Major Medical Organizations Research Articles

Tips for Addressing Screening Concerns: "Harms of Screening".

Early detection decreases deaths from breast cancer. Yet, there are conflicting recommendations about screening mammography by major professional medical organizations, including the age and frequency with which women should be screened. The controversy over breast cancer screening is centered on 3 main points: the impact on mortality, overdiagnosis, and false positive results. Some studies claim that adverse psychological effects such as anxiety or distress are caused by screening mammography. The purpose of this article is to address negative breast cancer screening concerns including overdiagnosis and overtreatment, effect on mortality, false positive results, mammography-related anxiety, and fear of radiation.

Transgender health research needed.

Ever since the Cass Review was released in April-an evaluation by the United Kingdom's National Health Service that has led to a ban on pubertysuppressing medication for transgender and gender diverse (TGD) youth-there has been criticism of the assessment and its recommendations, and concern about how it could be leveraged to more broadly affect public health care. In response, physicians, researchers, and major medical organizations worldwide have emphasized that scientific studies point to the benefits of medical interventions supporting gender affirmation. Indeed, more care innovation is needed, driven by community-led research, to improve the well-being of TGD people in ways that can benefit all of society.

Quality management of medical care in temporary storage of medicines in polyclinic conditions using standard operating procedures

The article presents the experience of one of the major medical organizations of the Samara Region Togliatti City Clinical Polyclinic No. 3 in ensuring safe storage conditions for medicines. Aim. Summarizing the results and spreading the experience of the Togliatti City Clinical Polyclinic No. 3 of ensuring the storage of medicines in a polyclinic. Results. Standard operating procedures approved by the chief physician of the polyclinic, which present clear and comprehensible information for medical personnel for use in their professional activities.

Paradigm Shift in Medicine: Integrating Naturopathic Care in the Treatment of Chronic Disease: Want to follow best practices in chronic disease treatment? Look to naturopathic physicians.

The current healthcare system too often relies on prescription drugs, leading to increased opioid use and addiction, despite major medical organizations recommending non-drug approaches as the primary treatment in many conditions. The importance of lifestyle changes to achieving whole-person health is increasingly recognized. Nature-based medicine, as routinely practiced by naturopathic physicians provide a valuable and noteworthy alternative approach featuring lifestyle intervention to chronic pain and disease management. These physicians undergo extensive training in holistic models of care and apply a systematic approach called the Therapeutic Order, which focuses on addressing the underlying cause of symptoms and using the least force necessary for treatment. Improved outcomes are realized with multifactorial personalized treatment plans including lifestyle, nutrition, stress management, and physical activity. Integrative medicine is on the rise and we support the shift to the inclusion of a patient-centered approach in the management of chronic pain and disease. Nothing in the practice of natural, holistic medicine precludes respect for science, and the reliance on evidence. Rather, medicine is at its best when practice can draw from the best offerings of all pertinent fields.

Gender‐affirming healthcare: Where are the risks?

Every major medical organization involved in providing health care to youth, including the American Medical Association, the American Academy of Pediatrics, and the American Psychiatric Association, supports gender‐affirming care for youth. However, states advancing bans on gender‐affirming care also promote the view that this approach is medically unproven, potentially dangerous, and in some views, a form of child abuse.

Long-Acting Reversible Contraception for Adolescents: A Review of Practices to Support Better Communication, Counseling, and Adherence.

Long-acting reversible contraception (LARC) methods, including levonorgestrel and copper intrauterine devices (IUDs) and the subdermal contraceptive implant, are the most effective reversible forms of contraception and thus are an important aspect of adolescent pregnancy prevention. While LARC efficacy, safety, and appropriateness are supported by major medical organizations and usage rates are increasing, overall LARC uptake among United States (US) adolescents remains lower than uptake of short-acting contraceptive methods. A better understanding of the barriers affecting adolescent LARC uptake and reasons for discontinuation could help facilitate effective communication. For example, learning how to improve adolescent-centered communication, shared decision-making, and motivational counseling strategies may be the first step to improving utilization rates. This narrative review includes three sections. First, this review will describe the history, mechanisms of action, and epidemiology of adolescent LARC use in the US and globally. Next, this review will describe key factors influencing adolescent LARC uptake, reasons for discontinuation, and multilevel barriers specific to adolescent LARC use. Finally, this review will characterize communication techniques and LARC counseling strategies for adolescents in the context of a reproductive justice approach set in the health belief model framework. The distinction between moving away from a presumptive counseling approach towards an adolescent-centered, shared decision-making approach to encourage parent-adolescent sexual health communication to lay the foundation of empowering adolescent reproductive autonomy should be the underpinning of all effective reproductive communication strategies.

Modeling the Potential Benefit of an Over-the-Counter Progestin-Only Pill in Preventing Unintended Pregnancies in the U.S.

ABSTRACT Almost half of the 6.1 million annual pregnancies are unintended. Barriers to accessing contraception including prescription requirements contribute to inconsistent use or nonuse. This has led to a call from major medical organizations for effective over-the-counter (OTC) contraceptives such as progestin-only pills (POPs). Studies have modeled the potential impact on an OTC POPs; however, they are based on women expressing interest versus actual use. The objective of this model was to utilize data from an actual-use clinical trial to calculate the potential impact of a POP, when they are available over the counter, on the number of unintended pregnancies in the United States. Data were obtained from a recent actual-use clinical trial that simulated OTC use of a norgestrel POP over a 6-month period. In this study, 883 women chose to pay out of pocket and use the norgestrel POP. This model compared the number of expected pregnancies among 2 cohorts of 100,000 women, one of which was based on the contraceptive mix of volunteers entering the actual-use trial, and the second was women exclusively using an OTC POP. The primary analysis set the failure rate of the OTC POP to 7%, the reported failure rate for oral contraceptive pills, and that of “no method” as 85%. The failure rate of the non-OTC POP cohort was that from the actual-use trial. A “tipping point” analysis was conducted to determine the failure rate of the OTC POP beyond which no unintended pregnancies would be prevented by OTC POP compared with the mixed-method cohort. At the 6-month time point in the actual-use trial, only 51.1% of subjects were continuing OTC POP use. A continuation-in-use analysis was conducted to determine what effect discontinuation might have on unintended pregnancy rate. According to the model, a total of 37,624 unintended pregnancies would occur if 100,000 women continued their current contraceptive method over the course of 1 year. If those 100,000 women had used the OTC POP exclusively for 1 year, 7000 unintended pregnancies would be expected. Thus, an estimated 30,624 fewer unintended pregnancies, a reduction of 80%, would be expected over 1 year by use of an OTC POP. The results of a sensitivity analysis that decreased the OTC POP failure rate from 7% to 3.5% resulted in an estimated 34,124 fewer unintended pregnancies and an increase in OTC POP failure rate to 10.5%, and reduction of “no method” failure rate to 46% resulted in an estimated 1461 fewer unintended pregnancies. The tipping point analysis identified an OTC POP typical use failure rate of 38% at the point which using the OTC actual-use trial method mix profile and a “no method” failure rate of 85% would result in equivalent unintended pregnancy rate to the OTC POP cohort. When revising estimates according to the continuation-in-use analysis, a reduction in unintended pregnancies of 59% over 6 months compared with the actual-use trial method mix profile (11,009 pregnancies prevented) was calculated. The results of this study suggest that the use of a POP when available over the counter will result in a significant reduction of unintended pregnancies in the United States.

Proceedings from the Second Medical Summit on Firearm Injury Prevention, 2022: Creating a Sustainable Healthcare Coalition to Advance a Multidisciplinary Public Health Approach.

Proceedings from the Second Medical Summit on Firearm Injury Prevention, 2022: Creating a Sustainable Healthcare Coalition to Advance a Multidisciplinary Public Health Approach.

Modeling the Potential Benefit of an Over-the-Counter Progestin-Only Pill in Preventing Unintended Pregnancies in the US

ABSTRACT Approximately 50% of the 6.1 million annual pregnancies in the United States are unintended. Despite widespread public knowledge of contraception, many barriers exist to access including prescription requirements. There has been support backed by peer-reviewed studies from major medical organizations to have a progestin-only pill (POP) available as an over-the-counter (OTC) medication. A recent actual-use clinical trial simulating the OTC use of a POP (norgestrel) over a 6-month period provided important data on the distribution of different contraceptive methods among potential OTC POP users. This model aimed to use data on the baseline distribution of different contraceptive methods from the actual-use trial to analyze the potential impact of the use of an OTC POP on the number of unintended pregnancies in the United States. This trial included 883 women that used the norgestrel 0.075 mg POP over a 6-month period. In the model, estimates were normalized to a population of 100,000 women, and the number of pregnancies expected among 2 hypothetical cohorts were compared using different contraceptive methods over 1 year. The first cohort consisted of women with contraceptive methods based on that of the volunteers entering the actual-use trial, and the second was women exclusively using an OTC POP as their contraception. A tipping-point analysis was conducted to determine the failure rate of the OTC POP beyond which no unintended pregnancies would be prevented by OTC POP use compared with the actual-use cohort before enrollment. Several sensitivity analyses were conducted, including the actual-use cohort distribution before enrollment being replaced with the contraceptive distribution reported in the 2017 to 2019 data from the US National Survey of Family Growth, capturing a higher percentage of users of the most effective methods and lower percentage of users of no method. A total of 37,624 unintended pregnancies were expected if 100,000 women continued their current contraceptive method mix assuming a “no method” failure rate of 85%. A total of 7000 unintended pregnancies were expected if 100,000 women used the OTC POP (7% failure rate) exclusively. When comparing the 2, over 80% and an estimated 30,624 unintended pregnancies would be prevented over 1 year using an OTC POP compared with a use profile based on methods use before enrollment in the actual-use trial. Sensitivity analyses altered the expected number of unintended pregnancies, but in each scenario, the overall number of expected pregnancies remained lower among the OTC POP cohort. The tipping point analysis revealed that the failure rate of OTC POPs beyond which there would be no further reduction in unintended pregnancies is 38%, decreasing to 12% with more conservative model inputs. The results of this study show that using data from an actual-use clinical trial, among 2 modeled cohorts of women using either a POP or a mix of contraceptives based on real clinical use patterns, there is a significant reduction in unintended pregnancy using an OTC POP. The model described here suggests that use of an OTC POP would result in a clinically meaningful reduction in unintended pregnancies in the United States.

Cannabis Conversations: Suggestions for Providers Serving Perinatal Patients

Major medical organizations have issued statements discouraging cannabis use in the perinatal period to minimize the risk of potential adverse outcomes. However, many pregnant individuals may decide to continue to use cannabis, or they may wish to quit, but have trouble discontinuing, potentially because they use cannabis to alleviate symptoms such as nausea, pain, sleep difficulties, or anxiety. Patients may not feel comfortable disclosing cannabis use or discussing alternatives, due to perceptions of cannabis safety, stigma, fear of legal repercussions, or mistrust in providers. Healthcare providers from diverse specialties interact with perinatal patients who use cannabis, yet guidance for them is limited. In this commentary, we encourage attention to understanding patients’ motivations for cannabis use. We offer general considerations for engaging in conversations with patients on this topic, including using a nonjudgmental, empathetic, and patient-centered approach to care.

The History of Medical Ethics in India

The History of Medical Ethics in India

In pursuit of inter-specialty consensus on excited delirium syndrome: a scoping literature review.

Excited delirium syndrome (ExDS) is a controversial and disputed diagnosis involving altered mentation, agitation, and, frequently, substance abuse. Recently, it has become a common pre-hospital diagnosis, serving as justification for use of force, restraint, and/or medication administration.To conduct a scoping review across three databases to describe the most frequently reported diagnostic criteria for ExDS, as well as to explore its use as a diagnosis for deaths of individuals in the custody of law enforcement.In 2021, three literature databases were searched: Ovid Medline, PsycInfo, and Scopus. Studies were included if they were peer-reviewed, English articles describing (1) ExDS symptoms, (2) substance intoxication with at least 2 ExDS symptoms present, or (3) centering on deaths occurring in the custody of law enforcement and attributed to ExDS. Key study data were extracted and the current literature was described qualitatively. Analysis took place between March and December 2021. A total of 97 studies were identified through initial abstract and secondary full-text review, with noted discrepancies in the definition of ExDS itself.After review, differences in ExDS diagnosis among organizations were explored, along with subsequent clinical impact, particularly in the pre-hospital setting. Resulting impact on patients, particularly those of minoritized ethnic and racial groups, was also noted. Prone aggressive restraint, in particular, is noted as an established risk factor for fatalities in ExDS cases. At this time, ExDS should not be utilized as a diagnosis; major medical organizations have an urgent responsibility to convene to formalize consensus-based diagnostic criteria or to propose alternate management guidelines for agitated and altered persons.

Managing atrial fibrillation: The intersection of cardiology, health psychology, and the patient experience.

Atrial fibrillation (AF) is the most common cardiac dysrhythmia and is an accelerating public health challenge. Challenges related to detection, management, and prevention of disability and dysfunction secondary to AF are increasingly apparent. The subspecialty of cardiology, cardiac electrophysiology, is primarily tasked with the treatment of AF. Patients with AF are often ambushed by the condition with approximately 28% to 38% of patients experiencing significant anxiety or depressive symptoms. Behavioral risk reduction can be targeted by achieving and maintaining a healthy BMI, abstaining from smoking, avoiding alcohol consumption, and sustaining regular physical activity. AF patients are also tasked with considering possible treatment options, adhering to medication regiments & lifestyle changes, utilizing wearable technologies, and managing emotional distress, to minimize health risks and optimize quality of life. Major medical organizations have called for integrated, multidisciplinary management as the treatment of choice for AF patients. Health psychologists bring valuable expertise but are not uniformly involved in the care of AF patients. The purposes of this article are to (a) review the existing research on the medical, psychological, and behavioral aspects of contemporary management of AF, (b) highlight the intersections between cardiac electrophysiology and clinical health psychology in managing AF, and (c) call for more health psychologists in this specialized area of cardiac electrophysiology. This opportunity for health psychologists may challenge the profession to further specialize as "cardiac psychologists" and mirror our medical colleagues. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Elevating the Needs of Minor Adolescents in a Landscape of Reduced Abortion Access in the United States

Elevating the Needs of Minor Adolescents in a Landscape of Reduced Abortion Access in the United States

Why We Swab: A library of stories in stem cell donation.

Stories are powerful in their ability to disseminate information in a meaningful way. We hypothesized that a stem cell donation story library optimized for social media could support the education and recruitment of committed unrelated hematopoietic stem cell donors from needed demographic groups. We developed Why We Swab, a library of stories on stem cell donation (facebook.com/WhyWeSwab; instagram.com/WhyWeSwab; twitter.com/WhyWeSwab), and evaluated its impact across social and traditional media as well as on eligible potential donors' knowledge and attitudes towards donation. As of December 2021, the library included 28 story arcs featuring 45 storytellers from diverse ancestral backgrounds, including 8 donor-recipient stories. Overall, the stories reached >92,000 people across social media. Notably, stories were republished by 18 print/ broadcast media outlets in Canada and by major medical organizations. A series of stories shown to 33 eligible potential donors improved mean total scores on a donation knowledge test (64% to 85%, p < 0.001), reduced mean ambivalence scale scores (3.85 to 2.70, p < 0.001), and improved participants' willingness to register as donors (45% to 73%, p < 0.005). Data are also shown demonstrating that stakeholders valued the library and that its deployment was associated with improved donor recruitment outcomes in Canada. Why We Swab is accessible and relevant to a wide audience, including stem cell donor registries and recruitment organizations seeking to improve their recruitment efforts as well as to blood and organ & tissue donation organizations who can adapt the Why We Swab model to their audiences.

ACSM-AMSSM Call to Action: Adapting Preparticipation Cardiovascular Screening to the COVID-19 Pandemic.

Preparticipation cardiovascular screening, designed to identify cardiovascular pathology responsible for sudden unexpected death, is recommended by all major professional medical organizations overseeing the clinical care of competitive athletes. Data from several large, prospective, cohort studies indicate that cardiac imaging findings consistent with inflammatory heart disease following COVID-19 infection are more common than most forms of heart disease associated with sudden death during exercise. This call-to-action document is intended to provide recommendations about how routine preparticipation cardiovascular screening for young competitive athletes - which has the capacity to detect both COVID-19 cardiovascular complications and pathology unrelated to infection - should be altered to account for recent scientific advances.

Balancing vision with pragmatism: The geriatric emergency department guidelines-realistic expectations from emergency medicine and geriatric medicine.

In 2014 the Geriatric Emergency Department (GED) Guidelines were published and endorsed by four major medical organizations. The multidisciplinary GED Guidelines characterize the complex needs of the older emergency department (ED) patient and current best practices with the goal of promoting more cost-effective and patient-centered care. The recommendations are extensive and the vast majority of EDs then and now do not have either the resources nor hospital administrative support to provide this additional service. At the 2021 American Academy of Emergency Medicine's Scientific Assembly, a panel of emergency medicine physicians and geriatricians discussed the GED Guidelines and the current realities of EDs' capacity to provide best practice and guideline recommended care of GED patients. This article is a synthesis of the panel's presentation and discussion. With the substantial challenges in providing guideline recommended care in EDs, this article will explore three high impact GED clinical conditions to highlight guideline recommendations, challenges and opportunities, and discuss realistically achievable expectations for non-Geriatric ED accredited institutions. In 2014 the Geriatric Emergency Department Guidelines were published describing the current best practices for geriatric ED patients. Unfortunately, the vast majority of EDs worldwide do not provide the level of service recommended by the GED guidelines. The GED Guidelines can best be termed aspirational for U.S. EDs at the present time.

Balancing Vision With Pragmatism: The Geriatric Emergency Department Guidelines-Realistic Expectations From Emergency Medicine and Geriatric Medicine

BackgroundIn 2014, the Geriatric Emergency Department (GED) Guidelines were published and endorsed by four major medical organizations. The multidisciplinary GED Guidelines characterized the complex needs of the older emergency department (ED) patient and current best practices, with the goal of promoting more cost-effective and patient-centered care. The recommendations are extensive and most EDs then and now have neither the resources nor the hospital administrative support to provide this additional service. DiscussionAt the 2021 American Academy of Emergency Medicine's Scientific Assembly, a panel of emergency physicians and geriatricians discussed the GED Guidelines and the current realities of EDs’ capacity to provide best practice and guideline–recommended care of GED patients. This article is a synthesis of the panel's presentation and discussion. With the substantial challenges in providing guideline-recommended care in EDs, this article will explore three high-impact GED clinical conditions to highlight guideline recommendations, challenges, and opportunities, and discuss realistically achievable expectations for non–GED-accredited institutions. ConclusionsIn 2014, the GED Guidelines were published, describing the current best practices for GED patients. Unfortunately, most of the EDs worldwide do not provide the level of service recommended by the GED Guidelines. The GED Guidelines can best be termed aspirational for U.S. EDs at the present time.

Saving Lives with Pride: Development and Evaluation of Multimedia Resources to Engage Gay, Bisexual, and Queer Men in Canada As Stem Cell Donors

Background: Since 2009, gay, bisexual, and other men who have sex with men (gbMSM) have been eligible to register as stem cell donors in Canada and donate to patients in need. However, many gbMSM are unaware of their eligibility to be donors. Targeted recruitment of gbMSM could augment efforts to recruit donors from needed demographic groups and support a more inclusive donor registry. Here, we describe the development and evaluation of multimedia to engage gbMSM in Canada as stem cell donors.Methods: Multimedia resources were developed by gbMSM in Canada, in collaboration with recruiters from Stem Cell Club (stemcellclub.ca) and were designed to highlight gbMSM eligibility and educate about the need for donors from diverse ancestries. Resources were reviewed for accuracy by transplantation experts and appeal by focus groups of gbMSM. The resources were published to stemcellclub.ca/savingliveswithpride/ and disseminated to members of the community of practice (CoP) in stem cell donor recruitment in Canada during an e-meeting. We evaluated stakeholder perspective on these multimedia and their impact 1) across social and traditional media; 2) on gbMSM eligible donors' knowledge and attitudes towards donation; and 3) on reducing barriers for gbMSM donation.Results: Multimedia developed included: infographics emphasizing gbMSM eligibility regardless of recent sexual contact (Fig. A); @WhyWeSwab (twitter.com/whyweswab) story arcs featuring a stem cell donor and a stem cell recipient (Fig. B) from the LGBTQ2+ community; TikToks and other short videos (Fig. C), and testimonials (Fig. D) featuring gbMSM advocating for their communities to register as donors; and statements from Transplant Hematologists emphasizing that gbMSM donors will be treated sensitively and with respect (Fig. E).33 CoP members from 6 provinces across Canada, and with a median of 2-years recruitment experience, participated in a survey post-publication. The majority felt the resources would engage gbMSM as donors (84%) and clarify gbMSM eligibility (87%); noted experiencing a lack of awareness from potential registrants on whether gbMSM were eligible to donate stem cells (69%); and felt that a national campaign to recruit gbMSM is needed (97%), would support a more inclusive registry (97%), and would augment recruitment of diverse donors (94%).37 gbMSM eligible stem cell donors (84% gay men and 11% bisexual men; from 13 different ancestral groups; living in 5 provinces across Canada) completed surveys evaluating the impact of these multimedia on their knowledge and attitudes towards donation. After being shown these multimedia, mean scores on a 4 question knowledge test improved from 66% to 93% (p<0.001, Fig. F); mean scores on the Simmons Ambivalence Scale significantly decreased from 38% to 24% (p<0.001, Fig. G); and participants were more willing to register as donors (59% vs 84%, p=0.027) and less likely to believe there are significant barriers to donation for gbMSM (51% vs 11%, p=0.033). Qualitative analysis of feedback from focus groups with these participants identified examples of how the multimedia decreased barriers to donation impacting gbMSM (Fig. H).Multimedia were included in a Pride Month (6/2021) Campaign in Canada, “Saving Lives With Pride”, and were shared on social media by LGBTQ2+ groups including on campuses (e.g. SFU Out On Campus), in the community (e.g. Abbey of the Long Cedar Canoe, JQT Vancouver), and nationally (e.g. Canadian Queer Medical Students Association). They were also profiled and shared by major medical organizations (e.g. Canadian Blood Services blood.ca/en/stories/stem-cell-club-volunteers-aim-save-lives-pride-month-campaign) and by media across Canada including CityNews (ctvnews.ca/health/pride-month-tiktok-drive-encourages-stem-cell-donations-from-gay-bi-men-1.5475113) and CTV News (toronto.citynews.ca/video/2021/06/17/doctors-turn-to-queer-communities-for-stem-cell-donors), who also highlighted the resources and their message as one of the top stories in Canada on 6/18/21 (ctvnews.ca/mobile/5-things/5-things-to-know-for-friday-june-18-2021-1.5475813).Conclusions: We developed an array of high-quality multimedia to support recruitment of gbMSM as potential stem cell donors and reduce barriers to donation. Our work is relevant to recruitment organizations worldwide seeking to develop more inclusive recruitment approaches. [Display omitted] DisclosuresNo relevant conflicts of interest to declare.

Development and Evaluation of a Library of TikToks to Support Recruitment of Committed Hematopoietic Stem Cell Donors from Needed Demographic Groups

IntroductionTikTok is a rapidly growing social media platform that allows users to develop and share short videos. We hypothesized that a library of videos developed through TikTok (TikToks) would support the recruitment of committed hematopoietic stem cell donors from needed demographic groups (i.e. young, male, from diverse ancestries).MethodsMembers of the community of practice (CoP) in stem cell donor recruitment in Canada (facebook.com/groups/stemcellclub) were activated to develop TikToks. Training was provided during e-meetings of the CoP (8/2020, 1/2021, 5/2021) and in a video published online (stemcellclub.ca/training), highlighting the principles of effective TikTok design. These principles included the use of engaging hooks, music, and calls to action; short duration (< 30s); high educational value; and appeal to diverse donors. The training also outlined how to: record content, adjust clip lengths, apply audiovisual effects, and share across social media platforms. A CoP TikTok committee was formed to develop and review TikToks prior to publication.Following launch, we evaluated stakeholder perspective on these TikToks and the impact 1) across social and traditional media and 2) on eligible donors' knowledge and attitudes towards donation.ResultsBetween 9/2020-7/2021, a network of TikTok channels was launched by CoP members, including a national donor recruitment TikTok library (tiktok.com/@stemcellclub). A total of 217 TikToks were produced across these channels (median length 17s, range 4-52s), covering a range of educational topics, designed for use in specific recruitment campaigns, and featuring unique video effects (Fig. A).The TikToks accumulated over 234,000 Views, 42,000 Likes, 3,000 Comments, and 14,200 Shares on TikTok, were republished by Canadian media outlets (e.g. CBC [twitter.com/cbcnewsbc/status/1361511367426080773], CTV News [ctvnews.ca/health/meet-the-women-hoping-to-recruit-more-stem-cells-donors-from-black-communities-1.5314038, ctvnews.ca/health/pride-month-tiktok-drive-encourages-stem-cell-donations-from-gay-bi-men-1.5475113], Victoria News [vicnews.com/news/most-black-canadians-wont-find-a-stem-cell-donor-in-time-this-group-is-working-to-change-that]) and were highlighted by major medical organizations (e.g. Canadian Blood Services [blood.ca/en/stories/meet-stem-cell-club, blood.ca/en/stories/stem-cell-club-volunteers-aim-save-lives-pride-month-campaign], American Association of Blood Banks [aabb.org/news-resources/news/article/2021/02/01/twitter-tiktok-aabb-virtual-journal-club-assesses-use-of-multimedia-resources-for-donor-recruitment]).33 CoP members from 6 provinces across Canada, with a median of 2 years of recruitment experience, completed a post-launch survey. The majority felt that TikToks promote donation in an attention-grabbing way (94%), engage younger donors (100%), and teach key points in a short time period (94%). The majority were confident in their ability to make TikToks (63%), but felt they would benefit from additional training (63%).46 eligible stem cell donors (from 12 different non-Caucasian ancestral groups; living in 5 provinces across Canada) completed surveys evaluating the impact of TikToks on their knowledge and attitudes towards donation. No participants were registered as donors and only four had a personal connection to an individual who needed a stem cell transplant. After being shown a series of TikToks, mean scores on a 6-question stem cell donation knowledge test improved from 59% to 73% (p=0.0012) (Fig. B); mean scores on a modified Simmons Ambivalence Scale decreased from 52% to 30% (p<0.0001) (Fig. C); and participants were more willing to register as donors (70% vs. 39%, p=0.0011). Participants reported that viewing TikToks positively impacted on their decision to register (87%), helped them understand stem cell donation (89%), and would help them talk about stem cell donation with friends/family (78%).ConclusionsWe report the first published experience using TikToks in a donor recruitment context. Our TikToks achieved significant social and traditional impact in a short period of time, and supported recruitment of committed stem cell donors from needed demographic groups. Our work is relevant to recruitment organizations worldwide seeking to modernize their recruitment approaches. [Display omitted] DisclosuresNo relevant conflicts of interest to declare.