Maintenance Of Cerebral Oxygenation Research Articles

Effects of percutaneous transluminal angioplasty and associated factors in access hand oxygenation in patients undergoing hemodialysis

In hemodialysis (HD) patients with arteriovenous fistula (AVF), changes in systemic or peripheral tissue circulation occur non-physiologically via the presence of AVF; however, associations between blood flow and tissue oxygenation in the brain and access hand are uncertain. In this study, 85 HD patients with AVF were included and evaluated for changes in flow volume (FV) and regional oxygen saturation (rSO2) in the brain and hands with AVF before and after percutaneous transluminal angioplasty (PTA). Furthermore, we evaluated the factors that determine access hand rSO2 without stenosis after PTA. Brachial arterial FV increased after PTA (p < 0.001), and carotid FV decreased (p = 0.008). Access hand rSO2 significantly decreased after PTA (p < 0.001), but cerebral rSO2 did not significantly change (p = 0.317). In multivariable linear regression analysis of factors associated with access hand rSO2, serum creatinine (standardized coefficient: 0.296) and hemoglobin (standardized coefficient: 0.249) were extracted as independent factors for access hand rSO2. In conclusion, a decrease in access hand oxygenation and maintenance of cerebral oxygenation were observed throughout PTA. To maintain access hand oxygenation, it is important to adequately manage Hb level and maintain muscle mass, in addition to having an AVF with appropriate blood flow.

Cerebral blood flow regulation in end-stage kidney disease.

Patients with chronic kidney disease (CKD) and end-stage kidney disease (ESKD) experience an increased risk of cerebrovascular disease and cognitive dysfunction. Hemodialysis (HD), a major modality of renal replacement therapy in ESKD, can cause rapid changes in blood pressure, osmolality, and acid-base balance that collectively present a unique stress to the cerebral vasculature. This review presents an update regarding cerebral blood flow (CBF) regulation in CKD and ESKD and how the maintenance of cerebral oxygenation may be compromised during HD. Patients with ESKD exhibit decreased cerebral oxygen delivery due to anemia, despite cerebral hyperperfusion at rest. Cerebral oxygenation further declines during HD due to reductions in CBF, and this may induce cerebral ischemia or "stunning." Intradialytic reductions in CBF are driven by decreases in cerebral perfusion pressure that may be partially opposed by bicarbonate shifts during dialysis. Intradialytic reductions in CBF have been related to several variables that are routinely measured in clinical practice including ultrafiltration rate and blood pressure. However, the role of compensatory cerebrovascular regulatory mechanisms during HD remains relatively unexplored. In particular, cerebral autoregulation can oppose reductions in CBF driven by reductions in systemic blood pressure, while cerebrovascular reactivity to CO2 may attenuate intradialytic reductions in CBF through promoting cerebral vasodilation. However, whether these mechanisms are effective in ESKD and during HD remain relatively unexplored. Important areas for future work include investigating potential alterations in cerebrovascular regulation in CKD and ESKD and how key regulatory mechanisms are engaged and integrated during HD to modulate intradialytic declines in CBF.

Anaesthetic techniques for carotid surgery

Carotid endarterectomy is performed for patients with embolic or ischaemic symptoms (e.g. transient ischaemic attack, cerebrovascular accident or amaurosis fugax) who have 70% or more internal carotid artery stenosis. The fundamental problem during the operation is maintenance of cerebral oxygenation during carotid cross-clamping. The perioperative mortality rate from stroke and myocardial infarction approaches 5%, thus there is considerable interest in improving surgical and anaesthetic techniques to minimize this risk.

Medical management of head injury and neuroprotection

Head injury continues to cause significant mortality and morbidity despite the advances in early and late management and rehabilitation techniques. The extent and prognosis of brain injury are influenced by the primary impact and initiation of secondary mechanism. Outcome is also dependent on resuscitation and maintenance of cerebral oxygenation. The initial management is aimed at preventing secondary brain injury and identifying those patients who may benefit from surgical intervention. Continuing care is based on the careful and timely transfer to the appropriate intensive care environment where maintenance and monitoring of cerebral oxygenation are used. A variety of techniques involving the manipulation of both cerebral perfusion pressure and intracranial pressure are employed. There are a number of, as-yet, unproven techniques under examination for affecting cerebral metabolism to provide a degree of protection against further damage.