Maintain Body Mass Research Articles

Abstract Tu112: The Outer Mitochondrial Membrane Protein Mtch2 Regulates Cardiac Metabolic Homeostasis and Body Mass

Introduction: MTCH2 is an outer mitochondrial membrane protein insertase and variants in MTCH2 associate with human heart failure and obesity. Hypothesis: Lower levels of MTCH2 predispose the heart to stress. Methods and Results: Cardiomyocyte-specific Mtch2 KO ( cMtch2 KO) mice were generated and develop systolic dysfunction accompanied by increased fibrosis and elevation of heart failure markers ( n =6). Prior to the development of cardiac dysfunction male cMtch2 KO mice maintain a leaner body mass compared to controls, consistent with the idea that cardiac MTCH2 drives whole body energy utilization. We hypothesize the increased energetic demand of maintaining cardiac function in younger animals shifts energy expenditure and results in lower fat mass. We found that young, pre-cardiomyopathic cMtch2 KO mice were sensitized to stress. When young cMtch2 KO mice were challenged to an acute dosing regimen of isoproterenol, compared to controls, hearts from cMtch2 KO mice failed to respond with physiological hypertrophy and animals could not maintain body mass ( n =7). We assessed mitochondrial function in cMtch2 KO mice. Isolated cMtch2 KO cardiomyocytes loaded with Mitotracker green and TMRE had reduced mitochondrial membrane potential compared to control ( n =20 cells/mouse, 3 mice/group). In the presence of glucose, oxygen consumption rates were reduced in cMtch2 KO heart tissue ( n =6), and targeted metabolomics of cMtch2 KO ventricle exhibited an accumulation of palmitate ( n =4), indicating cMtch2 KO hearts do not efficiently utilize glucose and fatty acids. To identify changes in the mitochondrial proteome we performed mass spectrometry on isolated mitochondria from control and cMtch2 KO mice ( n =4). Overall, proteins associated with fatty acid beta oxidation and pyruvate metabolism were reduced in abundance in cMtch2 KO hearts compared to control. Additionally, three potential insertase target proteins were reduced, confirming a critical role for MTCH2 in mitochondrial health. Conclusion: MTCH2 is vital for maintaining normal mitochondrial function. Reduction of MTCH2 sensitizes the heart to stress, resulting in impaired mitochondrial, sarcomere, and global heart function with effects on body composition.

Self-Management among Stroke Survivors in the United States, 2016 to 2021.

Background: Self-management among stroke survivors is effective in mitigating the risk of a recurrent stroke. This study aims to determine the prevalence of self-management and its associated factors among stroke survivors in the United States. Methods: We analyzed the Behavioral Risk Factor Surveillance System (BRFSS) data from 2016 to 2021, a nationally representative health survey. A new outcome variable, stroke self-management (SSM = low or SSM = high), was defined based on five AHA guideline-recommended self-management practices, including regular physical activity, maintaining body mass index, regular doctor checkups, smoking cessation, and limiting alcohol consumption. A low level of self-management was defined as adherence to three or fewer practices. Results: Among 95,645 American stroke survivors, 46.7% have low self-management. Stroke survivors aged less than 65 are less likely to self-manage (low SSM: 56.8% vs. 42.3%; p < 0.0001). Blacks are less likely to self-manage than non-Hispanic Whites (low SSM: 52.0% vs. 48.6%; p < 0.0001); however, when adjusted for demographic and clinical factors, the difference was dissipated. Higher education and income levels are associated with better self-management (OR: 2.49, [95%CI: 2.16-2.88] and OR: 1.45, [95%CI: 1.26-1.67], respectively). Further sub-analysis revealed that women are less likely to be physically active (OR: 0.88, [95%CI: 0.81-0.95]) but more likely to manage their alcohol consumption (OR: 1.57, [95%CI: 1.29-1.92]). Stroke survivors residing in the Stroke Belt did not self-manage as well as their counterparts (low-SSM: 53.1% vs. 48.0%; p < 0.001). Conclusions: The substantial diversity in self-management practices emphasizes the need for tailored interventions. Particularly, multi-modal interventions should be targeted toward specific populations, including younger stroke survivors with lower education and income.

DOES N-ACETYLCYSTEINE SUPPLEMENTATION DURING AN ALTITUDE TRAINING CAMP ENABLE TRAINING QUALITY AND SUCCESSFUL PERFORMANCE OUTCOMES? A COMPARATIVE CASE STUDY

INTRODUCTION &amp; AIMS Elite athletes regularly incorporate training at altitude into their programs to enhance performance. However, the additional stress of exposure to a hypoxic environment needs to be carefully managed by coaches and sport scientists. Supplementation with antioxidants, such as N-acetylcysteine (NAC) may support the athlete’s immune system to cope with this stress. Preliminary evidence also suggests NAC may further promote haematological adaptations to hypoxia. Combined, the potential health and adaptive benefits of NAC warrant further investigation. Conducting ecologically valid and scientifically robust research in an elite sporting setting can be challenging due to small sample sizes, an inability to experimentally manipulate training, and the inherent complexity of the training environment. To account for these challenges, a comparative case study approach was used. METHODS Thirteen swimmers completed a three-week ‘Live-High, Train-High’ camp in Flagstaff, USA (elevation 2,100m). Beginning four days prior to the camp commencing, swimmers where randomly assigned in matched groups to consume NAC (1,200mg per day; n = 6) or a placebo supplement (n = 7) for 14 days. With each athlete defined as a case, fuzzy-set qualitative comparative analysis was used to examine the configurational effects of attributes (i.e., antioxidant support, sufficient ferritin, maintained body mass) previously associated with successful altitude training camps on physiological and performance outcomes. RESULTS NAC was not a solely sufficient or necessary attribute for increased haemoglobin mass. Higher consistency in haemoglobin mass was observed with high training quality. NAC and high training quality contributed to performance improvements. CONCLUSION Swimmer responses were highly individual with successful physiological and performance outcomes achieved by some, irrespective of having attributes that can impair adaptation to altitude training. Subjective training quality provided important contextual information. Fuzzy-set qualitative comparative analysis is a novel approach in sports science to evaluate the interrelationship of attributes that can impact performance.

The Changing Landscape of Treatment for Cystic Fibrosis Related Diabetes

ObjectivePatients with Cystic Fibrosis related diabetes [CFRD] are treated with insulin and high calorie diets to maintain body mass. The combined CFTR modulator elexacaftor/tezacaftor/ivacaftor [ETI] decreases pulmonary exacerbations and improves nutritional status. We reviewed the effects of ETI on BMI, HbA1c and diabetes regimen in patients with CFRD over a period of three years. MethodsData of previously CFTR-modulator-naïve patients with CFRD and pancreatic insufficiency on ETI therapy were retrieved from an electronic health record database. Patients were followed for a mean duration of 2.7 ± 0.8 years after ETI initiation. Data pertaining to weight, BMI, HbA1c and diabetes regimen were collected at 6 months, 12 months, 2 years and at 3 years post-ETI initiation. Patients were then dichotomized based on their baseline BMI into a low BMI group and an “at target” BMI group. The effects of ETI on changes in weight, BMI, A1c and diabetes regimen were compared in both groups over a period of three years. ResultsTwenty-seven patients with CFRD (15 men/12 women), age 30.6 ± 11.5 (SD) years, BMI 22.4 ± 4.0 kg/m2, were included. Fifteen patients had low BMI (<22 kg/m2 for women, <23 kg/m2 for men) and 12 patients had at target BMI (≥22 kg/m2for women, ≥BMI 23 kg/m2 for men). Patients with low BMI had an increase in their BMI from 19.5 ± 1.7 to 21.4 ± 2.2 kg/m2 at one year (p = 0.002), and 21.8 ± 1.8 kg/m2 at three years (p = 0.004) after ETI initiation. Four patients (out of 15) in the low BMI group had achieved normal BMI by the end of study follow up. There was no change in weight in the at target BMI group. HbA1c and basal insulin requirements did not change in either group. Five patients started non-insulin therapies. ConclusionBMI increased after ETI therapy in CFRD patients with low BMI, but not in those with at target BMI. The use of non-insulin therapies is increasing in CFRD and should be evaluated in future studies.

Lessons learned from using wild-caught and captive-reared lesser scaup (Aythya affinis) in captive experiments.

Waterfowl are housed in captivity for research studies that are infeasible in the wild. Accommodating the unique requirements of semi-aquatic species in captivity while meeting experimental design criteria for research questions can be challenging and may have unknown effects on animal health. Thus, testing and standardizing best husbandry and care practices for waterfowl is necessary to facilitate proper husbandry and humane care while ensuring reliable and repeatable research results. To inform husbandry practices for captive-reared and wild-caught lesser scaup (Aythya affinis; hereafter, scaup), we assessed body mass and fat composition across two different aspects of husbandry, source population (captive-reared or wild caught), and housing densities (birds/m2). Our results suggest that housing scaup at low densities (≤0.6 m2/bird, P = 0.049) relative to other species can minimize negative health effects. Captive-reared scaup were heavier (P = 0.027) with greater body fat (P < 0.001) and exhibited fewer signs of stress during handling than wild-caught scaup. In our experience, scaup which are captive-reared from eggs collected in the wild were better for long-term captivity studies as they maintained body mass between and recovered lost body mass following trials. Researchers would benefit from carefully evaluating the tradeoffs of using short- and long-term captive methods on their research question before designing projects, husbandry practices, and housing facilities for waterfowl.

Association of body mass index with dietary intake and self-care health activities of mothers after postpartum: A mixed-method research in Chennai City, India

Background: Overweight and obesity have become serious health problems worldwide, with more than 1.5 billion adults classified as overweight according to the World Health Organization in 2020. Getting overweight after the gestational period is a common phenomenon and getting back to prepregnancy weight is a major challenging concern for mothers. This study aimed to explain the importance of maintaining body mass index (BMI) and evaluate the association of BMI with dietary intake and self-care health behaviors among mothers after the postpartum period. Methods: A mixed-method study was conducted among mothers after the postpartum period having children aged 2 to 10 years old. The current study was performed on a total of 17 mothers who were referred to comprehensive health service centers in Chennai city, Tamil Nadu, India. They were purposefully selected according to the inclusion criteria. Data were collected through face-to-face interviews and analyzed using SPSS software for testing the significance of the P value. Results: The majority of mothers (88.23%) were in the category of overweight and obese. The mean age of mothers was 26.53 ± 5.21 years. BMI was strongly associated with the dietary intake of mothers, hindrance in dietary intake of mothers, and self-care activities of mothers since the P-value was &lt;0.01 level of significance. Conclusion: This study reveals that the BMI of mothers has increased compared to prepregnancy. The adherence to the balanced dietary and self-care activity was very low. It is critically important to pay more attention to how individual, organizational, and societal interventions might assist mothers in attaining the target level of BMI.

Effect of live-storage period and temperature on oxygen consumption rate in the cold-water sea cucumber Parastichopus tremulus

Sea cucumbers are of great significance in marine ecosystems all over the world. The red sea cucumber Parastichopus tremulus is also considered commercially interesting but very little information is available on its ecology and physiology. This study aimed at investigating this North Atlantic species` oxygen demand in relation to live-storage period and temperature in an attempt to deliver some physiological puzzle pieces useful in a potential aquacultural context. Oxygen consumption rate (OCR) was measured in P. tremulus stored in a flow-through system for up to one year, and in recirculation systems at different temperatures (4, 8 and 12°C) for up to four weeks. Throughout the experimental period, biometric data were collected from the different treatment groups and a condition index (CI) calculated. The results showed that long-term storage affected OCR and CI, which increased and decreased with time, respectively. Storage at 4°C resulted in significantly lower OCR and higher CI compared to 8 and 12°C after four weeks, suggesting that 4°C may be best for maintaining body mass during short-term storage, whereas storage at 8 and 12°C may require supplementary feeding to avoid biomass loss. Data presented in this study may be useful for a range of applications, for example in a prospective aquaculture setting, for optimizing live seafood storage, but also for impact assessment and management of wild stocks.

Lean and Heavy Women May Not Use Energy from Alcohol with Equal Efficiency

To assess whether energy from alcohol is efficiently utilized to maintain body mass, we examined changes in energy intake of young women when they drank alcohol. The women ate controlled diets typical of the American diet with regard to macronutrients. Body weights were controlled to within 1 kg of entry level weights. The subjects were given alcohol (30 g/d) and no alcohol treatments for 3 mo each in a crossover design. The treatments were isoenergetic; for the no alcohol treatment alcohol energy was replaced with energy from carbohydrate. The average change in energy intake associated with the alcohol treatment was negligible when all subjects were considered collectively. There was, however, a divergence in response between lean and heavy subjects. Fifteen women required, on average, an additional 886 ± 147 (mean ± SEM) kJ/d to maintain body weight during the alcohol treatment, and these women were leaner (body mass index 22.6 ± 0.8 kg/m2 vs. 25.2 ± 1.0, P < 0.05) than the 22 women who required, on average, 559 ± 139 fewer kJ/d when on the alcohol treatment. This study suggests that all subjects do not use energy from alcohol with equal efficiency.

Acute stress and restricted diet reduce bill-mediated heat dissipation in the song sparrow (Melospiza melodia): implications for optimal thermoregulation.

We used thermal imaging to show that two environmental factors - acute stress and diet - influence thermoregulatory performance of a known thermal window, the avian bill. The bill plays important roles in thermoregulation and water balance. Given that heat loss through the bill is adjustable through vasoconstriction and vasodilation, and acute stress can cause vasoconstriction in peripheral body surfaces, we hypothesized that stress may influence the bill's role as a thermal window. We further hypothesized that diet influences heat dissipation from the bill, given that body condition influences the surface temperature of another body region (the eye region). We measured the surface temperature of the bills of song sparrows (Melospiza melodia) before, during and after handling by an observer at 37°C ambient temperature. We fed five birds a restricted diet intended to maintain body mass typical of wild birds, and we fed six birds an unrestricted diet for 5months prior to experiments. Acute stress caused a decrease in the surface temperature of the bill, resulting in a 32.4% decrease in heat dissipation immediately following acute stress, before recovering over approximately 2.3 min. The initial reduction and subsequent recovery provide partial support for the hemoprotective and thermoprotective hypotheses, which predict a reduction or increase in peripheral blood flow, respectively. Birds with unrestricted diets had larger bills and dissipated more heat, indicating that diet and body condition influence bill-mediated heat dissipation and thermoregulation. These results indicate that stress-induced vascular changes and diet can influence mechanisms of heat loss and potentially inhibit optimal thermoregulation.

Magnitude and Severity of Depression and Associated Factors Among Hypertensive Patients Attending Follow-up Treatment at Public Hospitals of Hadiya Zone, Ethiopia.

Co-morbid depression in hypertension leads to non-adherence to anti-hypertensive treatment. To assess the magnitude and severity of depression and associated factors among hypertensive patients attending follow-up treatment at public hospitals of Hadiya zone, Ethiopia, 2022. Hospital-based cross-sectional study was conducted from January 1, to January 31, 2022. The total sample size was 315 and used a systematic random sampling technique. Data were collected through a face-to-face interview. Data were entered using Epi-data Version 4.6 and exported to SPSS Version 25 for analysis. The goodness-of-fit test was done. Binary logistic regression was done, and variables with a p-value of < .25 in the bivariable analysis were taken into the multivariable analysis. Statistically significant was declared at a p-value of < .05 with an adjusted odds ratio and 95% confidence interval. The magnitude of depression among hypertensive patients was 37.1% (95% CI 31.7-43.9). Regarding the severity, 56.1% had no depression, 6.7% had mild, 17.3% had moderate, 14.7% had moderately severe, and 5.1% had severe depression. Body mass index: 19.12-24.9 kg/m2 [AOR 0.06, 95% CI: 0.02-0.23], body mass index: 25-29.9 kg/m2 [AOR 0.08, 95% CI: 0.02-0.35], absence of family history hypertension [AOR 0.39, 95% CI: 0.18-0.85], presence of co-morbidity [AOR 2.43, 95% CI: 1.34-4.42), low perceived stress scale [AOR 0.07, 95% CI: 0.01-0.56], low medication adherence [AOR 2.70, 95% CI: 1.17-6.24], and moderate medication adherence [AOR 0.29, 95% CI: 0.09-0.88] were significantly associated. About four in 10 hypertensive patients attending follow-up treatment were depressed. The mean score of severity of depression was mild. Body mass index, family history of hypertension, co-morbidity, perceived stress scale, and medication adherence were significantly associated with depression. Therefore, maintaining body mass index, screening and treating co-morbid illness, accommodating stress, and educating about medication adherence might minimize the risk of depression.

Simultaneous SGLT2 inhibition and caloric restriction improves insulin resistance and kidney function in OLETF rats

SGLT2 inhibitors (SGLT2i) are emerging as a novel therapy for type 2 diabetes due to their effective hypoglycemic and potential cardio- and nephroprotective effects, while caloric restriction (CR) is a common behavioral modification to improve adiposity and insulin resistance. Therefore, both interventions simultaneously may potentially further improve metabolic syndrome by enhancing carbohydrate metabolism. To test this hypothesis, cohorts of 10-week old, male Long Evans Tokushima Otsuka (LETO) and Otsuka Long Evans Tokushima Fatty (OLETF) rats were treated with SGLT2i (10 mg luseoglifozin/kg/day x 4 wks) (OLETF only) and/or 30% CR (2 wks at 12 weeks of age). CR maintained body mass in both strains while SGLT2i alone did not have any effect on body mass. Simultaneous treatments decreased SBP in OLETF vs SGLT2i alone, decreased insulin resistance index (IRI), and increased creatinine clearance vs OLETF ad lib. Conversely, CR decreased albuminuria independent of SGLT2i. In conclusion, SGLT2i treatment by itself did not elicit significant improvements in insulin resistance, kidney function or blood pressure. However, when combined with CR, these changes where more profound than with CR alone without inducing chronic hypoglycemia.

Weight History Association With Current Cardiorespiratory And Muscular Fitness

High cardiorespiratory and muscular fitness are often associated with lower body fat mass. Age-associated increases in body mass might be attenuated by maintaining a higher level of fitness into middle-age. PURPOSE: This study aimed to compare the cardiorespiratory and muscular fitness of individuals who have maintained body mass during adulthood to those who have had substantial increases and/or decreases in body mass in adulthood. METHODS: Obese, overweight, and non-obese adults were recruited to participate. Long-term health and weight history was collected retrospectively on 79 individuals. Total body composition, maximal oxygen consumption, grip strength, and maximal isometric knee extension strength were measured. Participants were subsequently categorized based on short term and long-term weight loss history, cardiorespiratory fitness, and muscle function for further analysis. RESULTS: Participants (31 Male, 45 female, aged 41.0 ± 12.3 years) were 29.2 ± 10.1% body fat having gained 9.3 ± 11.7 kg since 20 years of age. Current cardiorespiratory fitness as indicated by relative maximal oxygen consumption was 36.6 ± 12.0 ml*kg-1*min-1. No significant relationship existed between weight gain since age 20 and current cardiorespiratory fitness (r = -0.12). No differences in weight history were observed after classification of participants into high vs. low cardiorespiratory fitness nor high vs. low muscular fitness. CONCLUSIONS: Current cardiorespiratory and muscular fitness are independent of past body weight history. Despite the limitations of retrospective analysis of weight history and inability to determine previous levels of fitness, these results imply that high fitness might not be protective against age-associated body mass increases, but also that low fitness might not destine an individual to larger than normal gains in body mass

Staying cool and eating junk: Influence of heat dissipation and anthropogenic food on foraging and body condition in an urban passerine

Climate change and urbanization are two of the most important current global change drivers. However, most studies have focused on these issues in isolation, limiting our ability to predict the impacts of the two in tandem. During hot conditions, many birds reduce foraging activity to minimise heat gain, which can result in costly trade-offs, affecting their ability to maintain body mass. In urban environments however, higher anthropogenic food or water availability could buffer individuals from these potential costs. In this study, we explore the impacts of air temperature on the foraging behaviour and body mass of an urban passerine, the Red-winged Starling, Onychognathus morio in Cape Town, South Africa. In our study system (a university campus), anthropogenic food abundance fluctuates over short timescales, with food being more abundant on weekdays and less abundant on weekends. This system allows us to explore how birds respond to elevated temperatures during days of varying availability of anthropogenic food. We found that individuals increased heat dissipation behaviours with temperature, leading to an apparent trade-off between foraging and heat dissipation. However, despite reduced foraging time, starlings were able to maintain constant food intake rate and body mass with rising temperatures irrespective of the short-term food fluctuations. This suggests that overall food and water abundance in this urban environment buffered individuals from the effects of elevated air temperature, at least within the current range experienced in this system and outside of the breeding season.

Çocukluk Çağı Obezitesinde Fizyoterapi ve Rehabilitasyon

Çocukluk çağı obezitesi, beslenme değişiklikleri ve fiziksel inaktiviteye bağlı olarak ortaya çıkan, prevalansı gittikçe artan ciddi bir problemdir. Çocukluk çağında obezitenin neden olduğu kardiyorespiratuar ve metabolik hastalıklar yetişkinlik dönemi için de büyük tehlike oluşturmaktadır. Çocuklarda fiziksel aktivitenin azalmasıyla, aşırı kilo veya obezite ihtimali daha da artmaktadır. Fiziksel aktivitenin sürdürülmesi, doğru beslenme ve uykunun düzenlenmesi ile çocukluk çağı obezitesine yönelik koruyucu rehabilitasyon sağlanmaktadır. Doğru beslenme için, besin değeri düşük, yüksek kalorili yiyecekler yerine sebze ve meyve gibi lifli gıdaların tercih edilmesi gerekmektedir. Çocuklarda kaliteli uyku beden kitle indeksinin korunması ve obezitenin önlenmesinde büyük bir yardımcıdır. Düzenli fiziksel aktivitenin çocuklarda kemik gelişimi ve kilo kontrolünü sağladığı bilinmektedir. Çocukluk çağında yapılan düzenli egzersiz vücut kompozisyonun geliştirilmesi ve kardiyometabolik sağlığın sürdürülmesini sağlamaktadır. Çocuklara egzersiz alışkanlığının kazandırılması ve okulda yapılabilecek çeşitli egzersizlerle fiziksel aktivitenin artırılması hedeflenmektedir. Bu derlemenin amacı çocuklar için önerilebilecek alternatif egzersizler olan aerobik egzersizler, pilates, yoga, yüksek yoğunluklu aralıklı antrenman (HIIT) ve sanal gerçeklik uygulamalarını incelemektir.

Epidemiological evidence relating risk factors to chronic obstructive pulmonary disease in China: A systematic review and meta-analysis.

Chronic obstructive pulmonary disease (COPD), the most common chronic respiratory disease worldwide, not only leads to the decline of pulmonary function and quality of life consecutively, but also has become a major economic burden on individuals, families, and society in China. The purpose of this meta-analysis was to explore the risk factors for developing COPD in the Chinese population that resides in China and to provide a theoretical basis for the early prevention of COPD. A total of 2457 cross-sectional, case-control, and cohort studies published related to risk factors for COPD in China were searched. Based on the inclusion and exclusion criteria, 20 articles were selected. Stata 11.0 was used for meta-analysis. After merging the data, the pooled effect and 95% confidence intervals (CIs) were calculated to assess the association between risk factors and COPD. Heterogeneity between studies was assessed using I2 and Cochran's Q tests. Begg's test was used to assess publication bias. Exposure to particulate matter less than 2.5 μm in diameter (PM2.5) (pooled effect = 1.73; 95%CI: 1.16~2.58; P <0.01), smoking history (pooled effect = 2.58; 95%CI: 2.00~3.32; P <0.01), passive smoking history (pooled effect = 1.39; 95%CI: 1.03~1.87; P = 0.03), male sex(pooled effect = 1.70; 95%CI: 1.31~2.22; P <0.01), body mass index (BMI) <18.5 kg/m2 (pooled effect = 1.73; 95%CI: 1.32~2.25; P <0.01), exposure to biomass burning emissions (pooled effect = 1.65; 95%CI: 1.32~2.06; P <0.01), childhood respiratory infections (pooled effect = 3.44; 95%CI: 1.33~8.90; P = 0.01), residence (pooled effect = 1.24; 95%CI: 1.09~1.42; P <0.01), and a family history of respiratory diseases (pooled effect = 2.04; 95%CI: 1.53~2.71; P <0.01) were risk factors for COPD in the Chinese population. Early prevention of COPD could be accomplished by quitting smoking, reducing exposure to air pollutants and biomass burning emissions, maintaining body mass index between 18.5 kg/m2 and 28 kg/m2, protecting children from respiratory infections, adopting active treatments to children with respiratory diseases, and conducting regular screening for those with family history of respiratory diseases.

Mule deer do more with less: comparing their nutritional requirements and tolerances with white-tailed deer

Abstract Congeneric species often share ecological niche space resulting in competitive interactions that either limit co-occurrence or lead to niche partitioning. Differences in fundamental nutritional niches mediated through character displacement or isolation during evolution are potential mechanisms that could explain overlapping distribution patterns of congenerics. We directly compared nutritional requirements and tolerances that influence the fundamental niche of mule (Odocoileus hemionus) and white-tailed deer (O. virginianus), which occur in allopatry and sympatry in similar realized ecological niches across their ranges in North America. Digestible energy and protein requirements and tolerances for plant fiber and plant secondary metabolites (PSMs) of both deer species were quantified using in vivo digestion and intake tolerance trials with six diets ranging in content of fiber, protein, and PSMs using tractable deer raised under identical conditions in captivity. We found that compared with white-tailed deer, mule deer required 54% less digestible protein and 21% less digestible energy intake per day to maintain body mass and nitrogen balance. In addition, they had higher fiber, energy, and dry matter digestibility and produced glucuronic acid (a byproduct of PSM detoxification) at a slower rate when consuming the monoterpene α-pinene. The mule deers’ enhanced physiological abilities to cope with low-quality, chemically defended forages relative to white-tailed deer might minimize potential competitive interactions in shared landscapes and provide a modest advantage to mule deer in habitats dominated by low-quality forages.

Dietary approaches in management of noncommunicable diseases

The prevalence of noncommunicable diseases (NCDs) has increased drastically over recent decades, with 41 million deaths each year, equivalent to 71% of all deaths globally. Unhealthy food choices and food habits, excessive calories, and inactivity are apparent factors to NCDs, namely obesity, diabetes mellitus, cancer, and cardiovascular disease. Healthy dietary intake and calorie restrictions have a promising effect on longevity. Eventually, adopting these strategies may delay the onset and decrease the burden of NCDs. Recent findings proved that nutrition has a strong association with the prevalence of NCDs. American Institute for Cancer Research and the World Cancer Research Fund says 30%–40% of cancers are preventable by adopting healthy food choices, dietary restrictions, engaging in physical activity, and maintaining body mass index. This review focuses on dietary intake and dietary restrictions and finally leads to understand the vital role of gut microbiome in managing NCDs.

FKBP5 expression is related to HPA flexibility and the capacity to cope with stressors in female and male house sparrows

The hypothalamic-pituitary-adrenal (HPA) axis and its end products, the glucocorticoids, are critical to responding appropriately to stressors. Subsequently, many studies have sought relationships between glucocorticoids and measures of health or fitness, but such relationships are at best highly context dependent. Recently, some endocrinologists have started to suggest that a focus on HPA flexibility, the ability of an individual to mount appropriate responses to different stressors, could be useful. Here, we tested the hypothesis that expression of FKBP5, a cochaperone in the glucocorticoid receptor complex, is a simple and reliable proxy of HPA flexibility in a wild songbird, the house sparrow (Passer domesticus). We quantified HPA flexibility in a novel way, using guidance from research on heart rhythm regulation. As predicted, we found that adult sparrows with low stress-induced FKBP5 expression in the hypothalamus exhibited high HPA flexibility. Moreover, low FKBP5 expression was associated with greater exploratory disposition and were better at maintaining body mass under stressful conditions. Altogether, these results suggest that FKBP5 may be important in the regulation of HPA flexibility, potentially affecting how individuals cope with natural and anthropogenic adversity.

Performance and Health Decrements Associated With Relative Energy Deficiency in Sport for Division I Women Athletes During a Collegiate Cross-Country Season: A Case Series.

The purpose of this case series was to evaluate the presence of low Energy Availability (EA) and its impact on components of Relative Energy Deficiency in Sport (RED-S) in a population of female collegiate runners. Seven female NCAA Division I athletes (age: 22.3 ± 1.5 yrs; height: 169.7 ± 5.7 cm; weight: 58.3 ± 4.1 kg) were tracked from August until February, covering the beginning (Pre XC), end (Post XC) of their competitive cross country season, and beginning of the following track season (Pre Track). The athletes were assessed for female athlete triad (Triad) risk, energy availability, body composition, resting metabolic rate (RMR), nutritional intake, and blood markers (including vitamin D, ferritin, and triiodothyronine (T3)). From Pre XC to Post XC there were no significant differences in body mass, fat free mass or body fat percentage. At Pre XC, mean EA was 31.6 ± 13.3 kcal/kg FFM∙d-1. From Post XC to Pre Track, there was a significant increase in body mass (59.1 ± 5.1 to 60.6 ± 5.7 kg, p<0.001,d=0.27). From Post XC to Pre Track, there was a significant increase in RMR (1466 ± 123.6 to 1614.6 ± 89.1 kcal·d-1, p<0.001,d=2.6). For 25(OH) vitamin D, there was a significant reduction from Pre XC to Post XC (44.1 ± 10.6 vs 39.5 ± 12.2 ng·mL-1, p=0.047,d=-0.4), and a significant increase from Post XC to Pre Track (39.5 ± 12.2 vs. 48.1 ± 10.4 ng·mL-1, p=0.014,d=0.75). For ferritin, there was a trend towards a decrease from Pre XC to Post XC (24.2 ± 13.2 vs. 15.7 ± 8.8 ng·mL-1, p=0.07, d=-0.75), as well as a trend toward an increase from Post XC to Pre Track (15.7 ± 8.8 vs. 34.1 ± 18.0 ng·mL-1, p=0.08, d=1.3). No differences in T3 were observed across time points. Average Triad risk score was 2.3 ± 1.4. Notably, 5 of 7 athletes met criteria for moderate risk. Despite many athletes meeting criteria for low EA and having elevated Triad risk assessment scores, most were able to maintain body mass and RMR. One athlete suffered severe performance decline and a reduced RMR. Surprisingly, she was the only athlete above the recommended value for ferritin. Following increased nutritional intake and reduced training volume, her performance and RMR recovered. Changes in body mass and body composition were not indicative of the presence of other concerns associated with RED-S. This exploratory work serves as a guide for future, larger studies for tracking athletes, using RMR and nutritional biomarkers to assess RED-S.

Five-Year Change in Body Mass Index Predicts Conversion to Mild Cognitive Impairment or Dementia Only in APOE ɛ4 Allele Carriers.

Body mass index (BMI) has been identified as an important modifiable lifestyle risk factor for dementia, but less is known about how BMI might interact with Apolipoprotein E ɛ4 (APOE ɛ4) carrier status to predict conversion to mild cognitive impairment (MCI) and dementia. The aim of this study was to investigate the interaction between APOE ɛ4 status and baseline (bBMI) and five-year BMI change (ΔBMI) on conversion to MCI or dementia in initially cognitively healthy older adults. The associations between bBMI, ΔBMI, APOE ɛ4 status, and conversion to MCI or dementia were investigated among 1,289 cognitively healthy elders from the National Alzheimer's Coordinating Center (NACC) database. After five years, significantly more carriers (30.6%) converted to MCI or dementia than noncarriers (17.6%), p < 0.001, OR = 2.06. Neither bBMI (OR = 0.99, 95%CI = 0.96-1.02) nor the bBMI by APOE interaction (OR = 1.02, 95%CI = 0.96-1.08) predicted conversion. Although ΔBMI also did not significantly predict conversion (OR = 0.90, 95%CI = 0.78-1.04), the interaction between ΔBMI and carrier status was significant (OR = 0.72, 95%CI = 0.53-0.98). For carriers only, each one-unit decline in BMI over five years was associated with a 27%increase in the odds of conversion (OR = 0.73, 95%CI = 0.57-0.94). A decline in BMI over five years, but not bBMI, was strongly associated with conversion to MCI or dementia only for APOE ɛ4 carriers. Interventions and behaviors aimed at maintaining body mass may be important for long term cognitive health in older adults at genetic risk for AD.