolution have modest and non-significant prospective associations with one another. We also find no support for a connection between being divorced/separated and subsequent job loss. Unemployment appears to increase risk of union dissolution; by attending to duration we uncover gender differences in this relationship.

Reliability and validity of the Chinese version of the post-traumatic embitterment disorder self-rating scale (PTED-21) among inpatients in general hospital.

Embitterment and in some cases also post-traumatic embitterment disorder (PTED) are relevant problem in the general population and even more so in psychiatric patients. PTED screening should be an essential component of routine mental health management, which can be done by the 21-item Post-traumatic Embitterment Disorder Self-Rating Scale (C-PTED-21), which measures the intensity of reactive stimulus bound embitterment. The PTED-21 German version was translated into Chinese, and 200 nonpsychiatric inpatients, reporting major negative life events, were recruited through convenience sampling to evaluate test performance. Ninety patients were selected for retest 2weeks later to examine scale reliability. Factor analysis was used to assess construct validity and receiving operating characteristic curve analysis based on the "PTED standardized diagnostic interview" to assess diagnostic utility. Correlations with depression, somatic symptom, and anxiety scales were examined to assess aggregate validity. The C-PTED-21 demonstrated high internal consistency (Cronbach's α=0.944) and good test-retest reliability (total score r=0.783, individual item r value range, 0.635-0.889). Factor analysis revealed three common factors consistent with PTED core features. Total C-PTED-21 score was strongly correlated with the score on the nine-item Patient Health Questionnaire depression scale (PHQ-9, r=0.735). Mean PTED-21 score ≥1.6 points distinguished clinical PTED as defined by diagnostic interview with 97.6% sensitivity and 90.5% specificity (AUC=0.988, 95%CI: 0.976-0.999). The results show that the C-PTED-21 can assess the severity of PTED with good reliability and validity.

BIPOLAR AFFECTIVE DISORDER;

Introduction: Bipolar Affective Disorder is a chronic, recurring illness. There is evidenced relationship between life events (particularly adverse interpersonal events) and the onset of bipolar episodes. Objective: To determine the association of different Psychosocial risk factors for relapse in patients with Bipolar Affective Disorder. Study Design: Descriptive cross-sectional study. Setting: Psychiatry Outpatient Department (OPD) of Jinnah Post Graduate Medical Centre (JPMC), Karachi. Period: January 2016 to July 2016). Subjects and Method: Total 146 patients of both genders aged between 18 to 60 years were enrolled in study. Diagnosis of Bipolar Affective Disorder was based on diagnostic criteria of International Classification of Diseases 10th version [ICD-10]. For the identification of psychosocial factors Holmes and Rahe stress scale was used. Results: A total of 146 patients of both genders with average age of 31.44 ± 10.40 years. Among 146 cases, 97 (66.40%) were males and 49(33.60%) were females. Out of 146, 79(54.10%) were married, 61(41.80) were single. Among 146 patients the psychosocial factors were identified individually. The death of spouse, recent marriage, marital separation and death of close family member or friend, pregnancy were the psychosocial factors associated with relapse with p-value of less than 0.05. Conclusion: The psychosocial factors or adverse life events do trigger the course of Bipolar Affective Disorder. The major negative life events such as death of spouse or close family member or friend, the marital issues are predominant.

Psychological distress among Ugandan adolescents living with HIV: Examining stressors and the buffering role of general and religious coping strategies

ABSTRACTHIV infection increases the risk of psychological distress among adolescents living with HIV (ALHIV), which, in turn, increases risky behaviours such as medication non-adherence, substance use, and sexual risk-taking. The majority of studies on psychological distress among ALHIV have been conducted in high-income countries; data on the prevalence and correlates of psychological distress among ALHIV in sub-Saharan Africa (SSA) are scarce, yet over two-thirds of the global population of ALHIV resides in SSA. The purpose of this study was to identify the contextually relevant correlates of psychological distress among Ugandan ALHIV. Utilizing the stress and coping framework, we explored the risk and protective factors for psychological distress in cross-sectional sample of 464 ALHIV (aged 12–19; 53% female) at a large HIV treatment centre in Kampala, Uganda. The stressors associated with psychological distress included daily hassles, major negative life events, HIV-related quality of life, and stigma. Protective factors included psychosocial resources such as religious coping, satisfaction with social support, and general coping style and behaviours. Social support and optimism were significantly associated with psychological distress. Findings underscore the need for mental health services for ALHIV in Uganda and other resource-limited settings.

A Prospective Longitudinal Study of Mental Health Symptoms Among Perinatally HIV-Infected and HIV-Exposed but Uninfected Urban Youths

PurposeSignificant gaps persist in our understanding of the etiological factors that shape the progression of mental health symptoms (MHS) among perinatally HIV-infected (PHIV+) and perinatally HIV-exposed but uninfected (PHEU) youths. This study sought to assess the changes in MHS among PHIV+ and PHEU youths as they transition through adolescence and to identify the associated psychosocial factors. MethodsData were drawn from a longitudinal study of 166 PHIV+ and 114 PHEU youths (49% male, ages 9–16 years at baseline) in New York City. Individual interviews were administered at baseline and subsequently over a 5-year period. MHS were assessed using the youth version of the Diagnostic Interview Schedule for Children. Predictive growth curve analyses were conducted to assess longitudinal changes in MHS and identify the relevant factors. Level I predictors included: time, major life events, household poverty, caregiver mental health, and neighborhood stressors. Level II predictors included youths' sociodemographic characteristics (e.g., age, gender, HIV status) and baseline future orientation scores. ResultsThe changes in youths' MHS followed a quadratic growth curve and were positively associated with the number of major negative life events and neighborhood stressors experienced. Youths' HIV status, household poverty, and caregiver mental health were not significantly associated with youths' MHS. ConclusionsFindings suggest that irrespective of youths' HIV status, major life events and neighborhood stressors increase MHS among PHIV+ and PHEU youths. There is a need for interventions to reduce the impact of stressors on the mental well-being of PHIV+ and PHEU youths.

Prenatal stress changes learning strategies in adulthood

It is well known that stressful experiences may shape hippocampus-dependent learning and memory processes. However, although most studies focused on the impact of stress at the time of learning or memory testing, very little is known about how stress during critical periods of brain development affects learning and memory later in life. In this study, we asked whether prenatal stress exposure may influence the engagement of hippocampus-dependent spatial learning strategies and caudate nucleus-dependent response learning strategies in later life. To this end, we tested healthy participants whose mothers had experienced major negative life events during their pregnancy in a virtual navigation task that can be solved by spatial and response strategies. We found that young adults with prenatal stress used rigid response learning strategies more often than flexible spatial learning strategies compared with participants whose mothers did not experience major negative life events during pregnancy. Individual differences in acute or chronic stress do not account for these findings. Our data suggest that the engagement of hippocampal and nonhippocampal learning strategies may be influenced by stress very early in life.

Zooming in on Life Events: Is Hedonic Adaptation Sensitive to the Temporal Distance from the Event?

This paper analyzed the effect of major positive and negative life events (marriage, divorce, birth of child, widowhood, and unemployment) on life satisfaction. For the first time, this study estimated the effects of life events not with a precision of 12 months but of 3 months. Specifically, two questions were addressed: (1) Does the precision of the temporal localization of the event (i.e., 12 or 3 months) affect the observed trajectories of life satisfaction, and (2) is the precision of the temporal localization more important for negative life events? As expected, results showed that the precision of temporal localization allows a clearer view on hedonic adaptation, in particular following negative life events.

P02-426 - Self disclosure and self criticism in adolescents

BackgroundThe purpose of the study was to examine the relationship between self-disclosure and self-criticis, positive and negative life events, social support, and a number of well-being and distress variables.MethodsFifty-one adolescents suffering from emotional difficulties and 47 healthy adolescents participated in the study. The following questionnaires were administered to the subjects: Major Life Events Questionnaire, Minor Life Events Questionnaire, Self-Disclosure Questionnaire, Self-Criticism Questionnaire, Social Support Questionnaire, Depressive symptoms questionnaire, Mood questionnaire and demographic questionnaire.ResultsThe study group was characterized by a greater number of major negative life events, a lower level of social support, and a higher level of distress indexes. In the whole sample a positive relation was found between life events and the social network size, and also between positive life events and self-disclosure level and between it and satisfaction from social support. We also found a positive relationship between the negative life events and some of the distress indexes. In addition, there were gender differences in self-disclosure: the girls were more willing to disclose themselves to a close friend in comparison to the boys. A negative relationship was found between self-criticism and social network size. Moreover, self-criticism was related positively to suicidal tendency indexes and was negatively related to positive mood. Finally, a negative relationship was found between social support and some of the distress indexes.ConclusionsThe results of the study confirmed most of the research hypotheses. The theoretical and clinical implications of the study are discussed, as well its strengths and limitations.

Life Satisfaction Dynamics with Quarterly Life Event Data*

AbstractUsing life satisfaction responses from Australian panel data we examine the questions of when and to what extent individuals are affected by major positive and negative life events, including changes in financial situation, marital status, death of a close relative, and being the victim of crime. The key advantage of our data is that we are able to identify these events on a quarterly basis rather than on the yearly basis used by previous studies. We find evidence that life events are not randomly distributed, that individuals anticipate major events to a large extent, and that they fully adapt to many events within 12 months. The estimates can be used to calculate monetary values needed to compensate individuals for life events. Using a new valuation methodology that incorporates these dynamic factors produces considerably smaller compensation valuations than those calculated using the standard approach.

Suicidality, depression, major and minor negative life events: a mediator model.

Background: Major negative life events are associated with higher suicidality. In this association, two mediating paths were hypothesized: (a) via minor negative life events and (b) via depression.Methods: Ninety-six adolescent primary care patients were recruited in clinics, a physician’s office, and school nurses’ offices. Results: (1) Minor negative life events were associated with depressive symptoms and suicidality. (2) Depressive symptoms were associated with suicidality. (3) Depressive symptoms mediated the association of minor negative life events with suicidality. Conclusions: Findings suggest that minor negative life events may be associated with suicidal ideation among adolescent primary care patients, and that depressive symptoms may mediate the association of minor negative life events with suicidality.

A Problem Solving Intervention for Hospice Caregivers: A Pilot Study

The Problem Solving Intervention (PSI) is a structured, cognitive-behavioral intervention that provides people with problem-solving coping skills to help them face major negative life events and daily challenges. PSI has been applied to numerous settings but remains largely unexplored in the hospice setting. The aim of this pilot study was to demonstrate the feasibility of PSI targeting informal caregivers of hospice patients. We enrolled hospice caregivers who were receiving outpatient services from two hospice agencies. The intervention included three visits by a research team member. The agenda for each visit was informed by the problem-solving theoretical framework and was customized based on the most pressing problems identified by the caregivers. We enrolled 29 caregivers. Patient's pain was the most frequently identified problem. On average, caregivers reported a higher quality of life and lower level of anxiety postintervention than at baseline. An examination of the caregiver reaction assessment showed an increase of positive esteem average and a decrease of the average value of lack of family support, impact on finances, impact on schedules, and on health. After completing the intervention, caregivers reported lower levels of anxiety, improved problem solving skills, and a reduced negative impact of caregiving. Furthermore, caregivers reported high levels of satisfaction with the intervention, perceiving it as a platform to articulate their challenges and develop a plan to address them. Findings demonstrate the value of problem solving as a psycho-educational intervention in the hospice setting and call for further research in this area.

Synergy between Molecular and Contextual Views of Coping among Four Ethnic Groups of Older Adults

The coping styles of four ethnic groups of older adults in response to negative life events were analyzed in a population-based study of 1118 residents of Brooklyn, New York. Using a molecular approach, data regarding the context of events and the corresponding coping responses was obtained. Open-ended semi-structured interviews allowed participants to describe recent negative life events and explain how they coped. An empirically derived coding system distinguished four major negative life events: Death, Illness/Injury, Empathic Response to Distress of Others, and Interpersonal Conflict. Nine major styles of coping emerged: Medicate, Active Coping, Passive Response, Prayer, Stoicism, Social Support, Positive Self-Talk, Acknowledgment of Emotions, and Distraction. Gender and ethnic differences in coping styles were found. Although ethnic specificity in coping emerged when context was considered, the few effects of ethnicity suggests that the major normative events of later life may pull for generic coping responses.

Prenatal psychosocial stress exposure is associated with subsequent working memory performance in young women.

The aim of the present study was to examine the association between prenatal psychosocial stress exposure and subsequent prefrontal cortex-dependent working memory performance in human adults. Working memory performance was assessed using an item-recognition task under 10 mg hydrocortisone (cortisol) and placebo conditions in a sample of 32 healthy young women (mean age = 25 +/- 4.34 years) whose mothers experienced a major negative life event during their pregnancy (Prenatal Stress, PS group), and in a comparison group of 27 healthy young women (mean age = 24 +/- 3.4 years). The two groups did not differ in the placebo condition, however, subjects in the PS group showed longer reaction times after hydrocortisone administration compared with subjects in the comparison group (p = .02). These findings provide support for an association between prenatal stress exposure and the potential modulatory effect of cortisol on working memory performance in young adults, which may reflect compromised development of the prefrontal cortex in prenatal life.

Prenatal exposure to maternal psychosocial stress and HPA axis regulation in young adults

Epidemiological studies have reported associations between measures of size and weight at birth and disease risk in later life. Alteration in the regulation of the hypothalamic–pituitary–adrenal (HPA) axis in response to prenatal stress has been proposed as one underlying mechanism. The present study investigated in humans the association of prenatal psychosocial stress exposure with subsequent HPA axis regulation in adult life, with a focus on measures of response to challenge and feedback sensitivity. Healthy young adults whose mothers experienced severe stress during their pregnancy in form of major negative life events (e.g. death of someone close; prenatal stress (PS) group, n = 31) and an age-matched comparison group (CG, n = 30) underwent the Trier Social Stress Test (TSST) and a 1 μg ACTH 1–24 stimulation test. In addition, a diurnal cortisol profile was assessed. ACTH concentrations following a standardized behavioural challenge paradigm (TSST) were marginally significantly higher in PS subjects than in CG subjects ( p = .06). Pre-TSST adrenocortical (cortisol) levels were lower ( p = .007), whereas the increase in cortisol in response to the TSST was higher ( p = .03) in PS subjects compared to CG subjects. Cortisol concentrations following a pharmacological stimulation test simulating pituitary activity (ACTH 1–24 test) were significantly lower in PS than in CG subjects ( p = .006). No differences emerged between the two groups in basal diurnal cortisol levels. This study provides first evidence in humans of an association between prenatal psychosocial stress exposure and subsequent alterations in the regulation of the HPA axis.